Ukulungiselela "i-Trifas": imiyalelo yokusetyenziswa, imizekelo kunye nokuphononongwa

Izimo ezinzulu kwiimeko eziphambili zengcinezelo kunye nokungaphumeleli kwentliziyo zihamba kunye nokuvuvukala kwezicubu ezincinci kunye nezitho zangaphakathi, eziyingozi kubantu. Ukususa umthamo ogqithiseleyo kumzimba usebenzisa i-diuretics, okwandisa umthamo womchamo kunye nokususa amaminerali. Enye yezo diuretics iyeza "Trifas".

Inkcazo yokulungiselela

Kwilungiselelo kukho inxalenye esebenzayo i-torasemide, isiseko sulfamonlantranilic acid. Le nkunkuma ihambelana ne-saluretics, eyenza umphumo wokulibala ekubuyiseni kwakhona i-chloride kunye ne-ioni ye-sodium ezintsheni.

Ifom yokukhutshwa

Kukho utshintsho oluthile lokulungiselela "i-Trifas", umyalelo wokusetyenziswa kwefayili echanekileyo kunye neyayifakile ehlukile. Ngamnye wabo, iimpawu zenyama kunye neekhemikhali zamathebhulethi nezisombululo zichazwe.

Iifom zeethebhulethi zikhutshwe phantsi kwegama lezorhwebo "i-Trifas 10" kunye nomyinge we-torasemide 10 mg kunye ne "Trifas COR" kunye nomthamo we-torasemide 5 mg. Inkcazo ibonisa ukuba amapilisi amhlophe anesimo setyhula engozini yokwahlula kwelinye icala kumlinganiselo omkhulu.

Ifom ye-liquids yokulungiselela i-Trifas ichazwe ngumyalelo njengesisombululo se-injections kwisilinganisi se-torasemide 10 mg nge-2 ml kunye ne-20 mg nganye nge-4 ml, isisombululo sokunyuka kwe-200 mg nge-20 ml ye-liquid. Ngokutsho kwenkcazo, ezi zixazululo ezingenambala ezingabonakaliyo, apho kungabikho ukufakwa kweengqungquthela.

Inkcazo yokwakhiwa kwamacwecwe

Kwiphepha elilodwa lokulungiselela "i-Trifas", umyalelo uchaza ukubunjwa: umxholo wecandelo elisebenzayo le-torasemide kwisixa se 10 mg okanye 5 mg, kwaye kukho izinto ezingasebenziyo ezigcina isakhiwo sebhebhulethi, ukuzinzileyo kunye nokukhuseleko kwithuba elichaziweyo. Ezi ziquka ushukela wobisi, isitashi sommbiwa, i-magnesium stearate kunye ne-aerosil anhydr.

Inkcazo yokwakhiwa kwezicombululo

Kwi-ampoules kunye no-2 ml yesisombululo somjovo we-sodium torasemide ifakwe kwisixa se-10,631 mg, elilingana no-10 mg we-torasemide.

Kwi-ampoules kunye ne-4 ml yesisombululo sejenji iqukethe i-sodium torasemide kwisixa se-21,262 mg, esilingana ne-20 mg ye-torasemide.

Kwi-ampoules nge-20 ml yesisombululo se-infusions, i-sodium torasemide ifakwe kwisixa se-212.62 mg, esilingana ne-200 mg ye-torasemide.

Ukongeza kwizinto ezisetyenziswayo, ixabiso elincinane le-sodium hydroxide, i- polyethylene glycol 400, i-trometamol iyachithwa kwi-injection yamanzi.

Inkqubo yesenzo

Kwilungiselelo "i-Trifas 10", umyalelo wokusetyenziswa uqulethe inkcazo yokubophezela kwe-torasemide engenayo kwi-lumen ye-nephron kunye ne-Na-K-Cl-cotransporter, eyinxalenye yeprotheni ekhoyo kwiseli, ekhusela ukuthuthwa kwe-K ⁺ , Na ⁺ ion Cl ^- ngokusebenzisa i-lumen yesiteshi.

Iimpembelelo zesirathisi zamacwecwe ziqala emva kweeyure ezingama-3 kwaye zihlala malunga neeyure eziyi-12. Isilwanyana sisebenza nangona kungekho miphumo evela kwezinye izidlo ze-diuretics, umzekelo, thiazide. Ukunciphisa ukuxhatshazwa kwendawo yokuhamba kweempahla ngokulinganisela ukulingana kwe-electrolytes kunye nokubopha ionic calcium mahala kwi-muscle ehamba phambili yodonga olujikelezayo, amayeza athobisa uxinzelelo lwegazi.

