Cytokine therapy - ntoni na? Ukuphonononga yonyango indlela therapy Cytokine

Kangangexesha elide, uluntu luye bezama ukufumana unyango lomhlaza. amalinge amaninzi ukuyoyisa le sifo ziye zancitshiswa ku zero, kodwa uphando oluqhubekayo. Ngokomzekelo, izazinzulu ziye zafumanisa ukuba kuyaphumelela kakhulu sisifo esibi ukuthumela yonke imikhosi yamajoni omzimba. Oogqirha immunologists, oncologists njalo sisebenzela kuyo. Ngoko ke wazalwa enye iindlela ekunyangeni umhlaza - unyango Cytokine. Yintoni na, khangela olandelayo. Kunika umdla ukwazi ukuba yintoni na ezi izimvo malunga nale ndlela yonyango.

Ithemba losindiso

E Moscow, kukho isizukulwana esitsha iziko Oncology - eklinikhi ithumba zizifo kunye nonyango Cytokine. Apha, amagqirha sebenzisa ubuchule zamvanje kunyango lomhlaza. ndlela zemveli, ezifana ichemotherapy, radiotherapy notyando kwikliniki esetyenziswa kunye nonyango Cytokine. Oncologists, immunologists baye basungula indlela ekhethekileyo kunyango apho kungekho iseli esempilweni awehlelwa, kwaye umhlaza kutshatyalaliswa kunye neziphumo ebezingalindelekanga encinci. Le ndlela unyango ubizwa ngokuba "unyango Cytokine." Kuyinto ngenxa ekufundweni ithumba zizifo kwabonakala ngale ndlela eyodwa yokujongana yokugula.

Yintoni na zizifo basis ithumba?

Xa imizimba yethu thina babeka yonke imikhosi ukuze yena nako ukulwa usulelo kunye nangezilonda. Eyona Umgaqo ithumba zizifo - a ukukhuthazwa zokuzikhusela zomzimba enkenenkene nomhlaza. Oosonzuluwazi baqaphela ukuba zonke ezinezigulo sikhatshwa omzimba ephantsi kakhulu. inkqubo yomzimba yokuzikhusela yethu wenziwe:

• iiseli igazi ezahlukeneyo, izihlunu (macrophage, T-iiseli, B -kletook, iiseli dendritic , etc ...);
• izinyibiliki, nahodyaschizhsya kwisithuba intercellular, ezithwala imiyalezo evela kwiseli uye aze enze umsebenzi effector.

Emva ukufunda ngenyameko lweziphumo ziiphagocytes mononuclear, kwafunyaniswa ukuba enze indima wokhuseleko, kufuneka ukuba amandla okutsala ukwetyisa izinto kwamanye amazwe. Kwakhona, ezi seli othatha inxaxheba kwiinkqubo ezininzi omzimba emzimbeni.

In ukudumba ukusabela ziiphagocytes uncedo ekulweni nangokurhala, nikhonze zikhusela. Ezi seli bavelise protein ukuba anazo, njengoko kanti, ubuchule bokukhupha imiqondiso ukuya kwinqanaba intracellular kunye nempembelelo kwiiseli nge receptor.

Kufuneka amandla ukulwa ngamathumba ezahlukeneyo. unyango eklinikhi Cytokine kwethumba zizifo e Moscow usebenzisa le ndlela ikhethekileyo zomhlaza yokulwa. Oogqirha bakwazi ukwenza imikhosi yangaphakathi emzimbeni ukuba alwe ngamathumba. Le ndlela ibizwa ngokuba unyango Cytokine. Yintoni na, sihlolisise.

Ntoni "unyango Cytokine"?

Okokuqala, kufuneka kunokuthiwa igama indlela livela kwi cytokines iiproteni, leyo ubanike ithuba lokuba alwe ngamathumba. Therapy ungenziwa kusetyenziswa cytokines, ebizwa ngokuba "unyango Cytokine." Yintoni na le nto ingaqhelekanga iiproteni?

Cytokines - ziiproteni ziveliswa egazini, omzimba kunye nezinye iinkqubo zomzimba, ukuba adlulisele imiqondiso ukulungiswa kwaye bayakwazi ukuphembelela ngokusebenzisa receptors phezu iiseli. It ukulungiswa cytokine Kubaluleke kakhulu ukugcina uzinzo kunye ukuzeyisa komzimba kwimo norm okanye ukungaqheleki zophendlo lwezifo. Cytokines kutshabalalisa cells ithumba kuphela, ngoxa enxulumene nezempilo. Kwakhona ukubona isiphumo yabo immunostimulatory. Yintshukumo cytokines zingahlulwa zibe ngamaqela ezininzi:

1. Ukuba isebenze ukukhula kunye nemfundo kwiiseli abatsha.
2. Ukukhusela umzimba kwezifo kunye nomthamo ngu ukusebenza ngomhla iiseli macrophage kunye granulocytes.
3. Igalelo ekukhuleni, ukusebenza kunye nohlenga lymphocyte abaqolileyo.
4. Yenza macrophage cytotoxic kunye neeseli ezingababulali zendalo.

