"Moxifloxacin": imiyalelo ukusetyenziswa, inkcazo, ukubunjwa

Le medicament "moxifloxacin" isiphumo amayeza eziza kuxoxwa koku, libhekisela kwiqela quinolones. Isixhobo uba bactericidal, isiphumo antibacterial. Emva koko, siza kuxubusha yintoni eyenza amayeza "moxifloxacin". Imiyalelo yokusebenzisa, analogue ziya kwakhona aboniswe kweli nqaku.

ukusebenza

Njani na i-arhente esebenzayo "moxifloxacin"? Inkcazelo ichiza kufuneka uqale inkcazelo indlela yegalelo laso phezu iintsholongwane. ukusebenza Bactericidal lithetha ezinxulumene inhibition (ingcinezelo) of IV topoisomerase ziibhakteriya kunye II. Oku kukhokelela uqhushululu kwiinkqubo phindana ukhutshelo, ukulungiswa DNA biosynthesis iiseli abe nenkani. Ngenxa yoko, kuza intshabalalo yabo. Medicament "moxifloxacin" yemiyalezo ichaza njengoko a zintsholongwane olubanzi.

ukumelana

Kwi umsebenzi antibacterial iziyobisi "moxifloxacin" musa kuchaphazela iindlela bandiqumbisayo kwinkcaso tetracyclines, macrolides, aminoglycosides, cephalosporins kunye penicillins. It zingaphawulwa kakuhle kwaye isiphumo lomnqamlezo-ukuxhathisa. De kube ngoku, amatyala uzinzo plasma azizange zichongwe. Uxhathiso kwichiza "moxifloxacin" ekuphuhliseni kakhulu ngokucotha ukuguquka ezininzi.

uluhlu yomsebenzi

Lithetha "moxifloxacin (umyalelo manual - proof) kuchaphazela Ngeentlobo ezininzi iintsholongwane Igram-akhabayo kunye navumelanayo-Igram, iintsholongwane esiti-fast, anaerobes, iintsholongwane Nedlac (mycoplasma, chlamydia, njalo njalo), kunye neebhaktiriya abanganyangekiyo macrolide beta-lactam amachiza isibulala-zintsholongwane .

sokufunxa

Xa efumene ukufunxeka ngomlomo beziyobisi "moxifloxacin" olukhawulezayo phantse ngokupheleleyo. bioavailability Absolute xa ehanjiswa yegazi nokusebenzisa nezibilini - zomyalelo 91%. Xa ufakwe ngomlomo (50-1200 mg idosi, 600 mg / ngosuku iintsuku 10) pharmacokinetics linear olufanelekileyo lwechiza. Le xi amakhulu 400 mg baphawula emva kweeyure 0.5-4. Xa isicelo esisodwa ngokutya ukufikelela ukwanda kwithuba ubude Cmax (iiyure ezimbini) kunye nokunciphisa yayo nge-16%. Ngoko Ubude Ukunciphisa kuhlala ingatshintshanga. Kunjalo, ezi data musa anexabiso bezonyango evumela ukusetyenziswa ichiza "moxifloxacin", kungakhathaliseki ukuba ukutya. Emva nokubandakanywa enye efakwa ka 400 mg ukuze xi iyure iphezulu kwenzeka ekupheleni ukumnika.

ukwabiwa

Kwiintsuku ezintathu isicelo ifikelele kuvuselele. Ukubambana kwiiproteni plasma - malunga ne-45%. Uphawula distribution ngokufanelekileyo ngokukhawuleza i "moxifloxacin" amalungu iziyobisi kunye namalaphu. Aphezulu kakhulu zinto inwebu wemiphunga yangaphakathi bronchi, isikhumba kunye ongama izakhiwo, sinuses, nakujoliso olutsha arhabaxa. Amathe kunye medicament Embi incindi ifunyanwa iiproteni engadityaniswanga, uhlobo free. Ayithandi iphezulu ngaphezu plasma. Kunye nalo eli chiza ifumaneka izixa ezikhulu kwizigqeba izicwili peritoneum ababhinqileyo amalungu obuni kwaye kulwelo peritoneal.

lokugaya

Medicine "moxifloxacin" (inkcazo ichiza kwi data ukuvula liquka ulwazi) eyipasile isigaba biotransformation yesibini. inkqubo kukhuthaza ukusebenza sezintso nakumathumbu kutshintsha ngohlobo iikhompawundi sulpho kunye glucuronide engasebenziyo. Le metabolites afumaneka plasma. ingqalelo ngaphantsi kunolo compound yokuqala. Uphononongo lubonise ukuba ezi mveliso ukuthotywa musa nefuthe elibi emzimbeni.

