"Felodip": imiyalelo yokusetyenziswa, ukuhlaziywa. Ezifana neziyobisi

Kutheni kulungelelaniswa "Felodip"? Imiyalelo yokusebenzisa le nyilisi iya kuchazwa ngokucacileyo kwinqaku elinikeziweyo. Kuye uza kufunda malunga noluphi unyango oluchazwe kuyo, yiyiphi imiphumo engalindelekanga, ingaba inokuchasene, ingaba ixabiso lini, yiziphi iimpawu ezinjalo kunye njalo njalo.

Ukubunjwa kweyeza, uhlobo lwalo lokukhululwa kunye nokupakishwa

Ngowuphi uhlobo onokufumana isilwanyana "Felodip" kwikhemisi? Umyalelo wokusetyenziswa kwala mayeza uthi ufumaneka kuphela ngendlela yamacwecwe asebenze ixesha elide. Kwaye umlinganiselo othile weli chiza unobumba ekhethiweyo:

• Iipilisi zombala ophuzi ngendlela yeententili ngaphandle kwento epholileyo ziboniswa ngumfanekiso 2.5. I-element esebenzayo yale mveliso yi-felodipine kwisixa sama-2.5 mg. Abaxhamli beli velisi yi-lactose monohydrate, i-hypromellose, i-microcrystalline cellulose, i-red iron oxide, i-povidone, i- titanium dioxide, i- propyl gallate, i-yellow oxide i-oxide, i-magnesium stearate, i-propylene glycol, i-colicid e-anhydr anhydr, i-talc. Xa kuthengiswa kwesi sidakamizwa kuza kwiiblisti zamacwecwe a-10, afakwe kwiipakethi zekhadibhodi.
• Iipilisi zemibala ebomvu ebomvu ngendlela yentsholongwane ngaphandle kweflethi iboniswa yinombolo 5. Inxalenye esebenzayo yalesi sidakamizwa i-felodipine kwisixa sama-5 mg. Abaxhamli beli velisi yi-lactose monohydrate, i-hypromellose, i-microcrystalline cellulose, i-red iron oxide, i-povidone, i-titanium dioxide, i-propyl gallate, i-yellow iron oxide, i-magnesium stearate, i-propylene glycol, i-silicon i-colloid i-anhydr, i-talc. Xa kuthengiswa kwesi sidakamizwa kuza kwiiblisti zamacwecwe a-10, afakwe kwiipakethi zekhadibhodi.
• Amacwecwe ombala obomvu obomvu ngendlela yeengcingo ngaphandle kweflethi kuboniswe ngenombolo 10. Inxalenye esebenzayo yeso sidakamizwa i-felodipine kwisixa se-10 mg. I-lactose monohydrate, i-hypromellose, i-cellulose microcrystine, i-red iron oxide, i-povidone, i-titanium dioxide, i-propyl gallate, i-yellow iron oxide, i-magnesium stearate, i-propylene glycol, i-colicid i-anhydr, i-talc. Xa kuthengiswa kwesi sidakamizwa kuza kwiiblisti ezili-10 zamacwecwe. Iibhanti zifakwa kwiipakethi zekhadibhodi.

Izakhiwo ze-Pharmacological zemveliso yeyeza

Yintoni idilesi yezokwelapha "Felodip"? Umyalelo ekusebenziseni la mayeza uthi i-blocker yeendlela ze-calcium ezicothayo. Olu lungiso luseqela le-dihydropyridine.

Eli liyeza liyakwazi ukuba nefuthe lokulwa ne-antianginal ne-hypotensive. Ukongezelela, iyanciphisa uxinzelelo (umlinganiselo) ngokunciphisa i-OPSS.

Ziziphi ezinye iipropati ezenza iyeza "Felodip"? Imiyalelo yokusetyenziswa kweziyobisi ibandakanya ulwazi olunefuthe elixhomekeke kwi-dochemic-dependence effect. Isilwanyana sinciphisa ubuninzi be-myocardium, kwaye sinokukhusela umzimba womntu kwiinkathazo zokuphinda zenziwe.

Le arhente ayinayo imiphumo engeyona inotropic. Inemiphumo encinci kwindlela yokuqhuba.

Pharmacokinetics yeziyobisi

Kuza kube nini ukulungiselela "Felodip"? Imiyalelo yokusetyenziswa, ukuphononongwa kwesi sixhobo kuthetha ukuba emva kokuba uthathe iipilisi ngaphakathi kwento esebenzayo yesicatshulwa ngokugqithiseleyo ixakeke kwi-digestive tract kwaye yenza ngokukhawuleza. Ngenxa yefom yefayili, ukukhululwa okuqhubekayo kwesithako esisebenzayo kuqinisekisa ukuxininiswa kwayo okufanayo egazini (ngemini), kwaye kukhokelela ekunyuseni kwinqanaba lokubamba.

