"Zyprexa": imiyalelo ukusetyenziswa. "Zyprexa": ncomo, analogs kunye Izimo

Inkqubo luvo lomntu liziko umyalelo yonke eziphilayo. Ukuba uneengxaki ungabona ezinxaxhileyo kuphuhliso, ngokwenyama ngokweemvakalelo, nasengqondweni. Okwangoku, kukho inani elikhulu iziyobisi ukuba basebenze imimangaliso ze akuncede ukumelana nezifo ezininzi. Omnye wabo - "Zyprexa". Eli nqaku liza kuqwalaselwa kule ncwadi amayeza myalelo. "Zyprexa" - ichiza elidla esimiselweyo ezingaqhelekanga kule luvo.

iimpawu amayeza we ichiza

Eli chiza fanele ukuba iqela neuroleptics ukususela kwi kuluhlu olubanzi iinkqubo ezininzi receptor. Kwenziwa uphando olwenziweyokwakunye apho kwafunyaniswa ukuba olanzapine, eyona nto ebonakalayo ichiza, iye kwingcinezelo ukuya serotonin, dopamine, kunye nezamkeli cholinergic.

Kwakhona bafumanisa ukuba olanzapine lwehlisa excitability ye-luvo dopaminergic mesolimbic kwaye babungena kwi yokuhamba striatal uvaleke abandakanyeka ekulawulweni kwemisebenzi motor.

Le esisebenza beziyobisi kuphucula isiphumo anti-ixhala ngexesha lovavanyo anxiolytic.

Medicine "Zyprexa" iza ngeendlela ezimbini:

• Xa uhlobo lwe amacwecwe, umboniso-camera.
• Lyophilizate for ukulungiselela isisombululo ngenaliti.

Le esisebenza iphambili kumalungiselelo liquka olanzapine. amacandelo Auxiliary kwi amacwecwe zezi:

• Crospovidone.
• wemagniziyam stearate.
• monohydrate Obumele.
• Kwincindi.
• Giproloza.

Ukubunjwa amacwecwe bhanya ukutyabeka ezi colorant emhlophe, i-inki eblowu ukutya, njengomthwebeba carnauba kunye hypromellose.

Ukubunjwa a lyophilisate ukuba isisombululo ukuba isitofu ibandakanya, ngaphandle kokuba into esebenzayo engundoqo, monohydrate lactose kunye tartaric acid.

Ziziphi ifomu ukuqesha ichiza ukunyanga isigulane, ugqirha kufuneka isigqibo kuphela.

Iimpawu zibonisa ukuba ukusetyenziswa kweziyobisi

Drug "Zyprexa" liye kuyabonisa olubanzi ukusetyenziswa, amaxesha amaninzi oko kumiselwe kule miqathango ilandelayo:

• Kwengqondo ngendlela oyingozi.
• enokuphazamisa imithambo-luvo ephelekwa iimfeketho zokufeketha, nemibono, wacinga disorder.
• Elibonakaliswe nzondo nokungathembani zezigulo luvo.
• ukurhoxiswa ngokweemvakalelo okanye ekuhlaleni.
• Iimpawu Uthando neyavela ngokuchasene nentsukaphi ngesifo sengqondo.
• Njengoko arhente umbala ukuba likakade schizophrenia.
• Yingqondo.

Akukho mfuneko ukuqesha ngokwakhe ichiza ngaphandle kokuba ubonane oyingcali, unyango loo naxa ingumbandela ozaliswe ziziphumo emibi.

unyango ngamachiza Scheme

Yintoni le ncwadi yokufundisa? "Zyprexa" yabelwa ekuqaleni konyango ngesifo kwi idosi ubuncinane. Ekuqaleni, loo nto iya kuba yanele ukuba-10 mg beziyobisi kanye ngemini. Ukusebenza yonyango ekudleni ayinasiphumo.

