Ichiza "Torcida": imiyalelo ukusetyenziswa, inkcazo, ukwakhiwa kunye nohlaziyo. "Torcida": imiyalelo zokusetyenziswa (tablets)

Kwiminyaka yakutshanje, oogqirha mihla nalapha ngaphakatyhi baqalisa ukumisela ukuba izigulane zabo eli chiza njenge "Torcida". Imiyalelo yokusebenzisa kuquka kuphela idatha ezingundoqo ezifunekayo ukuze umntu eqhelekileyo ezithatha ichiza, kodwa ke ngaphambi kokuba uthenge okanye emva ukufunyanwa ukuzama ukufunda inkcazelo engakumbi malunga esisixhobo.

pharmacodynamics

Le ichiza a saluretic. Kuyinto linoxanduva feedback inhibition reabsorption sezintso sodium kunye chloride ion, nto leyo ibekwe ukwenyuka inxalenye bomgaqo Henle, nto leyo eliboniswe ukuba ichiza "torsida" umyalelo manual.

Pharmacokinetics

Le ndoda, emva ulawulo efakwa yemali ngokukhawuleza iqala ukubonisa isiphumo umchamo. Kulo mzekelo isiphumo umda beziyobisi kuphuhliswa kwisithuba seeyure ezi-3 yaye kamva zigcinwa de iiyure ezili-12. Kwisiqalo lesi sicelo kuthetha diuresis ixhomekeke ngqo kwi idosi, nto leyo nalo lwabonisa ukuba ichiza "torsida" umyalelo manual.

Torasemide degree of iyabophelela kwiiproteni plasma kutsho kuma-99%, nto leyo nemiphumo emihle kakhulu, lo gama metabolites M1, M3 kunye M5 ezinxibelelene ngokulandelelana kwi 86,95 no-97%. Ubuninzi ukususwa kunokwenzeka isiqingatha-ubomi torasemide kunye metabolites zayo ezahlukeneyo enempilo wafunda, ukusukela iiyure ezintathu ukuya kwezine, nto leyo ithe yaphawulwa ngo ekuhambeni yolingo lwezonyango.

kugqitywe Iyonke osisiqu imalunga 40 ml / min., gama ireyithi sezintso imvume malunga 10 ml / imiz. Metabolite M5 uvelisa akukho isiphumo umchamo, lo gama zidityaniswe metabolites M3 kunye M1 emalunga nama-10% yezenzo pharmacodynamic bafakela emzimbeni womntu.

Iimpawu beziyobisi abantu zizifo ezahlukahlukeneyo

Ukuba isigulane kutyhilwa ukusilela kwezintso, ayichaphazeli yonke intsebenzo yeli zavunyelwa kunye nesiqingatha-ubomi torasemide, ngelixa sisenyusa ixesha metabolites M5 M3. Ngelo xesha zigcinwa ngokupheleleyo iimpawu pharmacodynamic ekuqaleni, kodwa ixesha amanyathelo iziyobisi ukusilela kwezintso kwakhona lungenasiphumo, kungakhathaliseki nobungozi besi sifo.

Ngaloo izigulane abafumana isibindi kwekhono, okanye ukusilela intliziyo, izihlandlo eziliqela ukwanda metabolite kukhuthaza torasemide kunye M5, okuboniswe ukuba ichiza "Torcida" umyalelo manual.

Isixa kweziyobisi imveliso umchamo phantse ngokupheleleyo ekwafanekisa le mali ukuba iqatshelwe lamavolontiye asempilweni, ngokunxulumene ngayo yena torasemide kunye metabolites yayo ntoni cumulate.

ubungqina

Kwiimeko ezininzi, iziyobisi nenzuzo esebenzayo anikwa oogqirha unyango exudates ezahlukeneyo okanye nokudumba ukubonakala ngokunxulumene ukusilela ngentliziyo. Kufuneka kuqatshelwe ukuba ichiza "Torcida" imiyalelo zokusetyenziswa (tablets) lubonisa ukuba emiselweyo, ukuba kuyimfuneko, uthomalaliso eqhelekileyo.

