ALT. AST egazini

ALT, AST - ziiproteni ezikhethekileyo - ngakumbi ngqo, i-enzayim eziqulathwe iiseli ukuba athathe inxaxheba yokucolwa ye asidi acid - iziyobisi apho iiproteni zakhiwa. Indlela ALT AST ziqulethwe kuphela kwiiseli zabantu. Inye kuphela isizathu sokuba ALT, AST egazini - umonakalo okanye ekutshatyalalisweni iiseli ababehleli kuyo. Ezi enzyme ayifumaneki kwi-mali efanayo (elilingana) kuwo onke amalungu. Ngoko ke, ukuba kumanqanaba igazi enye yezi enzyme, oko kube ngumqondiso zesi sifo ilungu elithile. Ngoko ke, umzekelo, ngethuba naziphi na izifo zesibindi UMTHETHO liphuma kangangoko ngaphezu ACT. In acute iposi engabalulekanga ALT kwakhona ngaphezulu kakhulu kunokuba abantu AST. umsebenzi AST leyo kakhulu anda kakhulu umonakalo hepatocyte. Ngokuqhelekileyo, umsebenzi AST libhekisela avareji umsebenzi ALT-1 ukuya ku-3 (njalo-ebizwa ngokuba 'de Ritis ingumlingani "). Malunga 10 okanye 15 kwiintsuku phambi kokuqala of iimpawu senyongo umsebenzi ezi-enzayim nakho kuyanda. Kunye kwiiveki ezimbalwa phambi kokuba imbonakalo hepatitis B kwakhona ALT ukwanda kunye AST, ofikelela kuma kwiveki yesibini okanye yesithathu sifo. Yaye ugeleza kakuhle le nto inesibetho ngomhla isixa 30-40e ALT abuyela yayo yesiqhelo, ngelixa inani UMTHETHO - ngo 25-31. Ukuba, ke, ukwanda ALT AST liphindwe, oku kubonisa ukuba necrosis welungu zizifo okanye okuphindwayo iqhubeka. Kodwa ukuba sifo liyagungqa ukusuka abukhali kwixesha ezingapheliyo - ngoko ke isixa-enzayim ngasentla egazini akuthethi linciphe ngokuhamba kwexesha ngoxa esitalini okanye baqhubeke bekhula.

Xa ukuhamba zesibindi kwesibindi , ezi enzayim nyuso ngokubonakalayo anayenza ngohlobo lwayo angasebenzi. Noko ke, ukuba ogulayo isibindi ukuqina ngohlobo esebenzayo, ukwanda ALT AST ukumelana, kodwa kunokuba amancinane. Olo ukwanda kwafumaneka uninzi abo bagulayo ukuba uhlobo esebenzayo isifo esibindini.

Ukulungisa ALT ukusebenzisa iimvavanyo sensitive ngaphezu kwezo zisetyenziswa ukugqiba isixa AST egazini. Ukumisela umsebenzi ezi-enzayim ukunceda uvavanyo lwegazi. ALT kakhulu ifumaneka kwiiseli amalungu ezifana kwesibindi, izihlunu skeletal, intliziyo, izintso kunye pancreas. Ukuba kubekho nawuphi na umonakalo kwezi amalungu (kaninzi - ngenxa sisifo), kule ALT mzekelo egazini, musa ekufuneka phantsi ukuba umzimba usempilweni ngokupheleleyo. Lokufunyaniswa ezingafunekiyo ukwandisa umsebenzi enqanda indima ebalulekileyo eyadlalwa uhlalutyo kwangethuba igazi. ALT, AST, ukuba ungene egazini, enye indlela ukuchaza cishe akunakwenzeka. An ngaphandle ungenza umchamo kuphela.

AST kananjalo zigcinwa myocardium, izihlunu skeletal, isibindi kunye izicwili luvo. Ngaphantsi ngaphezu kwizintso, injeke kunye nemiphunga. Ukuba imizimba zikhankanywe ngasentla zonakele, oko kukhokelela kukuba kwinqanaba egazini inyuswe AST kwaye ephezulu kakhulu kunesiqhelo. Ngoko ke, ukwanda ALT kunye AST - Nguwo lo ke umqondiso wokuqala ukuba naluphi - nayiphi na amalungu apho zifumaneka kwezi enzyme, kwenzeke ingxaki.

UNorma enzyme ukuba abasetyhini kunye namadoda akufani. I-avareji ALT oyindoda hayi ngaphezulu kwe iiyunithi 47 ilitha nganye, yaye abafazi ALT, AST - amaxabiso omabini angu mayingagqithi iiyunithi 31 ilitha nganye. Ngokuba abantwana, la manani zingakho ubudala ngesondo. Xa amakhwenkwe, izinga AST, ALT phakathi inokuba iiyunithi ezimbalwa ilitha ngaphezu isalathisi elifanayo oontanga babo nganye.

Akusoloko ukwanda ezi enzayim luphawu yokugula. Umzekelo, ALT ukwanda, AST kaninzi kwenzeka abo yenethiwekhi uphilile sohlobo B iantigens Oku kubonisa ukuba esibindini zibe nazimpawu, kodwa iinkqubo esebenzayo. Lidla unina nexhala wafunda oko uhlalutyo igazi - ALT, AST bandisa umntwana. Ukuba umntwana omncinci kwaye ayidluli ubudala seenyanga ezi-6 - kulo mzekelo, umgangatho ezi zinto egazini yakhe eliqingqiweyo, yaye - akukho kukwaphula eqhelekileyo.

Ukuba, njengoko kuboniswa uvavanyo lwegazi, ALT, AST xa abasetyhini abakhulelweyo ayikho eqhelekileyo, oko kungenzeka ngenxa yemfuza zebhayoloji kwabasetyhini. Malunga kwiinyanga ezi-6 zokuqala kwinkqubo lokukhulelwa ALT unokuwa (nangona kwezinye iimeko liphuma kweli xesha, nto leyo nayo uphawu izifo). Ngaphezu koko, nje phambi kokubeleka, inani lwezi enzyme, umfazi angaba mkhulu ngakumbi iqondo izihlandlo ezimbini ukuya kwezintathu. Oku kudla ubungqina obungenakuphikiswa uvavanyo lwegazi. ALT, AST, ukwanda ngexesha lokukhulelwa, ngokuqhelekileyo musa ukuthetha ngayo nasiphi na isifo.