Drug "Sotageksal", analogs kunye nengxelo phezu kwabo

Arrhythmia - yinto uhlobo izinga lentliziyo, nto leyo yahluke ukusuka sinus isingqisho yesiqhelo. Xa arrhythmias abantu kukho enye okanye eziliqela ukunyhashwa intliziyo. Le ngezifo unakho nosondeza rhoqo kunye namandla yokukhulisa izinga lentliziyo (tachycardia) kunye, icala, ukuhla zazo (bradycardia). Nokuphazamisa umsebenzi imisipha yenhliziyo kwaye emntwini esempilweni. Nangona kunjalo, kwiimeko ezininzi, arrhythmia leyo kunye nezinye izifo inhliziyo. Loo urhulumente Kungumngcipheko kuba excitability ukwanda esiqwini intliziyo - myocardium, nto leyo enokukhokelela ekugqibeleni ukusilela intliziyo xa sithe asanyangwa.

kukho ucwangciso olukhethekileyo ukuba kuqheleke izinga lentliziyo, enye yazo "Sotageksal". Analogue beziyobisi nalo esisetyenziswa ngokubanzi kwi yezonyango. La machiza ezivela kwiqela amayeza abe umsebenzi antiarrhythmic, beta-blocker. Xa ongena ebantwaneni, ukuba asithe receptors beta-adrenergic, ezo zifumaneka esihlunwini ezimkhuthuka, izihlunu ezesifuba nezinye zomzimba, kwaye banoxanduva impendulo komzimba lokuba ntshikilelo. kardioeffekt yongamileyo ukunciphisa kwefrikwensi nobushushu izinga kwentliziyo, wehlise senhliziyo Uhanjiso. Njengoko nempembelelo icwangcisiweyo zabona ukwehlisa uxinzelelo lwegazi phezu kweendonga iimpahla coronary.

ichiza

"Sotalol» (Sotalol) - owamkelwa igama ngamazwe ehlabathini beziyobisi "Sotageksal". Analogs ze kwengoma unokuba nefuthe ezahlukeneyo, kodwa efanayo antiarrhythmic. Eyona nto ephambili esebenzayo "Sotageksal" iqulethe sotalol hydrochloride. Ukongeza, kuquka inani elincinane amacandelo abancedisayo. Phakathi kwazo, - kwincindi, monohydrate lactose, starch umbona, nemagnesium stearate kunye nezinye yokuhlanganisa.

Ithuba lokugcinwa iipilisi okanye isisombululo injectable yiminyaka-5.

"Sotageksal" analogue kunye Nokuhlanganiselwa

Enye elucwecweni le mveliso iqulethe mg 40, 80 okanye 160 of into esebenzayo. It iveliswa ikakhulu amacwecwe ngeenxa White kunye icala elinye khaxa kancinane kwaye elikroliweyo kunye Sot segama. Ngasemva le lwecwecwe bisected esebenzisa nomthamo kuba lula lwemingcipheko. Bonke zipakishwe namadyungudyungu amaqhosha-10, kunye neebhokisi ikhadibhodi. isiqhuma ngalinye zingaqala namadyungudyungu-1 ukuya kwi-10 (of kumaqhekeza-10 ukuya 100 amacwecwe).

Kwakhona, "Sotageksal" evela ngokohlobo isisombululo inaliti efakwa. ampoule nganye iqulethe ml 4 iziyobisi. Ngowe-1 ml isisombululo 10 mg ngeempahla basic ecocekileyo. Ichiza kufuneka zikhuselwe elangeni emnyama kunye kwindawo eyomileyo, apho abantwana bayafikelela ulinganiselwe.

