Imiyalelo "Gonal-F." Inkcazelo yokulungiselela, Izimo, analogs kunye nohlolo

Enye yezona ndlela oqhelekileyo unyango ukungachumi kukuvuselela ovulation. Kuba amaqanda ezininzi ezifanelekileyo ukuchumisa, oko kuyimfuneko ukuqhuba kwanonyango pre-drug okhethekileyo. "Gonal-F" igqalwa enye amachiza sisebenzayo kule ndawo. Imiyalelo "Gonal-F" licebisa ngamandla unyango phantsi kweliso unyango olungqongqo.

inkcazo

Wonke umntu uyazi ukuba ngaphandle ovulation ukukhulelwa ayikwazi kwenzeke. Ngoko ke, abaninzi besini enobulungisa, ujongene nengxaki enzima enjalo ekufuneka isonjululwe ukuba uvuselelo kunye in vitro. Ugqirha abaya kufuneka kuqala ukwenza uvavanyo lonyango, achole inkqubo ehambisana inkqubo kunye amalungiselelo afanelekileyo.

Izixhobo kakhulu ekhuselekileyo nesebenzayo zisekelwe follicle oluvuselela ama - FSH (ayifane), nto leyo inoxanduva ekukhuleni zoboya kwabasetyhini. Imiyalelo "Gonal-F" ingxelo ukuba ichiza bobabo kolu didi, yaye indlela amanyathelo njengokuba kufutshane FSH zendalo. Thenga iyeza kuphela kagqirha kagqirha.

Ubungqina obubonakalayo buxela

Drug imfuno endle yamanina kwaye yabelwa xa ukuvula nokukhula zoboya. Iimpawu zibonisa ukuba ukusetyenziswa "Gonal-F" has oku kulandelayo:

• Ukungabikho ovulation kunye japan enganelisiyo emva kokufaka "Clomiphene".
• syndrome Polycystic ovarian (ngezifo ezinxulumene ukuphazamiseka kwamadlala ezibangela ukungasebenzi zamaqanda).
• Imfuno ukukhuthazwa zoboya ezininzi ze-IVF.

ngezifundo ezininzi yaqinisekisa ukusebenza ichiza xa kuyimfuneko uphuhliso zoboya ezininzi kwinkqubo hyperstimulation ovarian (zinqandwe). Yaye yasekwa ukuba isithako esebenzayo ikhuthaza ukukhula zoboya, yaye ngaloo ndlela kakhulu lunciphisa ubungozi hyperstimulation ovarian.

Isicelo abantu

Xa-non ukuthotyelwa nemisebenzi esisiseko ye gonads abangamadoda yenkqubo spermatogenesis - lokuqulunqa nokuphuhlisa madlozi - yaphulwe. Follicle ukuvuselela hormone eziyimfuneko ukuze 'ukuqala' yale nkqubo, okuhlala iintsuku 75. Ukubona karhulumente yezifo kunokwenzeka kuphela emva kokuba lokudlula kuxilongo zonyango kunye nokuziswa yobudoda.

Ingqondo (okanye ukubuyisela) ukuyilwa okuqhelekileyo gametes sex oyindoda ngamanye amaxesha kuthatha ixesha elide ngaphezu kokuba inkqubo efanayo kwabasetyhini. Ngenxa yoko esihle unyango kufuneka zihambelane ngokupheleleyo kunye nezincomo andrologist. Kufuneka esitya ukutya eyenzelwe ngokukodwa, ukunikezela ukusetyenziswa kotywala kunye nicotine. Kunyanzelekile ukuba ukuqesha ucwangciso olukhethekileyo. Imiyalelo "Gonal-F" libonisa ukuba ichiza ingasetyenziswa ukwandisa spermatogenesis xa amadoda okhawulezileyo naso okanye lufundiwe. Therapy kufuneka babe phantsi kweliso lomgadi oyingcaphephe lowo namava unyango ukungachumi.

