Iziyobisi for migraine - triptans. Nomthamo kunye neempawu amanyathelo

Migraine - le sesinye sezifo kwemininzi eqhelekileyo, nto leyo ukunciphisa ukusebenza izigulane ezininzi. Esi sifo sichaphazela malunga ne-6% yamadoda ne-18% abasetyhini. La manani kakhulu phezulu. Nakuba kunjalo, ama-60% abantu abaphethwe kwesi sifo, ngokuzimeleyo uthathe analgesics ezahlukeneyo intlungu. Njengomgaqo, izenzo ezinjalo mandundu kuphela ikhondo sifo.

Yithi akukho analgesics

Abantu abaninzi abaphethwe uqaqanjelwa, asazi ukuba ayeke ngayo uhlaselo, yaye emva kwexesha ukuthatha ntlungu. Ukususela kule nomphumela unyango incinci kakhulu. Okanye ngaba kukudala. Oku kubangela ukuba isigulana iqala kancinci ukwandisa umthamo iyeza. Ngenxa yeso senzo kwandisa kuphela ingozi nomonakalo wezintso, ukuphuhliswa gastritis. Kwezinye iimeko, analgesics inani kungakhokelela kubunzima ezimandundu - ukuvela yintloko-uqhutyelwe iziyobisi.

Kungenxa yoko le nto ukuba unazo naziphi na iimpawu migraine kufuneka zithetha kwiingcali. Self-amayeza kulo mzekelo, zingangunobangela kuphela imeko yesigulane. Ngenkulungwane ye-19 ngasekupheleni iqela elitsha ngokupheleleyo yadalwa iziyobisi antimigraine - agonists uyakhetha ka 5 NT 18 / D-receptor. Ezi zinto yezabelo ka-gidroksitritamina 5. Anegama igama labo - triptanity. Iziyobisi for migraine esi sizukulwana kakhulu kakuhle ngaphezu analgesics eziqhelekileyo. Ukongeza, ezi zixhobo zibe zifikeleleka ngakumbi kuzo zonke iindidi izigulane.

Njani iziyobisi

Triptans - unyango eziphuhlileyo esi sifo mnandi, migraine. Kukholelwa ukuba onke la machiza asebenza ngendlela efanayo. Noko ke, elinye isigulane kunceda nje ezimbalwa inani elikhulu triptans. Ngoko ke, lo ukhetho lokugqibela le mveliso ihlala kuphela isigulane. Ukuze ukujonga ukusebenza a triptane othile, kuyimfuneko ukuhlola amachiza ngexesha yokuhlaselwa migraine. Ubuncinane ezintathu kubo mabaye. Ukuba ichiza uye wanceda, inokusetyenziswa kwixesha elizayo. Kakade ke, lo ukhetho zingachaphazela kakhulu ixabiso le a triptan. Ngapha koko, la machiza eqolo. Ukongeza, uqulungqo ngamnye nemiphumo ethile iintlungu. Ukongezelela, kubalulekile ukwazi ukuba yintoni na ezi triptans ukuba migraine, inyathelo inkalo, iindlela ulwamkelo kunye Izimo.

Kuqala kwinto zonke, loo mithi anefuthe emithanjeni receptor. ngenxa yenza valiweyo imithambo yegazi inimba yobuchopho, kwakunye inceda ukwehlisa yintloko.

Ezo amalungiselelo abe selectivity sezingeni eliphezulu. Kungenxa yoko le nto triptans kuba nefuthe imithambo yegazi laseDura. Le yenye amakhono abo. Noko ke, kuba nafuthe izitya neuropathy sentliziyo. Kufuneka kuqatshelwe ukuba triptans - amachiza migraine ezithintela kokuvela intlungu kwinqanaba receptor, ibekwe ngumongo spinal ye-luvo trigeminal. Oku kunciphisa kakhulu uvakalelo intlungu.

Ukongeza, ezi machiza ukunciphisa nezihlandlo likakade, kwakunye ngempumelelo ngakumbi kuphelisa iimpawu ezinxulumeneyo, ezifana isandi kunye photophobia, ukugabha kunye isicaphucaphu.

Fields of action of triptans

Ukuze siqonde indlela la machiza izinto, kukunika izisekelo:

1. Vasoconstriction, elise ebuchotsheni.
2. inyathelo Anti-ukudumba: ukuncitshiswa ukudumba, nto leyo ibeka uxinizelelo phezu kwalapho.
3. Ingcinezelo uchwayitile luvo trigeminal nokunciphisa ubuntununtunu yayo intlungu.

