Beta-blocker

Beta-blocker zisetyenziswa iziyobisi umfutho ukususela gqira ekuqaleni. Ekubeni ekufumanekeni kweziphumo lokuqala unyango kunye nomhla ngempumelelo yabo zibhalwe kakuhle kwizifundo eliqela ilawulwa, kwakunye xa kuthelekiswa ne nefuthe ngakumbi iindlela zale mihla.

Beta-blocker zisetyenziswa ngempumelelo ukuya kwabancinane uxinzelelo lwegazi ze iyaluthintela uphuhliso isifo sentliziyo kunye nokufa. Indlela isenzo sabo umfutho isekelwe phezu ukuncipha imveliso kwentliziyo ngenxa ukuncipha kwamandla kunye ukwenzeka kwesibeleko. Ukongeza, beta-blocker negalelo kwezithandani of secretion of renin kwi juxtaglomerular (okoloklubochkovom) izixhobo wezintso kwaye kulo mba, ukuba ngempumelelo ukucinezela umsebenzi lo renin-angiotenzinaldosteronovoy kunye neenkqubo vasomotor central.

ukusebenzisa kwabo elide kungabangela ukuncipha lovukelo semithambo (total peripheral), ngenxa yokwanda uvakalelo baroreceptor kunye nemveliso eludongeni nemithambo of prostacyclin (prostaglandin vasodilating).

Various beta-blocker ezisetyenziswa ngeedosi ezilinganayo, kuba nemiphumo efanayo iqinile. ngokupheleleyo umfutho iphuhlise kwisithuba seeveki ezimbini ukuya kwezine. "Ukurhoxiswa" syndrome zingenzeka ngokuchasene nentsukaphi kunyango ixesha elide. Ukuvimbela yayo ichiza na wayeka ngoko nangoko, yaye ngokuthe ngcembe ukunciphisa ithamo iintsuku ezilishumi elinesine.

sesichengeni Systemic nemithi, ingakumbi non-uyakhetha, kungabangela uphuhliso yeziphumo ngokwezonyango ebalulekileyo ezesifuba noncardiac icala.

Iqela lokuqala luquka ukuphazamiseka ngasemva ngokwasengqondweni-ngokweemvakalelo (ukudakumba, zokulala, njalo-njalo), iimpawu nokuphefumla (bronchospasm), vasoconstriction neuropathy (claudication ngakanye, kwiziphelo ezibandayo, njalo-njalo), buthathaka kwezihlunu, induku. ziphumo bezingalindelekanga Extracardiac zimele kuphazamisane umsebenzi sezintso okubangelwa igazi flow reduced kidney, nobunzima lipid kunye ekudleni ukutya.

Obubonakala wentliziyo libandakanya:

• umsebenzi lokumpompa yokophula kwentliziyo sihambisana iimpawu ze intswelo;
• ukuvimba (sinoatrialnaya atrioventricular) intliziyo kunye bradycardia;
• hypotension nxamnye ukuncipha ngokugqithisileyo wegazi;
• ukusebenza antiarrhythmic.

Kufuneka kuqatshelwe ukuba iindidi zeepropati amayeza blocker ikuvumela ukuba ukhethe ichiza eliphezulu phantse onke amatyala. Oku kufuna ingqalelo kunye tolerability yonyango, umngcipheko lisezantsi iziganeko ezibi, ubude sesichengeni kunye nohlobo meko onyango.

Ukuqeshwa beta-blocker njengoko kwanonyango kuphela kuvumela ukuba kuqheleke wegazi malunga 40-50% ezigulane kunye lwegazi. Xa kuthelekiswa ifuthe izigulane ebudaleni entsha, oluphakathi kunye nangaphezulu, isiphumo lisezantsi noko xa abadala. Ukusetyenziswa womchamo thiazide ezidityaniswe kunye beta-blocker akubikho umahluko. Ngenxa yoko, ukusebenza unyango idibanise enjalo kwandisa ukuya 78-80%.

Beta-blocker ukuba ukunyanga angina beshumayela indawo ekhethekileyo. Kule sifo, loo machiza asetyenziswa njengoko Anaprillin (obzidan), Sotalol, Atenolol, Konkor, Monotard.

Isiphumo zonke ezi amachiza ezijolise ekunciphiseni uxinzelelo lwegazi kunye "deceleration" izinga intliziyo. Esithathwa lwaso nasiphi na isiyobisi kufuneka zikhethwe gqirha kuphela ngamnye.

Imithi contraindicated somoya, izifo ezondeleyo pulmonary obstructive, ibhloko atrioventricular yesibini okanye isidanga wesithathu. Akucetyiswa ukusetyenziswa beta-blocker in kakuhle glucose ukunyamezelana, isifo esimbaxa peripheral, abadlali kunye nabantu besempilweni.