Asinakutsho ukuba ukungabi naso kwezi zizabisi akuxhomekeke kwimilinganiselo yokwelapha kwaye malunga ne-15%.

Ukubopha nge-plasma, okanye kunoko iiprotheni zayo, malunga nama-99%. Amachiza atyathwa kunye nobisi lwebele kwaye angena kwi-BBB, kunye ne-barrier barrier. Ngokusetyenziswa kwexesha elide lokusetyenziswa kwezinto ezingasebenzi.

Uphi i-drug "Felodip" edibeneyo? Icandelo elisebenzayo le-arhente lichanekile kwisibindi. Kule meko, i-metabolites engasebenziyo yakhiwa.

Isiqingatha-zobomi beziyobisi malunga neyure ezingama-25. Isilwanyana sikhiqizwa ngendlela yemetabolites (malunga nama-70%) kunye nomchamo kunye namanzi (30%).

Inkcazo yemveliso yeyeza

Ziziphi iziganeko isigulane esinikwe imithi "Felodip" (5 mg)? Umyalelo wale mayeza uqulethe uluhlu olulandelayo lwezibonakaliso zokusetyenziswa:

• Uxinzelelo lwengqondo
• Angina pectoris;
• Arrhythmia;
• Ischemic heart disease;
• Iziphazamiso ezijikelezayo;
• I-Raynaud's syndrome.

Ukungqinelana

Kwiimeko ziphi na ukunyanzeliswa ukuba uthathe izilwanyana "Felodip"? Iingxelo zoogqirha, kwakunye nomyalelo ohamba kunye, misela ukuba le mayeza ayinakusetyenziswa phantsi kwezi zilandelayo:

• I-infyoction ye-myocardial eyiyo, kunye nangenyanga leyo emva kokuphazamiseka;
• Angina engaqinisekanga;
• Ukutshatyalaliswa kwe-Cardiogenic;
• Ukungaphumeleli kwentliziyo, ngokukodwa kwinqanaba lokunciphisa;
• I-aortic stenosis (i-clinically significant);
• Ukukhulelwa;
• I-hypotension ye-Arterial (enzima);
• Ubuntwaneni kunye nentsha (iminyaka eyi-18);
• Ngethuba lokutya;
• Ukwenyuka kwengqondo kwesigulane kwisiyilisi okanye ezinye izixhobo ezivela kwi-dihydropyridine.

Kufuneka kwakhona kuthethwe ukuba le mpendulo imiselwe ngolondolozo olukhethekileyo kwizigulane ezine-hepatic kunye nokungaqiniseki komntu.

Isixhobo sonyango "Felodip": imiyalelo yokusetyenziswa

Iilwimi ze-Analogs ziza kuboniswa ngezantsi. Ngoku ndifuna ukukuxelela malunga nendlela eli liza kufuneka lithathwe ngayo ngokufanelekileyo.

Ngomfutho wegazi ophezulu, umlinganiselo kubantu abadala kunye nabantu asebekhulile umiselwe ngamnye. Njengomthetho, umthamo wokuqala weziyobisi u-5 mg kanye ngosuku. Ngexesha lokunyulwa kwesilinganisi esifanelekileyo, izigulane zincetyiswa ukuba zisebenzise iiphilisi eziyi-2.5 mg. Ukuba unesidingo esiphuthumayo, unokwandisa umthamo weyeza. Umthamo ophakathi kwesicatshulwa sokunakekelwa unyango ngowama-5-10 mg ngosuku.

Kwizigulane ezisebekhulile okanye izigulane ezinokukhubazeka kwesibindi ekuqaleni kwonyango, le nkunkuma imiselwe kwisixa sama 2.5 mg ngosuku.

Ngo-angina ozinzile, amayeza "Felodip" anqunywe ngabanye. Ngelo xesha, i-dosage yokuqala (kubantu abadala) i-5 mg kanye ngosuku. Ukuba kuyimfuneko, umthamo unganyuswa ukuya kwi-10 mg ngosuku. Umthamo ophezulu wentsuku yezilwanyana unama-20 mg.

Iibhilethi "Felodip" zingathathwa ngokudibanisa ne-ACE inhibitors, i-beta-adrenoblockers kunye ne-diuretics. Nangona kunjalo, kufuneka kuqatshelwe ukuba impembelelo ye-hypotensive iphakanyisiwe. Ngoko ke, kufuneka unyathelwe ngokukodwa ngokubhekiselele kwengozi yokwanda kwengozi.

Kwizigulane ezineengxaki ezinzulu zesibindi, umlinganiselo weyeza kufuneka unyanziswe.

Isilwanyana esifanelekileyo kufuneka sithathwe kuphela ekuseni, ngaphambi kokutya kwasekuseni. Kule meko, iipilisi akukho nhlobo ayikwazi ukuluma, ukuchithwa okanye ukwahlula.

