"Boudin" inhalation: imiyalelo ukusetyenziswa, inkcazo, ukwakhiwa kunye nohlolo

Xa unyango lwe sombefu inyumoniya kunye agonist beta-blocker ezisetyenziswa corticosteroids bephefumla ezinciphisa rhoqo kunye nobukhali iziqephu bronchospasm. Phakathi kweli qela lamachiza kukubonelela "Boudin" ukuze inhalation. ngokusetyenziswa "Budenita" manual iqulethe inkcazelo eneenkcukacha malunga nokusetyenziswa kweziyobisi, ngoko sinikela ingqalelo kuqwalaselwe iimpawu zayo eziphambili kunye bokuqonda zobugcisa isicelo ngexesha therapy nebuliser.

Ukwakhiwa lithetha "Boudin Steri-uNebhukadenetsare" (ukumiswa)

Imiyalelo ibonisa ukuba ichiza a ukumiswa ukuba inhalation, akanayo umbala ivumba, ezipakishwe nengqayi density ml-2, equlethe 1 mg (0.5 mg / ml) okanye 0.5 mg (0.25 mg / ml) lezithako budesonide esebenzayo. Le nto inxulumene iqela amayeza zamadlala glucocorticoid ukuba isicelo mlonyeni.

pharmacodynamics

Njengokuba ubungqina ichiza "Boudin" lokufundisa inhalation, budesonide (eyona nto ephambili esebenzayo) siqala ukusebenza anti-kukwalisa, anti-ezithintela ukosuleleka kunye anti-nokudumba. Ngokuvuselela protein lipocortin budesonide imveliso onesiphumo inhibitory kwi phospholipase yokuqaphela, nto leyo yenza ukuba kubekho ukuhla CD yokuqaphela, ukwehliswa imveliso prostaglandins kunye leukotrienes. Ezi nkqubo kwinqanaba zeselula kukhokelela ekuncipheni kwemveliso cytokine, ukunciphisa yokufuduka macrophage kwaye kukhokelela ekuncipheni nokungena zeselula. Ekugqibeleni oku kukhokelela ukuthoba izinga yabalamli ukudumba ebonisa kakuhle kothula yokuhlaselwa sisifo inyumoniya nokuzinziswa ikhondo yayo kwezonyango.

Njengokuba ubungqina ichiza "imiyalelo Boudin Steri-uNebhukadenetsare 'ukusetyenziswa, ukusetyenziswa kwayo rhoqo kukhokelela nokubuyiselwa nobuntununtunu umthi inyumoniya kwiziyobisi, dilates i bronchi. Oku kunciphisa ubuninzi ukusetyenziswa entsha, ukucutha ubuninzi esabangela secretion yesikhohlela inyumoniya, kunciphisa uvakalelo zamavumba nezidlo, nayo leyo kunempembelelo entle ikhondo kwezonyango sifo.

Eli chiza akukho msebenzi mineralocorticoid, kwaye akukho neziphumo zenkqubo ngenxa Namanyathelo athathwa kwingingqi, leyo kunciphisa amaza kunye nobukhali iziphumo ebezingalindelekanga ukunyamezeleka kakuhle ukusetyenziswa elide.

Njengoko medicament of "Boudin Steri-uNebhukadenetsare" umyalelo manual, analogs beziyobisi kwaye ukunyamezeleka kakuhle kwaye musa ukuba kukuvela iziphumo ebezingalindelekanga ezinxulunyaniswa ne usebenzisa corticosteroids zenkqubo yezemfundo.

Emva kokuba isicelo olunye isiphumo unyango iqalisa kwiiyure ezimbalwa, ukufikelela ibinzana ubuninzi emva kweeveki 1-2 emva ekuqaleni ukusetyenziswa. Ichiza zingasetyenziswa ngempumelelo ukwenzela ukuthintela inyumoniya sombefu uxinzelelo emzimbeni, kodwa ngenxa yokuba ixesha elide efukamileyo, ukuqala amanyathelo unyango phantse ayifanelekile isiqabu kwezifo ezinzima ebandakanya bronchospasm.

Pharmacokinetics

Ichiza ilawulwa usebenzisa డొమైన్ idomeyini. Xa imuncwe inkungu budesonide entle luhlala phezu komhlaba umthi inyumoniya. Malunga ne-15% beziyobisi ngenxa kukufakwa kwi sayo inyumoniya engena kwegazi kwaye umzimba ngokusebenzisa inkqubo cytochrome ukuya metabolites phantse engasebenziyo (umsebenzi wabo ukuya ku amaxesha 100 ngaphantsi kwe umsebenzi umbandela eqala). Malunga ne-70% ye ichiza idubule yi nezintso ngohlobo, yaye malunga ne-10% salawo ngokusebenzisa amathumbu.

