Unyango "sofosbuvir": ncomo. "Sofosbuvir" + "Daklatasvir": iingcali ncomo. "Sofosbuvir": uqeqesho oogqirha reviews

Isibindi luhlobo zokuhlanjululwa filter umzimba womntu. Imeko umzimba kuchaphazela ukusebenza kweenkqubo ezininzi kunye nomgangatho wobomi nophuhliso yoluntu ngokubanzi. Enye kwesibindi zimandundu ithathwa hepatitis C. Ngelo xesha langoku ukujongana nesi sifo liphuhlise oluninzi iziyobisi. Enye ithathwa izixhobo kakhulu (oko kukuthi kungqinwe nohlolo lonyango) "sofosbuvir".

Ubungqina obubonakalayo buxela ukuba ukusetyenziswa

Ngokubanzi sofosbuvir olubizwa esisebenza amacwecwe, kwaye brand ngokwayo unalo igama lorhwebo "Sovaldi". Ngaloo ndlela, kuyenzeka ukuba bathi ukuba olu nyango enganeno endaweni - generic "sofosbuvir" leyo ngokutsha ukuchaza ichiza njengenye amachiza ngokukuko kunyango sohlobo C. Le ndawo yakhe iphambili isicelo.

izinto Base - sofosbuvir - yinto inhibitor le NS5B polymerase viral, oko kukuthi, abangaphangeliyo inkqubo phindana wentsholongwane egazini - .. I-arhente causative sohlobo C. Noko ke, inkoliso iingcali zonyango musa singacebisi monotherapy "sofosbuvir" (nangona kunjalo kunokwenzeka umgaqo). Kodwa njengoko component engundoqo esebenzayo ye nothomalaliso entsonkothileyo iziyobisi antiviral "sofosbuvir" iimpendulo unembinana nje kuphela indlela ezintle, nezibonakalisa njengoko indlela ephumelelayo kakhulu. Ngokutsho zophononongo kwenziwa, ichiza ngokubambisana kunye nezinye iziyobisi wabonisa iziphumo ezigqwesileyo unyango sohlobo C (genotypes 1, 2, 3).

Unyango "sofosbuvir" abasebenzi bezempilo umntu ingxelo HIV kuphela ngabo izigulane zange kakubi, ndicelela nabo baye bafumana unyango phambi kokuba kunye namanye amachiza antiviral, kwaye ekupheleni unyango emva kwexesha ukufumana likakade.

Ngaphandle kwindawo echazwe ngasentla-sigqithisele, "sofosbuvir 'ncomo kunye neengcebiso oogqirha imiyalelo kuvumela ukusetyenziswa unyango izigulana kwesibindi.

Malunga nentsbenzo ichiza ochasene ne-HIV ne-hepatitis co-HIV (a imeko eliqhelekileyo), olu lwazi okwangoku ayifumaneki, nangona ichiza eboniswe ukusetyenziswa kwiimeko ezinjalo.

Izimo

Kwiimeko ezininzi, ichiza ngokwayo neziyobisi yayo nalawo sele ukunyamezeleka kakuhle zizigulane.

Nangona kunjalo medicament ukuba unyango sohlobo C "Sovaldi" (or "sofosbuvir") iimpendulo ezo ingculaza, njengoko nayiphi medicament kakhul mihla, uye Izimo kwizicelo ezithile.

Okokuqala, lo hypersensitivity ngamnye ukuya medicament engundoqo kunye namacandelo abancedisayo. Kufuneka balumke xa besebenzisa oko abafazi abo yokuzala. Ngokukodwa, ukuba "Sovaldi" ( "sofosbuvir") uphathiswe kubanjiswene ne "Ribavirin" yaye "interferon-alpha" (genotypes kweyona 3, 4, 5, 6, hepatitis) kufuneka kuphetshwe ezahlukeneyo iindlela ukukhulelwa. Kwakhona ungonqweneleka kakhulu ukunyanga ezi arhente ngexesha lokukhulelwa kunye zisanyisa.

