Ichiza "Mikosist": ncomo, analogue, ixabiso. Drug "Mikosist": imiyalelo yokusebenzisa

Drug "Mikosist" yemiyalezo uchaza njenge arhente nokubola. Eyona nto elikhutheleyo izenzo fluconazole chiza - inhibitor uyakhetha of sterol kudibaniso iiseli ezinzwaneni. It ofihla kwinkqubo cytochrome yabantu P450 akuthethi ukubonisa umsebenzi androgenic, kuyaphumelela ngokuphathelele ngamagciwane of mycosis.

Pharmacokinetics

Emva medicament ngomlomo okanye efakwa "Mikosist" (umsebenzisi ibonisa oku) kakuhle waya neencindi zomzimba kunye namalaphu. Xa isikhohlela, ulwelo peritoneal kunye articular, ematheni, ubisi lwebele kweziyobisi xi efana zafumana kwi plasma yegazi. Umxholo fluconazole kulwelo cerebrospinal kwizigulane kunye fungal meningitis yeyona asibhozo ekhulwini xi kwi plasma leyo, nayo, kuba umlinganiselo ngqo idosi. Xa isicelo-kanye yonke imihla ukuya kusuku lwesine-sesihlanu 90 ekhulwini iyazalisekiswa yoxinaniso kuvuselele. Ukuba ngosuku lokuqala ukuya kuthabatha ithamo ezingaphezu sokwenza izihlandlo ezibini, unokuba ngomhla wesibini ukufikelela 90 ekhulwini zokwanda kuvuselele. Elinanye ukuya elinambini ekhulwini bophelela fluconazole kwiiproteni plasma. Xa metabolites igazi peripheral nje andibhaqwa. Pharmacokinetics kuxhomekeke ncakasana kwi nezintso, ngokuba ichiza idubule ikakhulu abonisa ngayo, yaye malunga asibhozo ekhulwini - ingatshintshanga. Kwisithuba seeyure ezintathu dialysis uyondelelwano lwee- into esebenzayo kwi plasma lifinyele ngesiqingatha.

Ubungqina obubonakalayo buxela ukuba

Kucetyiswa ukuba basebenzise iziyobisi "Mikosist" thrush, kuquka ngokubanzi, zasasazwa, kumalungu obuni, xa ezinye iintlobo ezihlaselayo usulelo Candida, candidemia, kwaye kukho izinto akufaneleyo ukuvela thrush. Kwakhona ziboniswa ukusetyenziswa kweziyobisi kubantu abane mucosal candidiasis: pharynx; candidiasis yomlomo kuquka atrophic, evela benxibe amazinyo; emphinjeni. Medicine "Mikosist" umyalelo ncwadi ikhuthaza ilawulwa ukuba izigulana cryptococcal meningitis, okanye nokudumba, cryptococcosis, usuleleko cryptococcal ulusu okanye nemiphunga. Yena isicelo kwakhona kuthintelo ukuphinda ezi ukungaqheleki xa izigulane AIDS kwaye kwezinye iimeko abantu immunodeficiency. Amayeza asetyenziswa ukuthintela usulelo ezinzwaneni kubantu nangezilonda yingozi, basengozini ngenxa radiation okanye chemotherapy nokuzoyisa data. Kwakhona, ichiza "Mikosist" lisetyenziswa unyango nokungunda usulelo nasemiphakathweni kunye umntla, mycoses enzulu zikho, kuquka paracoccidioidomycosis, coccidioidomycosis, histoplasmosis kwizigulane kunye kwiinkqubo eziqhelekileyo omzimba.

Ifom umthamo, ukupakishwa, ukubunjwa

iintlobo ezimbini umthamo medicament iye "Mikosist": njengezingxobo kunye isisombululo nokubandakanywa. wenza njengezingxobo ukuba equlathe-50, 100 no-150 neemiligram-fluconazole. Bonke bephela gelatin nzima, kunye umzimba emhlophe ngaphaya kwawo, yaye zahluke kuphela ezineziciko umbala: y njengezingxobo equlathe milligrams 50 esisebenza, cap ukukhanya blue 100 - odidi, 150 milligrams - oluhlaza. Ikhontenti ubunzima olungumgubo eqinileyo okanye powder emhlophe (phantse abamhlophe). izithako kwi benza wemagniziyam stearate, anhydrous lactose, colloidal lesilicon dioxide, talc, titanium dioxide, umbona starch, gelatin, indigo carmine. Njengezingxobo eziqulathe 50 100 mg ka-fluconazole, ukuba ithunyelwa nemiqulu, inye, zimbini, namadyungudyungu ezine, iziqwenga zibe sixhenxe ngalinye. Kwaye abo eziqulathe milligrams 150 isithako esebenzayo - bayiqhekeza omnye okanye emibini.

isisombululo ukumnika na uhlobo ulwelo ngaphaya, ezingenambala okanye bebala olova. Enye eziqulathwe milligrams ezimbini milliliter ukwimo esebenzayo nganye. Awona macandelo eziziisekondari ngamanzi ukuba isitofu kunye sodium chloride. isisombululo kwabiwa kwiglasi ezineengqayi ezilikhulu ngeemililitha zingafakwa kwiibhokisi kwikhadibhodi. Iphekhi enye iqulethe igutyana enye.

