"Mirapex": imiyalelo ukusetyenziswa, inkcazelo, izimvo

Kweli nqaku uza kufunda zonke ukulungiswa "mirapex": ukubuyisela njani eli chiza, yintoni na isiphumo, Izimo, ziziphumo ebezingalindelekanga, imiyalelo yawo ngqo ngesandla sakhe. Ezi pilisi kunokubangela ukuziphatha engaqhelekanga kunye nefuthe impendulo yesigulane. Ngoko ke, ngaphambi kokuba lo amayeza "mirapex" imiyalelo zokusetyenziswa kufuneka ifundwe ngenyameko. Siya kunixelela ukuba malunga zokungahambisani ezi pilisi kunye nezinye iziyobisi.

Imihla iyoluka "mirapex": ulwazi ngokubanzi malunga ichiza nokubonakaliswa zokusetyenziswa

Le into esebenzayo yokulungiselela "mirapex" i pramipexole. amacandelo Auxiliary Amacwecwe: povidone, mannitol, starch, aerosil, wemagniziyam stearate.

Nale Unyango ngamachiza lwenziwa idiopathic (ezizimeleyo yezinye izitshanguba) syndrome of "imilenze ekucamngceni" kunye nesifo Parkinson kwakunye nezinye motor eling'awukazi nokuphazamiseka extrapyramidal.

Product: iipilisi "mirapex PD" 3 mg, 4.5 mg, 1.5 mg, 0.75 mg, 0,375 mg. Bona zipakishwe namadyungudyungu amaqhosha-10, uze emva koko kwiibhokisi kwikhadibhodi.

iipilisi ezimhlophe. Kufuneka kumngcipheko beveled nemilo mcaba kumacala omabini, omnye umntu ingozi enkulu.

Iipilisi kufuneka zithathwe ngomlomo, kungakhathaliseki ukuba ukutya. iziyobisi Yitya akuvumelekanga ngalo naliphi na ixesha. Kulo mzekelo, kufuneka ihlanjwe phantsi ngamanzi. umthamo nsuku yohlulwe ngamanqanaba amathathu.

Indlela yokusebenza (pharmacodynamics) "mirapex" Amacwecwe

into pramipexole esebenzayo eliquka ukulungiswa "mirapex" ngokukodwa kwaye selectivity ephakamileyo uphucula Impendulo iqelana of receptors dopamine D2. Ngenxa kuye, babuyekezwe yokunqongophala umsebenzi ngokwasemzimbeni kwimeko Parkinson kaThixo. Oku kubangelwa ukusebenza receptors dopamine kwi striatum. Ngoko pramipexole kuthintela ukonakala kwazo luvo eyenzeka ngenxa neurotoxicity okanye ischemia. It abangaphangeliyo okanye kunciphisa umyinge yokuqaphela, ukutya, ndimkhulule dopamine. Ngenxa luvo pramipexole akhuselwe kwimiphumo enetyhefu olwa-Parkinson arhente "Levodopa". Kwakhona ngenxa isiphumo yayo kunciphisa prolactin (yedosi-kuxhomekeke).

Kwimeko ukusetyenziswa elide iipilisi "mirapex 'ukuze ukunyanga isifo Parkinson kaThixo (iminyaka engaphezu kwamashumi amathathu) kunye syndrome of" imilenze noko amnye ebantwini "(ngaphezu konyaka) akazange atyhile kuncitshiswa ukusebenza pramipexole.

iinkqubo kwemichiza ebandakanya ukulungiselela "mirapex 'emzimbeni isigulana (pharmacokinetics)

into "mirapex" Active ichiza ngokupheleleyo yaye ngokukhawuleza wendele emva ulawulo ngomlomo. umthamo lwakhe nokwenziwa (bioavailability) phantse ingundoqo - ngaphezu kwe-90%. Le xi ubuninzi iziyobisi plasma waphawula emva kweeyure 1-3 emva kokutya. Kwizidlo njengeSpecific Absorption Rate pramipexole kunciphisa. Kulo mzekelo, ukutya ukutya akawatshintshi.

