Ichiza "Remicade": imiyalelo, real

Kukubek 'lithetha "Remicade"? Imiyalelo yokusebenzisa, ncomo ngomonde eli yeza kuya thaca ngezantsi. Kwakhona kweli nqaku, uza kufunda ngazo naziphi na iimeko, amisele ichiza, ingaba unazo Izimo kunye neziphumo ezibi, ngawaphi amacandelo ziyingxenye kuyo njalo-njalo.

Form, ukwakheka

Ukulungiselela "Remicade" ikhutshwa ngokohlobo ngumgubo lyophilized yenzelwe ukulungiselela isisombululo ukumnika. Eyona nto elikhutheleyo ichiza infliximab. Kwakhona iqulathe amacandelo ezongezelelweyo polysorbate 80, sodium hydrogen phosphate dihydrate, sucrose kunye monohydrate sodium dihydrogen phosphate.

iipropati key

Yintoni na iyeza "Remicade"? Imiyalelo Sebenzisa ithi ukuba i-arhente immunosuppressive.

Kuqhubeka ngaphakathi emzimbeni, ichiza uqalisa ukuba basebenzisane kunye iifomu ezinyibilikayo kunye transmembrane of ithumba necrosis alpha (TNFα), ukunciphisa umsebenzi yabo ukuyilwa izakhiwo ezizinzileyo.

iingcali Uphando lubonisa ukuba into ichiza esebenzayo kunciphisa nokungena eyiselula (ukudumba), kwaye inani zabamakishi ukudumba kwiindawo ezichaphazelekayo yethumbu. Ngenxa yoko kukho luyaphilisa olude olukhawulezileyo malunga inwebu yangaphakathi.

Pharmacokinetics

Zeziphi pharmacokinetic parameters kuye amayeza "Remicade"? Qaphela, impendulo ithi inaliti enye efakwa of infliximab xa isixa ukuya ku-20 mg / kg elandelwa ukunyuka bulingane ubuninzi eyavela.

isicelo okuphindiweyo beziyobisi ubangela olwenzeka kancane into esebenzayo serum.

Iindlela kubulawe ichiza khange iboniwe.

Ubungqina obubonakalayo buxela

Kuba yintoni iinjongo banokuthi banyulwe iziyobisi "Remicade"? Ukusetyenziswa kwale iyeza kuboniswe kwezi meko zilandelayo:

• isifo samathambo ngendlela esebenzayo (ukuba izigulane ngayo iziyobisi ezisisiseko antiinflammatory ukuba angabi). Therapy lwaqhutywa nodibaniso 'methotrexate ". Le indibaniselwano ivumela ukuba ekunciphiseni iimpawu zesi sifo, kwakunye nokuphuculwa welungu xa iyonke.
• isifo Crohn xa izigulane abadala. Kule meko kuyanceda ukuba 'Remicade "? Guide ithi ukuba uthomalaliso nale ukulungiselela kufuneka iqhutywe kwimeko ukunganyamezelani okanye kwawo, kodwa kunye Izimo ukuba ichiza eqhelekileyo. Xa isigulo ezinjalo "Remicade ikhuthaza lokuphelisa nya zonke zesifo izifo, uxolelo ukugcina impiliso ngokukhawulezileyo amanxeba, fistula wokuvala nokuphucula imeko yesigulane.
• isifo Crohn xa elivisayo. Unyango nalo eli chiza oluqhutywa kwimeko ukunganyamezelani okanye kwawo, kodwa kunye Izimo ukuba inkqubo esemgangathweni unyango. Medicament "Remicade" kunciphisa iimpawu kwaye ixhasa noxolelo yaye kuphucula umgangatho wobomi yezigulane abaselula.
• Okwenziwa sisilonda sikabhobhosi abadala. Drug "Remicade", nto leyo nophononongo thaca ngezantsi, ibhalwa apho unyango eqhelekileyo ukuba angasebenzi. Unyango yale arhente kunciphisa iimpawu zesi sifo, lo isifo wamathumbu impiliso, ukuncitshiswa okanye ukupheliswa GCS iidosi. Kufuneka kuqatshelwe ukuba, emva kokuba umsebenzi zesixhobo akubikho mfuneko kokuhlala esibhedlele.
• Okwenziwa sisilonda sikabhobhosi ebantwaneni. Unyango nalo eli chiza emiselweyo ukuba abantwana abaminyaka yobudala eyi-6-18, ukuba saba unyango angasebenzi eqhelekileyo.
• Ankylosing spondylitis (kunye kakuhle unyango standard). Njengoko uxilongo kunceda amayeza "Remicade"? Imiyalelo yokusebenzisa ingxelo ukuba esi sixhobo kwehlisa iimpawu zesi sifo yaye kuphuculwa ukusebenza omzimba.
• Ukhwekhwe (nge kakuhle unyango standard). Njengoko ukhwekhwe ekuncedeni "Remicade"? Iingcali Guest bathi eli chiza kunciphisa ukudumba eluswini kwaye normalizes inkqubo keratinocyte umahluko.
• arthritis Psoriatic (kuba kakuhle unyango standard). Le medicament "Remicade" alawulwa nodibaniso 'MTX "okanye njengoko monotherapy kunye Izimo nobandlululo ukuya yokugqibela. Ngenxa yoko, unyango kwanciphisa iimpawu samathambo, izigulane kwaphuculwa umsebenzi ezisebenzayo, kwakunye unciphisa iqondo radiographic yokuqhubela phambili samathambo psoriatic.