Analogs ne sotalol into esebenzayo iipilisi hydrochloride zenziwa:

• "Sotaleks" (160 mg).
• "Soritmik" (nge-0.16 g).
• "Sotalol Canon" (80 no 160 mg).
• "Darob" (80 no 160 mg).
• "Tenzol" (80 no 160 mg).

imiphumela kwemithi

"Sotageksal" analogue kunye ntonye beziyobisi ube nefuthe ngokukhawuleza anti-arrhythmic. Oku kuphunyezwa ngenxa ubuchule babo ukuvala receptors β-adrenergic kwaye zinqanda channels potassium. Iziyobisi ukwandisa ixesha pulses kunye reflex ixesha imithambo kunye ventricles. Ukwandisa ithoni inyumoniya agudileyo izihlunu kunye umaleko kwezihlunu beendonga isitya. Nciphisa contractility engabalulekanga.

hydrochloride Sotalol unesethi lonke kwiipropati. Akaphilanga chronotropic elibi, dromotropic, batmotroponoe nefuthe inotropic ka iziyobisi isiJamani "Sotageksal". Analogs, ukwakhiwa apho efanayo, ukuze abe elinye igama lebrendi. Kwakhona bakwazi ukunciphisa izinga lentliziyo kunye namandla awo. Ngenxa yale imfuneko mpilo engabalulekanga yehliswe kakhulu. Yaye ngenxa yoko, umthwalo entliziyweni lifinyele.

Absorption kunye kukhuthaza neziyobisi

Drug Ukunciphisa uba ukwanda. bioavailability wayo 90%, kunye nokufunxwa - malunga ne-80%. Zingaphelanga iiyure 2.5-4 ukuzikisa ingqondo lobuninzi esisebenza kuyafikelelwa emva kokufumana plasma. Emva ulawulo efakwa, isiphumo sele kubonakala emva kwemizuzu 5-10. Absorption kwenzeka-20% ngcono nangokukhawuleza ukuba uthathe iyeza ungatyanga. Ngenxa yokuba ukunyibilika iyeza nezikhongozelo iphantsi kakhulu, sotalol hydrochloride kufuneka kuthathwe ngaxeshanye iimveliso zobisi kunye namafutha koqoqobo kwesilwanyana.

Ngaphandle kokuba ebotshiwe kwiiproteni igazi, ichiza kusiwa ancedisana amalungu neuropathy ngokulinganayo kwiintsuku 3-4 wokwamkelwa rhoqo. Ngexesha elinye, kwaye kwaphunyezwa nempembelelo entle lwegazi. Xa cerebrospinal fluid xi isiyobisi esingekho ngaphezulu kwe-20%. Action emva Inaliti iyaqhubeka ukuya iiyure ezi-2. ukusebenza isaqhubeka emva nomthamo ngomlomo amacwecwe "Sotageksal" iiyure ezili-12. Analogs beziyobisi ekwakhiweni equlethe sotalol hydrochloride, nayo unokuchatshazelwa yokucolwa yi izintso kwazona kwi umchamo (90%) kunye endleni kwi-avareji kwiiyure 10-20.

Yiyo loo nto izigulane kunye nenkqubo kakuhle kwezintso kunye wokuchama ibonisa iyeza izilinganiso engaphantsi. Abantu abadala basoloko wabona ukonakala enxulumene ubudala umsebenzi kwezintso. Oku kunegalelo yokuba le nto iboniswa ngesantya esisezantsi kwaye bangaqokelela emzimbeni. Ngoko ke, eli qela izigulane ichiza ingasetyenziswa ngononophelo kwaye idosi uzimisele ngamnye.

Iyeza kunceda ukubuyisela exchange oksijini ancedisana, ephelisa nochuku, ixhala, uxinezeleko kunye neminye imiba echaphazela kwefrikwensi nobushushu izishunqulelo zentliziyo.

"Sotageksal": imiyalelo yokusebenzisa

Analogs beziyobisi kunye nearhente zisetyenziswa kunye negama yasekuqaleni arrhythmias kwangumqondiso kwentliziyo, ngenxa unyango ventricular arrythmia. Kodwa kukho isiphumo eyahlukileyo kwizigulane kunye iSifo efanayo. Ngoko ke, kufuneka atyumbe kwagqirha emva kokuba uviwo olunzulu kunye ngqongqo yesingqino.

