"Osterepar": yesikhokelo, ncomo, umenzi, analogue

Ukunciphisa izinga kwezimbiwa inwebu ithambo na unobangela isixa esikhulu umonakalo izixhobo amathambo kunye articular kubantu yamaqela yobudala ahlukeneyo. Lidla kwamathambo kunciphisa ngenxa yokwanda ithambo --ebizwa ngokuba resorption ithambo. Le kuqheleke nokomzimba phakathi ukutshatyalaliswa kunye nokudalwa ngethambo - le njongo ingundoqo unyango lwezifo hlobo. Enye amachiza asetyenziselwa ukunyanga kwamathambo, yi "Osterepar". Makhe sibone oko kuthethwa "Osterepar" imiyalelo ukulungiselela ukusetyenziswa, oogqirha zokwenene kunye nezigulane.

achaza kwemithi

Le into esebenzayo yokulungiselela "Osterepar" na alendronic acid, nto imelwe ekwimo sodium ityuwa - alendronate sodium. Indlela yesenzo weli ayenziwanga uphando ngokupheleleyo, nangona kusaziwa ukuba sokugcina lokungakhuseleki sodium alendronate kukuba ukubuyisela uzinzo entle phakathi ukutshatyalaliswa nokubuyiselwa yethishyu ithambo. Inxalenye yale nkqubo iqaphelwa ziyibuyisela osteoclasts - ezizodwa iiseli ithambo onoxanduva intshabalalo yayo.

Ukongezelela, kwakusazeka ukuba kunciphiso calcium plasma ibangela nokwanda yayo inwebu ithambo ngexesha uthatha ichiza "Osterepar". Imiyalelo yokusebenzisa uthi komeleza amathambo nokucutha umngcipheko waphuka.

Ezona mpawu pharmacokinetic of

Nangona isibakala sokuba sodium alendronate olufaneleyo enyibilikayo emanzini kunye nezisombululo zolwelo, ukufakwa kweziyobisi evela mithambo wamathumbu ayikho into elungileyo - kukufakwa umalunga-25% kuphela. Yinto eyaziwayo ukuba lubopha "Osterepar" kuhle kwiiproteni plasma (iqondo esibophelelayo yi 70-75%) ayipasiswanga umzimba emzimbeni.

Iimpawu "Osterepar" ukulungiselela

Imiyalelo yokusebenzisa ithi ichiza eboniswe deforming ithambo ukuphazamiseka ezaziwa ngokuba kwamathambo (kubandakanywa postmenopausal osteoporosis kwabasetyhini). Alendronate sodium esetyenziselwa unyango plasma inqanaba calcium ephakamileyo izigulane kunye neenkqubo amabi ngempumelelo.

Izimo

Esemthethweni "Osterepar" manual isiyobisi iqulathe uluhlu olupheleleyo Izimo ukuba ichiza ekujongwe. Ngoko ke, "Osterepar" sele contraindicated ukusetyenziswa ebantwaneni, njengoko imveliso yokugqibela kunye nocikizeko ukhuseleko ukusetyenziswa kwayo akucaci.

sodium Alendronate akukho kuboniswe ngexesha ukuyilwa lokwaphusa, lokondla iphethe ukukhulelwa. Kwakhona, ichiza contraindicated kumanqanaba plasma yehlise calcium yamathambo intswelo kunye novithamini D. Amanyathelo medicament kufuneka ingasetyenziswa kwizigulane anga umsebenzi sezintso excretory.

imiphumela emibi

Phambi kokuba ukuqaliswa bakwenzayo bezonyango belo alendronate sodium yaba, ukufunda kabini-blind placebo-control. Ngokutsho iziphumo zezi zifundo nezihlandlo reactions icala phakathi kwabantu abathatha isodiyam alendronate, yaba ngaphantsi kancinci nezihlandlo reactions olunzulu abanyangwa placebo.