Izimo

Unyango "Remicade" akuvumelekanga yokuziphatha xa:

• inkqubo kakhulu ezosulelayo (umz, nokudumba, ithumba, isifo sephepha, usulelo olungenelelayo) ;
• ukwanda Uvakalelo isigulane ukuba infliximab kunye neeproteni murine kunye naziphi na ezinye amacandelo ichiza;
• abangaphantsi kweminyaka emi-6 (sisilonda sikabhobhosi kunye nezifo Crohn yakhe);
• nokukhulelwa;
• Ukungaphumeleli intliziyo;
• ngaphantsi kweminyaka eli-18;
• ibele.

Drug "Remicade": imiyalelo ukusetyenziswa. Kwaye apho ukungena (ukuba kuphela esibhedlele)?

amayeza kujongwa kufuneka kuphela phantsi kweliso ingcali (okt esibhedlele) ngubani amava ezaneleyo loxilongo kunye nempatho enempumelelo kuzo izifo ngasentla.

Le isisombululo yaziswa dropwise yegazi phezu imizuzu 120. Izinga akufuneki ibe ml ngaphezulu kwama-2 ngomzuzu. Kumiselwe iinkqubo eziyimfuneko kunye nokusetyenziswa kwenkqubo ukumnika.

Le umthamo ichiza ixhomekeke kubungqina.

isifo samathambo

Xa ezinjalo umsebenzi uphethwe idosi yokuqala kufuneka sibe malunga ne-3 mg kg nganye. Le medicament ilawulwa ngokuphindaphindiweyo kwi kwiiveki 3-6. Emva koko sebenzisa it qho emva kweenyanga ezimbini.

Kwimeko ukuba isiphumo enyangayo sele engekaphunyezwa, ucinga ukupheliswa unyango.

Ngokuqhelekileyo ichiza "Remicade" kunye nesifo samathambo elawulwa kunye ne "methotrexate".

wenze umsebenzi

oyidlayo Initial xa uphethwe 5 mg nganye ubunzima bomzimba kg. Ithamo elinye ichiza ezilawulwa kwiiveki 3-6 kamva. Ke zonyango okwenziwa qho emva kweenyanga ezimbini.

Ukuba kuyimfuneko, ithamo angandiswa ukuba mg-10 kg nganye. Ifuthe unyango idla kubonwa kwisithuba seeveki ezili-14. Xa kunjalo, ukuba akunjalo, kufuneka uqhubeke unyango.

samathambo psoriatic

Psoriatic iziyobisi "Remicade" samathambo alawulwa ngendlela idosi yokuqala ka-5 mg kg nganye. Le medicament ilawulwa ngokuphindaphindiweyo kwi kwiiveki 3-6. Ngawo ke kwiiveki 7-8.

Ukumisela amayeza zinokudityaniswa with "methotrexate".

isifo Crohn kaThixo

Ekufumaniseni ezinjalo abadala ziboniswa ngeedosi elilodwa mg-5 kg nganye. Ukuba isiphumo enyangayo sele engekaphunyezwa ukuba iiveki ezi-2 edlulileyo, ichiza emgaqweni.

Ukuba intshukumo iziyobisi entle, izikimu zilandelayo:

• Ewiliko iye yaphathwa idosi enye kwi nokuhlanganiswa yokuqala, yaye emva kweeveki 3-6 zasetyenziswa. Emva koko, yenza izitofu qho emva kweenyanga ezimbini. Ukuba kuyimfuneko, ithamo angandiswa ukuba mg-10 kg nganye.
• Ichiza ilawulwa kuphela likakade iiveki ukuba ngaphezulu kwe-16 emva kokuba ukusetyenziswa yokuqala.

isifo Crohn kuzo abantwana abancinane

Crohn eliphakathi okanye kakhulu kubantwana abangaphantsi kweminyaka eli-18 kuquka ukusetyenziswa kwe-dose yokuqala ka-5 mg kg nganye. izitofu elandelayo kufuneka kwenziwe kwiiveki 3-6. Ke iyeza lisetyenziswa qho emva kweenyanga ezimbini ukuba kuyimfuneko, apha naphaya ukuba umthamo mg-10 kg nganye.

Ngokuqhelekileyo, ichiza kudityaniswe immunomodulators 6-mercaptopurine, "azathioprine" okanye "methotrexate". Ukuba isiphumo enyangayo sele engekaphunyezwa (iiveki 10-11), ukusetyenziswa kweziyobisi ayinqweneleki.

isifo Crohn kukaThixo kuhambisana fistula

A ithamo elinye ichiza xa kufunyaniswa isifo eso 5 mg kg nganye (xa abadala). Amayeza kuhlelo emva kweeveki 3-6. Ukuba isiphumo kwezonyango emva iinaliti 3 anayenza, ngoko unyango ngakumbi bekungalunganga.