Izimo

Kukho ezinye iimeko apho ukusetyenziswa kwale ichiza a non-ekucetyiswa okanye akuvumelekanga ngokupheleleyo. Azichazayo sinamathele ichiza "Torcida" imiyalelo zokusetyenziswa (tablets - ingqalelo uhlobo), kukunikezela ezithile ezingundoqo:

• ubukho kwezigulane umfutho hypotension;
• uvakalelo kakhulu ukuba izinto abangabancedani okanye esebenzayo ezahlukeneyo, kwakunye nezinye sulfonylureas;
• akukhuthazwa ukuba izigulana ukusilela kwezintso kunye anuria;
• kunye nemisebenzi kakhulu isibindi;
• zonke iintlobo kwephulwa inkqubo balance lwamanzi-electrolyte;
• sifo;
• ukuba isigulane abaneengxaki kakhulu kwinkqubo womchamo;
• zonke iintlobo ukunyhashwa inkqubo degree eliphezulu conductive intliziyo;
• utshintsho yezifo emfanekisweni jikelele igazi acid-noseko ubume yomntu;
• yokuphazamiseka ukusebenza izintso olubangelwa izilonda nephrotoxic kwezinto ezahlukeneyo.

Phakathi kwezinye izinto, ayikhuthazwa tu into yokuba ukusebenzisa esi sixhobo for abafazi bahlale ngexesha ekhulelwe okanye zisanyisa.

isetyenziswa njani na?

Ukuba usebenzisa ifomu ulwelo, i-arhente kufuneka ufakwe yegazi kuphela ngokucotha, njengoko oko kungqinwa ichiza "Torcida" umyalelo manual. Ixabiso zesixhobo (ukusuka engange ezingamakhulu amahlanu) yinto efikelelekayo ngokufanelekileyo ke ngoko abantu abaninzi kungabikho ngxaki ukuze kuthotyelwe ngokufanelekileyo kunye okukhomba ukuba ukusetyenziswa kwayo.

umthamo Initial enye imalunga-10 mg ngosuku, ngamanye 2 ml la malungiselelo. Ukuba kukho inzuzo encinane lwezonyango, ngoko ithamo angandiswa kabini. Kodwa ke ukuba akukho lula ukuphumeza ukusebenza ngendlela eyiyo, ngoko ke ithamo angandiswa nokuba kabini, kodwa ke unyango kufuneka zihlale ubuninzi iintsuku ezintathu.

nokudumba Acute pulmonary

Xa usebenzisa le arhente ayiphilise nokudumba etsolo pulmonary, ithamo yokuqala yi-20 mg, ngoxa kuxhomekeke umfanekiso bezonyango le idosi ogcweleyo maliqhutywe yonke seyure. Kufuneka kuqatshelwe ukuba unyango enjalo idiphu iyonke mayingabi ngaphezu 100 nganye torsemide ngosuku.

Kuba unyango olulandela-up Kucetyiswa njengendlela iveki ngaphezu kokuba, nayo ephawula ukuba ichiza "Torcida" imiyalelo zokusetyenziswa zingasetyenziswa ukutshintshela ulawulo ngomlomo kufuneka ingasetyenziswa efakwa. Price (reviews ukuliqinisekisa) njenge elucwecweni unabo, into engamanzi ifikeleleka ezininzi, ngoko ke ikhosi epheleleyo yonyango azifane kubangela na ubunzima. Kuyo nayiphi na imeko, idosi iphezulu enokwenzeka yemihla ngemihla ukuba ngaphezu kwe-100 mg.

ukusilela hepatic

Kwimeko iindlela izigulane ongaboniyo hepatic kufuneka ulisebenzise ngobulumko eliphezulu, njengokuba kulo mzekelo kukho ingozi eyandileyo lamanani torasemide kwi ekwakhiweni plasma yegazi. Ziphawuleka ngokwahlukeneyo ukuba ichiza "torsida" (10 mg) kule yesikhokelo (tablet okanye ukulungiselela ifomu elulwelo - ezingabalulekanga).

abadala

Kuba unyango kwezi zigulane akuthethi ukunika indlela ngamnye nokukhetha idosi. Kubalulekile ukuphawula ukuba akukho izifundo eziphambili lwezonyango kwi luthelekiso neenkqubo zonyango ulutsha kunye nabantu abadala singàphunyezwa, ngoko ke kungcono ukuba uthethwano kunye ugqirha pre-abafanelekayo.