Okwangoku, impembelelo i "sofosbuvir" iinkcukacha zabantu okuzala luyafumaneka. Kwakhona akukho lwazi malunga nokhuseleko kunye nokusebenza beziyobisi izigulane abangaphantsi kweminyaka eli-18 ubudala.

Idosi ixesha ke unyango

Okokuqala kukuba ukugxininisa ukuba uthomalaliso antiviral yamkelekile ukwenza kuphela ezo iingcali zonyango abaye babe namava olwaneleyo ekunyangeni izigulana kwesibindi C. A irejimeni eqhelekileyo - tablet 1 (400 mg wenkqu esebenzayo) emini, kulo naliphina ixesha yokufakwa. Njengoko ipilisi ekrakra (ezifana ekuthatheni ncomo amayeza) "sofosbuvir" kufuneka wabaginya ngaphandle ukuhlafuna okanye ngokwaphula.

Ukuba cwecwe iye yamkelwa, yaye emva koko kwi kweeyure ezi-2 elandelayo Ukuqala ukugabha, kucetyiswa ukuba uthathe omnye tablet nye. Kwimeko ihlanza ixesha sele idlule, iiyure ezingaphezu kwama-2, athathe idosi enye ayikho imfuneko.

Ukuba ithamo elilandelayo ngenxa yezizathu ezithile wabuya waphuma waya Sexy (ixesha kokulibazisa hayi ngaphezulu kweeyure eziyi-18), kucetyiswa ukuba athathe idosi kuziphosa ngoko ixesha eliqhelekileyo ukuqhubeka unyango. Ukuba ukubambezeleka ngaphaya kweeyure eziyi-18 - ukulithatha ithamo elilandelayo ngexesha ngokwesiqhelo.

kolimo ayini

Njengokuba amacandelo prolechivanii adjuvant therapy kwi-hepatitis C, kunye ne "sofosbuvir" babeqhelisela sabelo "ribavirin", "interferon alpha", "Daklatasvira", "Ledipasvira", "Asunaprevira".

Ngokuqhelekileyo, ngaxeshanye "sofosbuvir" + "Daklatasvir" ngokutsha abasebenzi bezempilo kunye izigulane kwachazwa ngokuthi olusebenzayo ngokuchasene genotypes hepatitis C 1,2,3.

Ukuza kuthi ga ngoku, "Daklatasvir" zinoku-odolwa online WWW.ARV24.COM kunikelwa ezandleni zakho - kwinkampani kunye igama-elide bemi. Ngaphandle kokuba kukho esandleni yonke ingcaciso eyimfuneko malunga ubukho besi sifo.

Genotypes 4, 5, 6 uphathwa imithi complex "sofosbuvir", "ribavirin" yaye "Interferon alpha". ixesha Standard therapeutic ziiveki ezingama-12. Kwiimeko apho izigulane genotypes 1, 4, 5, 6 kufuneka Izimo ngokufumana "Interferon alpha" umiselwe okanye hypersensitivity ukuba iziyobisi, "sofosbuvir" ne "Ribavirin" lwanziwa ukufumana kwiiveki ezingama-24.

Tandem "Ribavirin" ne "sofosbuvir" yeziyobisi isithuba kweejini 2 iingcali ncomo kwakhona uchaze indlela ngokupheleleyo olusebenzayo udityaniso ukuba lwanziwa ukufumana isithuba seeveki hayi ngaphantsi kwe-12. Ezi medicament ezimbini, kodwa kwisithuba kwiiveki ezingama-24, xa isicelo 3 kweejini sohlobo C.

Ulwazi malunga nokusebenza unyango nodibaniso 'Ribavirin "yaye" interferon "kuba unyango lwe kweejini 1 ayikho.