Nomphumela ezintle ichiza, izikimu zilandelayo:

• yokungenisa kwakhona emva kweeveki 3-6, zizi ziphindwe qho emva kweenyanga ezimbini;
• i medicament ilawulwa kwi kokuwela ukuba kwathabatha kweeveki ngaphantsi kwe-16.

ankylosing spondylitis

Njengoko nokusetyenziswa kweziyobisi kwesifo "Remicade"? Imiyalelo zokusetyenziswa ithi kule sifo idosi kokuqala ichiza kufuneka 5 mg kg nganye. Emva koku, ichiza ilawulwa emva kweeveki 3-6.

Unyango kufuneka kuqhube ukuba, kwisithuba seeveki ezintandathu isiphumo ayikho azikaqapheleki.

ukhwekhwe

Xa unyango lwe ithamo ukhwekhwe yokuqala 5 mg iziyobisi kg nganye. isicelo okuphindiweyo le medicament elawulwa emva kweeveki 3-6, emva koko - kanye rhoqo kwiiveki ezisibhozo.

Inkqubo lokulungiselela isisombululo nokubandakanywa

Isisombululo kufuneka ilungiswe ngolu hlobo lulandelayo:

• Ibala ithamo kunye nenani yentsha.
• Le umgubo iziyobisi itshitshisiwe xa ml 10 ulwelo usebenzisa isirinji. Ukuze wenze oku, ukususa i-cap inyityilikiswayo igutyana (iplastiki), kwaye osule ngesiciko kunye notywala. Inaliti kufakwa kwiziko layo, kwaye ulwelo ikhokelwa khawugqobhoze eludongeni.
• Ewiliko kwakudalwa ngenyameko (nentshukumo ejikelezayo) de umgubo iyapheliswa. Drug ulwelo kufuneka ibe ezingenambala okanye ithinti omthubi. Ukuba ngexesha okuxuba alephuze amagwebu igutyana walibumba, kuyimfuneko sokufaka isisombululo lemizuzu emi-5. Amaxwebhu oyidlayo lokugqibela ekhona amasuntswana iyakhanya entle.
• Umthamo uwonke iyeza ilungiswa kwi 0.9% chloride (250 ml) of sisombululo sodium. Ukulungiselela le njongo engamanzi uzilungiselele idityaniswe ebhotileni, esele iqulethe sodium chloride. Zombini ezi ziqendu ixutywe.
• Intshayelelo yokulungiselela lwenziwa kweeyure ezingama-3 emva ukulungiselela isisombululo zeziyobisi.

Akuvunyelwe ukungena ichiza kunye nezinye ii-arhente ngokusebenzisa inkqubo efanayo. Ukuba kukho izinto ezingafanelekanga okanye amasuntswana ngaphaya kwi yesisombululo, ayikhuthazwa tu.

mali ingasetyenziswanga iziyobisi ukuba zisetyenziswe.

imiphumela emibi

Xa usebenzisa medicament, abasabela ecaleni kulandelayo:

• ukudakumba, namdla, ukwanda ixhala, isiyezi, somnolence, uvalo, kunesifo, ukugula ngengqondo, intloko ebuhlungu;
• nokudumba yemiphunga, sinusitis, bronchoconstriction, dyspnea, negazi, inyumoniya, epistaxis, iphika, pleuritis;
• conjunctivitis, keratoconjunctivitis, endophthalmitis;
• ukufukuka kunye womchamo izifo;
• tide, ukuphazamiseka ejikeleza peripheral, bradycardia, ecchymosis, hematoma, inkantsi semithambo, syncope, iyangongoza, cyanosis, petechiae, arrhythmia;
• thrombocytopenia, igazi, neytrotsitopeniya, leykotsitopeniya, lymphopenia, lymphadenopathy, lymphocytosis;
• cheilitis, ukuqhina, cholecystitis, reflux, diverticulitis, urhudo, isicaphucaphu, ukungacoleki kokutya, umsebenzi isibindi kakuhle;
• irhashalala eluswini, isikhumba owomileyo, alopecia, seborrhea, ukurhawuzelela, abrasions, irhashalala, ukubila anda, dermatitis, amagciwane, intsumpa, hyperkeratosis, erysipelas, kophulwa umthetho ibala lesikhumba, mlilo bullous.

Izimvo kulungiselelwa

Ngoku uyazi ukuba mawuzisebenzise njani ichiza "Remicade". Imiyalelo zokusetyenziswa ichiza sele kuchaziwe ngentla.

Kwiimeko ezininzi, ingqalelo indlela ukumelana msebenzi. Ngoko ke, impendulo evela izigulane ivame kakhulu entle. Abantu abasebenzisa lo isisombululo, ingxelo ukuba emva kokuba isitofu intlungu iphelile phantse ngokupheleleyo. Noko ke, ezinye izigulane woyike ukuxhomekeka, oko kunokubangela.