Phakathi abasabela ezibi ezibangelwa iyeza "Osterepar" izigulane yaphawula ukuphazamiseka ye phecana zesisu (ukuqunjelwa, iintlungu esiswini, ukuphazamiseka kwesitulo eneengcinga isisu) kunye nenkqubo luvo (intloko ebuhlungu). Kukho nezinye iziphumo ebezingalindelekanga ezinxulumene nokusetyenziswa "Osterepar" iziyobisi. Imiyalelo yokusebenzisa ibonisa negazi ezinqabileyo kakhulu ezifana angawokubhuda okanye ukurhawuzelela.

oyi

Ukuthatha "Osterepar" iipilisi kufuneka usele amanzi okusela eziqhelekileyo nezinye iziselo (amanzi ezimbiwa, ubisi, isiselo iziqhamo) zingachaphazela indlela bioavailability wehlise ukufunxeka kwayo. Ekubeni alendronate sodium inokuba kukucaphukisa ngokwezahlulo aphezulu phecana zesisu, cwecwe kufuneka zithathwe namanzi amaninzi (nekomityi egcweleyo). Kwindawo tye, kukho ingozi enkulu yokuba izilonda esophageal kwi lolwamkelo esikolweni "Osterepar" iziyobisi. Imiyalelo yokusebenzisa ubhala ukuba akuyomfuneko ukuba iyure ubuncinane isiqingatha i ukuya kulala emva ezithatha ichiza, ngokunjalo amayeza phambi kokuba alale.

Amanyathelo iziyobisi ezimiselwe ukuba izigulane ukuba izifo lwamazinyo, kuquka ithumba genesis. Xa kunikwa "Osterepara" Kucetyiswa ukuba bangenele uviwo olupheleleyo amazinyo kwaye enze lenguqulelo epheleleyo kwisisu ngomlomo. iinkqubo zamazinyo kufuneka kuphetshwe ngexesha ulwamkelo.

Xa Unyango ixesha elide (iminyaka engaphezu kwesinye enesiqingatha) iziyobisi iqela bisphosphonates, kunokubangela yamophula inyonga kwi inxalenye proximal. Kwimeko apho kukho ukwaphuka isigulane Kucetyiswa ukuba athumele zoviwo lesibini yifemur ukwenzela ukunciphisa amathuba okuba kwakhona zaphuka-. Ukongezelela, "Oseoreparom" uthomalaliso wayeka de uvavanyo lomngcipheko-inzuzo unyango.

ingqalelo eyodwa kufuneka ukuqeshwa "Osterepara" xa izigulane ezithatha glucocorticoids. La machiza ayakwazi zokunciphisa ukufunxeka kunye, ngokulandelelana, i-calcium kunye novithamini D ukutya emzimbeni. Kwezi izigulane, hypocalcemia wesinxibo nazimpawu kwaye sibonise kakhulu phambi yofuzo. Ukuze kuthintelwe le ingxaki ngexesha lokuhlolwa hypocalcemia ekucetyiswa ukuqinisekisa calcium eyaneleyo kunye novithamini D. yolwamkelo

Ichiza ungamiselwanga ukuba izigulane kunye nezifo enqabileyo zemfuza wabangela ezinxulumene nobuhlanga lactose.

Ichiza alunasiphumo kwi umyinge basabela kunye nokukwazi ukuba basebenza ngoomatshini. Noko ke, simele sikhumbule ukuba kukho iingxaki kunye nezenzo ezingalunganga emva kokuthatha i "Osterepara" zingachaphazela ezi nkqubo.

okwenziwa Drug

"Osterepar" akukhuthazwa ukuba zisetyenziswe ngokuhlangeneyo kunye aspirin, ekubeni aspirin kwandisa iziphumo ebezingalindelekanga alendronate sodium (ingakumbi ukusebenza kwayo iphecana emathunjini). Noko ke, "Osterepar 'Wanyamezela kakuhle izigulane zifumana unyango ezongezelelweyo ne non-steroidal amachiza-ukudumba. Sekunjalo, umntu kufuneka uyeke ukusetyenziswa odityanisiweyo la machiza namachiza anti-ukudumba nonsteroidal ngokwabo kunokubangela iziphumo ebezingalindelekanga ebalulekileyo.