Ayifane arhente esetyenziselwa unyango izigulane abaye baba ukhwekhwe (ukhwekhwe) okanye ubunzima seswekile kunye kakuhle ekudleni ukutya. Lumkela aqeshe abantu babe imbali nokwaliwa ukho, lithetha "Sotageksal". Analogue ukuba unako ukucinezela uvakalelo komzimba kwizinto komzimba. Ngenyameko imithi isetyenziselwa ukunyanga izigulana kunye nokusilela ngentliziyo, ezithandwa misinga rhoqo. Izigulane abaye baba iposi engabalulekanga, umngcipheko arrhythmia ulilolile ngethuba lolwamkelo esikolweni "Sotageksala".

Idosi unyango ithuba

Kuxhomekeka ebukhulwini esi sifo uzimisele kunye nobude unyango iziyobisi "Sotageksal". Imiyalelo yokusebenzisa (analogs lingaba neminye imiyalelo yokwamkela) iqulethe ezi zincomo zilandelayo:

• tablet bususiwe yonke, hayi zingahlafunwa kwaye namanzi amaninzi;
• Reception lwenziwa iiyure 1-2 phambi kokuba isidlo;
• ukuthatha amayeza amaxesha 2-3 ngosuku.

umthamo unyango kwangoko yemihla ngemihla mayingabi ngaphezu 80 mg (1 tablet) lwegazi kunye tachycardia. Nangona kunjalo, xa engekho olifunayo isiphumo idosi enyangayo landa. Ngokuthe ngcembe, kubekho isithuba seentsuku 2-3 oko hlengiswe ukuya 240-320 mg ngosuku, kodwa kuphela xa esibhedlele. Ngempumelelo kakhulu ukunyuka okuthe chu kakhulu umthamo mg 80 ngeveki.

Ithamo ephezulu inokuba iipilisi 6 iziyobisi ngosuku "Sotageksal". Analogue, esithathwa apho ukuze kwandiswe ukuba ugqirha ibona kuyimfuneko, uya kuqeshwa ngamnye. Nokuba kukho isoyikiso ebomini, isixa-mali ka esisebenza mayingabi ngaphezu 480 mg ngosuku.

Ukuba izifo isigulane langoku sezintso esebenza, irejimeni yonyango ekhethiweyo njengomsebenzi of yokususwa creatinine. indyebo yalo (ukuya kuma-30 mg / min), ithamo uqobo zancitshiswa izihlandlo ezibini ukuya kwezine.

izitofu efakwa wenza kabini ngosuku, zibe naliti ampoule of ml-2. Le isisombululo lesitofu ngokucothayo ngapha imizuzu 5-7. Ngexesha unyango, ulawulo olufunekayo of wegazi, ukubetha, le izintso kunye nenkqubo wokuchama, ukucoca creatinine in serum.

ubungqina

Iimali eyenzelwe unyango ezi zifo:

• tachycardia, ventricular;
• Wolff - Parkinson - White;
• cardiomyopathy;
• beats ngaphambi ventricular;
• prolapse valve mitral;
• Paroxysmal fibrillation atrial imithambo;
• lwegazi (high blood pressure);
• nokuthintela kunye nokunyanga iposi engabalulekanga (kwezinye iimeko).

Obunzima umsebenzi kakuhle kwezintso, ugqirha kunyanzelekile ukuba onke esweni xi ukwimo esebenzayo kwi serum igazi ukunyenyisa ithamo "Sotageksal" iziyobisi. Analogs ye kubonakala zokwamkelwa ziyafana. Kodwa ke, nangona oku, yabo ababambeleyo elinye ichiza kwabanye akuvumelekanga ngokungqongqo. Ukurhoxiswa unyango kufuneka kwenzeke ngoko nangoko, kodwa ngokuthe ngcembe. ukumisa elirhabaxa kungabangela kukwehla imeko lwezonyango.

