Ukulungiselela "Algezir Ultra": imiyalelo yokusetyenziswa, inkcazo, ukubunjwa kunye nokuhlolwa

Kungekudala, oogqirha bavame ukutyumba izigulane "Algesir Ultra". Umyalelo wale sixhobo unolwazi kwaye uchaza iimpawu zokusetyenziswa kwazo kwiindidi ezahlukahlukeneyo zezigulane, kodwa akuboneleli ngcaciso eninzi malunga nokuba le nkonzo isebenza njani emzimbeni.

Pharmacology

Kwindlela yokwakhiwa kwesilwanyana - i-NSAID, ephuma kwi-naphthylpropionic acid. Kwinkqubo yokuthatha le nkunkuma inxamnye ne-inflammatory, antipyretic, kunye nefuthe le-analgesic, esoloko ibonakaliswe ukuphononongwa nge "Algesir Ultra." Umyalelo kwisixhobo sichaza nale miba.

Inkqubo yesenzo sonyango ihambelana ngqo ne-inhibition ye-enzyme ene-COX, eyenza sikwazi ukucinezela ukuhlanganiswa kwe-prostaglandids kwi-arachidonic acid ngokufanelekileyo ngokusemandleni. Kwakhona, eli arhente linikeza ukuxothwa kwe-platelet aggregation.

Ingqwalasela ekhethekileyo kufuneka ihlawulwe kwinto yokuba ngexesha lokulawulwa kwesifo se-drug syndrome sehla, kubandakanywa iintlungu zomzimba kunye nokuphumla. Kwinkqubo yokwamkelwa kwamathunywa okunciphisa, ukuqina komso, ukunyuka kwamanzi kukhula, okuphawulwa phantse wonke umntu oshiye ingxelo malunga ne-Algesir Ultra. Umyalelo uphinde uqulethe ulwazi olunjalo, ngeli xesha libonisa ukuba umphumo wokuchasana unokufezekiswa ekupheleni kweveki yokuqala yokunyanga.

Pharmacokinetics

Emva koko, ukuthatha le mayeza ngaphakathi naproxen uqala ukukhawuleza ngokukhawuleza kwindlela yokutya. I- _{max max} kwi-plasma iqala ukugcinwa emva kweeyure ezingama-1-4 emva kokulawula. Kufuneka kuqatshelwe ukuba ukusetyenziswa ngokufanayo kwesi sidakamizwa kunye nokutya kunokunciphisa izinga lokumitha, kodwa akunciphisi ukutywala. I-Naproxen ihluke ngokufanelekileyo ekumanyeni ukulawulwa kwamaritha, kodwa kule meko kukho ukukhawuleza okukhulu, xa kuthelekiswa nokungenisa.

Kwiinkalo zonyango, le nto ibopha kwiiprotheni zeplasma malunga nama-100%. Ukuxinwa kwe-naproxen kwiplasma kwandisa ngokwemilinganiselo ekusebenziseni amanani ukuya kuma-500 mg, ngelixa kumaqondo aphezulu kukho ukunyuka kwemvume, ngenxa ye-saturation epheleleyo yeeprotheni ze-plasma.

I-Naproxen iyahlukana kwi-synovial fluid.

I- _1/2 i malunga nama-13 iiyure. Phantse i-95% yexabiso elipheleleyo le dose ekugqibeleni lidityaniswe kwimeko yomguko, 6-O-desmethylnaproxen kunye nezidibaniso zayo ezahlukeneyo. Bonke abanye kwixa elizayo emva kokumkelwa kwamathambo.

Isistim

Kubalulekile ukuba uqaphele ukuba kuyacetyiswa ukuba i-dose ngayinye isetyenziswe ngokuhambelana nesikolo sesifo kwisigulane. Ukulungiselela "Algesir Ultra" umyalelo uthi abantu abadala bayacetyiswa ukuba bathathe kwiiyitifiketi ze-0.5-1 g ngosuku ngemilinganiselo emibini ehlukeneyo, ngelixa umthamo wansuku zonke unyango oluqhelekileyo lufanele lube malunga ne-500 mg.

Umthamo omkhulu wemihla ngemihla ungama-1.75 g.

Isisiseko sabantwana

Ukuba unyango luqhutyelwa kwizigulane ezineminyaka eli-1 ukuya kweyesi-5, kufuneka basebenzise i-2.5-5 mg ngeekhi nganye ngosuku ukwenzela ukuba amanani amathathu ngosuku, kunye nekhosi ephakamileyo yokunyanga kwimeko enokuba ngu-14 Iintsuku. Xa unyango lwe-arthritis yabantwana kwiminyaka engama-5 ubudala, i-dose yemihla ngemihla ichanekile kwaye i-10 mg nganye ngeekhi.

Ukusebenzisana kokwelapha "i-Algezir Ultra"

Imiyalelo yokusetyenziswa ithi xa isetyenziswe ngexesha elifanayo kunye ne-antacids, equka i-aluminium kunye ne-magnesium, kunye ne-sodium bicarbonate, ngoko kuloo nto ichaphazela kakubi ukunyuselwa kwe-naproxen, ebaluleke kakhulu kwinkqubo yokwenza unyango.

