Ichiza "Metozok": imiyalelo ukusetyenziswa, analogs kunye nohlolo

isifo sentliziyo kunye imithambo yegazi onokuphazamisa abantu abaninzi. Ukuphelisa ezi zifo, ukumisela "Metozok". Imiyalelo yokusebenzisa kucetyiswa ngamandla phambi kokuba usebenzise ezi pilisi udibane nogqirha kwaye musa ukuthatha amachiza ngokwabo, kuba Izimo ezinzulu. Imithi inceda izifo angina, ukusilela kakhulu intliziyo, tachycardia, migraine kunye nezifo ezifana nayo.

isakhiwo

Ixesha elisikiweyo yindlela "Metozok". Imiyalelo ukusetyenziswa ikuchaza ngokweenkcukacha ekwakhiweni kwezi tablets.

A medicament nge umthamo 25 mg eliquka 23,83 mg asebenzayo nto metoprolol tartrate, 50 mg imalunga 47,66 mg isithako esebenzayo 100 mg - 95,32 mg.

Okunye yakhiwa medication: hypromellose, ludipress LTSE, povidone, colloidal lesilicon dioxide, wemagniziyam stearate.

YeCwecwe coating iquka into esele zenziwe "Opadry II», nto leyo zipeyintwe-orenji. Oku kuquka amacandelo afana Polyvinyl utywala, talc, macrogol, titanium dioxide, yellow intsimbi oxide umbala, obomvu, namnyama kunye indigo.

Iipilisi bamele iyeza elide-ngokwenza, ukuba zigqunywe esingxotyeni salo kukukhanya-eluhlaza. Ngaba setyhula, khaxa macala omabini.

Dragee kwi isixa 30 ezitransparenti ngeebhotile zeplastiki eziqwenga 10 kumadyunguza aluminium. Ibhokisi yekhadibhodi iqulathe kumadyunguza ezintathu.

Nomakhi "Metozoka" yinkampani Russian JSC "Akrikhin".

inyathelo imithi kunye farmadinamika

Jonga cardioselective beta1-blocker ipilisi "Metozok". Imiyalelo yokusebenzisa ichaza ngokupheleleyo amanyathelo amayeza olufanelekileyo lwechiza. Eli chiza akukho inwebu uzinze mihlaba kunye nomsebenzi sympathomimetic. umfutho Lubonakala, inyathelo antianginal kunye antiarrhythmic.

mali Small β1-adrenergic receptors ukucola intliziyo, zehlisa ukusebenza kwinkampu catecholamine compound evela ATP, kunciphisa ekhoyo ngoku ion calcium, yakha chronotropic ezimbi, BATM, dromo- kunye neziphumo inotropic. Ekuqaleni ukusetyenziswa kweziyobisi kwandisa iimpahla ukumelana lulonke. Oku kungenxa ukukhuthazwa yokuvimba α-adrenoceptor kunye β2-adrenoceptors. Emva kweentsuku ezimbalwa (1-3), imbuyekezo isigulane yakuqala, kodwa yonyango lwexesha elide yehlise ukuxhathisa peripheral nemithambo.

impembelelo umfutho kwenzeka ngokunciphisa inani yokumpompoza kwegazi ngomzuzu, kunye nemixube renin ngokusebenzisa umsebenzi inhibition lomsebenzi renin-angiotensin-aldosterone kunye nenkqubo luvo, kwakunye ukuvuselela susceptibility le baroreceptors le arch aortic, yaye ekugqibeleni kunciphise amanani peripheral novelwano. Kunciphisa kwaphakanyiswa wegazi imeko yokuphumla le. zokucutha kwenzeka ngexesha umsebenzi ngokwasemzimbeni kunye ntshikilelo nasengqondweni. Le umfutho ihlala ngaphezulu ngemini.

impahla Antianginal ibonisa ukuhla iimfuno ioksijini engabalulekanga, nto leyo ekugqibeleni kunciphisa umyinge intliziyo susceptibility umsipha kwimpembelelo innervation novelwano. Oku kunciphisa inani ukuhlaselwa sifuba angina kunye nokunciphisa nexesha labo. Ukwanda umsebenzi bokuphila komntu. Ngenxa yokwanda yengcinezelo nendawo ophela ukuzala kwi ventricle yasekhohlo kunye luthambe kwemisipha zombini ventricles kwandisa imfuneko oksijini abantu abaphethwe sisifo sentliziyo.

ukusebenza Antiarrhythmic kufikelelwe ingcinezelo arrhythmogenic obubonakala ukuba ichazwa njengokuba tachycardia, lwegazi kunye ezifana. D. Kuvela ukuncitshiswa esingalindelekanga excitation ethunjini kunye sinus isingqisho, kunye inhibition of AV-Umqhubi.

