Amalungiselelo hepatitis C "sofosbuvir": ncomo, imiyalelo zokusetyenziswa

Drug "sofosbuvir" kunye negama lorhwebo "Sovaldi" ikuvumela ukuba ukunyanga ngokupheleleyo hepatitis C, isiphumo ezintle ifunyenwe ngokukhawuleza ngokwaneleyo, nto ingqinwa kwizifundo zonyango.

Drug "sofosbuvir" baphathe kohlobo C imilo. therapy kudityaniswe nokusetyenziswa kwale iziyobisi kunye nezinye iziyobisi alawulwa kwizigulane abadala. Medicine kunye ukunyanga izigulane ezine-HIV kwii-HIV.

Ilungu elikhutheleyo tablets - sofosbuvir. Bona camera kwaye ziqulathe 400 mg ukwimo esisiseko. Le mpahla iqulathe Amacwecwe 28.

Kwiipropati behlasela iziyobisi "sofosbuvir"

Ichiza xi ukusebenza ngomhla RNA-Polymerase NS5B. Ngenxa yoko, umonakalo waso umzimba ezi Webhsayithi inkqubo yintsholongwane phindana, nto leyo ke arhente causative sohlobo C.

Apho ukuthenga "sofosbuvir" ngexabiso elifikelelekayo

Ulwazi omninzi oluncedo ngendlela ukuze ngokukhuselekileyo "Kakade kwi wobuyiselo" wakho, athunyelwa nich. I-resource inkulu yaye eyona nto ibalulekileyo ekuhlaleni na HCV.RU - Russian abathetha iqonga hepatitis "Misa", nto leyo yasekwa ngo-2000. Njengomgaqo, iminyango ezinkulu, lonke ulwazi lukhangelwe ngenyameko kwangaphambili kwaye uvavanyo yoluntu.

Ukuba ngaba uthathe ingqalelo kwiiforam, omnye kwezindululo ezininzi umdla esayifumanayo kwi-intanethi, ebizwa HCV24 UFIKELELO INKQUBO. Ukuze ufumane inkcazelo engakumbi malunga neenkonzo HCV24 kwi website esemthethweni yenkqubo.

Iimpawu zibonisa ukuba ukusetyenziswa kweziyobisi

"Sofosbuvir" amayeza emiselweyo ukuba izigulane hepatitis C, esi sifo xa wasiwa uhlobo ezigulo ezondeleyo. Ukuze siphumelele, unyango esebenzayo indlela ehlangene. Mhlawumbi ukusetyenziswa kweziyobisi kwiimeko apho umguli ukuba une-HIV ngaphandle Hepatitis.

Izimo ekufumaneni "sofosbuvir" iziyobisi

Amayeza musa ukusebenzisa xa hypersensitivity ukuba izinto ezisegumbini nokubunjwa kwayo. Ngaphandle kwento yokuba ichiza alunasiphumo kwi ukuchuma, ukuba kunqabile emiselweyo ukuba namakhosikazi aselekhulile okuzala. Ukusetyenziswa kweziyobisi ngethuba lokukhulelwa nokuncancisa akunconywa, njengoko unako ukwenziwa nto umntwana.

Xa kusenzeka ukukhulelwa, ukuhlanganiswa 'sofosbuvir "kunye ngeendlela ezifana" interferon alpha "yaye" ribavirin' sibe nefuthe elibi ikhondo layo. Ngenxa yesi sizathu, ngexesha unyango yokuzalwa ayinqweneleki. Amalinge apho ichiza "sofosbuvir" ivavanywe izilwanyana, lubonise ukuba esi sixhobo kuba nefuthe elibi kancinane kwi kwinzala. Ngaphambi kokuba kufuneka ufunde ngenyameko imiyalelo ichiza aze adibane specialist.

Izikali "sofosbuvir" iziyobisi

Unyango "sofosbuvir" ifomu ezingapheliyo hepatitis C abo iingcali abo namava afanelekileyo kwenziwa kuphela. Monotherapy singàphunyezwa, ichiza lisoloko kudityaniswe nezinye izinto. Abantu abadala basoloko bancome lwamkelo ngemihla ka-400 mg (1 tablet) iimali. nomnikelo yeCwecwe ngexesha izidlo.

