"Clopidogrel": analogue, ukusetyenziswa, manual, ixabiso

Kwezinye iimeko, oogqirha ukumisela amayeza "Clopidogrel"? Imiyalelo yokusebenzisa, analogs, ifom ukukhululwa, ukwakheka, iziphumo ebezingalindelekanga kunye izinto ezibonisa ukuba ukusetyenziswa kwale amayeza kuya kwenziwa ngokweenkcukacha kweli nqaku. Ukongeza, uya kufunda ixabiso uluvo kweziyobisi kunye nezigulane malunga nayo.

ifomu Release komsindo

ungathenga ichiza "Clopidogrel" Ngayiphi indlela? Guide ingxelo ukuba ichiza yakhululwa ngohlobo tablets, apho isale yayisoma film. Xa blister enye iqulethe iziqwenga-14, ebhankini - 14 okanye 28, cardboard bundle - iipleyiti 1 okanye 2 ngamayeza. Eyona nto iphambili esebenzayo i clopidogrel ifomu hydrogen sulphate kwi. Awona macandelo abancedisayo eziqulethwe kuqulunqo iziyobisi ziquka lactose anhydrous, nemagnesium stearate, starch pregelatinized, ioli kukaCastor hydrogenated, polyethylene ethers 6000 kunye microcrystalline kwincindi. ngeso lenyama bhanyabhanya, leyo camera tablet equka titanium dioxide, hypromellose, aluminiyam lacquer (ngokususela idayi Ponceau 4 R), kunye polyethylene ethers 400 no-6000 kusetyenziswa medicament 'Clopidogrel' (ixabiso iya aboniswe ngezantsi) nge kubekho udederhu drugstores, kodwa kuphela xa kukho imithi.

iimpawu kwemithi

Kunyango ngamachiza, kunciphise zegazi udibaniso eyabangelwa ngamanye agonists. Ibambela amayeza "Clopidogrel" (imiyalelo ukusetyenziswa, ixabiso, ncomo, kunye nabanye ingcaciso eluncedo ziyafumaneka kwi website zonyango ezininzi thaca kwiphepha) iiyure ezimbini, akhawunti ngempumelelo enkulu iintsuku 4-7 phantsi imeko wokwamkelwa 50-100 mg ngosuku. ukusebenza Antiplatelet ihlala phakathi kweentsuku ezisi-7 ukuya kwezili-10 kulo lonke ixesha lobomi zegazi.

Pharmacokinetics

Emva ulawulo ngomlomo beziyobisi "Clopidogrel" (75 mg - idosi standard) ako ngokukhawuleza ukusuka phecana zesisu, kunye ingqalelo kwinxalenye ulwelo yegazi linyuke kancinane, kodwa emva kweeyure ezi-2 efika kwinqanaba apho kumiselwa (0.025 g / L).

It awulungelelananga umzimba sisibindi. Le metabolite Eyona nto ithe engasebenziyo of a carboxylic acid (malunga nama-85% ukususela izinto elijikeleza plasma). I-avareji xi liphezulu emva kokusetyenziswa ngokuphindaphindiweyo "clopidogrel" yi-3 mg / l, oku kungabonakala iyure enye emva kokungenisa.

into esebenzayo kunye metabolite lisenza ebotshiwe kwiiproteni plasma. Unxibelelwano uhlala anganeliseki.

Emva Ulawulo ngomlomo "clopidogrel" 14C-enombhalo phantse isiqingatha iidosi uvela ukuchama, malunga nowama-46% - ituwa iiyure 120. T1 / 2 metabolite eziphambili - Iiyure ezi-8.

Ukwanda metabolite izihlandlo ezininzi izigulane emva kokuba engama-75 ubudala, oku akuthethi ukutshintsha zegazi udibaniso kunye nexesha owophayo.

I-plasma yegazi yilahleko kidney xi le metabolite uvela ml-5 ukuya kowe-15 / min, kanti xa ubuzaza isifo avareji lwalo 30-60. Ngaphandle kwento yokuba ifuthe inhibitory kwizigulane kunye adenosine diphosphate - eyabangelwa zegazi udibaniso lancipha, eli nani lenyuswa laya ukopha xesha, ngokunjalo lamavolontiye asempilweni.

ubungqina

Ngaba uyazi, apho iinjongo ugqirha emiselweyo imithi ukuba izigulane 'Clopidogrel "? Analogs, waza wamisela medicament ngenxa ekuthinteleni ingxaki thrombotic of stroke kobuchopho, iposi engabalulekanga neuropathy isifo wegazi occlusive. unyango ngaxeshanye kunye acetylsalicylic acid kunye "clopidogrel" njengoko kuboniswe yokuthintela iingxaki thrombotic, nto leyo ibe ngunobangela ahlekise coronary syndrome.