Lithetha "moxifloxacin", oko kumiselwe kulo?

Ichiza Kucetyiswa ukuba ezimbi ezosulelayo ukudumba abadala kwavusa amagciwane ukuba ubuntununtunu kuso. Ngokukodwa, ukufundwa kugqabaza exacerbation lokuhamba kwemigudu yomoya, sinusitis etsolo, ufumene yoluntu-pneumonia (ezibangelwa iintlobo iintsholongwane bembonisa uxhathiso ezininzi in t. H. The olwa). Lithetha "moxifloxacin" imiyalelo zokusetyenziswa olucetyiswayo lwezifo yezihlunu ezithambileyo kunye ulusu, izakhiwo ongama nzima amanxeba (abosulelwe unyawo seswekile kwakunye), kunye nosulelo intra-esiswini (iinkqubo polymorphic, amathumba intraperitoneal njalo njalo). Yabelwa xa medicament evela iStreptococcus pneumoniae ukumelana elwa ezininzi, kuquka ubukho ezimelene nemithi penicillin, amaqela amabini okanye ngaphezulu iziyobisi sesibini isizukulwana cephalosporins, macrolides, tetracyclines. Izenzo ezibonisa zikwaquka amanxeba ukudumba kwi amalungu zangasese uhlobo gingxi. Xa endometritis kunye salpingitis ziyakhuthazwa ukuba siqwalasele indlela (njengoko kubonisiwe yi eqhotyoshelwe ichiza imiyalelo 'moxifloxacin "ukusetyenziswa). wamehlo esimiselweyo conjunctivitis ziibhakteriya, wamqumbisa amagciwane ingqalelo medicament. Kuyimfuneko ukuba uthathe ingqalelo unyango ekhoyo yobunkokheli ezimbi esosulelayo.

Medicament "moxifloxacin": oyidlayo kunye nendlela wolawulo

Iimali ezinyuliweyo izibilini (ngomlomo) kunye yegazi. . Ubude imithi medicament "moxifloxacin", esithathwa apho - 400 mg / imihla, kuxhomekeke kuhlobo sifo namandla aso, kwakunye neziphumo zonyango lathi:

• Exacerbation ke kwemithambo - iintsuku 5-10.
• iintsuku 7-14 therapy ezilandelanayo (efakwa kulandele ukusebenzisa ngomlomo) - inyumoniya ezifunyenwe-Community.
• kwizihlunu ezithambileyo, isikhumba (nokunga), kunye sinusitis etsolo - kwiintsuku ezisi-7.
• Xa izifo intra-esiswini (nzima) - iintsuku 5-14 unyango yokulandelelana.
• Xa nzima izilonda nezakhiwo ongama ulusu - iintsuku 7-21.
• Xa ezimbi yokukrala amalungu zangasese - iintsuku ezili-14.

Ukuze ufumane inkcazelo engakumbi, liqulathe iqhotyoshelwe ichiza "moxifloxacin" umyalelo manual. Iipilisi kufuneka kungavunyelwa ukuba idle. Hlamba phantsi ngamanzi kuyimfuneko umthamo omncinci.

ukusebenzisa yendawo

Medicine "moxifloxacin" (amathontsi) linokwenziwa kwizigulana ngonyaka. Practice ibonisa ukuba ukuphucuka ngomhla wesihlanu. Emva koko kufuneka uqhubeke unyango imihla 2-3. Izigulane emehlweni ochaphazelekayo wafaka ukuhla kathathu ngemini. Ukuba akukho isiphumo iintsuku ezintlanu ndikuvuse umbuzo ukuchaneka unyango okanye isifo. Ubude unyango ixhomekeke ikhosi bacteriological kwaye zekliniki ebukhulwini ngezifo.

