Abamelene calcium - iziyobisi ebanzi-kuyoyonke

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Xa ibubomi kumzimba elawula ion calcium zidlala indima kunokuba ebalulekileyo. Isibakala ukuba calcium, ezendeleyo kwizisele ekwaziyo isebenze yonke zhiznenovazhnye iinkqubo intracellular ngendlela ephilayo, umz, ukuguqukela ATP ekampini okanye protini phosphorylation iinkqubo.

Ulawulo ion calcium emzimbeni

Calcium ungena iiseli ngeetshaneli ezizodwa, ezo iimolekyuli iiproteins ezinkulu kuqatshelwa ngokusebenzisa inwebu multilayer of iiseli. Ezi "imijelo", phakathi kwezinye izinto, kufuneka receptors ezithile, oluqhutywa ukuchongwa ion calcium, ngaphandle yokutsiba kunye namanye amasuntswana.

Ukuhamba ion icalcium ephilayo kulawulwa yimiba ethile zemveli ukuba abe imvelaphi neurogenic kwaye mediators ezidalwe ezifana acetylcholine okanye serotonin.

Iziyobisi ezithintela kwii-ion calcium zibe ziiseli

Studies lemithi kunganqanda imijelo calcium lokudlula yaqala kwi 60s kwaye usaqhubeka. Ekuqaleni ezi zifundo zivulekile avela kweziyobisi fenilakilamina, ngelo xesha sele ekucetywa ukuba kubekho ukusetyenziswa njengoko amalungiselelo koronorasshiryayuschih. Namhlanje wavula kakhulu inani elikhulu izinto ezinjalo, ezo zidibene kwiqela elinye, ezafumana igama - abamelene calcium.

Ukusebenzisa abamelene calcium

abamelene calcium ngoku esisetyenziswa ngokubanzi kwiinkalo ezahlukeneyo amayeza, oku kungenxa yokuba ngaka uluhlu olubanzi amanyathelo. Ngoko ke, umzekelo, abamelene calcium enokuchaphazela contractility engabalulekanga, Uhanjiso atrioventricular kunye nomsebenzi sinus node.

A isiphumo esifanayo bachasene aldosterone ezithintela isenzo ngenxa yayo receptor conductivity aldosterone, ngaleyo ndlela kwande isixa icalcium izisele.

Kwezinye iindlela iimeko lwezidumbu, ezifana hypoxia okanye ischemia, ion calcium ngokugqithiseleyo unako ukuphucula iinkqubo intracellular, ngaloo ndlela ukwanda kwemfuno izihlunu ioksijini, nto leyo enokukhokelela ekubeni iziphumo ezahlukeneyo zophendlo lwezifo. Kulo mzekelo, i abamelene calcium zibe nefuthe enyangayo, zinciphisa isenzo ion calcium kungena kwiinkqubo iseli.

abamelene Calcium yonyango izifo ezinxulumene ne CAS

ukusetyenziswa wayo osemqoka blocker channel calcium wafumana namhlanje unyango lwezifo sentliziyo. Iziyobisi zingachaphazela indlela conductivity kunye excitability wentliziyo, lineziphumo antianginal, kuphuculwe ukuhamba kwegazi coronary nokunciphisa uxinzelelo lwegazi.

Iziyobisi ezichaphazela Uhanjiso ezesifuba excitability namhlanje esetyenziswa iziyobisi antiarrhythmic, nto leyo Ukukhethwa eyahlukileyo iqela amayeza (angianginalnye iindlela).

Abamelene zichaphazela kakhulu udibaniso zegazi, ukunciphisa coalescence labo kunye nokuququzelela ahlazululwe of ziiplatelets. La machiza asetyenziswa ukunciphisa viscosity igazi sandise okubuyela kwimo yazo ziiplatelets. Ukwandisa amandla anticoagulant igazi isicelo bachasene kunye novithamini K eziphazamisana okanye ipoti ye prothrombin, uvimba ukuyilwa amahlwili fibrin.

Le spectrum yesenzo iziyobisi

LwaseNtshona Koloni ziba ntshukumo bachasene calcium na ezahlukeneyo ngokwenene, kuba ngoku zisetyenziswa kuphela ngokuphatha iintlobo eziphambili isifo sentliziyo, kodwa ngenxa yonyango migraine, isifuba, ukuphazamiseka ejikeleza lobuchopho. abamelene calcium zidlala indima ebalulekileyo unyango ukuphazamiseka engqondweni, esetyenziswa ukunyanga sokuxhuzula kunye zeDyskinesia kwizigulane kunye sengqondo.