"Flyuanksol": imiyalelo ukusetyenziswa, oogqirha yokwenene. Iziphumo ebezingalindelekanga "Flyuanksola" analogue beziyobisi

Iyintoni imithi ye "Fluansoxol"? Imiyalelo yokusetyenziswa kwesi sidakamizwa, ukubunjwa kwayo, iziphumo ezimbi, uhlobo lokukhululwa kunye neempawu ze-pharmacological ziya kuchazwa ngokucacileyo kweli nqaku. Ukususela kuyo uya kufunda kwakhona malunga nantoni na ukuchasiswa kunye nokuboniswa okukhankanywe ngokukhankanyiweyo kuye, kubaluleka kangakanani, kuya kwenzeka ntoni xa kunokudlula ngaphezulu, njl.

Ukubunjwa kweziyobisi kunye nendlela yokukhululwa kwayo

Sisiphi isithako esinomdla esenzayo isiza "Fluanxol"? Umyalelo wokusetyenziswa kwala mayeza uthi u-flupentixol hydrochloride usebenza njengesithako esisebenzayo.

Ngokuphathelele uhlobo lokukhululwa, namhlanje eli phephelo lingafumaneka kuphela kumaconsi, iipilisi kunye nesisombululo esise-oyile esenzelwe ukulawulwa kwe-intramuscular. Iyeza lokuqala lithengiswa ngeglasi engabonakaliyo ye-10 ml, okwesibini - kwipakethi yekhadibhodi yeempahla ezili-100 okanye ezingama-50, kunye neyesithathu-kwii-ampoules zeengcezu ezili-10.

Iipropati eziqhelekileyo zokulungiselela

Iyintoni injongo yeyeza "Fluansoxol"? Izimvo zezigulane malunga nale nkunkuma ziya kunikwa ngezantsi. Iipilisi kunye nesisombululo sejoyi ziyingxenye yezilwanyana zokulwa ne-antipsychotic. Banoxhalaxolytic, anti-depressant kunye nokuphucula. Impendulo emihle malunga nale nkunkuma iqulethe ulwazi olwenza ngokuphumelelayo imeko yomzwelo yesigulane kwaye igalelo ekutshintshelweni kwayo kwentlalo.

Iimpawu ze-Pharmacological zesibisi

Ziziphi iimpawu ze-pharmacological zesilwanyana "i-Fluanxol"? Imiyalelo yokusetyenziswa ibonisa ukuba eli liyeza liyi-antipsychotic ekhusela i-adrenoreceptors kunye ne-dopamine receptors kwingqondo. Ngenxa yesenzo senkunkuma esebenzayo, impembelelo yokuguqula ifezekiswe . Njengomthetho, oku kwenzeka ngeentsuku ezili-8 zokudla rhoqo kwesi sidakamizwa.

Ziziphi izigulane ezithethayo malunga neziyobisi "Fluansoxol"? Iingxelo zezigulane ziqulethe inkcazelo enomdla. Kwiimeko ezininzi, bayaqaphela ukuba le nkunkuma ikhawuleza ikhuphe iimpawu zesifo sengqondo kunye nokuxinezeleka, kwaye inceda kwakhona ukubuyisela ingcinga. Izigulane ezineengxaki zokungahambisani neengxaki zintetho ziyaxubusha kwaye zixhomekeke kuluntu.

Iimpawu zesilwayo

Amayeza eFluanxol asebenza njani? Ukuphononongwa koogqirha kunye nezinye iingcali zithi ubuqhetseba beli chiza kukuba kuxhomekeke kwidosi, inokusebenza kwisigulane ngezindlela ezahlukeneyo.

Impembelelo yokulwa ne-antipsychotic yeli chiza ibonakaliswa emva kokusetyenziswa kwe-arhente kwisixamali se-3 mg ngosuku. Ngendlela, ubukhulu beli galelo bunyuke kunye nokwanda kwimiyinge.

Kwisixa esingama-25 mg ngosuku, isichengiselwano asinayo impawu. Nangona kunjalo, kufuneka kuphawulwe ukuba kumaxabiso aphezulu, kunokubangela ukuba i-sedation engabonakaliyo.

Kulo lonke uluhlu lwemilinganiselo echanekileyo, i-agent ye-neuroleptic ine-effectololytic. Xa usebenzisa amancinci amancinci (ukuya kwi-3 mg ngosuku), isicirisi singasebenza njengesicatshulwa esiqhelekileyo sokuxinzezela.