Phambi tachycardia, supraventricular kunye sinus ezimile uzingela fibrillation atrial, thyrotoxicosis kunye nezinye izifo isixhobo ezisebenzayo kwentliziyo kunciphisa umyinge intliziyo, leyo kwezinye iimeko kukhokelela ukubuyiselwa sinus rhythm.

Ichiza le umbala obalaseleyo nxamnye migraine.

Njengoko lisetyenziswe ngokwemithamo yee-kwezonyango, alunasiphumo ngokukhawuleza kwi amalungu kunye adrenoceptors β2- kunye nafuthe kwiinkqubo pathways emzimbeni carbon. ukusebenza kwalo iyafana nefuthe "Propranolol".

Xa kokufumana ichiza kangangeminyaka eliqela, unga nciphisa ngokubaluleka ubungakanani cholesterol egazini. Xa ukufumana amathamo yemihla ngemihla 100 iziyobisi mg kuchaphazela ngaxeshanye kuzo zonke iintlobo zeHPV zingonobangela β-adrenoceptor.

"Metozok" (umyalelo manual iza iipilisi) zifunxe yi-95%. Abangaxhalabisiyo enyibilikayo kukutyeba. Libandakanyeka yokucolwa yokuqala-okupasa bioavailability yi-50% kwi ukusetyenziswa lokuqala amayeza 70% - kwezi ndlela zilandelayo. Le xi liphezulu into egazini waphawula emva kweeyure 6-12 emva nokudla tablet. Kwinkqubo unyango eqhubekayo ngcembe kwandisa bioavailability. Ukutya kwandisa bioavailability kwi-40%.

Active iziyobisi 10% aqhagamishelana iiproteni igazi. Kunokuba ngokukhawuleza bafakwa kwaye ingena umqobo igazi-ingqondo, ngumkhaya. Inxalenye ezithile singena ubisi lwebele.

It umzimba esibindini, kwaye metabolites ezimbini ziphambili zibandakanya izinto beta adrenoblokiruyuschey. Nethe beziyobisi ababandakanyekayo isozyme CYP2D6.

Kunomyinge isiqingatha-ubomi iiyure 3.5-7. Ichiza ongakhululwanga yi emzimbeni ngexesha olugqitha esikhumbeni.

metabolites yesininzi zikhona izigulane CC 5 ml / min., ke kulo mzekelo, umsebenzi walo yokuvimba beta-adrenoceptor ayinyuki.

Le bioavailability kwanda kunye ukuqina kwesibindi sifo. Kwakhona zanciphisa ubucukubhede iyonke.

"Metozok": zikhombisa ukuba ukusetyenziswa

Baqinisekiswa bathi le ukulungiselela nokuphelisa tachycardia, ukunciphisa intlungu ezesifuba omeleza impilo. Ubungqina obubonakalayo buxela ukuba iilozenji na lwegazi, ukusilela intliziyo ngendlela engapheliyo, ibekwe imbuyekezo bakala. Kwimeko yokugqibela, ichiza Kucetyiswa ukuba basebenzise kunye nezinye iindlela injongo ezintsonkothileyo.

Ezimiselweyo amayeza ischemia kwentliziyo "Metozok". Ubungqina obubonakalayo buxela kwenzeka ukuhlaselwa angina (kwifomu esitalini) ukunciphisa ukufa kwaye unciphisa amathuba kwakhona iposi-, emva usulelo oyingozi.

Ichiza Kucetyiswa ngokusilela intliziyo umzimba isingqisho, tachycardia supraventricular xa ndikho, ukunciphisa amaza yindibanisela zombini ventricles ngexesha fibrillation atrial kunye ventricular arrhythmia.