Ukuba i-ejenti isetyenziselwa kunye nama-antiticoagulants angangqalileyo, ke kunokubakho ukuphucula amancinci kwimpembelelo yale michiza, eyaziwayo kwinkqubo yokwenza izifundo ezizodwa zeklinikhi.

Kwakhona kwinkqubo yokuqhuba izifundo, umphumo wokusetyenziswa ngokufanayo kwesilwanyana kunye ne-amoxicillin yafundwa, oku kwaphumela ekuphuhliseni i- nephrotic syndrome kwiimeko ezithile . Ukuba "i-Algesir Ultra" yayisetyenziswe nge-acetylsalicylic acid, kwezinye iimeko i-concentration ye naproxen kwi-plasma yegazi iyancipha.

Iinkcukacha ezongezelelweyo zokusebenzisana

Phakathi kwezinye izinto, kubalulekile ukuphawula ezinye iimeko, eziboniswe kumyalelo wokulungiselela "i-Algesir Ultra" (amaphilisi):

• Xa kusetyenziswa ngokufanayo, unokwenzeka ukuba utshintsho oluthile kwimilinganiselo ye-pharmacokinetic ye diazepam inikwe;
• Ukuba le arhente isetyenziswa ngokufanayo nge-caffeine, umphumo we-naproxen unokuphuculwa;
• Xa zidibene ne- lithium carbonate , kunokwenzeka ukwandisa i-lithium kwi-plasma yegazi;
• Ukudibanisa ne-methotrexate kwandisa umlinganiselo wesetyhefu sale nkunkuma;
• Xa i-"Algezir Ultra" isetyenziselwa kunye neprobenecid, i-concentration ye naproxen kwi-plasma yegazi iyancitshiswa;
• Isicelo esisodwa kunye ne-salicylamide senza ukuba kunokwenzeka ukuphucula isenzo sale nto.

Kukho ulwazi olubonisa ukuba ukuba isilwanyana sisetyenziselwa ukudibanisa kunye ne-morphine, ekugqibeleni kunokukhokelela ekuphuhliseni i-myoclonus. Kwakhona, kunye nokusetyenziswa ngokufanayo kunye ne-prednisolone, kukho ukwanda okwenziwe kwinqanaba lokuxinwa kwale nkunkuma kwi-plasma yegazi. Ukongezelela, kukho ukusetyenziswa ngokufanayo kunye ne-furosemide, elungiselela ukuhla kwefuthe ledayuretic. Oku kuphawulwe malunga nesixhobo esinjalo njengesilwanyana "Algesir Ultra", ukuhlaziywa. Umyalelo uphinde ubonise le nkalo yeyeza.

Ukungqinelana nokukhulelwa

Kunconywa ukusebenzisa le myeza ngokulumkisa ngokugqithiseleyo kubasetyhini abakhulelweyo okanye abakhohlakeleyo, kwaye ngoku kukodwa oku kusebenza kulabo abangoku kwikota yokuqala okanye yesithathu. Into elandelayo kukuba emva kokuthatha le naproxen yeziyobisi iqala ukungena emngceleni we-placental, kwaye emva koko ikhutshwe ngobuncinane kunye nobisi lwebele.

Imiphumo emibi

Kufuneka kuqatshelwe imiphumo emibini emibi, ebonisa ukulungiselela "imiyalelo ye-Algesir Ultra" yokusetyenziswa. Iinkcazo kulo mzekelo zibonelelwa ngamaqela ahlukeneyo amabhunga:

• Inkqubo yokutya. Kwixesha lokumkelwa, kunokuhlambalaza, isisongela, ukuvakalelwa kwimeko yesigodi se-epigastric. Kwiimeko ezinqabileyo, zikhona izilonda ezinobomi kunye nezilonda zesifo sokugaya, kunye nokuphulwa kobuninzi bebindi kunye nokuphuma kwamanzi.
• Inkqubo yesantya ephakathi. Xa usebenzisa izilwanyana kwezinye izigulane, ukulala, ukuphathwa kwentloko, kwakunye nokunciphisa ijubane lokuphendula ngengqondo. Kwiimeko ezinqabileyo kakhulu, usebenzisa le sixhobo, kukho ukungahambi kakuhle kweentloko, njengoko kuboniswe ngumyalelo othi "i-Algesir Ultra" imiyalelo yokusetyenziswa. Okucacileyo akuchazi ngokucacileyo le nto yokusetyenziswa.
• I-hematopoiesis inkqubo. Ukusetyenziswa ngokungaqhelekanga kwesi sidakamizwa kubangela ukuba kwenzeke kwegranulocytopenia kunye ne-thrombocytopenia, kunye ne-hemolytic okanye i-anemia ye-anemia.
• Inkqubo yokuphefumula. Kwiimeko ezinqabileyo, i- eosinophilic pneumonia ingahlakulela .
• I-urinary system. Kwiimeko ezinqabileyo, ukukhubazeka kweentlobo zeentlobo zenzeke.
• Ukuphendulwa kwemizwa. Kwiqela elithile lezigulane, i-urticaria, i-skin shash kunye ne-quema ye-Quincke yabonwa ngethuba lophando, okuyiyo eyenziwa ngokusesikweni kwimizimba eyahlukeneyo eyenza isilwanyana, njengoko kuchaziwe kwi "Algesir Ultra" imiyalelo yokusetyenziswa. Unyango kulolu hlobo alunakunyuswa.