Olunye for isisombululo nokubandakanywa

Medicament "moxifloxacin" umyalelo manual lithethelela ukuba zingenele i iyure. Ichiza Kanjalo ukuba ingaphithikezwanga okanye uhlobo olufakwe. Isisombululo iyahambisana sodium chloride 0.9%, amanzi inaliti, isisombululo dextrose kwi iqela-10% ne-40%, 20% xylitol, "Iringa". Sebenzisa izinto ezingamanzi nje ngokucacileyo. Emva ukuxutywa le medicament kuhlala likriwa iintsuku lobushushu igumbi. Akufuneki zigcinwe indlela efrijini. Ukuba ukumnika ezikhutshwayo ilawulwa kunye nezinye ii-arhente, nganye lulungiselelwayo ngokwahlukeneyo.

imiphumela emibi

Ngenxa amayeza unyango "moxifloxacin" kusenokwenzeka ukuba wehlelwa zizifo fungal, leukopenia, igazi, thrombocytopenia. Kwezinye iimeko, uthomalaliso kukho ukwanda kwexesha prothrombin, thromboplastin lamanani tshintsha. Kwezinye izigulane ichiza kungabangela negazi, nokudumba laryngeal, urticaria, Njengokungeniswa anaphylactic, pruritus, eosinophilia, angawokubhuda. Kwiimeko ezinqabe kakhulu, kukho hyperglycemia, hyperlipidemia, hyperuricemia. Xa unyango ukuphazamiseka kwengqondo kunokwenzeka. Ngokukodwa, izigulane zinokuba ukungahlaliseki, ixhala, ukudakumba, depersonalization, nemibono, reactions ngengqondo, kunye neengcinga zokuzibulala. Iziphumo ebezingalindelekanga Common ziquka yintloko, isiyezi, iingcangcazela, ukozela, ukudideka, ukuphazamiseka incasa onovakalelo, ukuphazamiseka kokulala, nokudideka. Kwezinye iimeko, ngexesha unyango kunye namayeza kunokulungiswa ulungelelwaniso, ukuxhuzula, ephelekwa ibonwa lwezonyango, hypoesthesia, ukuphazamiseka ingqondo ivumba. A Inani lezigulane waba mandundu intetho, ingqalelo, peripheral neuropathy, kunesifo, polyneuropathy. Xa isetyenziswa ngokwemixholo, umbono inokuba mbi nangakumbi de ilahleko yayo. Nangona kunjalo, indlela yokugqibela ithathwa ukuba imeko idlule.

Impembelelo kwi nemithambo yegazi

Inxalenye impembelelo isicelo beziyobisi "moxifloxacin" le isongezo QT-lokuphumla izigulane hypokalemia, iyangongoza, vasodilation, tachycardia. Iziphumo ebezingalindelekanga ezinqabileyo ziquka lwegazi kunye hypotension, tachyarrhythmias ventricular, syncope. kunqabile kakhulu waphawula zokuma. Last kakhulu okufana abantu kubuphepha ischemia etsolo, bradycardia (ngokwezonyango ezibalulekileyo).

Impembelelo nezinye iinkqubo kunye namaziko

Kwezinye iimeko, ichiza kunokubangela ukuphelelwa umoya, kuquka imeko somoya. A Inani lezigulane babonakala ukuphazamiseka kwi lokugaya. Ngokukodwa, kwimvelaphi unyango-emergent isicaphucaphu, ukugabha, urhudo, iintlungu esiswini. Bambalwa iziphumo ebezingalindelekanga zithathwa imnyama, ukuqunjelwa, flatulence, gastroenteritis (ngaphandle ilunga), ukuqhina kwesisu. Ezinye izigulane ziye zachongwa stomatitis, dysphagia, wenze pseudomembranous. Uthomalaliso mhlawumbi liya kwandisa transaminases, kwekhono hepatic, uphuhliso sohlobo fulminant, ukusilela hepatic ekhokelela ezisongela ubomi. Kakhulu ngamaxesha bephawula ukusabela cutaneous bullous (ityhefu epidermal necrolysis, Stevens-Johnson syndrome). Ezinye izigulane abanamava myalgia, arthralgia, unditsho, ukwanda kwezihlunu, tendonitis, buthathaka kwezihlunu. ugqabhuka imicu kunokwenzeka kwiimeko ezinqabileyo, samathambo, iqinelwa ukuphazamiseka ngenxa yomonakalo kwinkqubo musculoskeletal. Izigulane on unyango ngamayeza unokuba neengxaki ebona kwenkqubo womchamo. Ngokukodwa, ephawulwe emzimbeni (bawuphikisa lurhudo okanye ukwehla kule umqulu engamanzi osetyenzisiweyo), kwekhono sezintso, insufficiency. Iziphumo ebezingalindelekanga Common ziquka ukubila, iintlungu nonspecific, umkhuhlane. Xa lo thrombophlebitis efakwa okanye phlebitis.

