Ichiza "El-Thyroxine": imiyalelo ukusetyenziswa, analogs, ncomo

Drug "Al-thyroxine" - zokwenziwa ihomoni, thyroxine analogu emvelo. Emva kokufumana le medicament kukho uguqulelo kwenxenye thyroxine ukuya triiodothyronine, iodo hormone ebandakanyekileyo kuzo zonke iinkqubo pathways yaye unempembelelo enkulu phezu kwemisebenzi ngamalungu ezininzi. Ichiza lisetyenziswa kwiimeko apho yehla kakhulu umsebenzi lengqula.

Ukusetyenziswa koMgaqo-medicament iboniswa emva kokuba ukususwa esinobubovu lengqula kunye amatsha okuhluma kwawo zomzimba xa umsebenzi nobubovu akukho kakuhle. Maxa wambi iyeza emiselweyo kubantu uwuphakamisile umsebenzi lengqula, kodwa kuqala ukwenza unyango ukucinezela secretion ka emzimbeni ayodini-equlethe. Xa izigulane ezinjalo, emva kokuba isicelo i "El-Thyroxine" zicinezelwa inkqubo isizukulwana TTG leyo inxaxheba kule Yindibanisela thyroxine.

izithako drug Form release

"El-Thyroxine" ifumaneka emacwecweni. Le into esebenzayo yi levothyroxine sodium. Ukubunjwa ichiza bangenza inkcazo-ntetho inani ezahlukeneyo ngeekhomponenti ezingundoqo, ichiza ofanelekileyo amiselwe ngugqirha. izithako Auxiliary thaca sodium wesitatshi glycolate, calcium hydrogen phosphate dihydrate, ixesha-chain glycerides buso, dextrin kunye microcrystalline kwincindi. Eyahlukeneyo abenzi Isakhiwo bako abangabancedani zisenokwahluka kancinane.

Pharmacodynamics, pharmacokinetics, "El-Thyroxine"

Eyona nto elikhutheleyo neziyobisi thyroxine, apho isiphumo kwenzeka emzimbeni, enza umsebenzi ofanayo. "El-Thyroxine" kunegalelo kuqheleke iinkqubo pathways, iinkqubo zophuhliso kunye nokukhula. Isenzo ichiza emiselwe umxholo into esebenzayo. Ukusetyenziswa iingedosi ezincinane "El Thyroxine" kukhokelela kuphuhliso isiphumo steroid, ngaphezulu - kufuneka ukwandisa iseli kunye izihlunu ioksijini imfuno, nokukhuthaza iinkqubo oxidative, nokukhawulezisa ukutya kunye nokwaphuka carbohydrate, iiprotheni, amafutha. Ukongeza, xa amathamo aphezulu ichiza iyazingenela inkqubo luvo, nemithambo yegazi.

Le medicament iqala ukwenza emva kweentsuku ezintlanu emva kokuba isicelo lokuqala. Ukuze iinyanga ezintathu ukuya kwezintandathu zonyango rhoqo kunokwenzeka ukuba bahlukane le goiter ehlasela okanye sinciphise ubukhulu bayo.

Absorption kwenzeka ubukhulu becala apha emathunjini amancinci ngenxa yokufumana tablet bazila ayikho ngaphezu kwe-80%, kunye nokusetyenziswa ukutya lifinyele. elidityaniswe kakuhle kwiiproteni plasma, "El-Thyroxine", ingxelo ibonisa ukuba uqhagamshelwano lumalunga ne-100%, ngoko ke ichiza aluchaphazeli mhlawumbi olugqitha esikhumbeni okanye hemoperfusion.

Le xi liphezulu candelo eziphambili ezisisigxina emzimbeni emva kweeyure ezintlanu emva kokungenisa beziyobisi. ukususwa Partial beziyobisi izigulane kwenzeka ngeendlela ezahlukeneyo, ngokuxhomekeke kwinqanaba hormone emzimbeni.

Xa hypothyroidism ukususwa kwaso oluqhutywa iintsuku ezisithoba okanye ezilishumi, kunye euthyroid - ezintandathu okanye ezisixhenxe, thyrotoxicosis isiqingatha-ubomi kwemali ngokukhawuleza - ngeentsuku ezintathu okanye ezine.