Therapy lithetha "sofosbuvir" hepatitis C elinokuthatha ukuya kuma kwiinyanga ezintandathu. Amaxesha amaninzi kukho isidingo esinjalo xa kukho ezinye izinto ezimbi. Le yedosi kukhethiwe isekelwe ubunzima yesigulane.

Unyango kolimo kohlobo C:

• Genotypes 3-6 - ukuba ichiza eziphambili kongezelelwa "Interferon alpha" yaye "Ribavirin" (unyango kuthatha iinyanga ezingaphezu kwesithathu);
• genotypes 1, 4-6 - Ukongezelela basebenzisa 'interferon alpha "yaye" ribavirin "iinyanga ezintathu okanye" ribavirin "kuphela iinyanga ezintandathu (ngobuwena yesibini kwenziwa kuphela xa ekungakwazini ukusebenzisa indlela lokuqala);
• 2 kweejini - ichiza kudityaniswe "Ribavirin", ukuchacha ngokuqhelekileyo kwenzeka kwisithuba seenyanga ezintathu yokusebenzisa iyeza.

Ukuba kuyimfuneko, isibindi abantu abohlukeneyo, ihepatitis C ngubani na uyagula, phambi yokwamkela lunalo "sofosbuvir" emiselweyo kunye "Ribavirin". Ngexesha unyango lithetha "sofosbuvir" irejimeni yonyango kwezigulane ikhondo joint-HIV ne-hepatitis zingasetyenziswa iyafana.

Xa kukho iziphumo ezingalindelekanga ngenxa kulawulo idibene beziyobisi with "Interferon alpha" ephelekwa yanyhashwa of "Interferon" okanye ale ukuveza kunciphiso idosi esekwe ngaphambili. Ukuba uphuhliso kakhulu ziziphumo ebezingalindelekanga kukuba ityala, "Ribavirin", ithamo nokunciphisa okanye wenze ukupheliswa ichiza. zigqibo zenziwa yi igqirha khona. Kamva, xa isigulane babuyela eziqhelekileyo, unga zama ukuqalisa ukuthatha amayeza.

Besebenzisa "sofosbuvir" iziyobisi

Xa ukuphatha i-arhente "sofosbuvir" ukusetyenziswa kwamayeza ikhutshwa phandle kunye ekudleni. Ipilisi ebuhlungu, kuba awukwazi kuzityumza buze ikhefu, kufuneka ukuba imginye yonke.

Ukuba, zingadlulanga iiyure ezimbini emva kokuba ukuthatha ukugabha ipilisi kwenzeka, kucetyiswa ukuba basele enye. Kwiimeko apho ukugabha kwenzeka emva kweeyure ezimbini, esi senzo akuyomfuneko ukuyenza.

Xa les esithathwa xa kudlule iiyure engekho ngaphezulu kwe-18, kuyimfuneko ukuba athathe idosi kubuzwa ukuba liye ixesha, kufuneka sisele ithamo ngexesha ngokwesiqhelo.

Ukupheliswa unyango

Ukuba ngethuba unyango odityanisiweyo kuye kwayimfuneko kwi yokurhoxiswa omnye iziyobisi, lize liphelise amayeza "sofosbuvir". Manual ibonisa ukuba idatha kwi unyango abantwana abafikisayo, eqinisekisa ukusebenza kwale ndlela, akukho. Xa ngayo izigulane hepatitis abaphethwe lomonakalo kwezintso (ifom wobulali okanye ukumodareyitha), akukho mfuneko yokuba ukhetho ngamnye amathamo. Xa izigulane kakhulu sisifo emiselweyo idosi ethile nemali imizimba yazo.

Iziphumo ebezingalindelekanga "sofosbuvir" iziyobisi

Xa ukuphatha "sofosbuvir", "interferon" yaye "Ribavirin" kuvela iziphumo ebezingalindelekanga efanayo kwixesha unyango "interferon 'kuphela ne' Ribavirin". Kulo mzekelo, inkangeleko sawo ziyanyuswa.

Xa ichiza unyango edityanisiweyo "sofosbuvir" iimpendulo zibonisa ukuba ukuhlanganiswa yayo "Ribavirin" kukhokelela kuphuhliso le ithi:

• nochuku, nokudinwa;
• intloko ebuhlungu;
• iqondo yibilirubin okanye ukuncipha kwalo;
• isicaphucaphu;
• kokulala okanye iingxaki.

