"Ortanol": yintoni esiza, imiyalelo ukusetyenziswa, real

Yintoni na ichiza "Ortanol"? Ukususela oko kunceda iyeza? Iimpendulo zale mibuzo inokufumaneka ngezantsi. Ukongeza, esilishumayelayo amaxabiso imveliso wathi, Izimo zayo, analogs ndimkhulule ifomu.

Iipakethe ichiza, zayo ukwakheka, inkcazelo, uhlobo

Ukulungiselela "Ortanol" yenziwe ngohlobo ubungakanani njengezingxobo nzima № № 1 okanye 2. Oku kuthetha abe umbala omhlophe, kwakunye nombhalo «Ome 20» okanye «Ome 40 '(ngokuxhomekeke balawule). njengezingxobo Content amayeza imele zimise etyheli.

Oko kuquka amayeza "Ortanol"? Ukuphonononga lubonisa ukuba into esisiseko uthathwa ukuba omeprazole iziyobisi. Kwakhona ngayo amacandelo abangabancedani ezifana sodium croscarmellose, giproloza ephantsi endaweni, anhydrous lactose, microcrystalline kwincindi, phthalate hypromellose, povidone, polysorbate 80, talc kunye dibutyl sebacate.

Ukubunjwa yeqokobhe philisi ziquka: propylene ethers, hypromellose, butanol, carrageenan, ethanol anhydrous, shellac, potassium chloride, isopropanol anhydrous, titanium dioxide, inki inscribing kunye namanzi.

In ukuthengiswa medicament "Ortanol" (Isingxobo) ongena blister, wangumqulu oyincwadi ejolise ngqo kwiibhokisi kwikhadibhodi.

isenzo amayeza we ichiza

Yintoni i "Ortanol" (ukususela oko kunceda eli yeza, uya kufunda ngezantsi)? Ngokutsho imiyalelo, ichiza ngumqobo of pump Proton. Oku kunciphisa imveliso acid, oko kukuthi, ukucola phantsi umsebenzi we K + -H + -ATPase esiswini, okanye mandithi kwizisele zakhe Parietal. Kwakhona iibhloko Inqanaba lokugqibela le-esiswini acid secretion.

Drug "Ortanol", ixabiso yayo adweliswe ngezantsi, i prodrug. Esi sixhobo luvuliwe kwi medium asidi le tubules (secretory) iiseli Parietal. Ukongeza, lunciphisa secretion busebenza kunye carcinomas kungakhathaliseki uhlobo isivuseleli.

iimpawu Antisecretory le medicament kwenzeka phakathi kwimizuzu yokuqala 60 (ezona emva iiyure ezi-2). Inhibition we-50% ye-secretion ubuninzi kuyaqhubeka imini yonke.

A ithamo elinye ichiza ibonelela ingcinezelo olusebenzayo okukhawulezileyo nobusuku secretion emini esiswini. iphezulu ifika imini 4 unyango kunye shwaka emva kweentsuku ezintathu emva konyango.

Iipropati entshukumo zamachiza

Emva kokufumana ukulungiselelwa "Ortanol" oko ifumana ukufunxeka phezulu. Incopho lamanani omeprazole egazini waphawula emva kweeyure 0.5-3. Le bioavailability ngokupheleleyo kwesi ichiza 30-40%, kwaye uqhagamshelwano medicament kunye iiproteni zesiyilelo - 95%.

nethe Omeprazole esibindini zenze amathandathu avela pharmacologically engasebenziyo.

Kwisiqingatha ubomi ixesha iyeza ziiyure 0.5-1. Isiphumo njengoko avela yi kwizintso (70-76%) kunye kunye enyongweni (18-24%).

Abantu abanezifo sesibindi bioavailability beziyobisi yandiswa ngokubonakalayo, kwaye plasma nesiqingatha ubomi ifikelela iiyure ezi-3.

Xa izigulane ezingapheliyo zinomgutyulo isifo sezintso ehla. Oku kwenzeka ngokomlinganiselo ekuphungulweni CC.