Cytokines asetyenziswa Ubhaqo izifo kunye nonyango, kwakunye ngenjongo yokuthintela izifo.

Ngokusekelwe umsebenzi kwiiseli, ziyakwazi ukuchongeka izinto ezintle unyango Cytokine.

Isiphumo emihle unyango Cytokine

Yintoni Cytokine unyango in Oncology? Kunokwenziwa isigqibo ukufunda ngawaphi amanyathelo phezu umzimba unyango cytokine abagulayo.

Cinga ezimbalwa izinto ezintle xa usebenzisa unyango Cytokine:

• ukusebenza ukuvumbulula iiseli umhlaza kunye metastases.
• Ukwanda kakhulu ukusebenza kusetyenziswe amachiza.
• Uthintelo ithumba yokuphinda kunye metastases.
• Ukuncitshiswa kakhulu esibi iziganeko ichemotherapy, ekunciphiseni ezinetyhefu.
• Treatment kunye nokuthintela iingxaki ezosulelayo ngexesha unyango.
• Non-ziyityhefu kwaye ingasetyenziswa kwizigulane kunye ezimbi ezahlukahlukeneyo.
• Ingasetyenziswa ngokusebenzisana ne ichemotherapy okanye ngokwahlukeneyo.

Uqhelene nezi zinto ezintle, oko kuthathwa ukuba kule ndlela njengoko unyango Cytokine, iimpendulo HIV kuphela abaseleyo endlwini unyango lomhlaza.

A incinane

Unyango Cytokine ngokuba unyango lomhlaza lisetyenziswa ehlabathini ixesha elide. Nakuba kunjalo, amalungiselelo yokuqala zinetyhefu kakhulu kwaye ibanga iziphumo ebezingalindelekanga ezininzi, ezivame ngaphezu impumelelo yale unyango. Umzekelo, kwi-US naseYurophu baye baqalisa ukusebenzisa ngakumbi kule minyaka ingama-80 ulungiselelo lwe TNF-alpha (ithumba necrosis factor ). Faka kunokwenzeka xa kunokwenzeka ukuba kuyenzeka ukuba ikheswa umzimba ukuhamba jikelele ngenxa yetyhefu yayo ngokugqithiseleyo. Ichiza ujikeleziswe ngumntu umatshini intliziyo-lung kuphela emzimbeni apho kukho inkqubo ithumba, ukunciphisa ngokubonakala basabele ezibi.

Kukho iziyobisi asetyenziswa ixesha elide kakhulu ngempumelelo, ukuba amaqela amabini kwamachiza:

1. Interferon-alpha ( "Intron", "IFN", njalo njalo. D.).
2. Interleukin (IL-2).

La machiza kuphumelela kuphela unyango imelanoma kunye nomhlaza kwezintso. Kodwa oogqirha njalo bafuna iyeza eyayiza ndazisusa esi sifo soyikekayo.

ERashiya, uthomalaliso Cytokine iimveliso ezintsha kwaye isebenzisa zizifo clinic ithumba eMoscow.

Amalungiselelo therapy Cytokine

Ngowe-1990, ichiza "Refnot" yasekwa eRashiya, apho kusetyenziswa okwangoku. kuphuhliswa Kwathiwa , Doctor of Sciences Medical, ohambelana ilungu le-International Academy of Social Sciences VA Shmelev. Kuthetha ngempumelelo ulingo lonyango kwaye ukusukela ngo-2009 samkelwe ukuze unyango iintlobo ezahlukeneyo yamathumba. It zinezibonelelo eziliqela EC wakhululwa ngaphambili:

• Ichiza ayinabungozi, izihlandlo ezimalunga ne-100.
• Esisebenza ngayo ngqo kwi iiseli umhlaza nge receptors kumphezulu wazo.
• iiseli isebenze endothelial lymphocyte, nto leyo ekhokelela necrosis le thumba.
• Ukuncipha igazi ukuba ithumba, isixhobo kusichukumisa esizikithini, ulonakalise.
• Ichiza kwandisa umsebenzi antiviral of interferon amayeza izihlandlo 1,000.
• It kwandisa ukusebenza nechemotherapy.
• Kukhuthaza iiseli umbulali zendalo, kwaye anti-nethumba.
• Ngokuphawulekayo kunciphisa ipesenti ukuphinda kwi kwizigulane ngayo.
• tolerability Good.
• Akukho iziphumo ebezingalindelekanga.
• Oku kuphucula imeko jikelele yesigulana.