Indlela ukuthatha 'Mikosist "? balawule

Ithamo zisaqhubeka fluconazole kwi losuleleko cryptococcal lusuku lokuqala lonyango, 400 mg, ngemihla zilandelayo - 200-400 milligrams. Ubude unyango ixhomekeke kuqinisekiswa ukufunda mycological of the ukusebenza lwezonyango, oko kudla hayi ngaphezulu kwe ezintandathu - iiveki ezisibhozo. In cryptococcal meningitis ukusebenzisa imithi "Mikosist" imiyalelo zokusetyenziswa olucetyiswayo ezilishumi - iiveki ezilishumi elinambini emva isiphumo yaba iisampuli ukufunda ezingalunganga ulwelo fluid. izigulane AIDS emva kokugqiba unyango lokuqala eboniswe nokuthintela ukwenzeka cryptococcal meningitis ixesha elide yokwamkela lithetha "Mikosist" kwi ithamo ongekho ngaphantsi kwe ezimakhulu mabini milligrams ngosuku.

Xa izigulane candidiasis zikwi, candidemia kunye nezinye izifo ehlaselayo Candida, ngokuqhelekileyo ngosuku lokuqala ukuthatha milligrams ezine beziyobisi, kwaye ngemihla embalwa ezayo - ezimakhulu mabini milligrams yonke imihla. Kwimeko lwenkqubo igwele idosi kakhulu ukuze kwandiswe ezingamakhulu asibhozo milligrams ngosuku. Unyango kufuneka kuqhube ubuncinane kwiiveki ezimbini emva ngokupheliswa iimpawu kunye nokufumana inkcubeko igazi elibi. Ukuba candidiasis oropharyngeal, kuqukwa izigulane sifo kakuhle, idosi kweziyobisi ngosuku ezingama - milligrams ezilikhulu, ayise kwi kuba ixesha ezisixhenxe - iintsuku ezilishumi elinesine. Xa candidosis atrophic ngenxa kweeseli amazinyo ngokuqhelekileyo emiselweyo inani ngemihla milligrams mahlanu isiyobisi zidityaniswe kubola. Unyango waqhubeka iiveki ezimbini. Kuba nezinye izifo Candida (candiduria, esophagitis, isikhumba kunye mucosal candidiasis) idosi yemihla ngemihla imithi amahlanu - ikhulu milligrams, unyango yi elinesine - iintsuku ezingamashumi amathathu.

Ukuze kupheliswe kusisi candidiasis medicament "Mikosist" ibonisa yemiyalezo amkele zibangele xa isixa milligrams 150. Kunokuba ube ezine - iinyanga ezilishumi elinambini kanye ngenyanga ukuba basele philisi omnye (150 mg) ukunciphisa nezihlandlo likakade. Kudla ezimiselweyo candidiasis ukongeza ichiza "Mikosist" amakhandlela, umzekelo, "Terzhinan", "Clione-D", "Ginezol". Kuxhomekeka iqondo ingozi yosulelo fungal, kuthintelo candidiasis idosi yemihla ngemihla ocetyiswayo lwe ichiza ziyahluka ukusuka amahlanu ezingamakhulu amane milligrams.

Kwimeko mycoses ezinzulu ezisoloko zikho kusenokufuneka ukuthatha amachiza umthamo ezimakhulu mabini - milligrams angamakhulu amane ngosuku iminyaka emibini. Ubude unyango ixhomekeke ngamnye kunye nomfanekiso lwezonyango; kunye coccidioidomycosis, oko ekungabonini ukusuka elinanye ukuya kwiinyanga ezingamashumi amabini anesine, paracoccidioidomycosis - iinyanga ezimbini ukuya elinesixhenxe, histoplasmosis - ukusuka kwiinyanga ezintathu ukuya elinesixhenxe.