ichiza

component Active beziyobisi izenzo follitropin alfa - into okuvuselela ukukhula zoboya kakhulu kwabasetyhini kunye yokuphazamiseka kwinkqubo hypothalamic-yebhinqa. Le bioavailability beziyobisi xa ilawulwa kwesikhumba wayemalunga 70%.

izithako ezisebenzayo iqala ukuze yande eziphilayo emva ulawulo ngokuphindaphindiweyo. Kwiintsuku zokuqala 3 waphawula kathathu ukuba lizama uyazikhomba follitropin Alfa, oqala inkqubo inkanuko.

amacandelo Auxiliary equlethwe ichiza sodium hayidroksayidi yehayidrojini phosphate dihydrate, phosphoric acid, methionine, sucrose, polysorbate 20.

release Form

"Gonal F" ivelise yenkampani eyenza Italian "Industry Farmasyutika Serono Spa". Ifomu release arhente - isisombululo ukuba isitofu ongama kunye lyophilisates yolwelo.

Le iisirinji ngohlobo ezibayeni anokuqulatha 0.5, 0.75 no 1.5 ml. Ithamo liphantsi ehambelana ukuya micrograms 22 follitropin alfa (300 IU), eliphakathi - 33 mg esisebenza (450 IU). Le mali inkulu arhente esebenzayo eziqulethwe 1.5 ml - 66 micrograms ( "Gonal-F 900"). Ixabiso ichiza ixhomekeke kwindlela ekwakugquba ngayo into esebenzayo.

Pen has a kwisixhobo eyodwa isikali, ikuvumela ukulawula idosi. Kule fomu amayeza kuthenga ukubonga buyanceda iidosi ezahlukeneyo. Izinto eziluncedo ukuze aphumelele, yaye akukho mfuneko yokuba ukulungiselela isisombululo phambi inaliti nganye.

Lyophilizate ukwenzela ukulungiselela isisombululo ukuba isitofu bungxengwe ulwelo phambi kokuba zisetyenziswe kwiinkcukacha nganye. Umthamo ofunekayo i-pre-ubala oyingcaphephe kwimeko nganye.

Njani na unyango "Gonalom-F"?

Xa engekho ovulation unyango iqala kwiveki yokuqala sexesheni, ngaphandle menses rhoqo (ezinye kunokwenzeka rhoqo kutenxa). Inkqubo yokulola kufuneka kuphunyezwa phantsi kolawulo ultrasound phononongo, ikuvumela ukulawula ubungakanani zoboya. ithamo Ukuqalisa - 0,13-0,25 ml iziyobisi "Gonal-F 75". isisombululo Price equlathe 5.5 mg follitropin alfa, nguye kwanala ngeenxa 110 engange. Yandisa ithamo kwiiveki 1-2 ukuya 225 IU (ubuninzi).

Ukuba kwinyanga enye unyango ayiniki iziphumo ezihle, unyango ngamachiza kufuneka kupheliswa. oyidlayo yokuqala iza kwandiswa ukuze unyango olungaphezulu.

Xa imfuneko alawulwa hyperstimulation ovarian ichiza inokusetyenziswa ngendlela ka 150-225 IU. Le idosi iphezulu yemihla ngemihla mayingagqithi 450 IU. Therapy luqala iintsuku 2-3 ukuba sexesheni. Ngoncedo lwe ultrasound aya kubeka esweni ukukhula zoboya. Ubude unyango inokuba ukusuka kwiintsuku ezi-5 ukuya kweziyi-20. Emva kokuba iimela yokugqibela, iiyure ezingama-48 kamva, kongezwa chorionic gonadotropin kwabantu.

Abantu abanengxaki inkqubo spermotogenez lubonisa inkanuko. "Gonal-F" kule meko isetyenziswa ne chorionic gonadotropin yabantu. irejimeni yonyango ithi inaliti ongama beziyobisi kathathu ngeveki (ithamo 150 IU). Ubude unyango kufuneka ubuncinane iinyanga-4, emva koko kufuneka umntu ukuze uvavanywe. Kunye nokuphuculwa elincinane okanye abanalo konke iziphumo zonyango ingafikelela iinyanga ezili-18.

umthamo

Le naliti lokuqala ichiza kufuneka oyingcali esibhedlele. Ekubeni wabayala, kwixesha elizayo umguli Ungasebenzisa ebuhlanti wenze shot, "Gonal-F." Kufuneka kuqala baqhelane imiyalelo ichiza.