A Isisombululo isitofu kufuneka kancinane kulawulwa yegazi, kwaye ke ngoko nayiphi kwenzeka intraarterially egxininisa ngokwahlukeneyo kwi "torsida" imiyalelo iziyobisi zokusetyenziswa (ampoules).

imiphumela emibi

Kubalulekile ukuphawula ukuba la abasabela ezibi kungachaphazela indlela amalungu ezahlukeneyo, ngoko kwimeko nganye iya kuqwalaselwa ngokwahlukeneyo:

• nemithambo yegazi. Kulo mzekelo, lo gama ezithatha ichiza unokuba neengxaki ezikhoyo ezahlukeneyo eseleyo fluid kunye electrolyte, ngoxa kwiimeko ezithile enqabileyo sagxininisa alkalosis metabolic. Ukongeza, iindidi ezithile izigulane ukuphuhlisa isiphithiphithi, thrombosis, hypotension, ischemia ebuchotsheni kunye kwentliziyo, iposi etsolo engabalulekanga, angina kunye syncope.
• Luvo. Kwiimeko ezinqabe kakhulu, ingakumbi ngexesha kumabakala okuqala onyango, kusenokubakho intloko ebuhlungu, ukudinwa ngokugqithiseleyo, isiyezi, kunye amahlaba kwezihlunu.
• Le nkqubo yokwetyisa. Kwiimeko ezinqabe kakhulu, ukuze babe neengxaki akhoyo yenkqubo zokwetyisa inkqubo yendlela ukusebenzisa amayeza "Torcida". Imiyalelo yokusebenzisa uthi iziphumo ilandelayo ecaleni: isicaphucaphu, ukungabi namdla wokutya, ukugabha, urhudo, iintlungu esiswini. Kusenokwenzeka ukuba amazinga aphezulu ngokugqithiseleyo enqanda hepatic.
• Le nkqubo womchamo. Izigulane abafumana ukuphazamiseka ezahlukeneyo kwinkqubo ukuchama, kukho ukuchama noko kakhulu, nto leyo ekugqibeleni kukhokelela ukuba yokulibazisa Yolule bebomelele isinye. Kwiimeko ezinqabe kakhulu, ukuze simise izinga zokuzicingela creatinine kunye urea egazini.
• Lokugaya. Kwiimeko ezinqabe kakhulu, izigulane abhalwe ukunyuka kumanqanaba uric acid, lipids kunye iswekile egazini.
• kwinkqubo yegazi. Kwiimeko ezinqabe kakhulu, kunciphise inani elipheleleyo erythrocytes, leukocytes neeplatelets.
• Amajoni omzimba. Kwiimeko ezinqabe kakhulu, nerhashalala, photosensitivity, pruritus. Ngu "torsida" drug (inaliti) imiyalelo ukusetyenziswa ebonisa ukuba kwezinye iimeko emva ulawulo efakwa zingaqalisa ukuphuhlisa reactions hypersensitivity etsolo, apho isigulane kakhulu uncedo ngokukhawuleza kufuneka lubonelelwe. Kwiimeko ezithile, usenokuba iintshukumo eziqatha ulusu.

Ukuba sithethe malunga nefuthe kangako, lo paraesthesia ezinqabileyo, kwaye umlomo owomileyo. Ukongeza, ingqalelo ekhethekileyo kufuneka ihlawulwe yokuba kwiimeko ezinqabileyo kakhulu ebantwini kukho ongaboniyo, kwakunye ukuvela ukuduma, okanye ilahleko ngokupheleleyo kwetyala.

libanda

iimpawu eziye kwiimeko libanda, amachiza mzuzu akaziwa. Manual ibonisa ukuba xa kuthe kwakho libanda, ukuze abekhona diuresis namandla ngokwaneleyo, kwaye umngcipheko ukulahlekelwa of electrolytes kunye namanzi, ukozela kunye amential syndrome. Phakathi kwezinye izinto, i-libanda, kwenzeka ukusilela sentliziyo, hypotension kunye zezigulo ezahlukeneyo lokugaya.

Indlela yokuphatha?

Naliphi na iyeza ngqo mzuzu khange ibonakalisiwe, ingeyiyo eyomthetho. Kwiimeko ezininzi, ezi mpawu evela ukunxila, unyamalale ngokupheleleyo emva nokwehliswa oyidlayo okanye ukuphelisa ngokupheleleyo ukusetyenziswa kweli chiza, kwaye ukuba electrolytes libuyisele efanelekileyo kunye ulwelo ziya kunikwa, ekufuneka wenziwe phantsi kweemeko zolawulo oluphezulu. Torasemide is akukho ndlela evela kwi igazi olugqitha esikhumbeni.

Le ulwazi olusisiseko malunga ulungiselelo "Torcida" (imiyalelo ukusetyenziswa, ixabiso, reviews). Analogs zesixhobo ( "Britomal", "Sutrilneo") kwiimeko ezininzi ezahlukeneyo intshukumo kunye imiphumela efanayo, kodwa ke indlela amagqirha rhoqo wabelwa njengomnye kakhulu ngempumelelo kwiqela layo.