Izimo

Nawuphi arhente antiarrhythmic ayikwazi njalo zabelwe nomntu ogulayo, kuquka "Sotageksal". Analogs Izimo ziyafana, abakwazi akunakusetyenziswa phantsi kwale miqathango ilandelayo:

• hypersensitivity okanye izinto ezisisiseko isici okanye isixa encedisayo;
• ubuthathaka sinus engile;
• ukuncipha ko- izinga lentliziyo (bradycardia);
• iinkqubo ezingapheliyo obstructive pulmonary;
• isifuba inyumoniya yayinzima;
• ukusilela kwezintso;
• iposi engabalulekanga olunamandla;
• Ukungaphumeleli intliziyo etsolo okanye engapheliyo;
• yashiya cardiogenic;
• side QT lokuphumla syndrome ;
• yobudala yabantwana;
• komzimba, nokuthimliswa umzimba;
• ukukhulelwa kunye ibele;
• kuncitshiswa uxinzelelo (hypotension);
• Ukubulawa jikelele;
• nezilonda;
• isifo semithambo neuropathy;
• uphuhliso lohlobo tachycardia "pirouette" (imeko banesifo rhoqo kakhulu kwabasetyhini kunabesilisa).

amava elaneleyo ichiza ngexesha lokukhulelwa ayikho. Kuphela "Sotageksal" abaqeshwe ezibonisa ebalulekileyo. Nabalingani senyanga yokuqala ziyingozi isoyikiso kubomi ezingekazalwa, kunye nokuzithatha kungakhokelela isisu. data zophando ezithembekileyo malunga nokwamkelwa beziyobisi abafazi kuzala umntwana nangoku angenako.

Kwiinyanga zokugqibela unyango baya kubuyiselwa ngokuthe kwanciphisa iintsuku 2-4 phambi kunikezelo, umfazi ukuba ukunyamekelayo oko ngexesha lonke lokukhulelwa. Oku kwenzelwa ukuqinisekisa ukuba usana akazange abe ingcinezelo imisebenzi nokuphefumla, bradycardia okanye hypotension ngenxa ichiza "Sotageksal".

Analogue ngokusekelwe hydrochloride sotalol kufuneka ayekiswe ukuba xa umama oselula na lwebele, njengoko iziyobisi uyakwazi ukungena kwi ubisi lwebele kwaye ukufikelela phezulu lamanani apho. Ukuba ezibonisa unyango kufuneka kuqhube, ukuba ibele kubhetele ukuba ayeke, ngokubuyisela umxube ubisi olwenziwayo ngokobudala yomntwana.

side effects kanye libanda

Oku kunokuba neziphumo ezibi kwi sentliziyo, yonyango, wokuchama, yokuphefumla, yokucola ukutya luvo ukusetyenziswa central ixesha elide ichiza "Sotageksal". Analogs zinokubanga iziphumo ebezingalindelekanga efanayo. Isigulane bangaziva:

• ukuphelelwa umoya, ukwanda ukuhlaselwa angina, iimpawu ukusilela kwentliziyo, iintlungu intliziyo, vasospasm, Raynaud engqondweni ;
• isicaphucaphu, ukugabha, urhudo, iintlungu esiswini, ngegesi ngokugqithiseleyo, flatulence, intshukumo kwesisu nzima, inwebu yangaphakathi eyomileyo emlonyeni;
• ixhala, ukuphazamiseka, ukuphakuzela disorder, nemibono, nokuphazamiseka uququzelelo iimoto, ilahleko ukuva, utshintsho kwimo, iingcangcazela, ukudinwa, intloko ebuhlungu, isiyezi, nokungalali okanye, ukozela icala, ukwanda, amaphupha ixhala, ukudandatheka;
• conjunctivitis, keratoconjunctivitis, okanye syndrome iliso owomileyo (ingakumbi izigulane abanxibe lenses rhoqo), ukudumba inwebu, ukuncipha incasa kunye nevumba, iintlungu iliso, photophobia, acuity kakuhle ezibonwayo, ukuva;
• hypoglycemia (kubantu abanesifo seswekile);
• bronchospasm, laryngitis, tracheitis;
• urticaria, dermatitis, isikhumba ukurhawuzelela, erythema, ukhwekhwe, angioedema, ukwanda ukubila;
• inkunzi amandla ukudakumba, iintlungu ngexesha ukuchama, abafazi - kunciphisa yobuntu nokuphazamiseka kokuya;
• fever, buthathaka kwezihlunu, unditsho, cyanosis kweqondo.