Ubungqina obubonakalayo buxela

Njengoko budesonide iziyobisi esisiseko kunye analogue zazo ziboniswa ukuba unyango kunye nothintelo yokuhlaselwa sombefu, lo kwawo yokusebenzisa beta-adrenergic agonist uyakhetha okuthintela isifo kunye nokuzinziswa umfanekiso lwezonyango, ngokunjalo unciphise ngokwemithamo zonyango-arhente glucocorticoid ngomlomo. Ichiza iye isetyenziswe ngempumelelo kuba unyango lwe laryngotracheitis stenotic kunye ezingapheliyo obstructive isifo miphungeni.

Izimo

"Boudin Steri-uNebhukadenetsare" (ukunqunyanyiswa kuba inhalation) iya contraindicated phambi kukwalisa amacandelo omnye okanye ngaphezulu ukwakhiwa ichiza, kwakunye abantwana abangaphantsi kweminyaka emi-6. Ngononophelo olukhulu ichiza ezimiselweyo tuberculosis yemiphunga, kokoyiswa kungaPhefumli egazini, yintsholongwane, microflora fungal, isibindi. Ban on ngokusetyenziswa kweziyobisi phambi kwezifo ezosulelayo esibangelwa isiphumo immunosuppressive bengingqi isifo, nto leyo enokukhokelela ukuhla omzimba kunye phambili kwesifo.

imiphumela emibi

Ngenxa yokuba ichiza ilawulwa inhalation ngokusebenzisa డొమైన్ idomeyini, amathuba isahlakalo kome mucosal zomlomo yomoya eliphezulu, imvakalelo umqala obuhlungu kunye ukuluma, incasa kabi engaqhelekanga, hoarseness okanye hoarseness, ukhohlokhohlo. Oku kubangelwa ukunqamka isiyobisi mikrochastichek phezu mucosal.

Lidla enqabile waphawula ukuphazamiseka kwenkqubo luvo, leyo azibonakalisa ngokohlobo novalo kunye nokunyusa excitability le neuro-zengqondo, ukuphazamiseka zokuziphatha, intloko. Ukongezelela koko, izigulane nokusebenzisa "Boudin" maxa wambi baxabane nomzimba kuqatshelwe njengoko urticaria, urhawuzelelwa okanye anozizi eluswini, spasm of inyumoniya egudileyo kwezihlunu, kunye nophuhliso candidiasis le kwisisu ngomlomo kuvuleke iminxunya.

Kukuvela bronchoconstriction ngamazwi kunye dyspnea ngcembe emva kokuqalisa kwedosi yokuqala imuncwe ngenxa ukubacaphukisa ntshukumo nesiyobisi ngokuma isifo. Ngophuhliso nganeno isiphumo inhalation kucetyiswa ukuba ayeke kwaye akhethe enye unyango.

Nangona bioavailability ephantsi beziyobisi kunye neziphumo ubukhulu becala kwingingqi yaso, ukusetyenziswa elide ukuze aphuhlise iziphumo zenkqubo ye glucocorticoids. Lo msebenzi inhibition wabonisa le neuron adrenal, linyuke lokukhula ebantwaneni, ukuncipha amathambo bezimbiwa lexinene, uphuhliso ukunyhashwa umbono.

Kwezinye iimeko (kunqabile kakhulu) kunokubangela kwinwebu ulusu yobuso usebenzisa isigqumathelo డొమైన్ idomeyini. Ukuze kuthintelwe le ingxaki kufuneka zisetyenziswe iintsholongwane izisombululo imaski, yaye emva inhalation ulusu phantsi aphilileyo amanzi ashushu. Uyakwazi sikwakhupha akhululeke yerabha ubambe imaski ebusweni. A okunye okuhle ayanceda kusetyenziswe akabafuni okanye umlomo ngenxa inhalation.

Sebenzisa kwi ukukhulelwa kunye zisanyisa

Imiyalelo "Boudin" icebisa ichiza isetyenziswe ngobunono abasetyhini abakhulelweyo kunye ngexesha uncancisa (nangona data kwi kwimveliso ongena njengongekhoyo ubisi lukamama). Ichiza Kucetyiswa ukuba isetyenziswe kuphela xa inzuzo yalo unina luyazedlula iziphumo kunokwenzeka ezingalunganga kunye neengxaki olungekazalwa. Ngoko kuyimfuneko ukuba usebenzise budesonide zisezantsi ngempumelelo idosi evumela ulawulo ngokupheleleyo esi sifo.

okwenziwa Drug

Kwinqanaba yentsebenziswano phakathi kuqulunqo amayeza iyahambelana na isisombululo isotonic sodium chloride, kwakunye nezinye ukurhogele beta-agonists, mucolytics kunye expectorants. Ukuze kwandiswe ukusebenza kunye nefuthe therapeutic kwi iziyobisi spasm ekhulula inyumoniya la maqela abanokufakwa kunye egumbini డొమైన్ idomeyini. Ukwabelana bronchodilators kuphela kuphucula ukuhamba "Budesonide" apha emthini bronchoalveolar, kodwa nayo inegalelo umthondo yayo nzulu le mithambo.