Ngaloo ndlela, isilwanyana "i-Fluanxol" sinako ukunciphisa imiqondiso ephambili yengqondo yengqondo, kubandakanywa ukungaboni kakuhle, ukucinga kunye nokuphulwa kokucinga. I-propinhibitory properties (i.e., i-activation kunye ne-anti-attic), kwaye iyanciphisa ukuphazamiseka kwemizwelo, ekugqibeleni inegalelo ekusebenziseni izigulane ezineempawu eziphazamisayo, ziququzelele ukulungelelaniswa kwezentlalo kunye nokwandisa izakhono zabo zokunxibelelana.

Inkcukacha malunga nefom yefayili

Isilwanyana "iFluanksol Depot" isisombululo esinamafutha esenzelwe iinjongo zokulondoloza i-intramuscular. Ngamanye amagama, eli lonyango lifom yefakekhexol.

Xa usebenzisa isisombululo esinjalo kumancinci amancinci kunye nama-medium (ukuya kwi-100 mg nganye iintsuku ezili-14), isigulane asinayo impembelelo engabonakaliyo. Nangona ikhula kwizinga eliphezulu.

Iingcali zithini malunga nale fom yeziyobisi ("Fluanxol Depot")? Iingxelo zithi isisombululo esinjalo sinexesha elide lokubonakalisa isigulane, kunokuba isilwanyana kwiipilisi. Ngaphezu koko, ngenxa yoko, kunokwenzeka ukuqhuba unyango oluqhubekayo lwe-antipsychotic lula, olubaluleke kakhulu kwizigulane ezingathobeli imiyalelo yonyango.

Kuzo zonke ezi ngasentla, kunokugqitywa ukuba izidakamizwa "iFluanksol Depot" inako ukukhusela ukuphindaphindiwe okuqhelekileyo kunye nokuphazamiseka okuthe ngqo kwonyango. Iilenki ze-Intramuscular zingenziwa kwixesha eliphakathi kweeveki ezimbini okanye ezine.

Pharmacokinetics

Ndiza kuthatha ixesha elide ndiyithatha amacwecwe e-Fluanxol? Emva kokulawulwa komlomo, uxinzelelo oluphezulu lwento esebenzayo kwi-plasma ifumaneka emva kweeyure ezingama-3-7. Ukufumaneka kwezidakamizwa ngu-40%.

Icandelo elisebenzayo leziyobisi lithatha ngokungabalulekanga kwi-barrier barrier. Kufuneka kwakhona kuqaphele ukuba ngokwexabiso elincinci ludityaniswe nobisi lomama. Ngendlela, i-metabolites ayinayo imisebenzi ye-neuroleptic.

Ijojekane ye-Depo injection isebenza njani? Isikhokelo sichaza ukuba emva kokufakelwa kwe-intramuscular, i-cis (Z) -flupentientol dexanoate isicatshulwa (inzymatically). Kule meko, i-active element cis (Z) -flupentixol kunye ne-decanoic acid yenziwe. Ukuxinwa kokuqala kwe-serum kufinyelelwa ekupheleni kweveki yokuqala emva kwejojo.

Xa kuthatha amacwecwe ngaphakathi kwithuba lokususwa kwabo malunga neeyure ezingama-35. Ukuba i-injection yejoice isetyenzisiwe, ukuxinwa kwi-serum yehla ngokukhawuleza (emva kweveki ezi-3).

La mayeza anikwa ngendlela yemetabolites emathunjini, kunye neentso.

Iimpawu zokusetyenziswa kwe-antipsychotics

Kwiimeko ziphi izilwanyana "I-Fluanxol" eboniswayo? Isiphumo sawo singahluka, kuxhomekeke kumyinge.

Isilwanyana siboniswe kumanani ukuya ku-3 mg ngosuku ngemeko elandelayo yokugula:

• Ukuxinezeleka okulula kunye nokunyamezela, kuhamba kunye ne-asthenia, ukuxhalaba kunye nokungabikho kwamanyathelo;
• Iziphazamiso zengqondo ezibonakalisa ngokwazo nge-asthenic;
• Izifo ze-Neurotic (ezingapheliyo), zihamba kunye nokunganakwa, ukudandatheka kunye nokuxhalaba;
• Izimo ezixinzelelekileyo zokuxhalaba, kunye neemeko zokuxinezeleka kwengqondo ezingafunekiyo okanye umonakalo (umzekelo, ukuba isigulane sisebenzisa kakubi i-tranquilizers).