Xa ekufumaneni ichiza esisiseko kudityaniswe ukusetyenziswa "ribavirin" yaye "Interferon", ngokufuthi singabonakala:

• myalgia, iintlungu kwamalunga;
• ukungalali;
• isikhohlela, uphelelwa umoya;
• Amanqanaba aphezulu yibilirubin;
• neutropenia, igazi, ukungabikho zegazi count, lymphocyte;
• fever, kuthibaza;
• ucaphuka;
• fatigue njalo;
• isikhumba sakho silume, ufunga;
• Iimpawu engakhiyo iphecana zesisu;
• intloko ebuhlungu, isiyezi;
• imnyama.

Xa Ukongeza, i "Ribavirin" kodwa "sofosbuvir" isikhokelo ukulungiselela ibonisa amathuba encinane yokuphuhlisa ezi ziphumo bezingalindelekanga:

• igazi;
• nezitenxo kwezi wokugaya;
• ukudana;
• ukukhathala umkhuhlane;
• yombono;
• nengxaki yokumamela;
• myalgia;
• intlungu emva namalungu;
• nasopharyngitis;
• ukuba buthathaka iingcambu iinwele;
• ukurhawuzelelwa, kome kakhulu;
• ukukhohlela;
• ukubonakala dyspnea phantsi komthwalo.

Xa zidityaniswe unyango, "Ribavirin" yaye "interferon", abasabela ezibi zilandelayo ukuze kubonwe kwezinye iimeko:

• iingxaki nawenkumbulo umbono;
• ukulahleka kokufuma ngesikhumba;
• reflux;
• ukukhathala kuhlolwe esifubeni, emva;
• iingcambu iinwele amandla;
• ukudana;
• migraine;
• yombono;
• Mzoli, nokubonakaliswa wabugwala;
• nokuqunjelwa;
• ukukhohlwa;
• womise inwebu olunga- kwisisu ngomlomo;
• komzimba;
• ukuphelelwa umoya njengoko impendulo umzimba ukuba ntshikilelo.

reactions Ezingalunganga afumaneka ngokufuthi ixesha unyango "reviews sofosbuvir 'ziquka:

• ukwanda ucaphuka;
• fatigue njalo;
• ukuncitshiswa xi mpilo egazini;
• isicaphucaphu;
• intloko ebuhlungu;
• ukungalali;
• Amanqanaba aphezulu yibilirubin.

iziphumo ezibi Common zezi zilandelayo:

• nezitenxo kwezi wokugaya;
• amahlaba kwezihlunu kunye neentlungu kubo;
• igazi;
• ukuwa kweenwele;
• amalungelo inkqubo yokuphefumla;
• ukudana;
• ingqalelo yokudla;
• ukukhohlela;
• ukuphelelwa umoya, nto leyo impendulo umzimba ukuba ntshikilelo ngokomzimba;
• umkhuhlane;
• nokuthimliswa;
• yokuswela amandla;
• utshintsho zikwimeko eluswini;
• Abuzwa ngasemva kunye namalungu.

yonke Ixesha ukulungiselela lolwamkelo esikolweni "sofosbuvir" kufuneka ukuba uthathe indawo phantsi kweliso gqirha. Xa kungekho tyala akakwazi ngokuzimeleyo amisele kulungiselelwa elinikiweyo.

imithi

therapy Complex usebenzisa "sofosbuvir" kuthetha amanqaku iyakuvumela ukusetyenziswa kunokwenzeka ngaphezu umngcipheko okhoyo. Iingcali musa icebise unyango nalo eli chiza ngexesha elifanayo "Boceprevir 'okanye' telaprevir." Kukwasebenza kwanjalo kuyo ukuhlanganiswa ichiza kunye amayeza kuthathwa amanyathelo glycoprotein inducers olomeleleyo. Kuba iziyobisi kunye iipropati "Phenytoin", "Karbamatsepin". Kwezi asethi nga kuchongwa kwaye Wort St John kaThixo "Rifamycin". Ukukwazi ukudibanisa iziyobisi ezithile ezimiselwe gqirha.

oyi

Ikhosi ye unyango kufuneka yabelwe liyincutshe onamava. Kukho ubungozi komzimba, isifuba ibonakalisiwe, amehlo ebomvu, ukurhawuzelela zabo ukudumba, ukurhawuzelela, inwebu yangaphakathi, nokuthimliswa, angawokubhuda. Ezinye izigulane wawulahla ezingqondweni, mhlawumbi umothuko anaphylactic. Ukuba kukho Imiqondiso yokuba uxabane ufuna uncedo ugqirha xa kukho imfuneko - Ukulungiswa irejimeni yonyango, okanye ukupheliswa i "sofosbuvir" iziyobisi ngokubanzi.

