Iimpawu kunye nonyango lwe serotonin syndrome

Ukunyuka ngokukhawuleza kwinqanaba serotonin - imeko kunokuba kakhulu, nto leyo sikhatshwa ukunyhashwa mass kumsebenzi yonke eziphilayo. Ngokuqhelekileyo, ezi nguqu ke ngenxa yokuthatha iziyobisi ezithile okanye libanda, ziziyobisi ezahlukeneyo. Xa kungekho unyango ngexesha le meko igcwele ingozi, nemiphumo maxa wambi vuhlayiseki. Kuyimfuneko ke ngoko ukuba siqwalasele ulwazi malunga yintoni unobangela kwaye iimpawu serotonin syndrome. Yintoni unyango nga ukunikela amayeza mihla kunye nethala ngakumbi yokunqongophala konyango?

Serotonin syndrome: ntoni na?

Enyanisweni, ingcaciso yokuqala malunga nale meko kubonakala ukuba kudala kangaka. Ngowe-1960 eUnited States kumaphononongo okuqala kwapapashwa ngalo mbandela. Isibakala sokuba ngoonobangela onaso, leyo, enyanisweni, kunye nokwanda okukhulu ubuninzi bezinto kweziyobisi iiseli zemithambo-luvo, ngokwamazinga ezahlukeneyo, zinxulunyaniswa, lakhula.

Yinto eyaziwayo ukuba serotonin deficiency syndrome kukhokelela kuphuhliso uxinezeleko. Yaye kwinkulungwane esidlulileyo lwasungulwa unyango komgomo ezinjalo, ngoku eyaziwa ngokuba "yokunciphisa". La machiza kunceda ukwandisa umgangatho serotonin, eyaziwa edume ngokuba "ulonwabo hormone". Phantsi impembelelo yabo, chronic fatigue nokunganaki iyanyamalala kancane, kunye nabantu ngcembe abuyele ubomi obuqhelekileyo. Noko ke, izixa ezikhulu kakhulu serotonin lisebenza ityhefu, nefuthe elibi iiseli zemithambo-luvo, zibangela ubunzima disorder kwi eziphilayo. A syndrome efanayo inokuba ngenxa lakhula, yaye indibanisela lakhula kunye nezinye iziyobisi (umz, ezinye isiraphu ukhohlokhohlo njalo njalo. D.).

Enyanisweni, kwihlabathi lanamhlanje, amatyala serotonin syndrome abhalwa akunjalo rhoqo. Kodwa ke, ngokutsho oogqirha kunye nabaphandi, yenzeka kuphela ngenxa yokuba sigulo bezenze enobunzima iimpawu imperceptible, ezivame lunokusolwa nemithambo ukukhathaza okanye ukudinwa. Kuyimfuneko ke ngoko ukuba ukwazi kutheni serotonin syndrome Inokwenzeka, yintoni na yaye oko yayingako imiqondiso bamlandela.

Imisebenzi esemqoka serotonin

Kubalulekile ukwazi indlela yesenzo of "ulonwabo ihomoni", phambi kokuba ucinga umbuzo njani yaye kutheni nokuphuhlisa serotonin syndrome. Yintoni na le nto? Umsebenzi engundoqo ummiselo kwemisebenzi serotonin luvo ethile ebuchotsheni. Ehambahamba emqhokrweni zobuchopho ukusuka neuron mnye, le nto idityaniswe receptors ezithile inwebu yeseli luvo osecaleni, kokuyenza isebenze edubula nemithambo uyibona.

Kukho iinkqubo eziliqela ukuba banako ukulawula imali serotonin emzimbeni. Ingakumbi, le reuptake, apho molecule ubuyisela ukuprosesa neuron lokuqala (ngokuzenzekelayo, uninzi lakhula ezi inhibitors of serotonin reuptake) kunye ummiselo enzymatic, apho esebenzayo ninamathele iziyobisi hormone molecule okhethekileyo.

Serotonin ilawula iinkqubo ezininzi emzimbeni, kuquka:

• ixesha ebuthongweni kunye kuvukwe;
• emnyama;
• uphuhliso okanye Ukunyamalala imvakalelo asipholi;
• ukuziphatha ngokwesondo;
• iindlela thermoregulatory;
• umbono buhlungu;
• inkxaso kwezihlunu;
• motility le wokugaya;
• ummiselo ithoni yegazi;
• Kwakungqina ukuba serotonin ebandakanyeka kwinyathelo ezisebenza migraine.

Njengoko kubonakala, "iihomoni banoyolo" unike umzimba womntu asiyomvakalelo nje ibenza. Emva kokufunda umsebenzi weli, kunokwenzeka ukuba ukucinga ezinye iimpawu serotonin syndrome. Ngendlela, ukuba ubuninzi waphawula lwee- hormone kwi esikhondweni kwengqondo Ukwakheka reticular.