Xa kunjalo, ukuba isigulane enesifo hepatocarcinoma kunye / okanye abalindele utyando ukuze esinye isibindi, umkhuba ngokumisa "sofosbuvir" nodibaniso 'Ribavirin "iiveki 48 okanye kude kufike umhla utyando ukuze yotyando nofakelo lwamalungu omzimba. Oku kubalulekile ukuze ukuthintela usulelo kwesibindi emva abohlukeneyo.

zophononongo zibonisa ukuba basamkele "sofosbuvir 'kudityaniswe nezinye iziyobisi inika esitalini impendulo virological HIV ngo-92% amatyala yonyango adjuvant kwi unyango sohlobo C.

ziphumo bezingalindelekanga kunokwenzeka

Ekuhambeni eyiyo yolingo lwezonyango ichiza ukunyamezeleka kakuhle kakhulu zizigulane (ezo izilinganiso zabo). "Sofosbuvir" ebangela iziganeko ezibi kwiimeko ezininzi xa esetyenziswa nodibaniso 'Ribavirin "yaye" interferon ".

Xa zidibene "sofosbuvir" ne "Ribavirin" kaninzi ngokwaneleyo (ngaphezu kwe-10% amatyala) e ngehemoglobin yoxinaniso, ndanda yibilirubin kwangathi ngokubonakala ukudinwa unciphisa ukwakheka igazi, ukuba nochuku kunye ubuthongo, isicaphucaphu.

Ngokuqhelekileyo (ngaphantsi kwe-10% amatyala), le indibanisela iziyobisi kudale ukudakumba, ianemia, nasopharyngitis, yoxinaniso kakuhle, ukuqunjelwa, ukuqhina kunye nezigulo isisu, kukwalisa kwi eluswini (sokudlathuka kweenwele, amaqhakuvana). Ngamanye amaxesha izigulane aseleyo, yaye ezi Iireyithingi "sofosbuvir" asetyenziswa ngaxeshanye kunye "Ribavirin" yaba unobangela ilahleko kweenwele iqolo, amahlaba, myalgia, kunye asthenia.

Ukuba usebenzisa i oluntsonkothileyo amayeza ezintathu (ezimbini ogama ngasentla wongezelela "interferon alpha"), rhoqo (ngaphezu kwe-10% amatyala), kukho uluhlu olubanzi kakhulu iziganeko ezibi. Apha sithetha utshintsho egazini: ibizwa ukunciphisa inani lymphocyte, neutrophils neeplatelets, ianemia, amanqanaba yibilirubin ophakamileyo. Ngomhla inxalenye wokugaya inokuphuhlisa urhudo, isicaphucaphu, ukugabha. Ukongezelela, "sofosbuvir" (Instruction, angqina nomonde kunye neengcali zezempilo inkxaso) ingabangela ebuhlungu, isiyezi, khohlo, ukutswina, ukurhawuzelela krwada, myalgia ubuhlungu. Izigulane basoloko bethetha ukudinwa, ukuba nochuku, ukugabha, ubushushu bomzimba ukwanda.

Ngokuqhelekileyo (1 ukuya kwi-10%) izigulane zithi malunga kuloyiko kunye nophuhliso uxinezeleko, ukunciphisa ubunzima bomzimba, malunga nawenkumbulo ezinxaxhileyo of uqaqanjelwa. Kukho ulwazi malunga ngokonakala umbono, ilahleko iinwele, uphuhliso reflux kwakunye nokubamba-bamba umphefumlo xa ukunyuka umthwalo. Ngamanye amaxesha izigulane zithi malunga iintlungu emqolo esifubeni, amahlaba nokudinwa.

Into ekufuneka uyazi?

Ukuba isigulana umntu omnye okanye awunayo ngaphezulu imibandela - high lokuqala umthamo wentsholongwane egazini, abanesigulo ngendlela eliphambili, isikhumba ezimnyama kakhulu - unyango 'sofosbuvir "(reviews of neengcali kunye nemiyalelo yokusebenzisa njani inkxaso) kufuneka lenyuke nge kwiiveki ukuya ku-24. Xa uqhuba uthomalaliso indibaniselwano olusebenzayo ithamo "ribavirin" kukhethiwe ngokutsho ubunzima umzimba isigulane, okt. E. 75 kg ubunzima bomzimba ifuna 1.2 g medicament. yonke imali ichiza yahlulwe iinxalenye ezimbini esithathwe nokutya.

Ukunciphisa oyidlayo "sofosbuvir" ayikhuthazwa.