Oyidlayo therapeutic beziyobisi ziyahluka ukusuka mg-5 ukuya ku-20, kodwa umiselwe ngamnye ukuze isigulane ngasinye ngenxa karhulumente yayo. Emva lonke uphando, ukuba isigulane ukumelana angandiswa pamo iziyobisi, kodwa kuphela phantsi kweliso zonyango.

Phambi intshutshiso mania "Zyprexa" icwecwe yaphathwa isixa-15 mg kanye ngemini. Ngexesha unyango kuyimfuneko ukuba esweni imeko yomguli kunye idosi kuhlengahlengiswa njengoko kuyimfuneko.

Ukuba isigulane ukubandezeleka ukusuka insufficiency hepatic okanye kwezintso, azimiselweyo ichiza "Zyprexa" 5 mg, ukuba zikarhulumente eziqhelekileyo yaye kuthetha ukunyamezeleka kakuhle, ithamo angandiswa kancinci.

Ichiza kudla ilawulwa kwizigulane ngenaliti. Phambi kokuba wenze ngenaliti, kufuneka liyichithe kakuhle lyophilisate. Ukuze benze oku, imixholo igutyana unyityilikiswa ml 2 amanzi ngenaliti. Isisombululo uzilungiselele kufuneka icace kwaye ibe umbala omthubi.

Indlela ukuthatha? "Zyprexa", njengokuba sele kukhankanyiwe, wabelwa ukuba yincutshe. Ngoko ke, irejimeni yonyango, ukuba uthomalaliso oluqhutywa phaya ekhaya, kufuneka ukuba kuxoxwe ngayo ngugqirha.

Xa ulungiselela isisombululo ukuba isitofu kufuneka kukhunjulwe:

• "Zyprexa" songanyibilikisswa emanzini wawuqalekisa kuphela.
• Yinto ugalelwe kwi isirinji ofanayo neziyobisi "Diazepam".
• Compound "Zyprexa" yaye "Haloperidol" kukhokelela buthathaka yintshukumo kwichiza yokuqala.

Ukuba ugqirha ubeka iziyobisi "Zyprexa", idosi iya kuxhomekeka uxilongo. Ngokomzekelo, xa ngesifo idosi yokuqala mg-10 kanye ngemini. Ichiza kufuneka ilawulwe intramuscularly kuphela. Ukuba kufunwa imeko yesigulane, amayeza agwaze yesibini ungenza, kodwa hayi kwiiyure ngaphambi kwe ezimbini emva kokuba inaliti yokuqala.

izigulane abadala kunye nobukho ezithile izifo ezingapheliyo iziyobisi inokusetyenziswa ngendlela ka 2.5-5 mg.

Thathela ingqalelo ukuba ukusungulwa "Zyprexa" kungabangela iyawa uxinzelelo lwegazi ngethuba isitofu Kulungile ukuba babe kwindawo wobuxoki, ingakumbi xa kukho emva kokuba isitofu ukozela kunye nesiyezi. Kuyimfuneko ukuba amanga, okoko nje ugqirha emva koviwo akayi ukulungisa ukunqongophala ekunciphiseni uxinzelelo lwegazi kunye bradycardia.

Kufuneka kwakhona ukhumbula ukuba ukupheliswa "Zyprexa" kufuneka aqhutywe ngokuthe ngcembe, njengokuba ekuso ukuba ichiza ekubalekeni syndrome. Kufuneka usoloko zikuxoxe oku nogqirha wakho.

Elide therapy "Zyprexa" elithile emva isitofu indawo iipilisi xa kukho umthamo-5 ukuya kuma-20 mg ngosuku. Ugqirha kufuneka ukuchaza ngokweenkcukacha indlela ichiza "Zyprexa" elide kufuneka yamkelwe. Ophatha ndlela yaye yintoni na icebo imithi, esiye sakuphonononga, kodwa kufuneka ungalibali malunga neziphumo ezingafunwayo.

imiphumela emibi ichiza

Phantse onke amachiza ukuba unyango ukuphazamiseka kwenkqubo luvo ezinxulumene kwiqela, nekucetyiswa ukuba ukuthatha ngaphandle kokubonisana ugqirha. Le asinto umnyinyiva ukuba "Zyprexa" kuba chiza uluhlu kunokuba olunzulu yeziphumo ebezingalindelekanga:

• I-luvo unako ukuphendula intloko ebuhlungu kunye nesiyezi, ubuthathaka jikelele kunye sokulibala, kunesifo ukucalulwa ezahlukeneyo. Komhlaba kunye ukuqina kwezihlunu nazo kuyenzeka. Kudla kukho ukuduma, ukungeva ngeendlebe, iintlungu emehlweni, incasa ukuphazamiseka.
• Ngomhla inxalenye yegazi inokuba tachycardia, nokuncipha uxinzelelo lwegazi, utshintsho ECG, cyanosis. Analyses onokubonisa neutropenia, eosinophilia, leukocytosis, thrombocytopenia. Kwiimeko kakhulu, kunokwenzeka zokuma.
• Kukho ingozi nokuthimliswa, pharyngitis, laryngitis, ukhohlokhohlo landa. Ngaba zimbi isifuba, belele umngcipheko.
• Ukuxhuzula ukwandisa emnyama okanye ukudla, unxaniwe, ukoma em- ngomlomo.
• Isicaphucaphu kunye nokugabha.
• Exacerbation of gastritis kunye gastroenteritis.
• Ukophulwa kwesitulo kunye flatulence.
• izifo umzimba ngazo utshintsho ubunzima, uphuhliso seswekile, ukufa isiqaqa seswekile.
• Wokuchama ngumchamo, Ngokuzimela, zesibeleko abanesigulo, amenorrhea kunye nophuhliso zosulelo womchamo nazo ingafuneki nokubonakaliswa yokufakwa.
• Imiyalelo Sebenzisa ( "Zyprexa", njengoko sibona, ichiza ezinokubangela iindidi iziphumo ebezingalindelekanga ezingafunekiyo) ilumkisa ukuba uphuhliso samathambo, bursitis kunokwenzeka, mde izihlunu ithole kunye neentlungu emathanjeni.
• Isikhumba bangase ukubonakala ukoma ngokugqithisileyo, dermatitis, ngokobuninzi isilonda.
• urticaria kwenzeka rhoqo.
• Ezinye iimpawu ukuze kuphawulwe nangecesina, kuthibaza, chaza ezifana nomkhuhlane.

Ukusuka zonke ngasentla sinokugqiba ngokuthi "Zyprexa" ziziphumo ebezingalindelekanga lilikhulu ngokwaneleyo, ngoko ukuthatha amayeza kuphela iingcebiso kagqirha.

iimpawu libanda

Ukuba isigulana ayiyithobeli iingcebiso ugqirha ukuba umthamo ichiza, kukho umngcipheko libanda, nto leyo eyaboniswa mpawu zilandelayo:

• Tachycardia.
• ucaphuka kakhulu kunye ubuvila.
• Nentetho engekho mgaqweni.
• ukwazi kwamehlo.
• Yombono.
• syndrome Neuroleptic.
• Inhibition le umsebenzi nokuphefumla.
• Yesi wegazi.
• Arrhythmia.
• Kwiingozi ezimasikizi, zokuma nokuphefumla.

Xa uphawu lokuqala libanda, kuyimfuneko ukuba iphume esiswini, uthathe namalahle. unyango lingaze yenziwa ngokuhambelana wabonakala lwezonyango, kwaye rhoqo esweni umsebenzi amalungu abalulekileyo.

Izimo ukuba ukusetyenziswa kweziyobisi

Ukuze uphephe izinto ezingafunwayo emva kokuthatha "Zyprexa" kuyimfuneko ukufunda ngenyameko uluhlu Izimo. To ezo ziquka:

1. Ukwanda uvakalelo ichiza.
2. Ukudakumba -luvo.
3. Isiqaqa.
4. Iminyaka ukuya kutsho kwiminyaka eli-18.
5. Ngononophelo olukhulu kufuneka imiselwe ichiza "Zyprexa" kwi izifo kunye miqathango ilandelayo:

• Wezintso kwaye ukusilela wesibindi.
• Glaucoma.
• Sokuwa.
• hyperplasia Prostatic.
• Myelosuppression.
• Phenylketonuria.
• ileus unedumbe.
• Ukukhulelwa.
• Ngexesha lokuncancisa.