Ngenxa inxaxheba yeqela enqanda le cytochrome P450 yokucolwa of ithamo budesonide luya kuhlehliselwa-kuvavanywa kwisicelo neziyobisi zisidimaze okanye ukukhuthaza umsebenzi enzyme. Akunconywa ukusetyenziswa kweziyobisi kunye namachiza nokubola ezifana 'ketoconazole "yaye" Itraconazole ", njengoko oku kukhokelela ekwandeni uyondelelwano lwee-" budesonide "plasma.

Iziyobisi ezandisa umsebenzi enqanda microsomal ( "Phenobarbital", "Phenytoin", "rifampicin"), ukunciphisa umsebenzi "Budesonide".

umthamo

Pretty elula ukuyisebenzisa, "Boudin" ukuze inhalation. Imiyalelo yokusebenzisa lubonisa imfuneko yokusebenzisa i డొమైన్ idomeyini ye unyango. Ichiza ifakwa kwi isixhobo nebuliser, kwaye inhales. Ubude inhalation kunye idosi kufuneka zikhethwe kwimeko nganye kuthathelwa ingqalelo imeko lwezonyango yomguli kunye nobungozi besi sifo xa usebenzisa i "Boudin" inhalation iziyobisi. Lokufundisa abantwana ukusuka kwiminyaka kwiinyanga ezi-6 ukuya ku-12 ibonisa ukuba ukuqeshwa budesonide kabini balawule engaphantsi. Izigulane ezindala ngaphezu kweminyaka eli-12, ithamo ukugcinwa kufuneka zilungiswe ngabanye.

Ukuba kuyimfuneko, "Budenita" indibanisela ngeziyobisi glucocorticoid ngomlomo Kucetyiswa ukwandisa ithamo "Budenita" kuthintelo ukwenzeka nokunciphisa ubukhulu yeziphumo ebezingalindelekanga.

reviews

amagqirha Ukunyanga kunye nezigulane nihluthe ukusebenza ichiza. Oku kungqinwa uqwalaselo ngokutsha (ukunqunyanyiswa for inhalation Teva «Boudin" - ichiza entle ethandwayo) nokusungulwa. Isimo sengqondo esihle wambumba kweziganeko esezantsi yeziphumo ebezingalindelekanga kunye nonyango olusebenzayo kakhulu. Iimbono zakhe malunga "Boudin" Ingcamango yokuba inhalation abantwana (uqeqesho, idosi enikwe kweli nqaku) kufuneka oomama, nto leyo nayo kungenxa obunamanani aphantsi yeziphumo ebezingalindelekanga. inhalation usebenzisa nebulizers yalula (leyo inokwenziwa ngeendlela ezahlukahlukeneyo zokudlala) kubantwana abaselula nabo wathetha egameni ukusetyenziswa kweziyobisi, okanye analogue yayo.

libanda

Xa libanda etsolo mpawu kakhulu lwezonyango zikhona. Unyango ibonisa, kunye ukupheliswa ichiza kunye nokuqeshwa short-Acting zodidi lwentshukumo bronchodilator.

Kufuneka Makukhunjulwe ukuba ukusebenzisa elide "Budenita" xa amathamo sredneterapevticheskih kunene ukuze aphuhlise iziphumo ebezingalindelekanga kwinqanaba systemic (hypercortisolism, ukudandatheka of umsebenzi adrenal). Oku kungqinwa ngokuthi "Boudin" imfundiso inhalant. ixabiso layo ifumaneka ukusetyenziswa ixesha elide neziyobisi kwanonyango yokuqala isifuba inyumoniya.

Ezahlukileyo isikhokelo nengcebiso

Imiyalelo zokusetyenziswa ichiza "Boudin" ithi ukuba akukho ilungiselelwe ukuba akhulule ukuhlasela nokoyika bronchospasm. Ixesha avareji isiphumo zonyango lwe-10 iintsuku, kodwa oko kwandiswa yi phambi kwi mithambo komthi inyumoniya okanye isixa esikhulu viscous yencindi secretion. Kule meko kungenzeka ukuba aqhube unyango kunye glucocorticoid yomlomo kunye utshintsho olandelayo kuphela "Boudin Steri-uNebhukadenetsare" inhalation.