Kwimeko libanda, kuyenzeka:

• kwezithandani imisebenzi intliziyo;
• ukuphelelwa umoya;
• asystole, niphele, ubuthathaka, isiyezi;
• cyanosis of yesiqephu;
• amahlaba imisipha;
• bradycardia kokubanjwa inhliziyo;
• yashiya yegazi;
• bronchospasm;
• tachycardia.

Nangona iimpawu ezinjalo ngokunzulu libanda, ukufa kunqabile. Xa Ityhefu iziyobisi kufuneka kuqala ukuba ziyeke ukuthatha amayeza "Sotageksal". Analogs kunye generics sotalol hydrochloride kwimveliso eyiyo ukusuka iphecana zesisu emva kokungenisa amachiza izifunxi. Kwimeko unyango kwangumqondiso libanda, iyaboniswa. Kwiimeko ubuthi kakhulu lavage kuyimfuneko esiswini kunye nokugabha, nokugcina imisebenzi ubomi obalulekileyo nezibilini. ngeedosi kakhulu kususwe ngokupheleleyo olugqitha esikhumbeni. Pathways yandisa iswekile yegazi kungenzeka izigulane esitya ukutya engqongqo okanye yindlala.

Analogs kunye generics "Sotageksala"

Sotalol hydrochloride equlethwe imveliso eziveliswa eSwitzerland kunye eJamani, phantsi igama lorhwebo "Sotageksal". Analogue awo ziboniswa kunye nezinye iziyobisi ngezithako ezahlukeneyo, nto leyo ukongeza isiphumo antiarrhythmic akhulule aqaqambayo, ukunciphisa uxinzelelo lwegazi kunye nokuphucula ukusebenza imithambo. Ezi ziquka:

• "Inderal" "Inderal", "obzidan", "Pranolol" (esisebenza - propranolol) asetyenziselwa ukunyanga ischemia, arrhythmia kunye noxinzelelo lwegazi.
• "Pumpan" - arhente ngamayeza esekelwe kumacandelo yemifuno.
• "Magnerot" iqulethe wemagniziyam orotate dihydrate isetyenziswa ngokuphatha kwemithambo yegazi, ukuphazamiseka of lipid ukutya.
• "Korvitol" (metoprolol tartrate) kakuhle ukuba uqaqanjelwa.
• "Nebilet" (nebivolol hydrochloride) iboniswe lwegazi, isifo kobuchopho.
• "Qudesan" (drop) - isongezelelo eziphilayo ngokusekelwe coenzyme Q10 lokhuseleko kunye nokunyangwa arrhythmias.
• "Etatsizin" (etatsizin) lisetyenziswa kwi tachycardia;
• "Arrhythmia" "Amiodarone" (amiodarone hydrochloride) zisetyenziswa senhliziyo, tachycardia, arrhythmia atrial.
• "Propanorm" (propafenone hydrochloride) kusetyenziswa xa ventricular kunye arrhythmias supraventricular.
• "Neo-Giluritmal" (praymaliya bitartrate) iboniswe ngenxa arrhythmias ventricular, tachycardia.
• "Korgard" (nadolol) Iwendawo yonyango sifuba angina, migraine.