Serotonin syndrome: ngamachiza ezinto eziphilayo. Yintoni isekude ukuhlukunyezwa?

Njengoko sele kukhankanyiwe, le bezityholo, kuba inkoliso yaphuhliswa ngexesha uthatha amayeza athile, okanye zombini. Ngoko iziyobisi engabangela uphuhliso izifo ezinobungozi ezifana serotonin syndrome?

• "Tsipraleks" kunye nezinye inhibitors reuptake serotonin ezithambileyo monoamine oxidase.
• unyango ngaxeshanye kunye inhibitors monoamine oxidase kunye hormone, "clomipramine", "carbamazepine", "imipramine" yaye "Amitriptyline".
• inhibitors Mao kunye indibanisela amanye amachiza asetyenziswa ukunciphisa umzimba, ingakumbi "Dezopimona", "fepranona".
• Indibaniso ye SSRI okanye Mao inhibitors ngamalungiselelo eziqulathe L-tryptophan, Wort luthathe St. bakaYohane, bathabatheka ngokugqithiseleyo.
• Iindibaniso lithium iziyobisi bucala, ingakumbi i "Kontemnola" yaye "Kviloniuma".
• ukwamkelwa ngaxeshanye inhibitors kunye dextromethorphan (into leyo ifumaneka isiraphu ezininzi ukukhohlela, kuquka "Kaffetin Cold", "Glikodin", "Tussin Plus" kunye nabanye.
• Indibaniso inhibitors reuptake serotonin iziyobisi ezifana "dihydroergotamine", "sumatriptan" (iziyobisi migraine), "Levodopa" (asetyenziswe kwi isifo Parkinson ngayo).
• Kukho ubungqina bokuba serotonin syndrome zingenzeka ukusetyenziswa kotywala kwisiqalo unyango bucala.

Ngoko nangoko ke ilizwi kubalulekile ukuba kwangaphambili ukuba ukuphuhlisa syndrome kwisiqalo unyango yokuqeshwa kwagqirha, cishe akunakwenzeka. Konke kuxhomekeke ithamo amayeza, iimpawu ngamnye yomguli, ubudala bakhe kunye nezinye izinto ezininzi. Noko ke, ukuba emiselweyo lakhula, qiniseka ukuba uxelele ugqirha wakho onke amayeza okanye iipilisi ozisebenzisayo kunye qiniseka ukuba libonisane kusungulo inkqubo entsha unyango, ukuba ikho nokubakho eqhelekileyo isiraphu khohlo.

Eyona engundoqo iimpawu umfanekiso clinical

Njani na serotonin syndrome? Iimpawu ze kwesiqingatha amatyala kuvela emva kweeyure 2-4 emva kokungenisa. Kodwa ke iimpawu zokuqala ukuze abonakale nemini. Ngokunxulumene nemisebenzi engundoqo serotonin, Zonke iintshukumo zokwaphulwa kwemithetho kunokwenzeka bohlulwa babe ngamaqela ezintathu eziphambili:

• abagula ngengqondo;
• baneengxaki kwezihlunu kunye neenkqubo neuropathy luvo;
• izifo yawo.

Zonke ezi mpawu kunokwenzeka zichazwe ngezantsi, kodwa kuqala kufuneka ke ukuba Ukwaphulwa ezahlukeneyo akukho isiseko eyahlukileyo noqulunqo lwe unesifo enjalo. Kuphela uviwo ngokupheleleyo emzimbeni, izifundo elebhu, kwaye babe neempawu ezithile kunye nezinto ingozi kwenza kube lula ukufumanisa i serotonin kwemfuneko emzimbeni luvo.

abagula ngengqondo ngokusekelwe onaso

Indlela ukuqaphela serotonin syndrome? Iimpawu zidla ukuqala abagula ngengqondo, kuquka:

• ukuvukelwa ngokweemvakalelo;
• Akuchazwa, uloyiko elimsulwa kunye namaxhala, maxa wambi de uphaphazele;
• maxa wambi kukho omnye umfanekiso - umntu uziva nemvo imincili, novuyo olukhulu, umnqweno ukuhamba, ukuthetha njalo kwaye wenze into malunga noko;
• lomonakalo okhoyo lokuqonda;
• Kwiimeko kakhulu ngakumbi, kukho imbonakalo iimfeketho zokufeketha kunye nemibono.