Phantse isinye kwisithathu iyeza ithamo nto iphambili sibekwe esibindini, ngelixa ephawula intsebenziswano ekhawulezileyo thyroxine zikhoyo egazini. Oku kwenzeka ukuyilwa metabolites emva kokungenisa iipilisi "El Thyroxine". Imiyalelo yokusebenzisa kweengxelo ukuba ukutya ephambili isahlulo ichiza lwenziwa ebuchotsheni, izihlunu, sezintso zesibindi. Kukhuthaza metabolites eziveliswa izintso amathumbu.

Iimpawu zokusetyenziswa yokulungiselela "El Thyroxine"

unyango Ukufakwa isekelwe phezu ukusetyenziswa kweli chiza emiselweyo ukuba izigulane ithi hypothyroid of etiologies ezahlukeneyo, t. H. Hypothyroid (primary, eziziisekondari) zenzeka emva utyando kunye nicaphukile ngokusebenzisa yokwamkela leyo yakhiwa radioiodine . "El-Thyroxine" umyalelo kwi isicelo ikuvumela ukuba abele kwezi meko zilandelayo:

• izifo cerebro-hypophyseal;
• Hypothyroidism azalwa nayo;
• goitre euthyroid;
• isifo Hashimoto kaThixo, isifo Graves '(unyango kwi complex);
• zikhala ukutyeba okanye hypothyroidism cretinism, sikhatshwe iimpawu ezifanayo;
• hyperplasia euthyroid (unyango udibaniso);
• elikhala goiter nodular emva resection kwi ukuphazamiseka engekho ndlala (tablets isetyenziswa medicament umbala);
• ithumba yobubi (endaweni kunye nonyango suppressive);
• neoplasms, obubonakala ngokuba ngokwahlukeneyo kakhulu, hormone, enemo wolusu.

Amayeza asetyenziswa ukwenza iimvavanyo diagnostic. Maxa wambi abantu bathathe "El Thyroxine" elwe ukungabikho iingxaki kunye nobubovu lengqula, kodwa oogqirha musa kukholiswa ukusetyenziswa medicament ngenjongo enjalo.

Izimo ukufumana ichiza, "El-Thyroxine"

Le medicament alikho ilawulwa ukuba izigulane uvakalelo amacandelo yayo. Izimo ziquka:

• iposi engabalulekanga (isigaba oyingozi);
• isebenza gipokortitsizm ngaphambili lunganyangwa okanye thyrotoxicosis;
• ukudumba kwentliziyo izihlunu uhlobo oyingozi;
• galactosemia zamafa;
• syndrome, nto leyo enokuphazamisa kukufakwa ethunjini;
• elactase intswelo.

Ichiza isetyenziswa ngobunono izigulane seswekile sinwenwa, xa elibaleka nzima hypothyroidism, nto leyo ixesha elide ukuba siphethwe kakubi, kunye nezifo ezinxulumene ne izilonda senhliziyo:

• sredtsa isifo senhliziyo;
• wegazi;
• arrhythmia;
• iposi engabalulekanga (imbali);
• yegazi.

Ukuba isigulana na ezinye zezi zifo, ithamo zancitshiswa okanye ixesha kwiwotshi yamanani ekhethiweyo.

therapy

Ngexesha unyango, njengendlela "El-Thyroxine" amathamo akhethelwe ngamnye ukuze isigulane ngasinye zisekelwe kubungqina. Tablets musa ukuhlafuna, usele ungatyanga, imizuzu engama-30 ubuncinane. phambi kokuba atye. Izigulane abanezifo inkqubo sentliziyo lifikelele iminyaka emashumi mahlanu anesihlanu ngomhla 1 kg ubunzima unikwe kuma-0.9 mg beziyobisi. Abanye eboniswa 1.6 .mu.g ku 1.8. Ngelo lokuqala unyango, ithamo ekucetyiswa beziyobisi izigulana hypothyroidism zimi ngolu hlobo lulandelayo:

• Izigulane abaneengxaki kunye nemithambo yegazi, ichiza ochaziweyo 75 mcg ukuya 150, ongqamana idosi yemihla ngemihla.
• Xa izilonda sentliziyo, kwakunye kwizigulane abadala alawulwa beziyobisi isixa-25 g. Emva kweenyanga ezimbini pamo lanyuka ukuya 50 mcg. Kamva, le utshintsho parameter kunye kwisithuba efanayo, ukwanda ku-25 g, de ugqibe imali kangangoko kuqulunqo kunye TSH hayi eqhelekileyo.