Imiyalelo ukuba ichiza uthi, nangona amathuba neziphumo ebezingalindelekanga inkqubo kwinqanaba le usezantsi kakhulu, kunyanzelekile ukuba titrate idosi ubuncinane olusebenzayo zonyango kangangoko. Ekusebenziseni ichiza ebantwaneni ngenjongo ekuchongweni kwangethuba iziphumo ezibi kufuneka basoko belwakhele umkhanya umntwana kwithuba elithatha ixesha elide ukukhula. Ngophuhliso yeziphumo ebezingalindelekanga kufuneka azezi ithamo ubuncinane kakuhle, nto leyo evumela ukuba ukulawula ukuhlaselwa sisifo sombefu.

Yokuthintela usulelo ezinzwaneni em- ngomlomo ze isigulane kufuneka aziswe imfuneko ngamanzi emlonyeni kwaye susa iintsalela emva inhalation nganye. Oku kukhuthaza zokubuyiselwa sifo zasekuhlaleni kunye yangaphakathi ngomlomo.

features Technical Sebenzisa

Inhalation "Budenita" esebenzisa nebulizers cuke contraindicated. Ithamo ngempumelelo ichiza kufuneka ubalwe ngokuthathela ingqalelo iimpawu zobugcisa a డొమైన్ idomeyini ethile (kuthathelwa ingqalelo emoyeni uqina, umthamo nebuliser njalo njalo. D.) Yaye ke imeko yomguli.

Ngaphambi ngokusebenzisa ichiza "Boudin" inhalation డొమైన్ idomeyini kwi umyalelo డొమైన్ idomeyini inyanzelekile kufuneka ifundwe. Oko kuza kuthintela ukuba uqhagamshelwano engafanelekanga lesixhobo kunye ukusetyenziswa okungafanelekanga ichiza. Ukuba డొమైన్ idomeyini kusetyenziswa okokuqala, kucetyiswa ukuba ukuvavanya usebenzisa isisombululo sodium chloride komzimba, qiniseka isebenza kwaye ke isetyenziswe iziyobisi.

Phambi inhalation ibhokisi wachacha ampule iplastiki, oko kwavula ukudiliza lid, ichiza ibekwe egumbini డొమైన్ idomeyini ye-apparatus, ubeke phezu imaski ebusweni (okanye umlomo ska) kwaye wondla emoyeni kwemali. Ngexesha inhalations usebenzisa ingundaba kufuneka uphefumle kuphela ngomlomo wakho (ezinxitywa phezu impumlo ikliphu ezizodwa). Xa usebenzisa isicelo imaski yokuphefumla impumlo ekhethiwe ukunqumla.

Kuba inhalation Kucetyiswa ukuba usebenzise nebuliser nebandla vana abonelela inaliti zetoti omhle ichiza ngalo mzuzu wempembelelo livale yokuphuma amachiza ngexesha ukuphelelwa. Oku kwandisa ukuziswa kweziyobisi iinkuni bronchoalveolar kwaye kunciphisa ukulahleka amayeza ngexesha zingumphunga.

"Boudin Steri-uNebhukadenetsare": analogue, ixabiso

analogue Drug "Boudin Steri-uNebhukadenetsare" iziyobisi ezifana 'Pulmicort "yaye" Pulmicort Turbuhaler "," Kortimen "," Tafen "," Budoster "," Budenofalk "kunye nabanye abaninzi. Xa la machiza, njengoko kumalungiselelo "Boudin" inhalation, imfundiso efanayo ngenxa yobukho eyona nto efanayo esebenzayo. iindleko Data amachiza ixhomekeke network ekhemisti kunye mmandla, kwakunye idosi. Kwi-avareji, ixabiso isusela ukusuka engange-650 ukuya 2550.

isiphelo

medicament ngempumelelo kakhulu ukuba unyango kunye nothintelo yokuhlaselwa sisifo sombefu yi "Boudin" inhalation. Imiyalelo ukuba ichiza unika inkcazelo eneenkcukacha malunga idosi kunye nemiqathango yokusetyenziswa kweli chiza. Ngaphandle isicelo budesonide ngokungqinelana nemiyalelo esicetyiswayo iidosi le medicament kunika unyango olusebenzayo. Ukuba ngenxa yesizathu esithile awukwazi ukuthenga yokuqala, kukho analogue. "Boudin Steri-uNebhukadenetsare" (imiyalelo ixabiso zaziwa ngoku) kunisindisa kwizifo ezininzi isixokelelwano sokuphefumla.