Kubalulekile ukuphawula ukuba iimpawu kunye neqondo ubukhali uxhomekeke ngqo kwi ebukhulwini neziphumo enetyhefu. Ngokomzekelo, maxa wambi kuphela excitation okuncinane uyabonakala. Kwezinye iimeko kukho mandundu kweempawu zesi sifo engundoqo (umz, ukudandatheka), ngenxa iyeza kuyaqhutywa leyo. Kwiimeko ezininzi kakhulu, isigulana unesifo nokudideka, bedidekile ehlabathini umntu, abaphethwe iimfeketho zokufeketha kunye nemibono eyahlukeneyo.

Iimpawu eziphambili kwezityalo

Kukho nezinye iimpawu ezihambisana serotonin syndrome. Ukonakala evela ukunyuka elibukhali kwinqanaba le iyeza khangela enye indlela. E, i kwizigulo ezithile eziqwalaselwa yawo, kuquka oku kulandelayo:

• inimba abafundi, anda lacrimation;
• kwandisa izinga intliziyo, tachycardia;
• kwandisa izinga yokuphefumla;
• maxa wambi kukho fever (ngokuqhelekileyo, ukuba incinane, kodwa baloba nomkhuhlane degrees 42 kwezinye izigulane);
• ukwanda elibukhali kwi uxinzelelo lwegazi kunye neempawu kwamanani de ilahleko lokuqonda;
• imbonakalo ukoma emlonyeni kunye nezinye inwebu yangaphakathi;
• nokukhawulezisa motility emathunjini, nto leyo enokukhokelela ukuya kwizigulo ezifana norhudo, ubucaphucaphu kakhulu nokugabha, flatulence, ukuqumba kunye neentlungu esiswini ngegalelo bawayo;
• uziva kwasebusuku;
• Intloko, maxa wambi uqaqanjelwa.

Njengoko ubona, iimpawu zesi sifo asingabo ngqo kakhulu, kuba iimpawu omnye zikhatshwe zezinye izifo elinesibini.

nokuphazamiseka Neuromuscular phezu yangasemva syndrome

Njengoko sele kukhankanyiwe, serotonin silawula ukosuleleka neemvakalelo-luvo. Kungenxa yoko le nto utshintsho kwinqanaba weli kuchaphazela umsebenzi neuromuscular. Nalu uluhlu lwe ukuphazamiseka okunokwenzeka:

• ukwanda ngamandla kwe ikhaliphe imicu (ngokukodwa abo ikhaliphe lomzimba asezantsi);
• ukuphuculwa kwezihlunu kwaye ngamanye amaxesha ukuya nokoma kwemisipha;
• okukhawulezileyo ngokuzenzekelayo nokurhwaqela spasmodic zezihlunu ngamnye (ngamanye amaxesha amaqela yonke izihlunu);
• bengcangcazela le imilenze;
• iintshukumo ngokuzenzekelayo le yeso (ukulungiselela le njongo amayeza elithi "nystagmus" lisetyenziswa);
• maxa wambi kukho ekuthiwa neliso spasm, nto leyo sikhatshwa ceca ngokuzenzekelayo le amehlo phezulu okanye ezantsi;
• abhalwe izikhathi ukuxhuzula;
• ukunganxibelelani kakuhle;
• iingxaki ngentetho, oko ifiphale kunye inaccuracy oko kwenzeka ngenxa ucutheko ngokuzenzekelayo zonke izihlunu izixhobo ukuhambisana.

Kuyaqondakala ukuba zonke ezi mpawu zingentla serotonin syndrome kwenzeka ngamaxesha. Kwiimeko ezininzi, izigulane ubunzima kuphela ezinye ukunyhashwa, kwaye ke ngoko une sifo kakhulu kwinkqubo.

Ubungakanani sandla izifo

Xa yesilungu yohlulwe manqanaba mathathu ebukhulwini syndrome, ezifana:

• isifo onobulali sikhatshwa, njengoko umthetho, ukubila ukwanda, lafa engenamandla ezandleni ngamadolo, kungekhona ukwanda ngokukhawuleza kakhulu izinga entliziyweni. Ikhaliphe kwakhona ziqine kancinane, nangona iqondo lobushushu emzimbeni lingaphumi. Ngamanye amaxesha isigulane ungaqaphela umfundi komlomo. Kulindelekile kuphela ukuba abantu ezineempawu ezifanayo kunqabile ukuya kugqirha, kwaye ziqhube ukuthatha iziyobisi, ngenxa yokuba ezi mpawu zingentla ezinokubangelwa luxinzelelo okanye overexertion.
• In ngokulinganisela picture kwezonyango sifo ucaca ngakumbi. Izigulane waphawula ukunyuka okukhulu lobushushu emzimbeni (degrees ngamanye amaxesha ukuya ku-40), kunye noxinzelelo lwegazi, komlomo ezisingisileyo abafundi, ukuncitshiswa izihlunu, motor nemincili engqondweni. Ngokuqhelekileyo, ezi mpawu ukuba umntu afune uncedo, kodwa ngelishwa, ukubeka uxilongo oluchanekileyo akusoloko kusenzeka.
• Ezimandundu serotonin syndrome kuyingozi kakhulu, njengoko kunokukhokelela iingxaki. Kule fomu leengxaki waphawula ukuba tachycardia nkqi, ukwanda koxinzelelo lwegazi, ifiva, aqaqambayo de ngumkhinkqi, ukuphazamiseka luvo, nokudideka. Izigulane bakholisa ukuba namava nemibono ecacileyo kakhulu. Xa engekho uncedo kwangexesha ukuze nokuba yonakele kwezihlunu, isibindi nezintso. Amaxesha amaninzi, izigulane kuwa isiqaqa. Ngamanye amaxesha kuphuhliswa zomzimba ezininzi, nto leyo ngokuqhelekileyo kuphelela ekufeni.