iiproteni C lubopha pramipexole kancinane (ngaphantsi kwama-20%). It has a unikezelo umthamo omkhulu - Iilitha ezingama-400, nto leyo ethetha ukuba xiyimiso egazini lisephantsi. Ngezinga elincinane ekucaca ukuba inkqubo ukutya iziyobisi. Malunga nama-90% ngeengqalutye zedosi "mirapex" kwazona yi izintso, nge-80% - ingatshintshanga. Le pramipexole endleni ifumaneka imali engaphantsi kwe-2% yesixa osetyenzisiweyo beziyobisi. Izitho neencindi zomzimba ukuba zihlanjululwe ukusuka 'mirapex "iipilisi kwi ngesilinganiso ml 500 / min.

Besebenzisa "mirapex" iziyobisi ngexesha lokukhulelwa

Ndingasebenzisa ngexesha lokukhulelwa "mirapex" icwecwe? Imiyalelo zokusetyenziswa ichiza kwenza kucace ukuba ifuthe ichiza malunga nophuhliso Umbungu esizalweni kwaye zisanyisa awuthunyelwanga uphando.

Isiphumo kunokwenzeka of pramipexole kwiisistim abasemagunyeni ukuba inkqubo ifakwe zaye kufundwe imifuniselo kwizilwanyana. Ayizi engabonakali Kukwaphula Palsy ngexesha lokukhulelwa in imivundla kunye neempuku.

Kukhuthaza pramipexole ibe ubisi lwebele khange kufundwe. Umntu kuthathwa nje ukuba into kunganqanda zisanyisa, kuba iziveliso ezilawulayo hormone luteotrophic. Ngoko ke, musa ukuthatha "mirapex" ipilisi ngexesha lokuncancisa.

Ngexa lokukhulelwa, ichiza kufuneka kwenziwe kuphela xa inzuzo engase ukuya unina zinkulu kakhulu umngcipheko elizayo olungekazalwa.

Izimo kusetyenziso mirapex tablets ' "

Drug "mirapex" asikwazi kuthathwa kwimeko hypersensitivity ukuya pramipexole, kwakunye nabantu abaye bengekafiki kwiminyaka eli-18 ubudala.

Ngononophelo olulodwa Kucetyiswa ukuba basebenzise iipilisi phantsi koxinzelelo lwegazi sinciphile kwaye ukusilela kwezintso.

Iziphumo ebezingalindelekanga "mirapex" kweziyobisi luvo

Ukulungiselela "mirapex" - macwecwe esinokubangela luvo ezilandelayo reactions:

• ukudideka;
• ukuqaleka ngokugqithisileyo ukulala okanye ukungabikho;
• ukuba nemibono;
• kunesifo;
• asthenia;
• nesiyezi;
• syndrome extrapyramidal;
• hypoesthesia;
• lafa;
• myoclonus;
• DYSTONIA;
• ukudana;
• waphazamiseka;
• kokuzibulala;
• hypokinesia;
• Ataxia;
• ukukhathazeka;
• syndrome neuroleptic amabi.

Kugcine kubonakala uhlobo komzimba, ukuphazamiseka sezingqondweni yokucinga, ngqongqo kwezihlunu, lability yawo, akathisia.

engemihle iipilisi "mirapex" kwezinye iindlela umzimba womntu

inkqubo Musculoskeletal zinako ukuphendula ukusetyenziswa kwamayeza "mirapex" kubonakaliswa;

• imisipha hypertonic, unditsho zabo, twitching;
• ivela kwamalunga, myasthenia gravis okanye bursitis;
• iintlungu esifubeni, entanyeni okanye umqolo (kwi lumbosacral).

Kananjalo zenzeka umahluko kwinkqubo yokwetyisa. Xa oku kwenzeka:

• ukulahleka emnyama;
• nokuqunjelwa;
• isicaphucaphu;
• ukuqunjelwa;
• flatulence;
• sorhudo;
• ukuphalaza;
• umlomo owomileyo;
• ukusika imvakalelo esiswini.

lolwamkelo esikolweni "mirapex 'nokuphefumla beziyobisi kungabangela kuphuhliso sinusitis, pharyngitis, nokuthimliswa, ezifana nomkhuhlane syndrome. Kwakhona isahlakalo ukuphelelwa umoya, ukhohlokhohlo eyonyukileyo kunye notshintsho ilizwi kunokwenzeka.