Njengoko ubona, triptans ngenxa migraine - amachiza esebenza kakhulu enokuthi ayeke ukuhlasela zesi sifo. Eyona nto ibalulekileyo kukuba ukukhetha siyobisi ekunene

Eluncedo nengeloncedo triptans

Phakathi eziluncedo yeemveliso ezinjalo kukuba Ukubonelela ngolawulo olusebenzayo intlungu iimpawu ezinxulumene, inyathelo ngokukhawuleza. Ukongeza, ezi triptans zingasetyenziswa ukunyanga isifo kumacandelo yobudala ahlukeneyo.

Kakade ke, naziphi chiza nezingalunganga. Ngokugqibeleleyo ukunceda triptans ukuba migraine kunye intloko ebuhlungu. Noko ke, kwiinkalo amanyathelo kula machiza nangoku ayiqondwa ngokupheleleyo. Ukongeza, asinguye wonke umntu akwazi ukuthatha triptans njengoko impilo yabo. Akuvunyelwe ukuba basebenzise la machiza abantu abanengxaki nesifo sentliziyo. Kolu luhlu kukho abo ke egazi igazi kunye noxinzelelo lwegazi angendawo ekhoyo.

Isizukulwana sokuqala

amalungiselelo Migraine - triptans - phantsi kwemiqathango ethile yahlulwe kumaqela eziliqela. Lo wokuqala kwaye isizukulwana yesibini. ichiza ngamnye eziluncedo zawo nezingalunganga. Ngoko ke, isizukulwana yokuqala bokwenyaniso "Sumatriptan". Lo siyobisi sokuqala. Wayeqonda phantse ngokupheleleyo yaye uhlobo umgangatho unyango migraine. Ngokwenene na kwiimvavanyo zeklinikhi phambi kwawo, Wendelisa 60 amawaka abantu abathathe inxaxheba. Ngokuba lixesha lokuqala ichiza yafunyanwa ngama-GlaxoSmithKline ngo-1989.

Ngokomthetho "sumatriptan" yaqaphela ngohlobo amacwecwe eqhelekileyo, amacwecwe wawutyabeka, zokutshiza. Ngamnye kubo isebenza ukukhetha. Isiphumo esiphezulu emva kokuthatha iipilisi kwenzeka emva ezibini nesiqingatha iiyure, zokutshiza - imizuzu engama-90.

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Triptans - nemithi migraine, yelo qela - baninzi. Ukongeza, azikho ngokwaneleyo efunda. Bazivelise okanye bazenze ngohlobo iipilisi. Phakathi kakhulu ngempumelelo zezi:

1. "Natriptan" - isiphumo kuye kwaphawulwa iyure malunga emva kokungenisa. Iintlungu lifinyele. kangangoko lwenzeka emva kweeyure ezimbalwa.
2. "Frovatripan" - eli chiza thile buthathaka, kodwa wafumana imiphumela ngaphantsi kubonakale ebezingalindelekanga ezingemnandanga.
3. "Zolmitriptan" - usebenza emva kwemizuzu eli-15 emva kokuba yolawulo. Isiphumo esiphezulu ifunyanwa emva kweyure malunga. Eli chiza kuhle kakhulu ukuba ahlasele incopho.
4. "Rizatriptan" - efanayo yokulungiselela sizukulwana sokuqala, kodwa nemiphumo ucaca ngakumbi.
5. "Almotriptan" - eli chiza mkhulu "Sumatriptan" izihlandlo eziliqela eyiyo. Isiphumo esiphezulu ifunyanwa emva kweeyure 1.5.
6. "Relpaks" - le ichiza lokuqamba ngakumbi ngokubhekiselele igalelo imithambo yegazi ingqondo. Nangona wentsebenzo uyafana kakhulu "sumatriptan".

Iziyobisi for migraine (triptans): Ixabiso kunye neziphakamiso kwi yolwamkelo

Ukwenza kucace ngakumbi apho zikhona iziyobisi, esilishumayelayo itafile:

iimpawu reception

Ngoko ke, ukuba indlela engcono triptans ukuba migraine kunye yintloko? Imiyalelo kulo mzekelo kuya kunceda ukuqinisekisa idosi kunye nexesha wokwamkelwa. Eyona nto ibalulekileyo - khumbula ukuba kwimeko ntlungu kwandisa ngcembe yaye ungenaye uhlobo migraine, uthathe amayeza enjalo sicwangciso siyicacisa mqondo. Kulo mzekelo, kufuneka uthathe iintlungu non-ngqo. Oku kubaluleke kakhulu. Ngokuqhelekileyo, triptans kufuneka athathwe emva kokuphela aura, okanye ungadlulanga owe ngaphezu kweeyure ezimbini emva kokuqala kabi. Ukongeza, xa migraine triptan kwaye zingasetyenziswa kunye nezinye iziyobisi, ezifana metoclopramide okanye domperidone.