Ichiza kakuhle zezigulo ezisebenzayo intliziyo, ezo zihamba tachycardia kakhulu. Lidla ngokusetyenziswa ukuvimbela migraine. Kwacetyiswa ukuba ukufumana i "Mezotok" zikhombisa iziyobisi. Le ngxoxo ilandelayo ijonga Izimo.

Izimo nokusetyenziswa

Kuyo nayiphi na imeko esalelweyo ukuthatha amachiza ngokwabo ngaphandle kagqirha kagqirha. Iipilisi ukuba engamiswanga yokothuka cardiogenic AV-kwafa ubungqongo-II III. Musa ukusebenzisa isixhobo kwi kwibhloko sinoatrial kunye nabagulayo sinus syndrome. Inceda ban ukusetyenziswa bradycardia (50 u. / Min) ukusilela zentliziyo acute kunye ezingapheliyo decompensated. Contraindicated "Metozok" (umsebenzisi ikuchaza ngokweenkcukacha isicelo zonke iimpawu medicament) ukwenzela hypotension, iposi engabalulekanga, zisendaweni nqanaba nokoyika uphuhliso, sisifo, feohromotsite, ukuphazamiseka kwendlela ejikeleza yoluvo. Ngamandla bacetyiswa ukudibanisa iipilisi kunye inhibitors Mao nezitofu efakwa "Verapamil".

Akukho mfuneko ukusebenzisa iyeza kubantwana, ogama yobudala sele bengekafiki kwiminyaka elishumi elinesibhozo ubudala, ngexesha lokuncancisa, abantu abane ngxaki ukubanyamezela lactose, kwakunye malabsorption syndrome, hypersensitivity ukuya beta-blocker, kuquka metoprolol kuyo.

Amanyathelo emiselweyo medicament xa seswekile, mna isidanga AV-block kunye Prinzmetal angina. Ahlale evule amehlo kufuneka kubangela lactic metabolic, isifo nesi sifo inyumoniya kunye nesifo pulmonary, isibindi kunye nenkqubo kwezintso. Phantse akukho emiselweyo unyango myasthenia, feohromotsite, hyperthyroidism, ukudakumba, ukhwekhwe, ukungasebenzi kakuhle kwi kwegazi peripheral, ngexesha lokukhulelwa kunye nabantu abadala.

Ulingo lwezonyango abasetyhini abakhulelweyo impembelelo ichiza sele kuqhutywa. Kwakhona akukho data kubungakanani elalana beziyobisi ibe ubisi lwebele. Ngoko ke, xa abantwana zisanyisa iipilisi phambi ukusetyenziswa kuyimfuneko ukuba udibane nogqirha.

"Metozok": imiyalelo yokusebenzisa

Izimvo ezinye izigulane ingxelo ukuba ichiza kunokubangela iziphumo ezingalindelekanga ngohlobo ukudinwa. Ngoko ke kubalulekile ukulandela imithetho kwaye zifumana idiphu ekhuthazwayo. Ukuba ugqirha ayikho oyichole iphathwa ngamnye, kufuneka usele kwityala ipilisi zakudala "Metozok". Imiyalelo yokusebenzisa icebisa ukusebenzisa ichiza kanye ngemini kusasa, kungakhathaliseki ukuba ukutya. Dragees nje zingahlafunwa kwaye kwehle nge yamanzi. Ukwenzela ukuphepha bradycardia, ithamo amayeza ebegqwese ukwanda.

Phambi angina kunye noxinzelelo lwegazi, nokunyanga nge-50 mg ngosuku. Ukuba isiphumo ayizange iphumelele, idosi yemihla ngemihla yanyuswa ku 100-200 mg / imini, kwaye lwegazi - kwezinye iimeko - unyango kuncedisana elinye iyeza umfutho.