Phakathi kwezinye izinto, kulungelelaniso olukhethekileyo ukuba kwimeko yokusetyenziswa kwamacandelwana, kukho umngcipheko weemfihlo ze-mucoid kunye nokungcola kwegazi elincinci okanye ukubonakala kohlwayo olubi.

Liyasetyenziswa nini?

Kwiminyaka embalwa edlulileyo, oogqirha banamhlanje baye baqalisa ukuchaza eli gulane kwizigulane zabo ngexesha lokunyangwa kwezifo ezahlukahlukeneyo, kubandakanye nalabo bachaza imiyalelo yokusetyenziswa kwe-Algesir Ultra. Ixabiso lale mveliso lifikeleleka phantse wonke umntu, kwaye ngoko ke imiselwe ngokuphindaphindiweyo kuninzi yeendlela ezininzi ezifanayo.

Ngokukodwa, kubalulekile ukuphawula izifo ezininzi eziphambili, kwindlela yokonyango esisetyenziswa ngayo kakhulu:

• Osteoarthritis;
• I-rheumatoid arthritis;
• I-Ankylosing spondylitis;
• Ukuqhaqhaqhaza kwegout;
• Isifo seArticular;
• Neuralgia;
• Myalgia;
• Ubuhlungu emgodini;
• Ukuqhaqhazela ngokugqithisileyo kwezicubu ezithambileyo okanye inkqubo ye-musculoskeletal.

Phakathi kwezinye izinto, "i-Algesir Ultra" idlalwa njengomncedisi ekhatheni izifo ezahlukahlukeneyo ezichaphazelayo nezivuzayo ze-ENT, i-dysmenorrhea yokuqala, i-adnexitis, kunye namazinyo kunye neentloko.

Ukungqinelana

Kukho iziganeko ezininzi apho esi sixhobo asikhuthazwa ukuba sisebenzise, kwaye oku kubonisa umyalelo wokulungiselela u-"Algesir Ultra" kwisicelo (inkcazo). Ukugqithiswa koogqirha kwakhona kubonisa ukuba le nkunkuma ayikhuthazwa kakhulu ukuba isebenziswe kwezi zilandelayo:

• "Aspirin triad";
• Zonke iintlobo zezilonda ezinobomi kunye nezilonda esiswini kwendlela yokuxhamla esiswini;
• Ukuchazwa kweengxaki kwimisebenzi yeentso;
• Ukuchithwa kweprogram ye-hematopoiesis;
• Ukuchazwa kwezibandezelo kwimisebenzi yesibindi;
• Ukuba nobukhulu obuphezulu kwi-naproxen kunye nezinye izinto eziyingxenye yale nkunkuma.

Phakathi kwezinye izinto, ukusetyenziswa kwesi siluleko akukhuthazwa kubantwana abangaphantsi kweminyaka elilodwa, njengoko kuboniswe ngumyalelo othi "i-Algesir Ultra". Ixabiso le mveliso ngu-85-90 ruble. Iipilisi ezili-10.

Imiyalelo ekhethekileyo

Ukuqaphela kakhulu le sixhobo kufuneka isetyenziswe kunyango lwezifo ezahlukahlukeneyo zeengtso kunye nesibindi, umzila wesisu emlandweni, kunye nokuhluleka kwentliziyo, uxinzelelo lwengqondo okanye ubukho beempawu zesifo se-dyspeptic. Ngokukodwa, kufuneka ukuba kunyanzelekile ukudibana nogqirha malunga nokuba le nkunkuma ingasetyenziselwa ukunyango okuphambili.

Kwonyango kufuneka ihlale ilawula ngokufanelekileyo inkqubo yomsebenzi wezintso kunye nesibindi, kunye nomfanekiso wegazi lombhobho. Ukuba kuyimfuneko ukugqiba iqondo lokuxinwa kwe-17-ketosteroids, ukungena kwe-naproxen kuyakufuneka ikhutshwe iiyure ezingama-48 phambi komhla wokufundwa ocetywayo.

Ingqwalasela ingakumbi kufuneka ihlawulwe kwinto yokuba ukuthatha eli liyeza lichaphazela ukukwazi ukuqhuba iimoto nokulawula iindlela ezahlukeneyo. Kule nto, kulungile ukuyeka kuzo zonke izinto ezinobungozi ezichaphazelekayo ezihambelana ngqo nesidingo sokugxininiswa kwengqalelo kunye nokunyuka kwejubane lokuphendula kwengqondo, ngelixa i-Algezir Ultra isetyenziswa. Imiyalelo yokusetyenziswa kwilisi ngokwahlukileyo icacisa le ngongoma.