Ukuba isicelo joint "Solfosbuvira" yaye "interferon alpha" ukuphuhlisa kubonakaliswa ezimbi uphawu ichiza yokugqibela, wafumana umthamo we "Interferon" kufuneka ukunciphisa okanye uyeke ukuthatha eli amayeza (imithetho eneenkcukacha ekunciphiseni umthamo okanye ukurhoxiswa ichiza, kukho imiyalelo ezizodwa).

Xa kanye senzo efanayo xa kukho indibanisela "sofosbuvir" ne "Ribavirin", yaye liphuhlise nefuthe elibi nangokwamkela lokugqibela - liyancipha zedosi okanye eyeka wamkelekile ngokupheleleyo, "Ribavirin". Emva ukuphucula iziphumo zeemvavanyo kwegazi, kwamkelekile ukuzama ukuqalisa ekufumaneni "ribavirin", ukuqala 600 mg yaye ngokuthe ngcembe bethwele 800 mg. Ayikhuthazwa ukunyusa ithamo ukuya kwindawo yokuqala.

Ukuba ukususa elinye iyeza odityanisiweyo unyango kuyimfuneko ukuba ayeke ngokupheleleyo ukuthatha "sofosbuvir" - izimvo kwiingcaphephe nemiyalelo imiyalelo yosetyenziso ziyafana kulo mba.

Intsebenziswano kunye nezinye izinto

abasebenzi bezempilo akukhuthazwa ukuba izigulane ngaxeshanye kunye ichiza kuqwalaselwa ukuba usebenzise amanye amachiza antiviral (ngaphandle kokuba ugqirha ngokuphatha) kwisithuba xa unyango abathwele hepatitis. "Sofosbuvir" iingcali ncomo bakugqala kunokwenzeka ukudibanisa ngento enye kuphela kwiimeko apho inzuzo kulindeleke ukusuka indibanisela iziyobisi kunokuba nobungozi yeziphumo ezibi.

Kukwakho iqela iziyobisi, ukusetyenziswa ezimanyene "sofosbuvir" asikwazi kakhulu ukunciphisa ukufakwa kwayo ( "sofosbuvir") apha emathunjini. La machiza - of anticonvulsants - ziquka "Phenytoin", "Phenobarbital", "carbamazepine" yaye "Oxcarbazepine." amayeza iqela Antimycobacterial kwakhona iquka ezinjalo lithetha "Rifabutin", "rifampicin", "Rifapentine". Ukususela Izithako eengcambu absorbability aphantsi kakhulu "sofosbuvir" kwangathi Hypericum. Kwakhona kucetyiswa ukuba ukudibanisa amayeza kunye inhibitors protease HIV, "i-tipranavir", "Ritonavir".

imiyalelo Special

Kuphela ukuba ugqirha umisela ukhetho lasekunene irejimeni yonyango kohlobo C, kunye iziyobisi lalathelwe "Ledipasvir", "Asunaprevir", "sofosbuvir", "Daklatasvir". Ingxelo evela kwizigulane zonke generics "Sovaldi" esihle.

Nangona kunjalo, kufuneka kukhunjulwe ukuba, izigulana ukusilela kakhulu kwezintso, umthamo idosi kufuneka zikhethwe ngokukodwa. Akukho mfuneko ekube- umthamo abo abaphethwe ngobulali sisifo zokumodareyitha. Ngokubhekiselele ukusilela wesibindi, akukho mfuneko yokuba ulungise ithamo izigulana nayiphi iqondo nobungozi besi sifo.