Ezi zindululo zilandelayo ukwenzela ukusetyenziswa elizimeleyo ichiza:

1. Phambi kokuba ukugwaza, "Gonal-F", kufuneka ahlambe izandla zabo ngesepha namanzi kwaye mhlawumbi ukuqhubekekiswa ngakumbi kubola.
2. Ukubola phezu ecocekileyo izinto ezifunekayo: ipeni isirinji, igutyana ibe luthuthu amanzi ngenaliti, ilaphu utywala.
3. Kuyimfuneko ukuba kulungiselelwe usiba, asuse le chap, wabeka idosi olufunwayo uze ufake inaliti.
4. Lyophilisate (umgubo) exutywe ngamanzi ukuba isitofu ngokusungula elulwelo igutyana kunye into elomileyo. I-inshorensi yerabha kufuneka inaliti okuhlatywa ukuvula ibhotile akukho mfuneko. Ulwelo kufuneka kuqaliswa kancinci.
5. Kubalulekile ukuba ukucofa emoyeni isirinji de idosi efunekayo, ufaka ngenaliti igutyana kunye nesisombululo (ngaphambili asiphethule phantsi), ukwazisa umoya ukudayala ngenani elithandekayo iziyobisi.
6. Le ngesirinji kufuneka kubakho amaqamza. Ukuze bahlukane kubo, kufuneka kufunyanwe umnwe wakho iindonga isirinji kunye amaqamza uye phezulu. Ngoko kuyimfuneko ukuba tyhala impompo kunye ukukhulula umoya kwemfuneko.
7. Isikhumba kufuneka baphathwe magciwane (utywala) kuyo inaliti.
8. Le Inaliti kwenziwa kwesikhumba kwi 45 okanye 90 degrees. Kabukhali ukuba cofa ibhola ayikho imfuneko. Ichiza kufuneka iphathwe kancinci.
9. Kuba administration "Gonal-F" nge iintlanti isirinji kwanele cofa isiqalo iqhosha. Inaliti kule divaysi ibhityile nezincinane, ngoko intlungu ngobulali okanye phantse engekho.
10. Emva kokuba Inaliti nesiza isitofu kufuneka ikhatshwe swab yomqhaphu zifakwe kubola.
11. ngesirinji ezilahlwayo zilahlwe emva le nkqubo.
12. Kunye izibambo yenaliti-isirinji kufuneka isuswe, ubeke phezu isiciko. Kuba ukuphululwa elilandelayo kuyimfuneko ukusebenzisa inaliti entsha, leyo ifike ne ichiza.

imiphumela emibi

Ukulungiselela "Gonal-F" inokubangela iziphumo ebezingalindelekanga ngexesha unyango. Amanye amabhinqa iqaphele ezi mpawu zilandelayo:

• inkqubo Reproductive - badla ukuphuhlisa cysts ovarian.
• Nefuthe elibi ichiza nga kuchaphazela amalungu lokugaya. Oku kuchazwe ukubonakala isicaphucaphu, ukugabha, urhudo, ubuhlungu kunye neentlungu esiswini.
• Inaliti zingenzeka ukudumba okanye anozizi esikhumbeni.
• amatyala ukusabela komzimba kubangelwa kakhulu inqabile: irhashalala, ukurhawuzelela, ubunzima ukuphefumla, angawokubhuda.
• Ngomhla inxalenye yenkqubo luvo - ukuze abe yintloko rhoqo ngakumbi.
• Ubuncinane rhoqo kukho amatyala nefuthe elibi kwinkqubo yegazi (thromboembolism).

Imiyalelo "Gonal-F" lubonisa ukuba abantu abane unyango zingavela amaqhakuva, ukwanda kancinane ubunzima bomzimba. Kukho iimeko nekunqabileyo varicocele, gynecomastia.