imithetho isicelo

ukulungiselela ngedriphu efakwa kufuneka ilawulwe ngesantya hayi ngaphezulu kwe mabini ngeemililitha ngomzuzu. Akukho mfuneko ukutshintsha idosi yemihla ngemihla xa betshintsha izigulane ukusuka efakwa namayeza ngomlomo. A Isisombululo ukumnika iyahambisana dvadtsatiprotsentnym solution glucose; izisombululo Hartman and Ukukhala; isisombululo sodium hydrogen carbonate, potassium chloride kwindawo iswekile, sodium chloride (0.9%). Nokubandakanywa mazenziwe kusetyenziswa izixhobo eziqhelekileyo fluconazole ukuba gazi, usebenzise enye yezisombululo zilandelayo.

imiphumela emibi

Uninzi izigulane wathabatha ichiza "nohlolo Mikosist 'ngayo ushiye elungileyo. Drug okunene ngempumelelo ishenxisa usulelo ezinzwaneni kodwa inokubangela iziphumo ezibi. Ngoko ke, ukususela kwinkqubo kokudla umngcipheko isicaphucaphu, flatulence, umsebenzi isibindi okungaqhelekanga, iingxaki kunye ukunambitha, urhudo. Kwakhona, abanye abantu zithetha kukuvela yintloko, ukuxhuzula, ukuba nesiyezi. Bathi ukuba iziganeko ezinjalo wavela nje emva kokuba uthathe ichiza, "Mikosist". Izimvo ezinye izigulane eziqulathe ulwazi malunga nophuhliso nezidlo ichiza therapy ngohlobo erythema, irhashalala, angioedema, urticaria. Phakathi kwezinye iziphumo ebezingalindelekanga ezinokubakhona kuphawulwe alopecia, fibrillation ventricular, umsebenzi kidney kakuhle, hypertriglyceridemia, hypercholesterolemia, kunye hypokalemia.

Izimo

Xa uhlobo njengezingxobo akufuneki emiselweyo amayeza abantwana phantsi iinyanga ezintandathu ubudala (ezisanda kuzalwa uvunyelwe ukusebenzisa ichiza ngokohlobo isisombululo ibe nokubandakanywa). Musa ukusebenzisa eli chiza "Mikosist" abafazi phindeke (abasetyhini abakhulelweyo kufuneka isabelo kuyo ngononophelo), kwakunye abantu uvakalelo oluphezulu ukuya izithako ifakiwe kwengoma. Ukukhawulelana neemfuno eyandileyo ukusebenzisa isilumkiso izigulane insufficiency kwezintso / hepatic, wayengabunyamezeli acetylsalicylic acid.

libanda

"Mikosist" ibhalwe amatyala libanda, iziyobisi. Izimvo abantu abathatha ichiza ngeedosi kakhulu, bonisa uphuhliso urhudo, isicaphucaphu, ukugabha. Kwiimeko kakhulu, kukho ukuvela sokuwa, ukuziphatha paranoid, nemibono. Umntu zikhala libanda, kufuneka asiwe esibhedlele, apho lavage esiswini kuya kwenziwa kuye, dialysis, diuresis ngenkani, unyango nomqondiso.

"Mikosist" okanye "i-fluconazole": kuba kokona kulungileyo?

Ngoko ke umbuzo ebuzwa yi izigulane. Enyanisweni, omabini amachiza ziyafana, singatsho ukuba ziyafana. Umahluko kuphela kukuba chiza "Mikosist" yenza ukuba inkampani Hungarian zoxubo "kaGidiyon Richter", ngoxa "fluconazole" - ukulungiswa imveliso yasekhaya. Kakade ke, oku kunefuthe elingqalileyo amaxabiso amayeza. Ukukhetha into yokuthenga - "Mikosist" okanye "i-fluconazole" - abaninzi bakhetha ichiza, Yeyiphi eyona ndlela yongayo. Eneneni, umahluko kakhulu ngexabiso. Ngoko ke, ngokuba diphu "Mikosista" (enye philisi equlathe milligrams 150 ka-fluconazole) kufuneka uhlawule umlinganiselo 295 engange, lo gama iphakheji efanayo "fluconazole" iindleko engange 8-20 kuphela. Ixabiso avareji kwibhotile 100 ml isisombululo ukumnika "Mikosist" ngu 311 engange.