Indlela yokwenza "El-Thyroxine" kwiimeko ezahlukeneyo, kuyimfuneko kukuqonda ugqirha. Ukuba imeko iimpahla kunye intliziyo iba mandundu, kuyimfuneko ukuhlaziya indlela yonyango kwezifo kwenkqubo sentliziyo.

Xa hypothyroidism azalwa uhlobo ithamo ichiza zikhethwa yobudala. Izigulane zincinane (iinyanga ukuya ku-6) ilawulwa 25 micrograms iziyobisi, kodwa hayi ngaphezulu kwe-50, idosi efunekayo imihla ukususela micrograms-10 ukuya kwi-15 kilogram nganye. Abantwana abangaphantsi kweminyaka akukho unyaka ngaphezulu kwe-1, amisele mg-50 kg nganye. Ukuba ubudala isigulana kuluhlu kweminyaka omnye ukuya kwemihlanu, idosi ubuncinane yi-75 mcg, kodwa hayi ngaphezulu kwe-100 micrograms. Emva kweminyaka emithandathu ubudala (abantwana abangaphantsi 12) uvumelekile ukuba asebenzise 100 Iimali mcg elingagqithiyo ithamo 150 mcg. Abanye abantwana oyifunayo ithamo olukhethiweyo kwi uluhlu micrograms-100 ukuya-200.

Ngexesha unyango, amayeza, "El-Thyroxine", njengoko kuxeliwe imiyalelo ukusetyenziswa kwabantwana abangaphantsi kweminyaka emithathu idosi yemihla ngemihla luthetha ukunika kanye. Emva ukondla yolawulo kweziyobisi ingaqhuba iye ngaphandle sisiqingatha seyure. Xa unyango kwabantwana abaselula isisombululo olulungiswe amacwecwe.

Kwiimeko ezininzi, abantu abaphethwe hypothyroidism, ukuthatha iyeza ubomi. Abo phendla thyrotoxicosis, emva kokuba uphuhliso karhulumente euthyroid "Thyroxine" Kucetyiswa ukuba zingasetyenziswa ngokusebenzisana ne antitireoidinymi kuthetha ixesha elimiselwe ngugqirha.

Ukusetyenziswa kweziyobisi ukunciphisa umzimba

Ukuze balahle umzimba usebenzisa micrograms-50 ngosuku ithetha. Ukusetyenziswa idosi yemihla ngemihla amanyathelo ezimbini ekufuneka wenziwe kusasa. Kunye lithetha "El Thyroxine" thatha β-blocker in izilinganiso ezikhethiweyo esekelwe kwi-frequency ukubetha. Xa umthamo olunye ukunyuka wavumela "Thyroxine" ukuze micrograms 150. Yandisa ithamo ngokuthe ngcembe, emva kokwandiswa ulwamkelo kuthetha wahlulwe kathathu. Kulo mzekelo, indlela yokugqibela kufuneka kwenziwe ungadlulanga owe-18:00. Kwakhona, ukwandisa ithamo β-blocker, isixa eyimfuneko ichiza unyule ngamnye, ngokulinganisela intliziyo lokuphumla kufuneka sibe uluhlu ibetha ukusuka kuma-60 ukuya kuma-70 ngomzuzu.

Ngamanye amaxesha kufuneka ukunciphisa ithamo lithetha "Al-thyroxine". iziphumo ebezingalindelekanga lubonisa imfuneko ukurhoxisa okanye ukunciphisa idosi iziyobisi. Le khosi kufuneka liqhubeke inyanga, musa ukuthatha amayeza elide ngaphezu iiveki ezisixhenxe.