Kungenxa yoko le nto kuyo nayiphi na imeko ukuba ukungabahoyi mpawu kuba oko bazimilise njenge eqhelekileyo serotonin syndrome khulu. Njani, kwaye kule meko ukuba ngaba kukho unyango olusebenzayo?

uncedo lokuqala kule meko

Kuthekani ukuba umntu kurhanelwa serotonin syndrome? Emergency Care ngokuqhelekileyo yi kumiwe ekhawulezileyo ichiza, nto leyo eyavusa le meko. Ngokuqhelekileyo, kufuneka ngokuqinisekileyo uthathe isigulane esibhedlele.

It kuqala lavage esiswini, okwenza ukuba ukuyihlambulula umzimba ichiza elo akakafiki ixesha lokuba ame. Ngenjongo enye, izigulane ezimiselweyo iziyobisi kunye nezinye sorbents deducing ubuthi emzimbeni. Kwiimeko mnene iziganeko ezinjalo kwanele ukwenza abantu bazive ngcono. Impawu ziyawa emva kweeyure 6-12.

Njani na unyango lwe onaso?

Ngelishwa, ukurhoxiswa ngeziyobisi asihlambulule umzimba lowo doti akusoloko ngokwaneleyo. Ngoko ke yintoni unyango kufuna serotonin syndrome? Zonyango, Kakade ke, kuxhomekeke eqongeni kunye nobukhulu. Ngokuqhelekileyo, umntu oqeshwe bachasene receptor serotonin, kuquka "methysergide" yaye "Cyproheptadine". Ngaphezu koko, ukuba unyango kwangumqondiso, leyo ixhomekeke ubukho izifo ezithile.

• Ngokomzekelo, xa sokuwa nokoma kwezihlunu zibeka benzodiazepines, kuquka "lorazepam" yaye "Sibazon".
• Phambi fever zenziwa ngaphandle rubdown ebandayo kunye nezinye iinkqubo. Into yokuba ukunyuka kwamaqondo obushushu xa serotonin syndrome hayi inxulunyaniswa nangokurhala, kunye nokonyuka contractility kwezihlunu, nangenxa neziyobisi eqhelekileyo antipyretic kwaye nonsteroidal anti-ukudumba akukho isiphumo. Le ngaphandle kuphela paracetamol, nangona kunjalo kufuneka zisetyenziswe ngononophelo.
• Xa ubushushu ukuya ku-40 kunye relaxants ngaphezulu kwezihlunu ephathwa nomntu ogulayo. La machiza zinceda imisipha, ukuphelisa ifiva, ukuthintela uphuhliso zezigulo ezahlukeneyo, kubandakanywa iingxaki kunye igazi ekunqandeni.
• Kwakhona ukumnika efakwa ndiqhuba ukubila ngokugqithiseleyo, urhudo, ukungakhululeki kwezihlunu kwaye kungakhokelela ekubeni emzimbeni.
• Ngaphezu koko, kuyimfuneko ukuba iliso uxinzelelo lwegazi kunye izinga intliziyo yesigulane, ukuba kuyimfuneko normaliziruya la manani encediswa iziyobisi.

Kwiimeko ezininzi, unyango olwenziwe kakuhle ngcono imeko yomguli kunye ukuze uphephe imiphumo. Ngelishwa, kwiimeko ezinqabileyo, ingakumbi xa isigulane khange inikwe unyango ngexesha elifanelekileyo, serotonin syndrome kunokukhokelela sokonakalisa inwebu izihlunu, isibindi kunye nomonakalo wezintso, kwalapho, yaye ekugqibeleni ukufa. Kungenxa yoko le nto kuyo nayiphi na imeko akufuneki olova uthathe yokunciphisa kunye nezinye iziyobisi.