Ukuba isigulana uye ubuncinane enye yezi zifo zilandelayo okanye iimeko kufuneka ukuba ngokuqinisekileyo wazise ugqirha wakho.

Ukuthatha ichiza ngethuba lokukhulelwa nokuncancisa

Ukuba umfazi uchitha unyango with "Zyprexa" kwaye ukhulelwe, kufuneka wazise ugqirha wakho. Ichiza ngexesha ixesha lokumitha umntwana kufuneka athathe kuphela xa isibonelelo ukuya unina zinkulu kakhulu ingozi enkulu ukuba umntwana okhulayo.

"Zyprexa" - antipsychotic, onako ukungena kwi ubisi lwebele, ngoko ngexesha unyango ngamachiza kufuneka siqhubeke ukondla usana lwakho, kungcono ukuba batshintshele yokondla ngumntu.

iingcebiso ezithile ngexesha unyango

Yengqondo badla ukumisa ukhetho kwi ichiza "Zyprexa", ixabiso apho, ngelishwa, Kuyinto phezulu. Ngenxa yoko, iphekhi enye iipilisi (. 5 mg, iziqwenga 28) uya kuxabisa imali engange-2500, yaye gutyana enye inaliti -. 239 bagcobe.

Phantse yonke imithi eli qela bayakwazi zivuse uphuhliso neuroleptic syndrome, yaye "Zyprexa" Akukho ngaphandle. Ngexesha unyango ngamachiza kufuneka balumke, kwaye ukuba kukho ukubetha obungazinzanga okanye tachycardia, arrhythmia, okanye ukubila, ubushushu bomzimba ukwanda, kufuneka uxelele ugqirha wakho.

obubonakala kwezonyango neuroleptic amabi syndrome kufuna ukuba ichiza irhoxisiwe ngoko nangoko.

zophononongo oluqhutywe apho kwafunyaniswa ukuba uthomalaliso ixesha elide "Zyprexa" lunqabe kunye zeDyskinesia, nto leyo eza kufuna ukuba ungenelelo lonyango. Kodwa musa ukulibala ukuba kukho ingozi yokuba uphuhliso kamva kule meko.

Ukuba kukho naziphi na iimpawu ukhwekhwe, kuyimfuneko ukuba alungise ithamo kwicala lokuncitshiswa yayo.

Phambi loxilongo "isibindi" amayeza kufuneka zithathwe ngononophelo kakhulu, ingakumbi kunye nokwanda AST kunye ALT. Ukuba manani bafikelele kwinqanaba ebalulekileyo, kuyimfuneko ukunciphisa umthamo "Zyprexa."

Eli yeza kufuneka zithathwe ngononophelo, ukuba imbali isigulane baba sokuwa okanye baboniswa rhoqo kwizinto ukuthoba embundwini nokuhlutha izinto.

Ukuba iimvavanyo isigulane wabonisa inani leeseli zegazi ezimhlophe okanye neutrophils, indlela "Zyprexa" kufuneka kwenziwe phantsi kweliso unyango kunye esweni ngamaxesha yemida igazi. Ngoko ibonisa imiyalelo ukusetyenziswa. "Zyprexa" nayo ifuna ukungqinelana ndinyanyekelwe ngexesha unyango xa:

• Kukho iimpawu zengcinezelo okanye ukuhlukunyezwa ezinomongo wethambo ityhefu.
• Ubukho yezifo ezihamba leyo anqanda umsebenzi umongo wethambo.
• Ukuba imbali isiguli radiotherapy okanye ichemotherapy.
• Ubukho hypereosinophilia.