Russia ivelisa "Sotalol Canon" yaye "Tenzol" kunye esisebenza efanayo njenge "Sotageksal". Analogue e Moldova, Ukraine kunye namazwe angabamelwane ezikhemisti elula ngaphezu siyobisi sokuqala. Iindleko iziyobisi ixhomekeke lizwe kunye nomakhi. amayeza Domestic bazikhanda ixabiso eziphantsi kakhulu kwamanye amazwe.

reviews

Kubekho ukuhla okubonakalayo kuhluthwe frequency ngexesha fibrillation atrial, ukuba aselwa okokoko "Sotageksal". Analogs iirivyu nomonde engekho mihle. Akusoloko iziyobisi kbavelisi ezahlukeneyo izinto ezifanayo, nokuba benayo kuqamba efanayo. Abantu abaninzi boyika ukuba abenzi abanganyanisekanga abonisa enamanani amakhulu esisebenza tablet nganye ngokoqobo apho. Ngenxa yale mpatho ayikwazi ukuzisa iziphumo ezilindelekileyo. Izimvo "Sotageksale", ngokuchaseneyo, emihle. Wasebenzisa ngempumelelo unyango entsonkothileyo kwezifo sentliziyo kwizigaba ngezigaba ezahlukeneyo.

Kwiimeko ezininzi kukho ukuphucuka kancinane kwiphondo ngokubanzi izigulane ngokuxhomekeke unyango entsonkothileyo. Ichiza buyafuneka kokubini cupping, kunye nothintelo. Xa nokubuyekezwa kwezigulane unesifo "paroxysmal fibrillation," iyeza inceda ukugcina intliziyo isingqisho yesiqhelo (ngaphandle, ukuba aselwa okokoko nje unyango maintenance). Noko ke, izigulane zithi ke bengasenabuganga ukuphakamisa yedosi zabo ngaphandle ingcebiso likagqirha ngenxa kumngcipheko iziphumo zazo emva kodlwengulo.

Ezinye iirivyu azikho nemiphumo emihle kakhulu kwi isidima ichiza. Kukholelwa ukuba sipapashiwe kwaye akayi kuba nako ukunyanga anaemia, arrhythmias ngeentsholongwane, hypokalemia kunye hypomagnesemia. Kuyaphawuleka ukuba brand hydrochloride sotalol amazwe kunzima ukufumana ezikhemisti zasekuhlaleni. Abantu babeqhele ukusoloko sisebenzisa njengendlela abafumana ubunzima kunye nokufunyanwa yayo. Ngoko ke, ngaphambi kokuqalisa unyango, qiniseka ukuba uya kuba nako ukuqhubeka ixesha elide.

Yintoni na zidityaniswe lolwamkelo esikolweni "Sotageksala"

Ngexesha izigulane unyango kuyanqweneleka ukuyeka yokuqhuba, ngebhayisekile, ngesithuthuthu. Okunye okuyingozi yonke imisebenzi zifuna ukwandisa ingqalelo kunye lengqondo yoxinaniso kunye focus. Xa efumene imali eyongezelelweyo ukuze kuncitshiswe uxinzelelo kusenokwenzeka ukuba hypotension. Akuvunyelwe ukudibanisa "Sotageksal" kunye iziyobisi ezifana:

• insulin, njengokuba sele kwandisa eyavela egazini;
• ion kunye abamelene calcium;
• kuthetha ukuba kumzimba jikelele okanye inhalation;
• inhibitor Mao;
• iodine aqulethe lemfuyo;
• womchamo;
• sezakhi yiergot;
• lakhula tetracyclic.

Iyeza le nto ilawulwa ngaxeshanye kunye antiarrhythmics of kwiklasi mna III. Kwakhona contraindicated kunokwamkela iziyobisi ezidakumbisayo, nadlamkisayo kunye antihistamines, antipsychotics, coumarin, relaxants. Kwakhona ezibangela uxinezeleko eyomeleleyo inkqubo luvo central. zomzimba ngaxeshanye kukhokelela ekwandeni uxinzelelo lwegazi kwaye depresses inyama engabalulekanga. Akuvunyelwe ukuba benze uvavanyo ulusu ukumisela iindidi zamavumba nezidlo. Oku kwandisa amathuba anaphylaxis, angioedema, kunye zizalwa.

Drug "Sotageksal" yakhululwa ngokumiselwa ezikhemisti. unyango eyahlukileyo arrhythmia ukuba baxabane ezibi kakhulu. Ngoko ke, ngaphambi kokuba uthathe amayeza, kufuneka usoloko udibane nogqirha.