Yintoni iziphumo yegazi kwinkqubo "mirapex" icwecwe? Imiyalelo zokusetyenziswa ichiza yazisa tachycardia kunokwenzeka uphuhliso, arrhythmia, angina sifuba, hypotension intolerance.

Eminye imiphumela emibi

Xa ekufumaneni ichiza "mirapex" iingxaki ezinjalo kungenzeka kwinkqubo enzala, njengoko iintshukumo yesisu ngakumbi, usulelo. Ngoko nokuba bekufanele ilahleko yobuntu kunye amandla.

Ukongezelela, usenokuba umbono kabini, cataract, conjunctivitis, ukushwabana yokuhlala, aleji, kunye neengxaki zokuva, uxinzelelo intraocular.

Ezinye ukusabela ebuhlungu umzimba:

• abanesigulo retroperitoneal;
• effusion pleural;
• nokungena pulmonary;
• komzimba;
• nokudumba zomzimba.

Idosi Administration "mirapex" Amacwecwe

Ukusebenzisa ichiza kufuneka ngaphakathi, ngemihla ka-3. Initial ithamo "mirapex PD" tablets - 0,375 mg ngosuku. Ngcembe ukunyusa ubungakanani ichiza eziyimfuneko (zonke iintsuku ezisi-7) ukuze ufumane isiphumo enyangayo ezinqwenelekayo. Kwiveki yesibini unyango yonke imihla kufuneka ningagqitywa 0.75 mg kwi wesithathu - to 1,5 mg yekota yesine - ngu 2.25 mg kwi imfuno yesihlanu ukuba usele amayeza "mirapex" 3 mg yonke imihla, ngomhla yesithandathu - 3,75 mg, owesixhenxe - 4.5 mg.

Xa ukusilela ezingapheliyo kwezintso, idosi hlengiswe ngokususela intsebenzo of yokususwa creatinine. Imali ngqo ichiza kufuneka amiselwe ngugqirha.

Iziphumo libanda ipilisi "mirapex"

Ukuba usebenzisa kwaphulwa "mirapex" umthamo iziyobisi ke, ezi mpawu Inokwenzeka wavele nemibono, hyperkinesia, isicaphucaphu, ukugabha, kunciphisa uxinzelelo lwegazi kunye nokuvuka.

Ngenxa yale meko, lo ebubuvuvu ayifakwanga. Amatyala libanda, iziyobisi "mirapex" azifani. Kucetyiswa unyango lingaze, lavage esiswini nawazibonayo olutshintshayo. Ukuba kukho Imiqondiso yokuba libanda kakhulu excitation kwenkqubo luvo, kuyimfuneko ukusebenzisa amalungiselelo, neuroleptics.

Ukusebenzelana tablets "mirapex" kunye namanye amachiza

Pramipexole enxulumene plasma protein kancinane kunye biotransformation. Ngoko ke, intsebenziswano yayo kunye nezinye iziyobisi echaphazela ezi nkqubo kwenzeke.

Neziyobisi zinqanda okanye gqiba imveliso kwezinto esebenzayo okanye samovyvodyaschiesya cationic ngokusebenzisa tubules kwezintso, kungaba asabela kunye iipilisi "mirapex". Imiyalelo zokusetyenziswa ucacisa ukuba kule meko ekunciphiseni isantya izicwili kubonakale ukucocwa ulwelo zebhayoloji okanye zombini imithi okanye omnye wabo.

Ukuba ngaxeshanye mirapex "iipilisi 'kusetyenziswa la machiza, kufuneka sinikele ingqalelo nemibono kunokwenzeka, zeDyskinesia, ukuphazamiseka. Ukuba le miqondiso kwenzeka, ukuba umthamo ichiza kufuneka incitshiswe.