Ke ukuba isitshizi, kufuneka zisetyenziswe kwindawo isicaphucaphu zomlomo ngokwaneleyo kwaye, kakade, ukugabha. "Imigran" ingasiwa ukuphelisa imo migraine. Triptanity linokukwenziwa nje kuphela kuphuhliso sifo, kodwa kumaxesha phakathi kuhlaselwa ukuze kuthintelwe. Oku avunyelwe iimeko xa:

1. umgangatho yesigulane wobomi engaboni kakuhle.
2. NSAIDs kunzima kakhulu ukuba ukunyanga.
3. ukuhlaselwa Migraine kwenzeka qho ngaphezu kabini ngeentsuku ezingama-30.

Indlela ukujongana siphethwe

Ukususa ukuhlaselwa migraine, kuyimfuneko ukuba baqale bazame ukuthatha 1,000 milligrams acetylsalicylic acid, i caffeine othululwayo elithozamisayo equlathe, okanye milligrams 10 ichiza "Motilium". Ukuba emva kwemizuzu engama-45 ukuba intloko akupheli, kusenokwenzeka ukuba usebenzise triptan.

Kufuneka kuqatshelwe ukuba kwiimeko apho yokuhlasela ezintathu iintlungu nonspecific akazange ukunika isiphumo ofunekayo, ungenza ngokukhawuleza uthabathe sicombululo sazo migraine. Ukuba kwakukho aura, ukusetyenziswa aspirin ixabisa kuphela emva kokuba iqalile, yaye emva kokuvela buhlungu - iziyobisi migraine (triptans).

Kuthekani ukuba iintlungu wabuya?

Malunga nama-50% ezigulane kukho imbuyekezo nentloko ebuhlungu kwiintsuku nje ezimbalwa. Iingcali bacebisa ukuba meko kwakhona ukuthatha amayeza migraine - triptans. Kufuneka kukhunjulwe malunga idosi iphezulu yemihla ngemihla ichiza. Ukuthatha ichiza akukho ngaphambili ngaphezu kweeyure ezimbini emva ipilisi yokuqala. Ukuba ebuhlungu unako azisebenzisele, isiguli endaweni triptans iintlungu nonspecific.

Kubalulekile ukuphawula ukuba ukuqaleka iimbuyekezo zidla waphawula kwizigulane kunye neendywala ngokwaneleyo elide nobuhlala ngaphandle kokuthatha amayeza iintlungu iiyure ezingaphezu kwama-24. Naxa ngexesha uthatha nawuphi na rhoqo triptan iziganeko ezinjalo kuye zahlala zilolo hlobo zazilulo. Kodwa ke, iingcali zikholelwa ukuba ukusetyenziswa "Eletriptan" yaye "naratriptan" inceda ukunciphisa inani bahlaselwe ezintsha.

Ukuba akukho ziphumo

Kukho amaxesha apho iziyobisi migraine (triptans) kunye neziyobisi ezingekho-ngqo musa ukunika isiphumo efunekayo yaye akafuni ukuphelisa intlungu. Kulo mzekelo, ugqirha angakunika kwanonyango oluxandileyo, eliquka esiwusebenzisayo iziyobisi anticonvulsant, kwakunye B-blocker. La machiza aquka "nadolol," "acebutolol", "penbutolol", "Labetanol", "Betaxolol" kunye nabanye.

engemihle triptans

La machiza kufuneka ithathwe iintsuku ezili-10 kuphela inyanga. Kungenjalo, usenokuba neengxaki ezithile. ukusetyenziswa kakhulu njalo triptans kungakhokelela intloko ebuhlungu, olwenzeka xa izigulane abafumana ichiza. Ukongeza, iziyobisi amanyathelo uneziphumo ebezingalindelekanga, kuquka:

1. Imvakalelo imfudumalo kunye ukuqina kwi imilenze, ukozela, ukudinwa, isiyezi, uvakalelo.
2. nesisu engabalulekanga okanye udakada, okwenziwa sisilonda kobuchopho, ukopha sorhudo, umlomo owomileyo, iintlungu esiswini kunye isicaphucaphu.
3. Myalgia kunye kwemisipha buthathaka.
4. vasospasm Uqhaqho, iposi engabalulekanga, angina sifuba, tachycardia, iyangongoza.
5. Polyuria, kwaye rhoqo ukuchama.
6. Anaphylaxis, angioedema, urticaria.

Phezu kwayo yonke le nto, triptans ukuba migraine - iyeza ekhawulezileyo-esebenza. Ukuba uthathe iziyobisi ngqo ngokwemiyalelo, ngoko akukho ngxaki. Le Ububi kuphela ezibalulekileyo kumayeza anjalo - iindleko. Asinguye wonke umntu imali yokuthenga iziyobisi enjalo.