Kuba abantu abanezifo sentliziyo udidi II ngokutsho yokuhlela NYHA, ngaphandle nqanaba etsolo iinyanga ezintandathu kwaye ngaphandle utshintsho olubalulekileyo unyango kwiintsuku ezilishumi elinesine yokugqibela, kodwa idosi yokuqala ka-25 mg kanye ngemini. Kwiiveki ezimbini kamva, xa umthamo kuyimfuneko yemihla ngemihla lanyuka ukuya 50 mg, yaye emva koko, emva kweeveki ezimbini ngaphezulu, - ukuya ku-100 mg kwaye ngexesha elinye (iintsuku 14) yanyuswa 200 mg.

Xa III-IV ukusilela intliziyo ezondeleyo congestive, nokunyanga kwibakala ka 12.5 mg kanye ngemini kwaye kuphela emva kweeveki ezimbini inani lanyuka ukuya 25 mg njalo njalo - de idosi iphezulu-yemihla ngemihla mg 200. Nale uphethwe kwizigulane kunye ukwanda idosi enyangayo kufuneka abe phantsi kweliso elibukhali likagqirha kufutshane, ekubeni imeko inokuba mandundu kwezinye izigulane.

Faka eli chiza emva uthintelo ngokuphindaphindiweyo iposi engabalulekanga kunye nezinga ukusilela ngentliziyo kwelo idosi enyangayo yemihla ngemihla ka-100 mg.

Izigulane nokuphazamiseka ezisebenzayo wentliziyo, apho kukho kwakhona tachycardia, iyeza emiselweyo 50 mg ngosuku. Ukuba kuyimfuneko, idosi yemihla ngemihla landile ukuya mg 200.

Ukuthintela ichiza migraine Kucetyiswa ukuba nisele 100-200 mg ngosuku.

Musa ukulungisa idosi konwaywa abadala kunye izigulane ukusilela kwezintso abakhoyo olugqitha esikhumbeni.

isifo sesibindi kuchaphazela ekupheliseni metoprolol kusuka emzimbeni, ngoko kulo mzekelo, ngexesha lonyango ilungiswa ithamo enyangayo, kungakhathaliseki ukuba imeko yesigulane.

libanda

Kufuneka ube ngononophelo kwaye kuphela phantsi imiyalelo ugqirha ukuba uthathe iipilisi "Metozok". Guide uchaza Izimo apho yokwamkela ichiza akwenzeki. Iingcali Sigxininisa ukuba-non ukuthotyelwa kwemithetho amathamo reception kunokwenzeka overdosing, nto leyo sikhatshwa ventricular extrasystole kunye tachycardia, imvakalelo ubunzima intloko, izandla neenyawo, kwakunye nokwanda kakhulu uxinzelelo lwegazi.

Unyango ikhutshwa phandle kwizitofu efakwa lwe alpha-blocker beta-blocker kunye.

imiphumela emibi

Njengoko kukhankanyiwe, kwezinye iimeko, ngexesha uthatha ichiza, "Mezotok" ukuze besehlelwa ziziphumo ebezingalindelekanga. Ngokutsho kwisigulana, kusenokuba ukunyuka koxinzelelo lwegazi, ukwanda izinga intliziyo, fibrillation ventricular, arrhythmia kwentliziyo, kunye bradycardia kardialgiya.

Ngomhla inxalenye Central nervous nesiyezi System ibonakala, imvakalelo zingqondweni ngenxa yokoyika, ixhala, ukuphazamiseka kokulala, intloko ebuhlungu, amahlaba kwezihlunu, iingcangcazela, Ukopha ebuchotsheni, paresthesia.

Kuba icala ezinye izigulo, ngokwendlela nokubuyekezwa oogqirha kunye nezigulane zabo iimpawu ezifana eluswini libunile, ischemia ulusu kule ndawo isitofu, aleji, necrosis, ukujaduka phezu komhlaba esikule emva ulawulo lwezitofu ongama.

Kwimeko ziziphumo ebezingalindelekanga, iBhunga waphakamisa ichiza "Metozok" umyalelo manual. Analogs kweli chiza kuya kukunceda ukuba ukhethe ugqirha okunyangayo.

oyi

Zibaluleke kakhulu ekuqeshweni i "Metozok" zikhombisa iziyobisi. Analogs zisetyenziselwa ukunyanga ezi zifo akukho inqabile kakhulu. ophawula zabo specialist, kuhlolwe ngenyameko imeko yomguli, kwimeko yokuba "Mezotok" ngenxa yesizathu esithile akaphenduli.