Amacwecwe soGuquguquko lweProgram "mirapex 'iziyobisi' Amantadine" yaye "L-dopa"

Kwenzeka ntoni xa lolwamkelo esikolweni "Levodopa" iziyobisi ezidibeneyo "selegiline" iipilisi "mirapex PD"? Imiyalelo ithi ukuba pharmacokinetics yomenzeli esebenzayo aluchaphazeli nanto yokuqala okanye yesibini. Ngelo xesha malunga nokwenziwa ngokupheleleyo kwaye kukhuthaza ichiza ngendlela yemvelo "Levodopa" icwecwe "mirapex" azinakanwa.

Pramipexole waye wafunda impefumlelwano ichiza "Amantadine". Kodwa ukuhambelana kunokwenzeka unyango, ekubeni iindlela efanayo zinomgutyulo.

Xa ithamo kulungiselelwa "mirapex" lenyuka, imali yesicelo "Levodopa" ekucetyiswa ukuba bunciphe. Inani namanye amachiza antiparkinsonian kufuneka zigcinwe rhoqo kwinqanaba elifanayo.

Features ukulungiselela soGuquguquko "mirapex" kunye namanye amachiza

Ngenxa amathuba neziphumo ezongezelelekayo ngononophelo kakhulu Kucetyiswa ukuba basebenzise iipilisi "mirapex" kunye nadlamkisayo, utywala, kunye neziyobisi ezinceda ukwandisa pramipexole yoxinaniso egazini (umz, ichiza "Cimetidine").

isikhokelo oluthile nokusetyenziswa "mirapex" tablets

Thina echaza ichiza ayikhuthazwa ukuba ngokusebenzisana antipsychotics.

Xa unyango lwe dopamine agonist iziphumo ebezingalindelekanga eyaziwa kukho ukudideka kunye nemibono. Kwiimeko "mirapex" amacwecwe zidityaniswe kunye ichiza "Levodopa" ukungaqheleki ezinjalo rhoqo ngakumbi kwi zigaba kamva kwesi sifo ngakumbi monotherapy ekuqaleni.

Ugqirha kufuneka azise ogulayo kukuvela nemibono olubonakalayo kunokwenzeka. Oku effect icala kuchaphazela ukukwazi ukuqhuba izithuthi kwaye ukwenza izigqibo ezifanelekileyo.

Xa ukupheliswa elibukhali amacwecwe kwimeko Parkinson kaThixo zabonwa imbonakalo iimpawu efana neuroleptic amabi syndrome.

ukuziphatha Anomalous kokusetyenziswa "mirapex" iziyobisi

Izigulane nabo ukuzinakekela, kubalulekile ukwazi ukuba ulwamkelo iziyobisi dopaminergic, kuquka "mirapex" iipilisi (reviews ukuqinisekisa oku), kubangela ukuziphatha okungaqhelekanga malunga nesigulane eso. Kungahle hyperphagia (likhoboka kukuzingxala), ukuthenga zophendlo lwezifo (umnqweno ukhathazeka ukwenza oluninzi purchases), ukugembula kunye hypersexuality. Kwiimeko ezinjalo kuyimfuneko ukunciphisa umthamo ichiza okanye ngcembe uyeke ukuthatha kuyo.

Isilumkiso kokusetyenziswa "mirapex" tablets

Medicine "mirapex" kufuneka ziphele isilumkiso izigulane kunye ukubakhona kwezifo ezinzima kwenkqubo sentliziyo. Ekuqhubeni unyango ngamachiza dopaminergic kukho umngcipheko hypotension intolerance. Ngoko ke, ulawulo uxinzelelo lwegazi, ingakumbi lokuqala unyango.

Xa ongaboniyo kuyimfuneko ukuhlola rhoqo ngoko nangoko emva kokuba ukuqeshwa amacwecwe "mirapex" kunye ngamathuba ezichazwe phambili.

Izigulana kufuneka banikwe yokuba ichiza ukuze abe okulalisa. Kukho amatyala ubuthongo ngesiquphe kunye nobuthongo kakhulu emini imisebenzi imihla. Kuquka oku kwenzeka ngalo naliphi na ixesha kulawulo oomatshini ezinzima okanye izithuthi ukuqhuba.