Xa unyango sohlobo C kunye nokusetyenziswa ngokusekelwe "sofosbuvir" unyango dibaniso ayikhuthazwa ukuba wenza leyo misebenzi ezifuna yoxinaniso ophezulu kunye nesantya ngayo lengqondo.

uhla amanani

Iindleko iziyobisi ndiziphethe eJamani liphakathi 18 ukuya kuma-20 amawaka euro. Kwaye ukuba yithenge nokuba le ntengo kuya kufuneka kokumiselwa kugqirha khona. Loo Ixabiso eliphezulu wamcacisela ngenxa yokuba inkampani-umphuhlisi kufuneka kubuyiswe zonke iindleko zalo uphando, uphuhliso kunye nokuvavanywa ichiza.

iindleko sitshiphu amayeza kubathengi, generic (analogue zitshiphu uphawu ineempahla esebenzayo twatse ngokupheleleyo). Kubalulekile ukuba inkxalabo enjalo "Daklatasvir", "Asunaprevir", "Ledipasvir" yaye "sofosbuvir". ncomo Consumer ziqulathe ulwazi malunga neendleko aphezulu ngala machiza, nakuba kunjalo, ukuba sithetha amashumi amawaka euro thina.

Ukuqalela ngoMatshi 2015, ngokutsho mvume kwinkampani-phambili, imbambano "sofosbuvir" imikhosi Natko waqalisa iinkampani Indiya ezixuba amayeza (Kakade ke, ngemvume yoMphathiswa of Health of India).

Okwangoku, iRussia lokwenene kwiivenkile intanethi ukuthenga impahla (tablets 28) iziyobisi "sofosbuvir" 39 900 engange (1 tablet buxabise yabathengi mali malunga 1800 engange). Yinto eqolo, kodwa kanye ukuphakheja efanayo ndiziphethe "Sovaldi" uya kufuna utyalo-mali ka-1.5 million engange, eseyiphantse 35 amaxesha ngaphezulu ngexabiso ngaphezu naziphi iindleko oluthile.

Ngokusebenzisa ngamatyathanga ekhemisi de awukwazi ukuthenga eli chiza, t. To. Inkqubo isatifikethi kwamachiza amatsha eRashiya imide.

Uluvo kwabathengi kunye amagqirha

Le medicament wathabatha izigulane genotypes ezahlukeneyo kwesibindi, abanesigulo amanqanaba ahlukeneyo kunye indices of transaminase kwaye kakhulu ngaphezu mmiselo, ngokuqhelekileyo viral load yakho iphezulu.

Uninzi lwezigulane abathatha amayeza, eshiya ingxelo eyakhayo malunga "sofosbuvir" ithetha. Ngubani baphathwa (reviews ziqulathe rhoqo ulwazi) ngaphambili hepatitis C interferon lubonisa ukuba iziyobisi abakwazi nokulithelekisa. Interferon kunokubangela ezininzi ziziphumo ebezingalindelekanga, kwaye zonke izigulane kufuneka ukuba amandla ukuba sithwalwe ngazo. Ke ukuba indibanisela 'sofosbuvir "yaye" Daklatasvir "(kaninzi izigulane zithi malunga ibhayisekili enjalo), kuphela ipesenti encinane iphathwa nale arhente wathetha kuphuhliso neziphumo ezingalunganga ezincinane njengokuba nesiyezi, intloko ebuhlungu, abangenamandla nelahleko elifutshane elide nolungelelaniso. Nangona kunjalo, ezi mpawu musa ukuya nayiphi kuthelekiswa neziphumo ebezingalindelekanga i "interferon" kunye neziphumo kwesibindi. Ekupheleni kweeveki 2-3 unyango xa izigulane ezininzi, ekubuyeleni isiqulatho abaqhelekileyo kwi transaminases esibindini. Ukususela kwiveki yesithathu onyango antivirals ezintsonkothileyo "sofosbuvir" yaye "Daklatasvir" xa izigulane ezininzi ebusweni emzimbeni sohlobo C virus negative.

Kwakhona, izigulane ezininzi ingxelo unciphiso ebalulekileyo abanesigulo kwiinyanga ezimbalwa, ukusetyenziswa unyango udibaniso.

Abo abathengi eziye oluntsonkothileyo amayeza ezintathu - "sofosbuvir", "Daklatasvir", "Ribaverin" - nawo uyakholiswa kakhulu kunye neziphumo zonyango.

Phantse bonke abathengi "sofosbuvir" intetho malunga idabi wokwenene unyango sohlobo C xa kuthelekiswa interferonotherapy. Kakhulu ngcono impilo kunye nomgangatho wobomi - ubungqina ngqo.