Njengoko kuchaziwe ngaphambili, le TNF-alpha na drug zinetyhefu kakhulu kwaye kuchaphazela kuphela indawo ephambili thumba.

Enye iziyobisi kakuhle kakhulu kwaye isetyenziswa kunyango Cytokine - yi "Ingaron". Oku kusekelwe ichiza "Interferon-ekhatywayo nth ingcambu." Ukulungiselela "Ingaron" okwaziyo uvimba imveliso iiprothini wentsholongwane egazini kunye RNA wentsholongwane egazini kunye DNA.

It wazibandakanya ngo-2005 kwaye kusetyenziswa unyango kunye nothintelo ezi zifo:

• Hepatitis B no-C
• AIDS ne-HIV.
• tuberculosis miphungeni.
• Izifo ezibangelwa papilloma virus.
• chlamydiosis enzala.
• Umhlaza.

Kwaye ukuze ukuthintela iingxaki kuzo ukunyanga granulomatosis ezigulo ezondeleyo.

Kuba unyango kunye nothintelo lwe-SARS kunye nokusetyenziswa influenza "Ingarona" nokunyanga solution yangaphakathi.

Xa ukuphatha "Ingaron" Ithumba isebenze kakuhle receptors leeseli umhlaza, nto leyo ke kuchaphazela "Refnot". Ngoko ke, Cytokine unyango olusebenzayo ukusetyenziswa ngokuhlangeneyo kwezi amachiza amabini.

Action "Ingarona" imi ngolu hlobo lulandelayo:

• Kumisa DNA wentsholongwane egazini kunye RNA iiseli.
• Ayisebenzi intracellular yayintsholongwane eyosulela iintsholongwane, iintsholongwane, nezinye izinto.
• It kwandisa umsebenzi macrophage.
• It kwandisa umsebenzi neeseli ezingababulali zendalo.
• It ulibuyele phenotype wendalo iiseli ezonakeleyo.
• Azikhuli ukukhula iiseli zomhlaza.
• Ukusonakalisa, ngokuba kukho ezinye iintlobo iiseli zomhlaza kwinqanaba zeselula.

• Ime ukukhula imithambo yegazi ithumba.
• Ngokuphawulekayo abangaphangeliyo ukukhula yamathumba.
• Yenza uxinzelelo lwegazi eziqhelekileyo.
• Kwehlisa lipoprotein.

Iziyobisi "Refnot" yaye "Ingaron" kunye isetyenziswa kunyango Cytokine ngempumelelo. Unyango ngale ndlela ibamba ithumba zizifo kunye nonyango kwikliniki Cytokine eMoscow.

Cytokine therapy ngubani onokusinceda?

Uhlolisiso lubonisa ukuba ibambe kwiveki phambi kokuba unyango ichemotherapy Cytokine nciphisa ngokubaluleka neziphumo ebezingalindelekanga ityhefu. Ukuqhubeka unyango Cytokine emva ichemotherapy ukukhusela umzimba zizifo asakhasayo, ukuphucula le okukwazi anti-HIV. Nokulunga unyango ziya kwandisa kakhulu.

indlela therapy Cytokine isetyenziswa kunyango yamathumba ezifana:

• umhlaza womlomo wesibeleko kunye zesibeleko.
• ngamathumba Mammary.
• Mesothelioma.
• Lung umhlaza.
• Umhlaza isisu, emathunjini amancinci emathunjini.
• Yamathumba zepancreas.
• umhlaza kwezintso.
• Yamaqanda.
• Isinye.
• wobuchopho.
• ithumba ye emphinjeni.
• Sarcomas amathambo kwizihlunu ezithambileyo.

• Glioma.
• Yamathumba-luvo.
• umhlaza Skin, wolusu.

therapy Cytokine xa granulosa Ithumba kwakhona ukuba zombini uthintelo kunye nonyango.

Le Cytokine therapy ndlela xa inganeli?

Nicinga ukuba amalungiselelo Cytokine unyango akanaye iziganeko ezinzima, linokusetyenziswa phantse bonke. Noko ke, kukho udidi lwabantu le unyango contraindicated:

• Abafazi abakhulelweyo.
• Ngexesha lokuncancisa.
• Phambi sokucalulana leziyobisi ukwenza up, leyo kunqabile kakhulu.
• izifo komzimba.

zomhlaza abaninzi siyanyangeka ngu unyango Cytokine, leyo sathetha ngayo ngaphambili, kodwa nangezilonda ka ndlala ungakwazi ukungena ngokwenani labo, njengoko amayeza interferon kuba nefuthe elibonakalayo ubume kunye nomsebenzi. Oku kunokubangela iseli Imbuqo kuphazamise umsebenzi wayo. Cytokines babe yayibaluleke kakhulu kuphuhliso izifo samathambo, kuquka lengqula. Oku kuxhomekeka akukaqondwa kakuhle. izigulane ezinomhlaza ngezakhi AITom Cytokine unokunceda khona? Ukuthetha ngayo kamsinyane. Ekubeni indlela therapy Cytokine lubandakanya iziyobisi kunye interferon "Ingaron".

