Elwa TSifran. Drug wokusebenza

Medicine "TSifran" yi- arhente elwa kunye spectrum ezibanzi amanyathelo kwaye bobabo kwiqela amayeza of fluoroquinolones. amacandelo Active ye ichiza ciprofloxacin kunye tinidazole. Ngenxa kwezithandani ye DNA gyrase amagciwane DNA amagama inhibition, ezi izinto ezisebenzayo besebenza kakhulu ezininzi Cya gram-negative.

Ngokukodwa, umsebenzi yezenzo bactericidal yokulungiselela "TSifran" amanqaku yemiyalezo malunga nale ntsholongwane: Neisseriagonorrhoeae, Neisseriameningitidis, Haemophilusinfluenzae, Pseudomonasaeruginosa, Salmonellaspp, Escherichiacoli kunye namanye amagciwane iintlobo ezivelisa kwaye ongavelisi penicillinase, kwakunye iintlobo methicillin ezingatshiyo kunye Enterococcusspp, Chlamydiaspp, Mycobacteriumspp, Legionellaspp ... amagciwane.

isenzo amayeza of medicament imiyalelo bactericidal ebanzi spectrum "TSifran" zokusetyenziswa na ngolu hlobo lulandelayo: ". Esi sixhobo senzelwe ukuba unyango ezimbi ezasulelayo ngempumelelo unyango kweenkqubo ukudumba - izifo mixed okubangelwa umsebenzi ezincinane aerobic kunye anaerobic lenyama".

Pharmacokinetics

Izithako ezisebenzayo ze 'TSifran "iziyobisi imiyalelo ukusetyenziswa ibhekisela isebenzisane kakhulu. Kwaye ciprofloxacin kunye tinidazole babe kukufakwa entle phecana zesisu.

Ukuqwalasela ngamnye izithako ezisebenzayo beziyobisi, kufanele kuphawulwe ukuba ciprofloxacin unamalunga-70% bioavailability. ukufakwa kwayo zehlile noko, lo gama ukusetyenziswa ukutya. Eli chiza permeability ezilungileyo ancedisana neencindi zomzimba, kuquka ithambo, izihlunu, amafutha, kunye intlala kwithishyu. Yena lingena singene amalungu yenkqubo wokuchama, kuquka emzimbeni ezifana endlaleni. Yaba imfihlelo yona ityhila eliphezulu yoxinaniso isiqulatho kiprofloksatsina, njengoko, eneneni, kwaye amadlozi, ematheni, inyongo, nkovu ulwelo, yencindi yomlomo.

Tinidazole bioavailability ezahlukeneyo epheleleyo. Eli candelo iwela ngokukhawuleza kwi zoqhaphelo eziphakamileyo izihlunu zomzimba womntu singena eliphakathi ulwelo, ingakumbi ulwelo cerebrospinal, nto leyo buzinze efanayo kwinqanaba plasma. Malunga nekota isixa kwezinto tapeworm kwazona kwi umchamo ingaguqukanga, malunga ne-10% ngesi ngohlobo metabolites, inxenye kakhulu encinane candelo ushiya umzimba iingqatha.

Ubungqina obubonakalayo buxela ukuba "TSifran" imiyalelo iziyobisi zokusetyenziswa ibhekisa unyango olungumxube iinkqubo esosulelayo. Phakathi ezimbi ngakumbi ngqo, ngenxa yonyango yamachiza ethathelwa ingqalelo nesetyenziswa, ezi zifo zilandelayo:

• osteomyelitis ezingapheliyo ;

• intra-esosulelayo iinkqubo arhabaxa;

• segazi amoebic nokuxaxaza igazi Uhlobo engumxube (amoebic amagciwane);

• periodontitis, periostitis kunye nezinye izifo ezosulelayo le kwisisu ngomlomo;

• zoxilongo arhabaxa izifo;

• sinusitis ezingapheliyo;

• izifo yesikhumba nezihlunu soft;

• sisifo esosulelayo postoperative;

• lung ithumba.

Omnye wabo, kunye nezinye izifo ezibangelwa ziibhaktheriya aerobic kunye anaerobic novelwano yintshukumo macandelo zeziyobisi.

ukulungiselela wazivuma "TSifran" postprandial. Iipilisi kufuneka zithathwe ngamanzi ngokwaneleyo. izigulane abadala ezithatha ichiza kabini ngosuku elucwecweni 500 / 600mg okanye 250 / 300mg ezimbini. Izigulane abangaphantsi kweminyaka elishumi elinesibhozo ubudala, ichiza ayikho iphethwe. It is akukhuthazwa ukuba zisetyenziswe ukhulelwe.

Izimo ukuba ukusetyenziswa kweziyobisi okuchazwe ngayo kunyango i uvakalelo bhetele ukuya amacandelo eziyinxalenye tsifran kunye ngezifo igazi, porphyria.