Ngubani na eyabelwe indlela?

Xa amayeza "moxifloxacin" Izimo zezi zilandelayo:

• Imicu ngezifo embalini ezithe savela ngenxa yeqela unyango quinolone antibiotics.
• Ukufumaneka elongate QT-kwithuba lokuphumla (iziphene okanye lufundiwe).
• ukuphazamiseka Electrolyte (ingakumbi hypokalemia unqandayo).
• Bradycardia (ngokwezonyango ezibalulekileyo).
• ukusilela Heart ne umsebenzi ejection reduced ventricle ekhohlo.
• Ukunyhashwa Intliziyo isingqisho (kwimbali).

Xa ukunyamezelana lactose, iswekile-galactose malabsorption, yelactose ngxaki nayo akucetyiswa medicament "moxifloxacin" (composition iziyobisi iquka lactose, ngoko ke ezimbi zikhankanywe zifakiwe kuluhlu). Not abelwe uthetha okhulelweyo okanye phindeke. Iipilisi kunye nesisombululo lavunyelwa ukuba izigulane kuyo kwiminyaka eli-18 ubudala. iziyobisi kuphakanyisiwe kwimeko hypersensitivity ukuya amacandelo.

iimeko ezizodwa

Isilumkiso kuyafuneka ukuqeshwa ichiza kwizigulana abanala makhwiniba luvo central ezibabeka kuphuhliso ukuxhuzula. Iqela umngcipheko ibandakanya izigulane States proarrhythmic. Ezi ziquka, ingakumbi, iquka ischemia etsolo, ingakumbi abadala kunye nabasetyhini. Kwakhona ukubona isilumkiso xa izigulane zesibindi ukuqina. hlengahlengiso idosi kufuneka ngexesha unyango kuthetha odityanelweyo yandisa uyondelelwano lwee- potassium.

Ukuze ufumane inkcazelo engakumbi,

Practice ibonisa ukuba ichiza ukunyamezeleka kakuhle izigulane ezininzi. Iingcali badla amisele isixhobo izilonda esosulelayo. Oku kubangelwa yinto yokuba chiza a ukusebenza ophezulu iintsholongwane ezininzi. Noko ke, kusoloko kukho ingozi yokuba ziziphumo ebezingalindelekanga, ezifakwe kunye imveliso ulumkisa "moxifloxacin" umyalelo manual. Analogs beziyobisi xa kukho imfuneko kufuneka sithathe ugqirha ngabanye. Faka isixhobo okunjalo mithi: "Avelox", "Vigamoks", "Rotomoks", "Moksifur", "Moksin" kunye nabanye. Xa imiphumela emibi, ukonakala kweendlela isahlakalo esibukhali kwaye iimpawu ayichazwa kwisishwankathelo, kufuneka ufune unyango ngoko nangoko. Xa usebenzisa amathontsi kufuneka musa ukudibanisa imali ngokugqithiseleyo emehlweni ichiza kaThixo. Ukuba oku kuyenzeka, kufuneka ngokukhawuleza kangangoko kunokwenzeka namanzi amaninzi. Kwimeko ukwandiswa libanda yeziphumo ebezingalindelekanga.

Ekuphetheni

Ichiza "moxifloxacin 'ingqalelo antibacterial ngokwaneleyo esinamandla. Ngokuphathelele oku kakhulu ayikhuthazwa ukuba aphule ummiselo kagqirha. Ngokukodwa, kumayelana inani namatyeli ongathathi yesicelo. Musa ngaphezulu oyidlayo. Inaliti efakwa kufuneka yenziwe kwisifundo ekhethekileyo yi intonga lilungu abaqeqeshiweyo abaza kukwazi ukunceda xa kuyimfuneko. akufanele yini self-medicate. Xa kungekho iziphumo unyango kuyimfuneko ukubona ugqirha. ngaphambi nje ukusebenzisa iziyobisi "moxifloxacin" kufuneka ufunde ngenyameko imiyalelo.