Indlela yokudlula ngaphezulu

Ukuba usebenzisa iipilisi ze "Felodip" ngokungalunganga, ezi zinto zilandelayo zibonakaliswe kwizigulane: i-bradycardia kunye ne- hypotension ye-arterial (echazwe).

Xa kwenzeka ukuba iziganeko ezifanayo zichithe unyango olungumqondiso. Nge-hypotension ye-arterial (ivakaliswe), isigulane sinikwa isikhundla esingaphakathi, kwaye iphakamisa imilenze. Ngokubhekisele kwi-bradycardia, kule meko, isigulane senziwa nge-intramuscularly atropine kwisilinganiso se-0.5-1 mg. Ukuba kuyimfuneko, i-sodium chloride, isisombululo se-glucose okanye i-dextran isetyenziselwa ukwandisa umthamo we-plasma.

Ukuba ngaba amanyathelo angentla angasebenzi, isigulane sinqunywe izidakamizwa ezinefuthe elikhulu kwi-alpha-adrenergic receptors.

Imiphumo emibi yokuthatha amayeza

Ngaba ukwamkelwa kweyeza "Felodip" kunokuchaphazela umzimba womntu ngendlela engafanelekanga? Iziganeko zesilwanyana kunye nesilwayo ngokwayo ngokuqhelekileyo kubangelwa intloko, ubomvu buso, utywaba, ukubethelwa kwintlungu kunye nokhathala okwandayo. Nangona kunjalo, kufuneka kuqatshelwe ukuba iimpendulo ezinjalo zibuyiselwa. Njengomthetho, bavela ekuqaleni kwonyango, kunye nokunyuka kwamayeza omzimba.

Ngendlela, kuxhomekeke kumthamo weyeza unyango, isigulane sinokuba ne-edema ye-périphher. Ngokweengcali, zimela umphumo we-precapillary vasodilation.

Kwizigulane ezine-periodontitis okanye isifo segum, ukuvuvukala okuncane kweentlobo kungenzeka xa uthatha amayeza. Le nkqubo inokuthintela ukuba umntu ubone ucoceko olumlomo.

Kwezinye iimeko, ukwamkelwa kweyeza elisixubushayo kubangela iziphumo ezilandelayo:

• Isistim se-Cardiovascular system: i-palpitation, i-edema yeditha kunye ne-tachycardia.
• Impendulo yeDermatological: i-photosensitization, pruritus, urticaria.
• I-Peripheral, kunye ne-central system ye-nervous: i-paresthesia, intloko yesisu kunye nesisu.
• I-musculoskeletal system: arthralgia, myalgia.
• I-tractes tract: gingival hyperplasia, isiconguezelo, ukwanda komsebenzi we-enzyme yesibindi.
• Abanye: ukhathala okwenyukayo, ukuphendula kwe-hypersensitivity, kuquka i-angioedema.

Iingxoxo kunye neendleko zemveliso yeyeza

Ingakanani iyeza esilucinga ngeendleko? Lo ngumbuzo apho izigulane ezininzi zinikezelwa kulo myeza. Kufuneka kuqatshelwe ukuba namhlanje amayeza angathengwa ngamaxabiso alandelayo:

• Iibhilebhe kwisixa semali engama 2.5 mg (amaqhekeza angama-30) - ii-ruble ezingama-425 zaseRashiya;
• Iibhilethi kwisixa semali engama-5 mg (amaqhekeza angama-30) - ama-556 aseRussia;
• Iibhulile kwisixa se 10 mg (iinqununu ezingama-30) - 831 iRubles eRussia.

Yintoni engayenza indawo yeso sigqirha "Felodip"? Iingalogu zezi ziza zifumaneka phantse kuwo onke amayeza. Phakathi kwabo, ndifuna ukugqamisa amachiza alandelayo: i-Plendil, i-Felodipine-SZ, i-Felodipine, ne-Felotenz Retard.

Impendulo emihle kwizigulane malunga neziyobisi

Ukuhlolwa kwezigulane ze-"Felodip" imeko yokulungiselela ukuba isebenza kakuhle, kunye nokunyamezeleka kakuhle kwezigulane, kungakhathaliseki ukuba ubudala kunye nesondo. Ukongezelela, le nyanga inokuthi ithathwe ngabagulane abanesifo sikashukela, izifo zengqondo, isifo se-asthma kunye nezinye izifo eziphazamisayo, kunye ne- Raynaud's syndrome, hyperlipidemia, gout, nangemva kokufakelwa kwemiphunga.

Iingcali ezininzi zibona ukuba le nkunkuma ayinayo impembelelo kwiprofayili yepilid kunye nokuxinwa kwe-glucose egazini.

Impendulo engalunganga

Phakathi kwemibiko engalunganga yokuba izigulane zihamba malunga nale nkunkuma, umntu unokuphawula abo badibene neendleko eziphezulu zeziyobisi. Nangona a mayeza afuna ukuba ixabiso layo lihambelana ngokupheleleyo nekhono kunye nekhwalithi.