Ngexesha izifundo zovavanyo Therapy "Zyprexa" lunqabe kunye neziphumo ezibi anticholinergic, kodwa amava usebenzisa iziyobisi izigulane izifo ezihamba lincinane, ngoko unyango, xa kukho imfuneko, kufuneka kwenziwe ngononophelo kwaye kuphela phantsi kweliso zonyango.

ileus kunye ezivaliweyo isibiyeli neglaucoma nawo isiseko unyango ngononophelo "Zyprexa" iziyobisi. Isenzo ichiza kwinkqubo luvo kufuna ukungqinelana ngononophelo, ukuba kuyimfuneko indibaniselwano kunye namanye amachiza neziphumo ezifanayo.

Ichiza ke kudityaniswe utywala, ngoko ngexesha unyango akufuneki basele iziselo ezinxilisayo.

Ucinga ukuba ngexesha unyango 'Zyprexa "kungabangela ukozela, ngoko eli xesha kubhetele ukuba ayeke ukuqhuba isithuthi, kwakunye nokwenziwa komsebenzi efuna ingqalelo ngokugqithiseleyo.

Indlela ukudibanisa 'Zyprexa "kunye namanye amachiza

Yokucolwa ye eyona nto iphambili ebonakalayo ichiza nise utshintsho phantsi kweempembelelo inhibitors okanye inducers of cytochrome P450, leyo sizibhokoxe umsebenzi wabo nxamnye CYP1A2. Clearance "Zyprexa" ukuba lubekho kakhulu izigulane kuba ngumkhwa ezifana nokutshaya, ngokunjalo ezithatha ichiza "Carbamazepine".

zophononongo zibonise ukuba xa kukho nedosi enye ye-"Zyprexa" uthomalaliso "warfarin", "theophylline", "diazepam", "Imipramine", ukwehla zakutshanje yokucolwa uyalandelwa.

ulawulo ngaxeshanye ichiza yotywala igcwele iimpawu umthomalalisi lokuwandisa ichiza, nto leyo enokukhokelela ekubeni ibe buthathaka ingqalelo.

Co-lezolawulo "Zyprexa" "fluoxetine" kwandisa xi ubuninzi olanzapine kweziyobisi esebenzayo. Ke kuzo zonke izigulane, le okungenzeka amabinzana ezahlukeneyo, ngoko idosi hlengiswe kwi umntu ngokungqongqo.

Ukuba "Zyprexa" Ingcamango ezilawulwa intramuscularly libambisene benzodiazepines, kucetyiswa ukuba kuqhuba uviwo ngokucokisekileyo imeko bezonyango isigulana ngokunxulumene inhibition kwenkqubo bokuphefumla umsipha. izifundo kwezonyango olu dibaniso isiyobisi alubanga, ngoko ukuba kunokwenzeka oko kufuneka kuphetshwe.

Ukuqaliswa ichiza igcwele kuphuhliso bradycardia okanye uxinzelelo lwegazi esezantsi, kwaye unyango ngoko abanjalo kufuneka kwenziwe ngobuchule kakhulu izigulane abaneengxaki kwinkqubo sentliziyo, kunye syncope babonakala drop elibukhali kwi koxinzelelo.

Kufuneka kuqatshelwe ukuba ulawulo wamalahle iyasebenza okanye amalungiselelo esesiwini kunciphisa kakhulu inkqubo sokufunxa "Zyprexa" kwisiqwenga isisu, nto leyo enokuchaphazela kakubi ukusebenza unyango.

amanyathelo ngexesha therapy "Zyprexa"

Ukuba ngaba kukho iimeko ezinegalelo ukutya kancinci of olanzapine, kufuneka ukunciphisa izinga. To Ezi zinto zibandakanya:

• Female.
• Ubukho imikhwa emibi ezifana nokutshaya.
• yobudala Old.

Nangona kaninzi kakhulu ilawulwa "Zyprexa" le unyango kufuna ingqalelo ekhethekileyo kwizigulane abo okanye bafune ukuzibulala.

Ngexesha unyango kufuneka esweni umsebenzi transaminases hepatic, oku kuyinyaniso ingakumbi xa izigulane ongaboniyo hepatic.