Oko kwenzekayo iyeza

Amacwecwe okulungiselela "ii-Trifas" asetyenziswe kwisicelo kwixinzelelo olubalulekileyo, ukwenzela unyango kunye nokuthintela ukuqala kweemeko ezihlaselayo okanye ukuxhomekeka kwintliziyo.

Isisombululo sokulawulwa kwe-intravenous silawulwa nge-pulema e-edema, kunye nezixazululo zokungena kwamanye amazwe zisetyenziswe kwizigulane ezinomsebenzi wokunciphisa umonakalo xa isantya sokususwa kwemveli singaphantsi kwama-20 ml ngomzuzu.

Indlela yokuthatha iipilisi

Ngokubaluleka komfutho wexinzelelo, i-"Trifas" ilungiselelwe ukusetyenziswa, umyalelo wokusetyenziswa kwethebhulethi inconywa ukuba ihlulwe zibe ziqendu ezine kwaye uqale unyango nge-dosage ye-2.5 mg ye-torasemide. Ukunciphisa ingcinezelo ayifumaneki ngokukhawuleza, kodwa ngeveki yokuqala, isiphumo esiphezulu senzeka ngaphandle kweveki ezili-12. Ngaphandle kokungabikho komthelela osulelekileyo, i-dose yemihla ngemihla ye-"Trifas" yonyuswa inyanga ezintathu-ezintathu kamva, umyalelo wokusetyenziswa kwethebhulethi icebisa ukuba uhlulwe kwisiqingatha, ngasinye saloo mahlulo sine-5 mg ye-torasemide.

Ngomfutho wexinzelelo ophezulu, xa uxinzelelo lwe-diastolic luba ngaphezu kwe-115 mmHg kwaye umsebenzi we-renal ulinganiselwe, umonakalo ongeyomnye onokuthi unomdla ongenakwenzeka.

Xa ukuvuvukala okanye ukuvuvukala umhla we-5 mg we-torasemide okanye i-½ ingxenye yepilisi "i-Trifas 10", umyalelo wokusetyenziswa unolwazi malunga nokwandisa umlinganiselo kwi-20 mg ye-torasemide ngokungabikho komphumo, ohambelana namacwecwe amabini eziyobisi. Phuza amayeza kusasa, ngaphandle kokuphulaphula ingqibelelo kwaye uhlambulule ngamanzi. Ukutya kokutya akuchaphazeli ukufana kwamathebhulethi, kwaye ubude bonyango buhambelana nobume kunye nesifundo sesi sifo.

Indlela yokusebenzisa isisombululo seenjini

Ukuze unyango lwabantu abadala abane-Trifas, imiyalelo yokusetyenziswa iquka iziphakamiso ekusebenziseni umlinganiselo omnye we-2 ml, oqulethe i-10 mg ye-torasemide. Ukuba kuyimfuneko, i-dosage yansuku zonke iyanda ukuya kwi-4 ml, ehambelana ne-20 mg yesithako esisebenzayo. Ukuba isiphumo asinelisekile, umlinganiselo we-8 ml we-day ml, olingana no-40 mg we-torasemide, kodwa engadlulanga iintsuku ezingaphezulu kwe-3.

Imozulu ye-edema ye-pulmatic acmatic isuswa ngokulawula i-4 ml yesisombululo se-ampoule nge-10 mg ye-torasemide. Ngenxa yokusebenza ngokwaneleyo, emva kwesigama seyure, ukujova ngokuphindaphindiweyo kwe-4 ml yesisombululo seziyobisi kwenziwa. Kuyinto engathandeki ukudlula umthamo we-100 mg we-torasemide ngosuku, ehambelana no-20 ml we-"Trifas" isisombululo.