Imithi ye "Fluansoxol", eyafana nayo iya kuboniswa ekupheleni kwinqaku, inqunywe kuma-dosages ka-3 mg ngosuku okanye ngaphezulu xa kukho iziphambano ezilandelayo: iimeko zengqondo ezihamba kunye neengxaki zengqondo, iingxaki zokucinga, i-anergia, ukunganakwa kunye ne-autism.

Ukungqinelana nokusetyenziswa kwe-antipsychotics

Kwiimeko zingaphakanyiswa ukuba zisebenzise izilwanyana "Fluanxol"? Izikhokelo zokusetyenziswa ziquka uluhlu olulandelayo lweenkcazo:

• Ubudala beminyaka (iminyaka eyi-18);
• Ukucinezelwa kwenkqubo ye-nervous central;
• Ixesha lokubamba;
• Ixesha lokukhulelwa;
• Ukuxiliswa (i-acute) kunye neerbiturates;
• Yeka;
• Ukuxiliswa kunye ne-opioid analgesics;
• Pheochromocytoma;
• Utywala obunxilisayo lunzima;
• Iimeko zokuqubana;
• Ukunciphisa umongo we-Bone;
• Utshintsho kwi-pathological blood;
• Ukunyanzeliswa kwemvelo kwindlela yokusebenzisa i-neuroleptics esakhiweni se-thioxanthene.

Kufuneka kwakhona kuqatshelwe ukuba kwiimeko zokuxhatshazwa okanye ukuchulumisa, akukhuthazwa ukuba umyalelo wezilwanyana kumancinci amancinci (kufika ku-3 mg).

Isiza "Fluanksol": imfundo (amaphilisi, amaconsi)

Ukuze unyango lweengxaki zokuxhalaba nokuxinezeleka, isilinganisi sokuqala samayeza kwiipilisi kufuneka sibe yi-1 mg kanye ngosuku (mhlawumbi kusasa) okanye 500 μg kabini ngosuku. Ukuba akukho miphumo yokwelapha, ngoko ngeveki isixa sonyango singanyuka sibe ngu-2 mg. Kule meko, umlinganiselo wemihla ngemihla (2-3 mg) kufuneka uhlulwe ibe ngama-reception. Ukuba isiphumo asikho xa usebenzisa isicatshulwa kwi dose ephezulu (okt 3 mg), ngoko kufuneka ilahlwe.

Xa unyango lweemeko zengqondo, inani lemithi linikezelwe kuphela. Umlinganiselo wokuqala wemihla kufuneka ube ngu-3-15 mg kwi-3 ehlukeneyo. Ukuba kuyimfuneko, le mali inganyuswa ukuya kuma-20 okanye kwi-30 mg ngosuku. I-dose ephezulu ayifanele ibe ngaphezu kwama-40 mg.

Njengonyango oluxhasayo, i-ejenti inikwe umlinganiselo we-5-20 mg kanye ngosuku (ekuseni).

Ngokuphathelele amaconsi "Fluanksol", kufuneka athathwe ngaphakathi ngaphakathi. Ngokuqhelekileyo, oogqirha banika le fom yesilwanyana kuphela ukuba ngaba kungayiphi na into ayinakuyifumana ngamazwi ngomlomo (kwiipilisi). Isondlo sokulondoloza izigulane ngu-4-40 mg ngosuku.

Isisombululo se-Injection "Fluanksol": imiyalelo, ukuhlolwa kwezigulane

Isisombululo esinamafutha kwisilwanyana se-disotuscular injection kufuneka sijojole ngokujulile kwi-quadrant yangaphandle ye-buttock. Imilinganiselo kunye nekhefu phakathi kweenkqubo kufuneka kusekwe kuphela (ngokuxhomekeka kwimpembelelo yokwelapha).

Esi sigqirha sisoloko sisetyenziselwa kwisixa se-20-40 mg (okanye 1-2 ml) rhoqo kwiiveki ezimbini okanye ezine. Kufuneka kuqatshelwa ngokukodwa ukuba ezinye izigulane zingadinga iindleko ezinkulu kunye nexesha elifutshane phakathi kweejoke.

Ukuba umthamo ochanekileyo weyeza kumjovo (20 mg / ml) ungaphezu kwe-2 okanye i-3 ml nganye kwinkqubo, ngoko kuyimfuneko ukutshintshela kwisisombululo ngongxube ophezulu.

