Isifo Parkinson kaThixo

isifo Parkinson kaThixo (aka "Parkinson", oko "parkinsonism idiopathic", oko "parkinsonism ephambili," aka "PD", oko "Parkinsonism hypokinetic" yaye - "behlunguzela palsy") - kukho ukungasebenzi le novalo central uhlobo sisiba mandundu le nkqubo. iimpawu Motor ezihamba isifo Parkinson ezinxulumene iiseli substantia nigra ofayo off (kummandla embindini ubuchopho) ezibangela dopamine. Awu, inzululwazi yanamhlanje ayikwazi kodwa ukunika impendulo umbuzo wokuba kutheni ezi seli ngesiquphe aqale kufa. Ekuqaleni kwekhosi icace kakhulu zesi sifo iimpawu zibonakale abo ngandlel 'ithile, enxulumene intshukumo.

Iimpawu zesifo Parkinson iquka kum egubha, ngqongqo kunye iyalibala intshukumo kwaye, ngenxa yoko, kunye nentshukumo inyathelo le ngxaki. Kamva, kunye nophuhliso sifo, kusenokubakho ingxaki ekubamba kunye zokuziphatha. Kumanqanaba kamva zesi sifo izigulane laziwa ngokuba yingqondo. Ezinye iimpawu zesifo Parkinson ziquka iingxaki bubuthongo, iimvakalelo kunye sensorics. Parkinson kaThixo ixhaphake kakhulu kubantu abadala, yaye esi sifo kukuba kwiimeko ezininzi kwaphawulwa emva kweminyaka engama-50.

Lidla oogqirha xa esenza unesifo "isifo Parkinson kaThixo", nto inokongezwa kuyo okwangoku yaye igama "idiopathic", oko kukuthi, lowo ngqo, unobangela ngokukhawuleza ukuseka kunokwenzeka. Noko ke, amayeza eyaziwa iimeko ezininzi parkinsonism Nedlac apho ukuphuhlisa sifo yaba negalelo ngqo ke indlela imiba yemfuza.

Ukuza kuthi ga ngoku, izazinzulu ziye zachongwa eziliqela njengoko ethintela uphuhliso Parkinson kaThixo, kwaye igalelo kuphuhliso lwayo. Ngoko ke, umzekelo, kwaye ngokuqinisekileyo lufumanise ukuba ingozi yokuba esi sifo iintshayi ... ngezantsi. Kodwa abantu badla udibane nazo zinambuzane ezithile, phezu koko, kufuneka amathuba aphezulu yokosulelwa sisifo Parkinson kaThixo.

Pathologically esi sifo sizibonakalisa ngokuthi ukuqokelelana kwiproteni kwi kwizihlunu zomzimba, eyaziwa ngokuba alpha-synuclein. kuqokeleleka eyaziwa ngokuba "imizimba Lewy", bona ziyazibhaqekela ngaphakathi luvo lwe nigra substantia. Ukongeza, kukho nini na uphuhliso zaneleyo yemisebenzi izifo dopamine Parkinson kaThixo eveliswe yi ebuchotsheni.

imizimba Lewy i uhlobo bathe parkinsonism idiopathic. Inani iiseli eziqulethwe ukubandezeleka ebuchotsheni isifo Parkinson kaThixo, sisalathiso ngamnye, kodwa unako kunxulumana ngokona kuqatha nezifundo esi sifo ngamnye. Uxilongo isifo Parkinson kaThixo lidla isekelwe phezu iimpawu zesi sifo. iimvavanyo ezahlukeneyo neuroimaging zisetyenziswa ukuqinisekisa uxilongo.

iindlela nezolo, oluqhutywa unyango lwesifo Parkinson kaThixo, kwanele ukuba ukumelana ngempumelelo ekubonakalisweni okuqala nezifo ezichaphazela intshukumo. Nangona kunjalo, kunye nophuhliso sifo kunye elandelayo ukufa kweeseli evelisa dopamine, unyango ezinjalo ayisasebenzi kwaye ayisasebenzi. Ngaphezu koko, kuvela ingxaki izifo yesigulane, eyaziwa ngokuba "zeDyskinesia", esizibonakalisa ezixhuzuxhuzulayo ngokuzenzekelayo. Noko ke, ngokutsho iziphumo zophando zonyango emkhosini, le meko zinciphe ukutya kunye neentlobo ezithile lemisebenzi yesiqhelo. Ukongeza, kukho isiqabu kweempawu ukusebenzisa utyando nqgo kwengqondo enzulu. Le ndlela iye yaphumelela xa ukusetyenziswa nezinye iziyobisi kunye unyango musa uncedo. Noko ke, uphando olujoliswe ekufumaneni iindlela ezintsha oluthembekileyo nokunyanga izifo Parkinson kaThixo, uyaqhuba wenziwe.