Izimo

'Clopidogrel' (ixabiso ezikhemisti kummandla eMoscow imalunga 510 engange) ukuba bafake sibali ne:

• hypersensitivity;
• ukopha;
• syndrome haemorrhagic ;
• lomonakalo hepatic yayinzima;
• ukuchithwa pathology intracranial kwaye predisposing kuphuhliso ukopha (ithumba lung, exacerbation of isilonda Peptic, hyperfibrinolysis, isifo sephepha);
• intswelo lactose (ukuba iifom idosi equlethe iswekile milk), ilifa galactose ukunganyamezelani, malabsorption syndrome iswekile-galactose.

"Clopidogrel": nokusebenzisa balawule

Amacwecwe ngokwemiyalelo, ingahoywa nokuba izidlo. Yokuthintela iziganeko thrombotic kwizigulane kunye ngesibetho kobuchopho okanye iposi engabalulekanga, amagqirha ukumisela yonke imihla "Clopidogrel" 75 mg. Xa isifo etsolo, nto leyo ibangelwa uphuhliso necrosis yinqontsonqa kobuchopho kwemisipha intliziyo, unyango kufuneka ziqalwe kwi kwiintsuku zokuqala. therapy nokusetyenziswa "Clopidogrel" - elingekho ngaphezulu kweentsuku ezingama-35. Izigulane ekutyhwakrazeni kobuchopho ingathatha eli yeza iinyanga ezintandathu. Xa iingxaki thrombotic evela phakathi ACS ngaphandle kushenxiswe ST ceke, unyango eqalwe kunye nabo bafumana ezilahlwayo ukulayisha idosi (300 mg), ngakumbi oku ukuthatha ipilisi ngaphezu kwesinye ngosuku. ngempumelelo enkulu emsebenzini emva kweenyanga ezintathu. Ubude unyango kunye 'Clopidogrel' (analogs kunye generics thaca ngezantsi) akufuneki ngaphezu konyaka omnye. Ngokuchasene imvelaphi ahlekise coronary syndrome kunye ST ingxenye umphakamo rhoqo emiselweyo 75 mg beziyobisi kwi yonke imihla kunye okokuqala ukusetyenziswa ngexesha elinye-of a ukulayisha esithathwa xa zidityaniswe ne-arhente thrombolytic kunye acetylsalicylic acid. Xa kuvela iimpawu, kufuneka uye nothomalaliso udibaniso. Izigulane abangaphezulu kweminyaka 75 unyango inikwa ngaphandle ukulayisha idosi.

libanda

Kulandela ichiza ngeedosi kunene ekucetyiswa, kungqinwa ngokwanda ukopha ixesha kunye nezigulo ezilandelayo. Kwiimeko ezinjalo, uya kufuneka unyango olufanelekileyo. Kwimeko xa udinga ekhawulezayo ukulungiswa kwexesha ukopha, udinga ukutofelwa TM. Akukho iyeza ngqo.

Unxibelelwano namanye amachiza

ukwamkelwa ngaxeshanye "clopidogrel" kunye neziphumo warfarin ekwandeni kwireyithi nokopha, nto leyo esisizathu sokuba olu dibaniso ayinqweneleki kakhulu. Oku kwandisa amathuba ukopha kwaye unyango isiyobisi kunye amachiza nonsteroidal anti-ukudumba, aspirin, glycoprotein inhibitors kunye lweeHedfowuni.

imiphumela emibi

Treatment medicament 'Clopidogrel' (umsebenzisi, ixabiso, indlela yolawulo idosi zichaziwe ngokucacileyo kule material) kunokukhokelela nemiphumo engathandekiyo;