Medicament "Ortanol": yintoni esiza?

ukulungiselela kubhekwe eboniswe ukusetyenziswa kwezi zifo zilandelayo:

• reflux esophagitis;
• imizimba isifo isilonda zesisu (kuquka ukuthintelwa iphinde);
• States hypersecretory (nezilonda ntshikilelo wa emathunjini, Zollinger-Ellison syndrome, mastocytosis systemic, polyendocrine adenomatosis);
• ukulwisana Helicobacter pylori bosulela abantu abanesifo sisilonda le wokugaya (in kunyango zidityaniswe);

• ngonyango kunye nothintelo zesisu amalungu mucosal umonakalo zibangelwa NSAID (ukhukuliseko mucosal, ukuqunjelwa, isilonda Peptic).

Siphelisa imithi ukusetyenziswa

Yintoni na ichiza Izimo uye "Ortanol" (ukusuka yintoni eyenza le sixhobo, sasinixelele ngasentla)? Ngokutsho imiyalelo, ingqalelo ichiza ayinakusetyenziswa xa:

• zisanyisa;
• ebuntwaneni;
• hypersensitivity ukuya kweziyobisi iziyobisi.

Ngononophelo ingqalelo iziyobisi ezithile ezimiselweyo ukusilela kwezintso nesibindi.

Drug "Ortanol": mazwi

Eli chiza emiselweyo ngaphakathi kuphela. is he taken nje phambi kokuba isidlo (idla ngokuba kusasa phambi kwesidlo sakusasa).

Le philisi ne ichiza kufincelwe yonke ngamanzi. Xa kunjalo, ukuba isigulane akakwazi ukusebenzisa amayeza ngokupheleleyo, imixholo yawo songanyibilikisswa imali encinane ayikho ulwelo asidi kakhulu.

Le umthamo ichiza ixhomekeke kubungqina.

Xa nezilonda 12 duodenal isilonda medicament ilawulwa kwi mg 20 kanye ngemini iiveki ezimbini. Kwimeko elimisiweyo-kwakhona ukuba emva konyaka wokuqala loloyiko epheleleyo lungenzeki, unyango kwiveki ezimbini-.

Xa isifo wenze engawevayo amayeza onyango lokuqala, le arhente Kucetyiswa ukuba athathe idosi of mg 40 kanye ngemini. Ikhosi unyango kunye eli chiza kuthi uyinikwe kwiiveki ezine.

Njengezingxobo "Ortanol" okukhomba ezithe ezidweliswe ngasentla, izilonda sisilonda esiswini ukuthatha mg 20 kanye yonke imihla iiveki ezine. Ukuba loloyiko akwenzeki emva konyaka, kwakhona elimisiweyo-unyango-veki ezine. Xa isilonda esiswini, engawevayo amayeza onyango lokuqala, iyeza Kucetyiswa ukuba athathe idosi of mg 40 kanye ngosuku (iqondo kwiiveki ezisibhozo).

Ukunqanda uphinda- Helicobacter pylori oluqhutywa kwanonyango zidityaniswe. Kulo mzekelo, i medicament ilawulwa kwi-20 mg kabini ngemini phambi nokutya (iiveki ezimbini) xa zidityaniswe ne-arhente antibacterial.

Xa reflux esophagitis ichiza Kucetyiswa ukuba basebenzise kwi-mali ka-20 mg (kanye) iiveki ezine. Ukuba le ndlela ichiza ungakuvumeli ukuba ukugqiba ezibotshwayo, isigulane emiselweyo a yesibini ikhosi (iiveki ezine). Xa unyango kakhulu reflux esophagitis esi sixhobo sidluliselwa ukuya kwiiveki ezisibhozo.

Xa hypersecretory state kugqalwa iyeza heartburn alawulwa ngamnye. Esithathwa Kucetyiswa okuba abadala yi-60 mg (kanye), kwaye ubuninzi - 120 mg.

Xa kutyunjwa ichiza ngaphezu kwama-80 mg ngosuku, yahlulelwe kwii kwizigaba eziliqela.

Xa umonakalo zesisu isifo sitho, zibangelwa NSAID, kwakunye nokuthintela philisi "Ortanol" bacebisa ukusetyenziswa ithamo of mg-20 yonke imihla, phambi kwesidlo (ngokuba lonke ixesha unyango NSAID).

Kuba abantu abadala kunye nabantu kunye nesifo kakhulu zesibindi idosi iphezulu imihla-20 mg.