Injongo alendronic acid abasetyhini abafumana estrogen ezidityaniswe phambili kunye dlala, negalelo ekwandeni qatha ngakumbi namathambo kunye ukuhla okubonakalayo kwizinga resorption ithambo.

therapy umchamo Thiazide nodibaniso kumqolo uphawulo alendronic acid kukhokelela ekuncipheni kwe ilahleko calcium kunciphisa nefuthe "Osterepara".

Ityiwe libanda, iziyobisi

Ukuba yingozi alendronate ndazigcina a kwamathumbu disorder, wabonakaliswa ngokohlobo ukugabha, heartburn, esophagitis kunye zizilonda kwi sayo kwamathumbu. Ngomhla inxalenye yenkqubo skeletal kunye nenkqubo igazi kunokubangela hypocalcemia kunye hypophosphatemia.

Unyango ityiwe libanda, uyalwa ukuba iziyobisi iyabophelela kwi sayo amathumbu kunye inactivation yayo. Unakho ukusebenzisa ubisi, asidi, yokuhlanganisa calcium-based. Self-ukuzama ukumgabhisa akufuneki ukuba, ngenxa yokuba ichiza kungabangela ukukruquka nokutsha ze emphinjeni. Kuba lavage esiswini kuyimfuneko ukusebenzisa i probe. unyango lingaze, kwaye ezijolise uzinzo kwinqanaba icalcium kwi plasma yegazi.

Izimvo koogqirha kunye nezigulane

Kwi yokulungiselela "Osterepar" iimpendulo ohlukahlukeneyo, kodwa ubukhulu becala HIV. Xa izigulane ezithatha ichiza, ukubhavuma okubangelwa isiphumo esahlala beziyobisi phezu isifo ye phecana emathunjini. Kweli qela oogqirha, iziyobisi "Osterepar" analogs beziyobisi equlethe sodium alendronate ezisebenza ekunyangeni kwamathambo kwiGenesis ezahlukeneyo, ngokunjalo nezifo kwinkqubo musculoskeletal.

Analogs medicament

Kwimarike amayeza imelwe kukho inani elaneleyo analogs beziyobisi equlethe sodium alendronate njengoko njengempembelelo esebenzayo. "Alendronate" "Alendronic acid", "Alental", "Strongos" Tevanat ". Zonke ezo, kunye nezinye iziyobisi - analogue beziyobisi "Osterepar".

Imiyalelo yokusebenzisa analogue beziyobisi ayibonisi, nangona kunjalo, ukuba kukho inxalenye alendronic acid - ichiza zingasetyenziswa ngokukodwa ukuba unyango kwamathambo.

isiphelo

Kwamathambo - sifo singanyangekiyo, kunye nonyango yawo entsonkothileyo elide. Indlela ukuthetha "imiyalelo kweziyobisi Osterepar 'ukusetyenziswa, umenzi, izigulane kunye amagqirha, ukusetyenziswa ngendlela nempembelelo luncedo kwinkqubo skeletal, normalizing le calcium, iphosphate ukutya kunye nokunciphisa resorption ithambo.

Nangona kunjalo, ngexesha ulawulo ichiza, kuba kangangoko, kufuneka ulandele imigaqo elula ezimbalwa zichazwe kwi imiyalelo ukusetyenziswa, kunye nonxibelelwano rhoqo nogqirha wakho ukuze uphephe imiphumo engathandekiyo kweli chiza. Ngexesha unyango, musa singayikhathaleli ukuqeshwa eengcali, njengoko isitshixo kunyango ngempumelelo kunye bachache ngokukhawuleza.