Indlela yokusebenzisa isisombululo sokunyanga

Imiyalelo ichaza ukusetyenziswa kwamaseli okumnika abantu abadala. Imeko yesigulane ngeentso ezinganeleyo inquma umthamo weziyobisi. Isicelo siqala ngomlinganiselo we-5ml we-day ml, oqulethe i-50 mg ye-torasemide. Ukuba le dosi ayinyusa ukwanda komchamo, iyakhula ukuya kwi-10 ml. Ukwanda kwenyuka ukuya kwi-20 ml yesisombululo sokungeniswa kwe-"Trifas 200", esine-200 mg ye-torasemide, ivunyelwe. Ukuphinda kulandelelaniswe ukulandelelana kwe- intravenous kwenziwa emva kweyure eli-1, usebenzisa i-perfusor ukuseka izinga lokunyuswa kwe-0.4 ml ngomzuzu. Ukuze kube lula, i-ampoule diluted 500, 250, 125 okanye i-30 ml ye-0.9% isisombululo se-chloride okanye isisombululo se-5% seglucose. Umxube onjalo kufuneka usetyenziswe ngokukhawuleza, intsalela ithululelwe.

Ukunyanga okungafanelekanga akufanele kudlule iveki enye, kuyinqweneleka ngokukhawuleza kunokwenzeka ukutshintshela ukuthabatha amacwecwe.

Izixhobo zoMsebenzi

Ukusetyenziswa kwexesha elide lemiyalelo ye "Trifas" yokusetyenziswa njengemeko efuna ukubeka esweni rhoqo umlinganiselo we-electrolytes, ngakumbi ion i-potassium kwi-serum yegazi. I-glucose, i-creinine, i- uric acid kunye namafutha - zonke izikhombisi zifuna ukulinganisa ukwenzela ukuba zibonakalise ngokukhawuleza ukuphuhliswa kwesifo sikashukela. Ngexesha lonyango olufunekayo ukuqapha igazi legulane.

Xa ukhulelwe kunye nokulahlwa, kungcono ukuba ungasebenzisi le nkunkuma, kuba akukho datha echanekileyo kwokhuseleko lwe-torasemide kumntwana.

Isenzo sesilwanyana sinokunciphisa umsebenzi womntu xa uqhuba imoto kunye nezinye iindlela ezifuna ukunakwa. Musa ukudibanisa kunye neziyobisi.

Kuphi unyango oluchasene nalo

Akuyena wonke umntu onokuthatha isilwanyana "i-Trifas", umyalelo wokusebenzisa uluhlu lweemeko phantsi kokuba unyango luphikisana.

Ungasebenzisi:

• Ngobukhulu besisindo kwi-torasemide kunye neziphumo zayo ezidlulileyo;
• Nge-hypotension;
• Ukungaqiniseki kwamanzi;
• Nge-anuria;
• Ngokuphazamiseka okukhulu kwesibindi, kuquka i-coma okanye i-premo;
• Ngokunciphisa umthamo wegazi elihambayo;
• Ngomxholo ophantsi we-sodium ne-potassium egazini;
• Ngokungahambi kakuhle ngenxa yokunyuka kweprotate;
• Ngokugqithisa ngokugqithiseleyo kwe-oxalates kumalungu;
• Ngokunyuka okukhulu nokuqhutyelwa kweentliziyo zomzimba;
• I-balance-based balance;
• Nge-anemia kunye nenani elincinci lamaplatelet;
• Ukuphazamiseka komsebenzi weentso;
• Kubantwana abangaphantsi kweminyaka eyi-12 ubudala.

Imiphumo engafunekiyo

Uluhlu lwemiphumo emibi luquka umyalelo wokulungiselela "ii-Trifas". Iimbono zezigulane zibonisa ukuhamba kweziphumo ezithile ezingalindelekanga.

Amachiza asenza kwi-cardiovascular system ngokuphula umthetho omanzi-electrolyte, okukhokelela kwi-hypovolemia, i-hypokalemia, i-hyponatremia, i-alkalosis, i-headache, isiyezi, ukukhathala, i-muscle cramps, ukunyuka kwamanzi kwi-hypotension, i-clouding of consciousness, i-thrombosis, i-cardiac kunye ne-cerebral I-Ischemia, intliziyo yesifo sengqondo, i-angina pectoris, i-acute myocardial infarction, iphosa.

Kwi-system digestive, i-torasemide isebenza ngokubonakaliswa kokubanjwa, ukungabikho kokutya, isisongela, ukuhlanza, intlungu esiswini, isifo sohudo.

Izigulane ngeengxaki ze-urinary ezinxulumene ne-prostatic hypertrophy, ngokubunjwa kwe-urine olunzulu, ziva ukulibaziseka kwazo kunye nokwelula ngokweqile kwindonga yebladder.

Isichengululo sichaphazela iinkqubo zokuxilonga, ngokuphula umthetho kwi-plasma ye-uric acid, i-glucose, i-triglycerides kunye ne-cholesterol iqala ukuhlala, okwandisa ukugxininisa.