• inkqubo Blood coagulation: ngethuba ngenyanga yokuqala unyango kuvele legazi, kuvela hematomas; ubuncinane - ukopha elidibeneyo; amatyala ezikude - ukopha intracranial.
• inkqubo hematopoietic: kwiimeko ezinqabileyo - purpura thrombotic thrombocytopenic, granulocytopenia, ianemia, kuquka pancytopenia, kunye nezinye aplastic.
• luvo: kuvela wambi intloko ebuhlungu, paresthesia, isiyezi; ezinqabileyo - vertigo; amatyala ezikude - ukudideka kwengqondo kunye nemibono.
• imithambo yegazi entliziyweni, badla ukuyilwa hematoma; ngamanye amaxesha abe severe, vasculitis, bewuhlisele uxinzelelo lwegazi.
• isixokelelwano sokuphefumla: epistaxis, bronchospasm, Ukopha yemiphunga, pneumonitis Embi, hemoptysis.
• wokugaya: urhudo, ukuqunjelwa, iintlungu esiswini, ukopha evela wokugaya, gastritis kunye isilonda esiswini, ukugabha, flatulence, isicaphucaphu, ukuqhina, ukopha retroperitoneal, ukudumba, pancreatitis, stomatitis, sisibindi, hepatitis, ukwanda enzyme zesibindi.
• inkqubo Musculoskeletal: arthralgia, myalgia, samathambo.
• Ulusu: bullous irhashalala (Stevens-Johnson syndrome yaye ityhefu epidermal necrolysis, erythema multiforme), nangokhwekhwe, amaqhakuvana erythematous, kunye planus ulele.
• System wokuchama: hematuria, hypercreatininemia, glomerulonephritis.
• ziyabagulisa: nokudumba angioneurotic, ukugula serum, urticaria, pseudoallergy reaction.

Xa therapy nale yicesina ichiza kunqabile waphawula, nto leyo waqonda ngenxa yokufumana medicament, kwaye iliphawu nengqele eqhelekileyo.

oyi

Medicine "Clopidogrel" ngononophelo kakhulu xa uthatha Amathuba aphezulu ukopha ngenxa yokungenelela zotyando, ukuphazamiseka hemostatic. Ukuba kufuneka etyandiwe, nesiphumo antiplatelet ayinqweneleki kakhulu ukusuka kulawulo ichiza kufuneka zilahlwe kuba kwiveki phambi kwexesha elimisiweyo uqhaqho. amayeza ngokukhethekileyo ezimiselweyo okunzima umsebenzi kwesibindi, esinokubangela ukopha diathesis. Ukuba iimpawu ukopha kakhulu kufuneka bafunde inkqubo hemostatic. Ukongeza, imfuneko yokuba kubekwe iliso rhoqo ukusebenza umsebenzi olusebenzayo esibindini. Isilumkiso "Clopidogrel" lisetyenziswa kunye lweeHedfowuni, NSAIDs, warfarin. Xa uqhuba izifundo zovavanyo andafumana isiphumo umhlaza kunye ezinetyhefu beziyobisi, ukongeza, musa ukubeka ukuchaphazeleka amandla nolawulo lwezithuthi.

"Clopidogrel": analogs kunye generics

Izithethantonye (analogs) iziyobisi - iyeza kokuba intshukumo enye okanye nokwakheka efanayo. Ziziphi amayeza endaweni amayeza "Clopidogrel"? Analogs nokulungiswa into esebenzayo ezi zilandelayo: "Kardutol", "Detromb", "Agregal", "Trombeks", "Klopilet" "Trocken", "Plavix", "Plagril", "Plogrel", "Targetek", "Egitromb" "Clopidogrel Teva,".

ichiza ngamnye uneempawu ezahlukeneyo, ngoko ukusetyenziswa kuvumelekile kuphela emva kothetha-thethwano kunye nogqirha wakho.

Imibono malunga nemithi

Yintoni abantu bathi ngayo ukulungiselela ezifana 'Clopidogrel'? Izimvo lezigulane baba nethuba ukudlulisela kwizigulo ezimandundu kunye namanyathelo zotyando esihle kakhulu. Izigulane ingxelo isenzo eliphezulu eyiyo medicament, oko kodwa ezingenzelwanga ukuba reception ukuze self-amayeza. Analogue amayeza ukunceda izigulane ukhethe ukhetho ilungileyo phakathi kwabo lomlinganiselo ixabiso nomgangatho, kodwa injongo nokusebenza kakuhle kolawulo kufuneka ephathiswe liyincutshe onamava.