Iyeza 100 mg / ml kufuneka lilawulwe ngomsindo we-50-200 mg (okanye i-0.5-2 ml) rhoqo kwiiveki ezi-2-4. Xa kunzima ukuphindaphinda okanye ukugqithisa kwesi sifo, ukulawulwa kwexesha elilodwa le-arhente kwisixa semali ukuya ku-400 mg ngexesha eliphakathi kwe-2 okanye 1 ngeveki kufuneke ngezinye iixesha. Emva kokugqithisa kweempawu eziphambili, kuyimfuneko ukunciphisa kancane umyinge kwisondlo (20-200 mg nganye kwiiveki ezi-2-4).

Ukuba kuyadingeka ukuba ushintshe kwifomu yomlomo yesichengisiso ukuya kwonyango lokulondoloza ngeziyobisi zesibindi, kuyacetyiswa ukuba uthembele kwisicwangciso esilandelayo:

• Inani lemihla ngemihla (kwi-mg) yamachiza kwiiphilisi x 4 = idosi enye (kwi-mg) yesisombululo sejoyi rhoqo kwiintsuku eziyi-14.

Kufuneka kwakhona kuqatshelwe ukuba ngeveki enye emva kokulawulwa kwezidakamizwa kuyacetyiswa ukuba uqhubeke nokuthatha izilwanyana kwiipilisi, kodwa kwiseli encinci. Umthamo olandelelanayo kunye nekhefu phakathi kweenkqubo zenziwe ngokuhambelana nempembelelo yokwelapha.

Isisombululo esiphezulu sesisombululo sejoyi (isigaba esisodwa) si malunga ne 400 mg. Ikhefu phakathi kweeyunithi kufuneka libe yiveki enye.

Ngokutsho kwengxelo yezigulane, ngokusetyenziswa ngokufanelekileyo kweziyobisi kunye nokuthotyelwa kweengcebiso zonyango, kuphazamiseka kakuhle kwimeko yabo yesimo sengqondo.

Iziphumo eziPhakathi

Ngaba imithi yeFluanxol ingathintela umzimba ngendlela engafanelekanga? Imiphumo emibi ifumaneka kule nkunkuma, kungakhathaliseki ifom yayo. Masibhale uluhlu ngoku.

1. Inkqubo yesifo: i-hyperkinetic-hypertonic syndrome (extrapyramidal lung), ubuthathaka, i-akathisia, ukukhathala, utywaba, ukuphuza i-psychomotor, i-dyskinesia ye-tardive, i-dystonic kunye ne-neuroleptic i-syndrome eyingozi.
2. Intliziyo kunye nemithambo yegazi: i-tachycardia, i-orthostatic hypotension.
3. Iprogram yeHemopoietic: granulocytopenia.
4. Amalungu enkonzo: ukuphulwa kweendawo zokuhlala.
5. Isondlo sesisu: isambatho, i-jaundice ye-cholestatic, umlomo owomileyo, utshintsho olusesikweni kwiimvavanyo zesibindi.
6. Inkqubo ye-Endocrine: inzuzo yesisindo, i-galactorrhea, i-sweating, i-gynecomastia, ukungabi namandla, i-dysmenorrhea, ukwandisa ukutya, ukunciphisa i-libido, ukutshisa okutshisa.
7. I-urinary system: ukugcina umchamo.
8. I-allergies: i-dermatitis, i-photosensitization kunye nokugqithisa kwesikhumba.

Imiyalelo ekhethekileyo yokusetyenziswa

Unonophelo olukhethekileyo, unyango luyalelwe izigulane ezinesifo sengqondo esingaqhelekanga, i- convulsive syndrome, ukungaphumeleli kokuphefumula, i-glaucoma, isifo se-Parkinson, isisu esiswini kunye ne-duodenal ulcer, i-asthma, utywala, i-emphysema, ukugcinwa kwamanzi, ukugcinwa kwamanzi, ukungazinzi kakuhle kunye ne-prostatic hyperplasia.

Ukuba isiguli sele sithatha i-antipsychotics okanye i-tranquilizers ngefuthe lokudambisa, ngoko kwamkelwa kwabo kufuneka kumekwe kakuhle.

Xa unyango lwangexesha elide, ngokukodwa kwimilinganiselo ephakamileyo, kucetyiswa ukubeka iliso nokuvavanya imeko yesigulane ngenjongo yokulungisa umthamo wesondlo.

Ngonyango olufanayo ngexesha lesifo sikashukela, injongo yale nkunkuma ingadinga ukulungiswa komthamo we-insulin.

Xa kusetyenziswa i-neuroleptics, i-neuroleptic syndrome enokuthi ikhule . Iimpawu zayo eziphambili kukunyaniseka kwemisipha, i-hyperthermia, ukungazi kakuhle kunye nokungasebenzi kwesimiso se-nervous autonomic system. Ngeempawu ezinjalo, ukurhoxisa ngokukhawuleza kweziyobisi kunye nokutyunjwa kokugcinwa kweyeza.