Izimo

Eli chiza negalelo emzimbeni kwaye ngoko abasayi kwenziwa ngaphandle unyango ngaphambi. Le into esebenzayo kunye namacandelo ezongezelelweyo kufuneka bela xa kusetyenziswa. Ugqirha kufuneka zikuthathele ingqalelo oku akhawunti nyenyisa irejimeni yonyango.

Imiyalelo "Gonal-F" ilumkisa ngelithi ukuba ichiza aluvumelekanga ukuyisebenzisa abantu abane ukunganyamezelani okanye hypersensitivity kwizinto ekwakhiweni. Kulo mzekelo, ukuze aphuhlise uxabane kakhulu okanye ezinye iingxaki. Kwakhona Izimo ziquka:

• Wesizalo ivuza igazi umyalezo ezingaziwayo.
• ngezifo Oncologic of eveze zangaphakathi.
• cysts manqapha ovarian eziye yaphuhliswa yangasemva polycystic.
• Ukukhulelwa ne zisanyisa.
• ukungaqheleki bekhubazekile izitho, leyo awahambisani nokukhulelwa.

Incutshe sithabathela ingqalelo zonke comorbidities ezifumaneka kwimbali yesigulane. Kwezinye iimeko, akukho mfuneko yokusebenzisa izixhobo, "Gonal-F." Price of unyango kuxhomekeke ngethuba unyango kunye umthamo ichiza, kodwa unyango olubiza ungalungenisi isiphumo kulindeleke kwi ezimbi ezifana fibroids zesibeleko, ukuya exesheni ngaphambi kwexesha, ekuphazamiseni kwimibhobho Imibhobho.

Iimpawu ze isicelo

Phambi kokuba kokunika ichiza ukukhuthaza ugqirha iingcali unyango ukungachumi ovulation okanye inkqubo spermatogenesis,, kufuneka baziphathe uxilongo izibini zonyango, ukunceda kulawula ngaphandle phambi Izimo kunye nemfuneko unyango. Kwakhona kuyimfuneko nesigqibo seengcinga idosi ziya kufakwa.

Izigulane baye inkanuko "Gonalom-F" ngaphambi kokuba IVF kwandisa amathuba okufumana wayekhulelwe amawele. Ugqirha unyanzelekile ukuba wazise umfazi phambi kokuqalisa unyango.

ukusetyenziswa ngaxeshanye ichiza kunye nezinye izinto eziphembelela ukukhula zoboya, kungabangela uphuhliso hyperstimulation. Ukutyhubela unyango kuyimfuneko ukuba ukuqhuba diagnosis cuke esweni ukukhula zoboya.

"Gonal-F": ixabiso kunye nohlolo

iziyobisi Italian ukukhuthaza ovulation sele ixesha elide ezimiselweyo yonyango iinkunzi amadoda kwanabafazi. Le yenye zixhobo olusebenzayo (oogqirha abaninzi akubize ngokuthi "zokudubula enzima"). "Gonal-F" wabonisa iziphumo ezihle nokuba kwiimeko apho ezinye iindlela aziwayo baba namandla. Umthetho esisiseko emayilandelwe zizigulane, olawula yezonyango ngokupheleleyo inkqubo zoboya yokuguga kunye spermatogenesis.

Xa oyidlayo unyango lisenokuthi litshintshwe ezincinci kwaye ngendlela enkulu. Iindleko ichiza yahluka ukusuka 1100 engange. ukuya ku-16 000 engange. ( "Gonal-F" 900 IU). Ukongezelela ekusebenziseni izixhobo zexabiso, kunyanzelekile ukuba ukulandela imigaqo ethile kwi idayethi ecaleni ngokupheleleyo ukutya okungekho mpilweni, iimveliso eziphantse-ogqityiweyo.

Ngexesha unyango, balelwa ukuba usele utywala, nto leyo iba nefuthe elibi kwimveliso amadlozi, echaphazela ingqondo yebhinqa kunye ngxenye, ukuphazamisa nethe steroid ngesondo. Uvakalelo Ukwanda kule isidoda nicotine.