Ngokubhekisele iimpawu amayeza amachiza amabini, ukuba twatse, umahluko kunokubonwa ngaphandle ukuba izinga ukufunxeka: njengako idata ekhoyo, xiyimiso ubuninzi emzimbeni "fluconazole" ukuba afezekiswa emva kweeyure 1-2 emva kokuba isicelo, kwaye "Mikosista" - 0.5 iiyure -1,5. Noko ke, asingabo bonke izigulane baphendule amayeza ezimbini ngokulinganayo. Abanye ababoni nawuphi na umahluko phakathi kwabo, ngoxa olwesibini bakholelwa ukuba umgangatho kuxhomekeka kwixabiso, nto leyo ithetha ukuba ichiza ibiza kakhulu, ngcono. Wena uyakwazi ukufumana ncomo apho abafazi bathi emva kokuthatha i "fluconazole" thrush yabuya, kodwa "Mikosist 'ukuba siyitshabalalise ngokusisigxina. Kuyo nayiphi na imeko, ukhetho ngowakho.

analogs

Ukongeza "fluconazole", kukho eminye imithi ezinokuthi endaweni ichiza "Mikosist". Analogs medicament kokuba isithako njengelisebenzayo ukwimo enye, bamelwe kakuhle. Ngokohlobo njengezingxobo ngenxa yonyango Igwele kunye nezinye izifo fungal, ungasebenzisa "iDiflucan" iziyobisi "Flucostat", "mikomaks" kunye nabanye. Indlela ephumelelayo "Mikoflyukan" (tablets). "Mikosist" kuzo zonke ezi analogs ezahlukeneyo iziphawuli ezifana bioavailability, isiqingatha-ubomi, izinga ukufunxeka.

imithi

Kuyimfuneko ukuba esweni ngenyameko ixesha prothrombin kubaguli abafumana fluconazole kunye ngqo anticoagulants iqela coumarin, ngenxa yokuba kukho umngcipheko wokwandisa VWP. Xa concomitantly kunye sulfonylureas iziyobisi "Mikosist" niyolule wesiqingatha-ubomi kubo, ngoko kufuneka siqwalasele amathuba hypoglycemia. Kwimeko ka-fluconazole kunye nokwabelana phenytoin ukuze iqondo ngokwezonyango ebalulekileyo songeniselo xi lokugqibela, ke ngoko, ukuba kuyimfuneko kuhlanganiswa ofumana ithamo kufuneka incitshiswe. Kunye kunye nokwamkelwa lithetha "Mikosist" kwaye rifampicin ziya kumakishwa ukuncipha abasuka e-fluconazole ngoko umthamo "Mikosista" kufuneka ukwandisa. Ukusetyenziswa idibene i ithe azole kunye medicament kunye terenadinom contraindicated, njengoko unako ukuqulunqa kakhulu, arrhythmia ezisongela ubomi. Ukuba uthathe amayeza "Mikosist" kunye cisapride, ngazo reactions engathandekiyo ngakwicala wentliziyo, kuquka tachycardia ventricular. Ukusetyenziswa ngaxeshanye-fluconazole kunye theophylline inciphise avareji izinga uqinisekiso plasma yegazi yokugqibela, ngoko kunyusa amathuba nophuhliso yeziphumo ityhefu kunye libanda.

oyi

Kufuneka siqhubeke unyango with "Mikosist" de kuxolelwe lwezonyango kunye hematological. ukupheliswa ngaphambi unyango igcwele likakade. Njengoko sele kukhankanyiwe, izigulane insufficiency sezintso kufuneka basebenzise eli chiza ngononophelo eliphezulu, ngokuba kubhaliwe kwizondlo isikakhulu kwizintso. Esithathwa ngexesha kunyango ixesha elide kufuneka lwenziwe, kuthathelwa ingqalelo CC. Ngamanye amaxesha i-fluconazole ibandakanya iziphumo yityhefu ophezu kwesibindi, ngoko kuyimfuneko ukuba esweni ukusebenza kulo mzimba. Xa efumanise iimpawu amanxeba kufuneka ayeke amayeza.

Izigulane kwi imvelaphi "Mikosist" lithetha kuye ulubona ezinqabileyo reactions exfoliative cutaneous, ezifana necrolysis epidermal ziyityhefu kwaye Stevens-Johnson syndrome. Izigulane neoplasms abuhlungu kunye noGawulayo usesichengeni ukuvela iintshukumo eziqatha ulusu xa usebenzisa amalungiselelo equlethe i-fluconazole. Ukuba ngexesha unyango lwe ezinzwaneni ikhe yabangxamayo livela, ichiza ofuna ukurhoxisa. Ukuba ufumana irhashalala xa abantu abosuleleke invasive okanye systemic ezinzwaneni ugqirha kufuneka siqinise kweliso ukurhoxisa ichiza kwimeko iza kuphuhlisa erythema multiforme, okanye izilonda bullous. Ngexesha unyango, amayeza "Mikosist" (reviews ukuliqinisekisa) kungabangela nesiyezi, ngoko izigulane kufuneka silumke ngakumbi xa usebenza ubuchule kunye nolawulo kwezithuthi.