Kwiimeko ezininzi, isilwanyana "iFluanksol" ayibangeli i sedation. Kodwa nangona kunjalo, umntu kufuneka acinge ngempembelelo yayo enokukwazi ukulawula ngokukhuselekileyo umatshini okanye ezinye iindlela. Kwakhona ndifuna ukuphawula ukuba ngexesha lonyango (ngokukodwa ekuqaleni) izigulane kufuneka ziphephe imisebenzi enobungozi (ngaphambi kokugqiba impendulo kwiyeza).

Iimeko zokugqithisa

Ukuba iyeza lithathwe ngokungalunganga (kwimimandla ephakamileyo), ngoko kunokugqithisa ngaphezulu. Kule meko, iimpawu ezilandelayo zivela: u-hypo-or hyperthermia, ukulala, ukudibana, i- extrapyramidal disorders, ukutshatyalaliswa, ukuxhomekeka kwe-arterial hypotension kunye ne-coma.

Yintoni enokuyenza kule meko? Unyango oluxhasayo kunye nolusifo oluyimpawu luyimfuneko. Ukuba isilwanyana sithathwe ngomlomo, kufuneka ukuba uhlambe ngokukhawuleza isisu, kwaye uthathe i-sorbent. Ukongezelela, kubaluleke kakhulu ukugcina umsebenzi weempahla, intliziyo kunye nenkqubo yokuphefumula. Akukhuthazwa ukusebenzisa i-epinephrine, kuba ingakhokelela ekunciphiseni kwegazi. Izimpawu ze-Extrapyramidal zinokumiswa kunye neziyobisi "Biperiden", kunye nokuxinwa - "Diazepam".

Ukusebenzisana namanye amachiza

Xa kusetyenziswe ngokufanayo le meyeza, umphumo wokudambisa ama-barbiturates, i-ethanol kunye nezinye i-agents ezenza umonakalo ocinezelayo kwinkqubo yesistim ephakathi inokuphuculwa.

Isilwanyana "Fluanksol" asikhuthazwa kakhulu ukuba sisetyenziswe kunye nenkunkuma ye-guanethidine kunye neziyobisi ezinemiphumo efanayo. Le nyaniso yenziwa ngenxa yokuba i-neuroleptics inokubangela ukuba buthathaka.

Ngokusetyenziswa kwexesha elilodwa kweziyobisi "Fluanksol", kunokunciphisa ukusebenza kweziyobisi "Levodop" kunye nezinye iziyobisi.

Ngokulawulwa ngokufanayo kweyeza kunye nePiperazine kunye ne-Metoclopramide, umngcipheko weengxaki ze-extrapyramidal zanda kakhulu.

Kufuneka kwakhona kuqaphele ukuba imithi echasene ne-antipsychotic ngendlela yesisombululo somjovo akufanele ixutywe kunye nezinye izilwanyana.

Ixabiso kunye neempawu zokulungiselela

Yimalini sisiyobisi "Flyuanksol"? ixabiso layo kakhulu eliphezulu. Ngoko ke, ngokuba amacwecwe-50 ka-1 mg kuni kuya kufuneka ukuba uhlawule imali engange Russian malunga 500. Ukuba ufuna 100 amacwecwe 5 mg, ukuba kuthengelwa 1,200 engange. Ke ukuba uhlobo injectable beziyobisi, eyona nto ibiza kakhulu. yentsha kwama-10 (20 mg / ml) oosokhemisti ifuna malunga 2300 engange.

Kuthekani ukuba isigulane akakwazi ukuthenga amayeza "Flyuanksol"? analogue yayo zithengiswa phantse yonke ekhemesti imixokelelwane. Phakathi kwazo kukho ezi zilandelayo:

1. Isisombululo "Flyuanksol Depot". Kuyinto drug ngokukhawuleza kwaye zinamandla ngakumbi. Noko ke, amacwecwe kakhulu ibiza kakhulu.
2. "Klopiksol" amayeza. Xa ixabiso lisondele kakhulu yokuqala. Lenza ezithengiswayo ezipilisi kwaye Izimo ezimbalwa.
3. "Truksal" lithetha. Kuthengiswa amacwecwe. The main inzuzo wakhetha ukusetyenziswa kwayo kubantwana abaneminyaka-3. Iindleko ngentla kancinci yokuqala.