Unyango anganyula le somdlavuza nokuya kuphela.

imiphumela emibi

Njengoko kuchaziwe ngaphambili, ngokubonakala reactions ezibi mbaleko. Nangona kunjalo, ngeli xesha ezithatha ichiza "Refnot" waphawula kwiimeko ezinqabileyo ukwanda lobushushu degrees 1-2. Kulo mzekelo, kucetyiswa ukuba athathe "ibuprofen" okanye "Indomethacin". Ngomhla imiphumo iziyobisi azisayi kuchaphazeleka.

Ukuphonononga yonyango indlela therapy Cytokine

Kakade ke, ndifuna ukwenza ukufumana reviews lezigulane bafumana unyango indlela Cytokine.

Njengoko sisazi ukuba le ndlela zonyango isetyenziswa eRashiya kutshanje, kwaye ngokwenza oko eklinikhi kuphela ithumba zizifo kunye nonyango Cytokine e Moscow, le review ezininzi kunene. Abantu abaninzi lwemibuzo kwamachiza amatsha, njengoko ntoni inani elikhulu ngokuphamba kule ndawo, yaye la machiza eqolo. Noko ke, kukho izinto ezahlukeneyo ncomo esimele ingqalelo.

Ngokomzekelo, umntu sele unesifo somdlavuza wendlala degree 4. Xa unyango lwe ubuchule ngotyando walelwa. Ubhenele ekliniki, oko wacelwa ukuba bangenele unyango therapy Cytokine ngokusebenzisana kunyango hormone. Ngenxa yoko - kunciphiso ithumba, ukungabikho metastases. Njengoko kubonakala, Cytokine unyango kumabanga 4 umhlaza unika iziphumo ezihle kunye nethemba lonyango. Kwaye oku ityala ekwanti.

Lo mfana kwafunyaniswa ukuba unomhlaza lwesinye. Siye safumanisa ukuba kukho ekliniki kunye ithumba zizifo Cytokine therapy. Oogqirha utyando elinye ixesha, abelwa unyango ichemotherapy kunye nonyango Cytokine. Kubekho ukuba imeko iyathembisa. Ithumba lancipha kakhulu ngobukhulu, yuylo unyango waqhubeka.

Lo mfazi wafumanisa umhlaza webele. Iziko Oncology ekuhlaleni zanyanzelisa uqhaqho. Emva kokuba unyango kokuguquka nolwathi kwikliniki kwethumba uthomalaliso zizifo Cytokine. Chemotherapy kunye cytokines soyisa sifo, isifuba wasindiswa.

Unyango Cytokine kwethumba Zizifo rhoqo bafunda kwaye ziphuhliswe, kunye neziphumo ezakhayo zonyango - oku kububungqina kuphela ukuba ukulwa nomhlaza olwenziwe kwicala elifanelekileyo. therapy Cytokine yenza kube lula ukuyeka esi sifo, musa ayinike inkqubela, yaye eli ixesha elongeziweyo ukuba bayisebenzise ukufumana iziyobisi kuyilwa le sifo soyikekayo. Unyango Cytokine kunye nohlaziyo zizifo nethumba kakhulu ukufumana HIV kuphela, loo nto ibonisa impumelelo yale Umkhuba unyango yamathumba.

Izimvo ekliniki eMoscow

unyango eklinikhi Cytokine kwethumba zizifo kwi ingxelo eMoscow wafumana HIV kuphela. Abantu ukubhiyozela ngoncedo kunye nobuchule kwabasebenzi. Ukukwazi ukugcina umoya, beka ukuya iliza HIV kunye nokholo engcono. A lot of reviews ukuba bathi oogqirha angakunika unyango izigulane abanenqanaba kakhulu 4 umhlaza, xa iziko umhlaza eqhelekileyo sele inkunkuma ezi izigulane.

inani elikhulu amabali kwakhona kubhalwe apho oogqirha ziye zanceda ukugcina umbutho ochaphazelekayo, ukuphepha utyando. Konke oku kubonisa ubuchule kwaye ukulungele ukunceda. Kubalulekile ukwazi ngoku, ukuba kukho indlela unyango njengoko unyango Cytokine, yintoni na yaye oko kungenziwa xa usebenzisa yona. Oku kuya kunika ithemba abantu abaninzi. Eyona nto ibalulekileyo - ukulwa kwaye ithemba engcono.