Xa ibonakala kwisibindi, umxholo we-enzyme zayo, umzekelo, i-gamma-glutamyl-transpeptidase, inokunyuka.

Ngaphantsi kwezenzo zesilwanyana egazini, inani leeplatelet, i-erythrocyte kunye neelayicyte zeliyosi zinciphisa.

Imiphumo engathandekiyo evela kwisenzo se-torasemide idibene nokunyusa ukwanda komzimba, kubonakaliswe ngokubetha, i-exanthema, i-photosensitivity. Ngamanye amaxesha ukutshatyalaliswa kwe- anaphylactic kunokuhlakulela ekulawuleni isisombululo ngokukhawuleza, okufuna ukuphendula ngokukhawuleza.

Analogues

Umenzi wesilungiselelo sangaphambili "i-Trifas" yinkampani yaseJamani "iBell-Chemie AG Menaryini Group", evelisa uhlobo olusisigxina kunye nolomeleleyo lwamayeza. Kwiimakethe zonyango kwiRashiya, unokufumana iziyobisi zendalo eziqukethe i-torasemide. Zonke zizakhiwo ze-diuretic, indlela efanayo yokuthatha isenzo kunye neempembelelo ezifanayo ezibangelwa yintsimbi esebenzayo.

Izilwanyana "i-Trifas" ezifaniswayo ziveliswa zombini kwiifomethe zokulawulwa komlomo, kunye neendlela zesisombululo se-injections kunye ne-infusions.

Esinye sezichasiselo sisilwanyana "Diver", esenziwe ngumbutho waseCroatia uPliva Hrvatskaya doo. Isilwanyana sinikwe kwiipilisi ezinomlinganiselo we-5 no-10 mg we-torasemide.

I-analogue yesiJalimane isilwanyana "iTorasemid Sandoz", esenziwa yinkampani "Salutas Pharma GmbH". Kuveliswe ngendlela yamacwecwe aneengqungquthela zomzimba we-200 mg, 100 mg, 50 mg, 20 mg, 10 mg, 5 mg kunye no-2.5 mg.

Iibhilethi "iBritamor" kunye nezenzo ezide ziveliswa yinkampani yaseSpanish "iFerrer International SA". Le analog iqukethe u-5 mg kunye no-10 mg we-torasemide.

Isilwanyana "Toradiv" senkampani yaseUkraine "Farmeks Group Ltd" yenziwe kumacwecwe e-5 mg, 10 mg torasemide kwaye ngesimo sesisombululo sokujova i-5 mg torasemide nge-2 ml okanye i-4 mg yamanzi.

Uphononongo

Ulwazi olubalulekileyo kwizigulana luqulethe imiyalelo yokusetyenziswa kwilungiselelo elithi "Trifas". Impendulo evela kwizigulane ezithatha le mveliso, zibonisa ukusebenza kwechiza ekukhukhuleni. Ukusetyenziswa kwansuku zonke kwe-torasemide kunceda ukunciphisa umphumo wokugqithisa okwedlulele kwi-myocardium kwisifo senhliziyo. Ngonyango olufanelekileyo, izigulane zivame ukuvavanya ukuvavanya umphumo weziyobisi emzimbeni.

Kwonyango lonyango "i-Trifas 10", iimpendulo zemiyalelo zichaze ngakumbi kunezitethi ezingekho phantsi. Izenzo ezingathandekiyo ziqabile kakhulu, kodwa izigulane ezininzi, emva kokufunda icandelo elithi "Impembelelo engalunganga", zisoyika ukuthatha isiza. Kwaye, ngezelelo, imiphumo engathintekiyo ayifanele ukuba ibonakale, kodwa i-torasemide iya kunceda ukususa ukuvuvukala, ukususa ukwanda kwamanzi kunye nokunciphisa uxinzelelo lwegazi. Ukunciphisa inani lomkhuhlane liya kulungelelanisa zonke iinkqubo ezibalulekileyo, ukulungelelanisa ityuwa yamanzi nokuphucula imeko yesigulane kwintliziyo engaphumeleli.

Kukho ukuphononongwa malunga nokungaphumeleli kweziyobisi kwi-puffiness yomzimba. Kule meko, ugqirha oya kwiindawo kufuneka akhethe unyango olufanelekileyo kunye neyeza ezifanayo, kodwa ezingenayo i-torasemide.