"Sofosbuvir" analogue ze ichiza ayisetyenziselwa unyango izigulane abangaphantsi kweminyaka elishumi elinesibhozo, njengoko ukhuseleko le unyango asifumanekanga iqinisekiswa luphando.

Kuye kwaphawulwa ukuba izehlo reactions icala liphezulu izigulane abaminyaka yobudala eyi-35 eminyaka. Iqumrhu labantu abatsha olwamkele ngakumbi amayeza.

amalungiselelo ayimfuneko zikhethiwe igqirha kuthathelwa ingqalelo izinto ezininzi, kuquka izifo kweejini. Ngexesha unyango sohlobo kweejini yokuqala avumela indibanisela iziyobisi "Ledipasvir" yaye "sofosbuvir". Xa genotypes yesibini neyesithathu kunokwenzeka ukuba usebenzise "ribavirin" genotypes ekuqaleni okanye lesine - "ribavirin" ne "Interferon".

Uphononongo lubonise ukuba "sofosbuvir" kakuhle yokuphatha genotypes sifo 1-4. Kwiimeko ezininzi, ozinzisiweyo ngenxa impembelelo unyango kunye eli chiza xa kukho umntu hepatitis nje kuphela kodwa human immunodeficiency virus.

Ngexesha unyango, isigulane kufuneka lazise ethile ebomini babo. Awukwazi ukwenza imisebenzi enxulumene imfuneko ukubonisa ukuba nenkathalo engaphezulu yaye ukuphendula ngokukhawuleza ukuba kwenzeka ntoni.

Kuba abafazi abakhulelweyo umzimba idibanise ezingathandekiyo "sofosbuvir" + "ribavirin" + "Interferon".

Iindleko ichiza, ncomo, analogs "sofosbuvir"

Kubangel 'umdla ukwazi ukuba xa usebenzisa i "sofosbuvir" ixabiso nyango liya kuba phezulu kakhulu. Ichiza iyabiza, oko zingathengwa malunga 16-25 amawaka. Euro. Nangona ichiza ithathwa sisebenzayo ekulweni hepatitis ezisebenza C, kunokwenzeka ukuba akukho mntu ukunceda kuzo zonke iimeko, ngenxa yokuba umzimba nakanye ezahlukeneyo kwaye uziva ngokwahlukileyo iindlela ezahlukeneyo. Unyango kufuneka ndinyanyekelwe, ukhetho lwe ithamo efunekayo kufuneka wenziwe ugqirha, okuninzi kuxhomekeke ekufumanekeni yamava lobungcali unyango sohlobo "sofosbuvir".

Ngamanye amaxesha kufuneka 'sofosbuvir "replacement iziyobisi. Ukuphonononga lubonisa ukuba, ukuba unyango sohlobo C, nto leyo eye na ziphelisiwe kwinqanaba etsolo, indlela ugqirha anokuthi alungi-lungiswe, kuba nemiphumo efanayo. Phakathi nucleoside kunokwenzeka - "TSikloferon", "Ledipasvir", ". PegIntron" Ugqirha unakho ukumisela "Neovir" okanye "Algeron". Kuba unyango ingasetyenziswa "Ferrovir", "Daklatasvir". Kukho ababambeleyo ezifana "Rebetol", "Ingaron". Therapy angaba "EU reaferona", "Asunaprevirom" okanye "peginterferon". Ngokufuthi, oogqirha waguqukela "ribamidil", "Layfferona", "Altevira". A nomphumela ofanayo ifunyanwa ngenxa yokwamkela "Sovriada", "Pegasisa" "Meduna ribavirin." Ayikho indlela ephumelelayo kangako "Roferon A". Kukho nezinye iziyobisi amanyathelo efanayo - "Intron A," "ALFARON". Mhlawumbi ukusebenza konyango lwe-hepatitis B, ngokusekelwe nokusetyenziswa "Realdiron" okanye "Moliksana".