Kuyo unyango kufuneka bagadwe ngeliso elibukhali, ngenxa izalathi si zokunikwa ECG, uxinzelelo lwegazi, igazi kwegazi ezandleni nasezinyaweni, kwakunye kwemveliso intliziyo.

Xa izigulane umfutho wegazi kunye nokusilela intliziyo congestive, kuyimfuneko ukugcina uxinzelelo lwegazi iSystolic kwi 30-40 mm HG. Art.

Xa ukwanda koxinzelelo lwegazi, kulandele iimpawu tachycardia okanye bradycardia, maxa wambi kukho ukuphazamiseka kwesingqisho intliziyo. Kule meko, unyango kunye "Metozok" (manual ulumkisa malunga neziphumo ebezingalindelekanga kunokwenzeka) kufuneka imiswe. Ukuthintela ukuncipha zamabanga uxinzelelo lwegazi emva ukurhoxiswa ichiza, ithamo ebegqwese lifinyele, ingakumbi xa kukho iimela elide uvuza nokuqhubeka ukubeka isigulana ukuba uxinzelelo kuyehla kube ixabiso 70-80 mm HG. Art.

Xa abantu abadala inani receptors adrenergic, singangena ingakumbi liyancipha phenylephrine. Kwelinye icala, monoamine oxidase inhibitors, ukunyusa isiphumo ngokuveza of sympathomimetic, musani ukubacaphukisa intlungu entloko, arrhythmia, reflex ukugabha, emaxongo unesifo. Ngenxa yoko, izigulane usebenzisa monoamine oxidase inhibitors, iintsuku 2-3 ukunciphisa inani sympathomimetics.

Ngelo xesha, oogqirha musa singacebisi uthomalaliso ikhondo lomsebenzi ezinobungozi, olusekelwe phezu isantya basabela - zombini kwengqondo kunye nokomzimba.

Ngononophelo kakhulu kufuneka usele iipilisi umntu ogula sisifo sezintso, kunye nabantu abadala. Ichiza kufuneka kuthathwe kubantwana abangaphantsi kweminyaka elishumi elinesibhozo ubudala ngenxa yokungabikho ulwazi neziphumo zayo.

Ichiza ekhululwa ezikhemesti ngqongqo kagqirha.

Analogs medicament

Kuthekani ukuba "Metozok 'lingafanelekelanga ngenxa yesizathu esithile? Analogs usenokuphinda lingafumaneka kwi ekhemesti. Baye ncam into efanayo esebenzayo kwaye ngale ndlela kuchaphazela umzimba. Ezi amayeza ziquka:

• "Betalok".
• "Serdol".
• "Egilok C".
• "Vazokardin kunamandla."
• "Metoprolol".
• "Korvitol 50".
• "Metokard".
• "Emzok".
• "Atenolol".
• "Lidalok".

Ezi kunye endaweni enye "Metozok" analogue ziye zasetyenziswa xa unyango lwezifo sentliziyo ngempumelelo. Yonke imali ifuna indlela kakhulu, kwaye ke ayikwazi ukuba kuthathwe ngokwabo, ngaphandle kagqirha kagqirha.

baqinisekiswa

Ukulungiselela "ratings Metozok 'ikakhulu positive. Abantu bathi ukuba ukhululekile ukuba basele (pamo elicetyiswayo yi - tablet olunye ngosuku). Bethetha nayo intsingiselo. Izigulane ezininzi bathi emva ukusela azilibale kuthetha malunga Intlungu entliziyweni yam.

Iingcali endle yamayeza kwakhona adunyiswe ngamandla iipilisi "Metozok". Izimvo kumagqirha zibonisa ukuba ichiza olusebenzayo ekhuselekileyo, ngoko oko kudla emiselweyo cardiologists ukuba izigulane zabo. Iingcali zithi ngexesha unyango eyona nto ibalulekileyo - ukukhetha ukuba balawule, kungenjalo usenokuba neziphumo ebezingalindelekanga ezifana ukudinwa, isicaphucaphu, ukugabha kunye norhudo.