Izigulana kakuhle kidney hlengiso umsebenzi idosi iyafuneka.

icala izenzakalo

Yintoni ngayo izinto ebangela iziyobisi "Ortanol"? Ukuphonononga bathi imiphumela emibi zilandelayo:

• intloko ebuhlungu, ukungaboni, isiyezi, erythema multiforme, paresthesia;
• ukozela, isicaphucaphu, incasa ukuphazamiseka, urhudo, ubuthongo, flatulence;
• kukuphazamiseka, umlomo owomileyo, ukudakumba, izifo, ukudideka kwengqondo ingathityazwa;
• Encephalopathy, gynecomastia, hepatitis, nokudumba peripheral, ukugabha, kunye photosensitivity;
• iintlungu esiswini, thrombocytopenia, ukuqhina, pancytopenia, ukwanda umsebenzi phosphatase obrak wesibindi transaminase;
• isikhumba sakho silume, umsebenzi isibindi kakuhle, buthathaka kwezihlunu, ukuyilwa cysts esiswini glandular;
• alopecia, eosinophilia, ukwanda ukubila, bronchospasm, agranulocytosis, angioedema;
• leukopenia, myalgia, ifiva, arthralgia, reactions anaphylactoid, urticaria, nephritis Embi.

side effects kwenzeka isicelo-arhente ingxelo abanomoya nezidlulayo endalweni.

amacala libanda

Xa uthatha amayeza heartburn xa isigulane alandelayo iimpawu Inokwenzeka: intloko ebuhlungu, umlomo owomileyo, tachycardia, ukozela, isicaphucaphu, ukungaboni, ukugabha, ukudideka, landa ukubila.

Phantsi kweemeko ezinjalo, unyango nomqondiso.

imithi

Kunye omeprazole nokwamkelwa landa isiqingatha ubomi kunye nokwanda yoxinaniso "Diazepam", "warfarin", "phenytoin", kwakunye namanye amachiza ukuba umzimba esibindini kunye isoenzyme CYP2C19.

Absorption kuthetha anokuphazamiseka, lo bioavailability yayo emiselwe ubumuncu yejusi esiswini (umz: "Itraconazole" "ketoconazole" esters of ampicillin "cyanocobalamin" kunye neetyuwa nentsimbi).

Le bioavailability of digoxin xa co-elawulwa kunye omeprazole linyuke-10%.

iziyobisi kujongwa iphucula isiphumo inhibitory kwisistim namanye amachiza hematopoietic.

Akukho ngokwezonyango imithi ebalulekileyo iziyobisi esesiwini, caffeine, "theophylline", "Quinidine", "propranolol", ethanol, lidocaine kunye "metoprolol" lingakulungele.

izincomo ezithile

yobubi mabangezi phambi kokuba uqale unyango kunye omeprazole. Oku kungenxa yokuba le unyango ngamachiza bunokufihla iimpawu kwaye isenokuyilibazisa ingxelo echanekileyo isifo.

Okwangoku, akukho data kwi ifuthe imali kwi ubuchule bomntu ukulawula iinkqubo ze aqhube isithuthi.

Ixabiso kunye analogue

Yimalini eli chiza anti-isilonda, njengoko "Ortanol"? Ixabiso le ichiza malunga 100-115 engange. Kuba kubathengi abaninzi, ixabiso oku kwamkelekile na.

Yintoni indawo ichiza "Ortanol"? Analogs yale ukulungiselela zithiwe thaca ngohlobo "omez", "Loseprazol", "Gaseka", "Omelika", "omeprazole".

reviews

Izimvo njengezingxobo "Ortanol" ezincomekayo ukuba kakhulu. Izigulane bathi ichiza arhente antiulcer olusebenzayo. Ngokukhawuleza ephelisa heartburn kunye nokuziva noncwino uvutha esiswini.

Iingcali zithi beziyobisi mbuzo nempembelelo entle ekuhambeni izifo wokugaya kuphela xa yokwamkela yayo iye ingonyulwa gastroenterologist. Oogqirha ingxelo ukuba zabo ukuthatha eli chiza akuvumelekanga, njengoko kunempembelelo enamandla kakhulu.

Kukho kwakhona icala ezintle olu nyango ziquka nokufumaneka kwayo kunye nendleko eziphantsi.