Ukuba nokwenzeka wolusu okhulayo

Ngenxa yokuba izifundo zezifo lubonise ukuba izigulane ezinochaso Parkinson kaThixo basemngciphekweni wolusu. Ngaba unobangela wale sifo, okanye ezinye izinto, ezifana nokusetyenziswa "mirapex" ichiza iye ayasekwa.

Ukomeleza lo onaso of "imilenze noko amnye ebantwini"

wenza syndrome of "imilenze ekucamngceni" iziyobisi "mirapex" Njani? Baqinisekiswa ukuba iziyobisi dopaminergic ukuze ukuyikhulisa. Oku kuboniswa ngokohlobo kokuqala yangaphambili iimpawu ngokuhlwa syndrome yaye maxa wambi emva kwemini. Kulo mzekelo, iimpawu yandele kwamanye amalungu omzimba. I kubanjwa kangangeeveki 26 isifundo lwezonyango elawulwa, leyo eyenzelwe ukufunda koku, kukho umahluko omkhulu phakathi pramipexole kunye placebo amaqela ekuphuculeni iimpawu zesi sifo ziye zachongwa.

iimeko Ukugcinwa ezikhabhathini

"Mirapex" icwecwe libhekisela ukulungiselela uluhlu B. Store kufuneka ibe kwindawo emnyama. Kulo mzekelo ubushushu igumbi kufuneka ingadluli 30 ° C.

Ubude bethuba lokusetyenziswa kwe ichiza - iinyanga 36 (iminyaka emi-3) ukusuka kumhla kwimveliso.

Ukusetyenziswa "mirapex" iipilisi ebuntwaneni kunye neemeko nokuthenga

Ichiza contraindicated ukusetyenziswa ebantwaneni. Imvume pha abantu abafumana iipilisi, eziye wayeneminyaka eli-18 ubudala. Medicine "mirapex" yakhululwa Pharmacy noqeqesha ngenkqubo amayeza.

Drug analogue "mirapex"

Awunako, ngenxa yaso nasiphi na isizathu, ukuba ufumane tablet "mirapex '? Yintoni indawo ichiza, kufuneka uxelele ayinikiwe okanye kugqirha. Kwaye sihambise analogue zilandelayo.

1. "Motopram" iipilisi. Iimpawu zibonisa ukuba ukusetyenziswa: isifo Parkinson kaThixo. It zingenziwa wedwa okanye idityaniswe ngamayeza amayeza 'levodopa'. Iyasetyenziswa yeSicelo kakhulu okanye eliphakathi idiopathic le onaso of "imilenze noko amnye ebantwini".
2. "Oprimeya" iipilisi. Injongo: antiparkinsonian iyeza ivuselela ukudluliselwa dopaminergic kwinkqubo luvo.
3. "Pramipexole" iipilisi. Iarhente therapeutic ezisetyenziswa Parkinson kaThixo. Kukholelwa ukuba indlela yokusebenza inxulumene ngqo nokukwazi a pramipexole kweziyobisi zivuselela receptors dopamine kwi striatum.

Tablets "mirapex" - analogue okanye original? Akukho self!

Kulo kwiimveliso ezidweliswe ngasentla, ezo analogue of 'mirapex "iipilisi. Baye ezifanayo unique, international igama non-wezindlu (okanye ATC-ikhowudi), nto leyo isincomo yi-WHO (World Health Organization).

Ukuba ufuna ukuba afumane unyango usebenzisa iipilisi "mirapex" analogs nako enye enkulu. Kodwa ngaphambi kokuba endaweni indlela amisiweyo unyango, qiniseka ukuba ubonane yincutshe. Makungaze naphantsi kwazo naziphi na iimeko musa self! Oku kunokubangela iziphumo ezingenakuguqulwa ezibi kwimpilo yakho.

Isilumkiso! Eli nqaku inkcazo kulungiselelwa "mirapex" iya kuthi yongezwe kwaye uguqulelo kolunye ulwimi olulula le imiyalelo esemthethweni ukuze zisetyenziswe. ulwazi Drug inikwa ngenjongo ngokutsha. Xa kungekho tyala musa ungayisebenzisa njengendlela isikhokelo self-amayeza.