Musa umngena amshiye ukusetyenziswa kweziyobisi, ukupheliswa yenziwa ngokuthe ngcembe, ngokuthe ngcembe kunciphisa ithamo ku kwisithuba seeveki ezimbini. Xa urhudo na ngakumbi arhente othululwayo "Loperamide 'enye okanye ezimbini njengezingxobo yonke imihla. Phinda le khosi ijolise ekunciphiseni ubunzima, inokuba iiveki ezintathu okanye ezine.

ziphumo bezingalindelekanga kunokwenzeka

reactions ethile egwenxa ezingenzeka ngethuba unyango with "Al-thyroxine". imiphumela emibi xa usebenzisa amachiza ngokwemithamo acetyiswayo zinqabile kakhulu. Ngenxa kwanda ukuze ukwandisa ubunzima, iinwele na iwe, kunokwenzeka ukuvela iingxaki kunye nezintso. Abantwana abanesifo sokuwa kunye nengozi eyonyukileyo sokuwa, isifo kunokuba nzima ngakumbi xa igqithe ithamo iseti "Thyroxine". Xa unyango kunye ngeedosi eziphezulu kukholeleka ukuba uphuhliso iimpawu hyperthyroidism.

Phakathi kwezinye ziziphumo ebezingalindelekanga - ixhala, ukuphazamiseka ixhala, ukubonakala lomzimba lafa, iingxaki ubuthongo, iimpawu arrhythmia kunye tachycardia. Kwakhona, kusenokubakho ilahleko ubunzima kunye nophuhliso urhudo, phambi nokugabha. Mhlawumbi ukubila, ubukho iimpawu kunye kokuhlaselwa sifuba angina. Ezinye izigulane babe dermatitis komzimba. Ngophuhliso ngayo ebuhlungu ithamo "Thyroxine 'osezantsi umzimba okanye rhoxisa ichiza okwethutyana yaye kamva usebenzise umthamo ezincinane.

Ukudityaniswa kwamaxwebhu kweziyobisi notywala

Ngokuqhelekileyo, nedosi enye ye imali encinane kotywala inqaba elisezantsi akukho azinampembelelo isiphumo yomenzeli "Al-thyroxine". Ukuphonononga zibonisa ukuba ukusela utywala ngexesha unyango ngamana abo bantu kuphela ukuba akanangxaki neempahla kunye nentliziyo yegazi. Kwezinye iimeko, ukuhlanganiswa iziyobisi kunye notywala ikhokelela nemiphumo engathandekiyo. Mhlawumbi nje ukunciphisa ukusebenza unyango, kodwa yaphula kwesibindi, inkqubo luvo.

Drug analogue "El-Thyroxine"

Of analogs zezakhiwo endaweni "Al-thyroxine" ingasetyenziswa "Eutiroks", "Bagotiroks". Siyobisi ngokufuthi ekhethiweyo "Eutiroks" nto leyo eye kuyabonisa ezifanayo, Izimo kunye idosi. Ukusuka "El-Thyroxine" eyahluke kuphela xi ukwimo esebenzayo. Ukuba isigulana ayifaneleki, "El-Thyroxine" analogue amisiweyo ingcali kuthathelwa awohluke ngenxa eziphilayo.

Izimvo elungiswa "El-Thyroxine"

Ngamafutshane, babaxelela ukuba chiza xa esetyenziswa ngeedosi ezisezantsi ikhuthaza ukutshisa amanqatha ngenxa yokunyusa ukutya, kwezithandani wokutya kwandisa inkcitho caloric. Nciphisa ukubonakala iziphumo ebezingalindelekanga okanye ukuthintela uphuhliso uncedo lwabo ukuba β-blocker. Ukuphonononga zibonisa ukuba abaninzi oludibanisa amayeza kunye ndlela. Nangona isibakala sokuba "Thyroxine" lidla kunceda ukwehlisa umzimba, sebenzisa yona ukunciphisa umzimba ayikhuthazwa. Kubantu abasempilweni, amayeza kunokuba yingozi.

Xa unyango izifo ezinxulumene nomsebenzi lengqula kakuhle, ichiza ngokubanzi kakuhle, njengoko kuboniswa ngokutsha. Uchaza izixhobo kukhokelela balance okuqhelekileyo emzimbeni, ngoko ke izigulane bazive ngcono. Kukho izimvo ezingalunganga kuba maxa wambi ukuphuhlisa iziphumo ebezingalindelekanga. Nangona ichiza kwaye ukukwazi ukuba inani elininzi reactions ezibi, ixhasa ndlala, apho umzimba usebenza kahle.

Ukusebenzisa i "El-Thyroxine" ekuhambeni kwexesha asuswe abanale izifo okanye ukunciphisa ubuzaza iimpawu kubo bonke ubomi babo.