Izigulane, umsebenzi wakhe neyobungcali esidityaniswe uqhuba okanye ukwenza imisebenzi ezifuna ingqwalasela eyodwa kwaye ingqalelo, ichiza emiselweyo ngononophelo. Ukuba kunokwenzeka, kukho indawo kwelinye ichiza.

Ukuba kukho iimpawu syndrome elinobuhlungu neuroleptic ngohlobo ifiva, tachycardia, kwempixano kwezihlunu, kufuneka uyeke ezithatha ichiza.

Ekubeni Mzoli therapy motor "Zyprexa" kungabangela Mzoli, umnqweno rhoqo ukuhamba, kuyimfuneko ukunciphisa umthamo kancinane ize ilabele arhente antiparkinsonian.

analogue iziyobisi

"Zyprexa" analogue inamaqela ezimbini:

1. Ntonye, oko kukuthi, uMtyholi lo into efanayo esebenzayo. Eli qela kuquka amayeza zilandelayo: "Zalasta," "Olanzapine", "Parnasan", "Olaneks", "Normiton".
2. Iqela lesibini luquka amachiza ukuba abe phezu neziphumo ezifanayo emzimbeni womntu amayeza, ezifana "Azaleptin", "Viktoel", "Ketilept", "Kutipin", "Lakvel", "Nantarid", "Safris" kunye nabanye.

Ukuba ugqirha wakho emiselweyo amayeza therapy "Zyprexa", analogue kufuneka ingabi nguwashiywa nowashiywa ukuya kulanda, ngoko ukuze kufikelelwe isiphumo enyangayo ezinqwenelekayo. Kuphela ugqirha kunceda ukusombulula lo mba. Umnqweno endaweni isivumelwano isiyobisi kufanelekile, ngokuba ichiza "Zyprexa" amaxabiso kakhulu aphezulu, kodwa ukusebenza kwalo isekhona ibiza imali entle.

Izimvo kulungiselelwa

Okwangoku, phantse zonke isigulane phambi kokuba uye ekhemesti amayeza amiselwe ngugqirha, qiniseka ukuba ukubuza malunga izimvo abo sele bajamelene unyango. "Zyprexa" iimpendulo kudla HIV. Izigulane bangenele unyango kunye ichiza, ingongoma yalo kahle eliphezulu. Kwanasemva kokuba ikhondo iphambili kunyango, izigulane ezininzi bathi ulondolozo imithamo ichiza awukuvumeli sifo ukuba umva likakade nesele azikho. Good ukulwa ichiza sixinezelekile, ukusuka apho emva kwikhondo unyango ayikho, azafunyanelwa ndawo uhleli, nokuba kukho umnqweno ukuze aphile.

Kufuneka kuqatshelwe ukuba, nangona 'Zyprexa "liye uhlolo elungileyo, izigulane ezininzi phawula ngokubonakala neziphumo ezibi. Ngakumbi kaninzi kwenzeka ngenxa yale unyango abatyebe, ukutya aphazamiseka, abanye bathi iveze kunye nomnqweno rhoqo ukwenza into ethile.

Kaninzi, izigulane kwakhona akhalaze yexabiso eliphezulu kakhulu beziyobisi, leyo ayikuvumeli ukuba athathe amaqembu athile yabemi.

Okwangoku, omnye esi sifo yokugcina kumagqirha kukho inani elikhulu iziyobisi, kodwa ke kuphela emva kokuba uviwo olupheleleyo, ugqirha lukhethe omnye wabo. Ngoko ke, akukho mfuneko yokuba ngokuzimeleyo amisele unyango, iyeza efanayo inokuba neziphumo ezahlukileyo kwizigulane. Konke kuxhomekeke iimpawu ephilayo, imeko jikelele kunye ikhondo sifo. Oku ngokuyintloko simalunga amalungiselelo ukulungiselela unyango lwezifo e-nervous system. Thatha nokuzikhathalela wena uze uhlale usempilweni!