"Sofosbuvir" (eYiputa - ilizwe lokuzalwa kuthetha) - iyabiza ichiza, ngoko ufanele ulumke gqitha xa uthenga. Kubalulekile ukuba ahlawule ingqalelo angqina abantu abasele wathenga ichiza. Ngaloo ndlela akwazi ukwazi ukuba imiphumela kwenzeka qho kunye nokuba neziyobisi alwa kakuhle umsebenzi. Hayi nje Egypt ivelisa "sofosbuvir". India nayo yenza eli chiza.

Eli chiza liye kudlule nezilingo ezininzi lwezonyango. Ngenxa yoko ezintandathu ezinjalo iinkqubo imvume ichiza wenziwa ngokusekelwe iziphumo ezihle. Xa izifundo abantu 1947 inxaxheba, izigulane hepatitis C. Kuba isifundo abanyulwa abantu zange ngaphambili zanyangwa izifo zabo, izigulane isidumbu sakhe akaphenduli kuthomalaliso eyenziwa ngaphambili.

ukusebenza iziyobisi ukuba likwazi ukunyanga isifo kunye genotypes wokuqala ukuya kwelesine. Iziphumo ezincumisayo sele ifunyenwe ngenxa unyango izigulane zombini hepatitis B ne-HIV. Malunga nama-50-90% abantu ababandakanyekayo kuphando, nokubandezeleka kwesibindi B C, wabonakala impendulo virologic ngokuzinzileyo. Izigulane ezininzi kunye uhlobo ezingapheliyo sohlobo nosuleleko yi-HIV ngenxa yokuba ukusetyenziswa kweziyobisi wafumana isiphumo esifanayo. impendulo Virological egcinakeleyo kubonisiwe 76-92% yabantu abane coinfection.

Abantu abaninzi abaphethwe luhlobo chronic sohlobo B C, eshiya ingxelo, qaphela ukuba emva enkalweni ikhondo emiselweyo unyango imeko yabo babuyela esiqhelweni. Kwiinyanga ezintathu indibanisela unyango ezibonisa enqanda isibindi kuba yesiqhelo, emva ezintandathu kweenyanga esi sifo kukuba kunokwenzeka ukuba umlibale igazi le ntsholongwane ayikwazi ukuba andibhaqwa. Malunga iziphumo ebezingalindelekanga ngenkankulu okhankanywe, zisoloko minor: ukudinwa, ukudinwa. Nokuba ezibotshwayo, simele siqiniseke ukuba esi sifo akakabuyi.

Abanye abantu isifo ichiza kweejini yesibini kunceda ngenyanga nje enye, iziphumo zohlalutyo ezilungileyo, i-arhente causative sohlobo C egazini ayikwazi ukubonwa emva "sofosbuvir" iziyobisi unyango. iziyobisi Price kunokuba elikhulu, kodwa, efuna okuphilisa ulibale ngale sifo ekhathazayo, C hepatitis, abantu basengozini. miphumela idla qatha okanye eliphakathi okanye azikho kwaukubakho. Sekunjalo, ichiza kwenziwa ngcono phantsi kweliso nogqirha wakho. Akukho ingxelo embi, nto leyo ethetha ukuba xa ugqirha wakho emiselweyo amayeza ekunene ingqalelo kuzo zonke iinkalo omzimba wesigulane, impilo yakhe, ngaphandle ubukho Izimo, ngesiphumo unyango kufuneka libenesiphumo. Kubalulekile ukuqonda ukuba oyingcali abafanelekayo unyango sohlobo C isebenza kubaluleke kakhulu ukufumana iziphumo ezilungileyo bachache ngokupheleleyo. kweliso likagqirha esisigxina kaThixo, ukuthobela zonke iingcebiso kunye nokugcina ubomi obusempilweni ngokuqinisekileyo kuya kukhokelela ekubeni impilo engcono. Nokuba esi sifo asipheli ngempumelelo ngokupheleleyo, uya kuphucula uhlalutyo izikhombisi, nto leyo eza mfuneko kuba nempembelelo entle kwimpilo.