"Glibenclamide": imiyalelo ukusetyenziswa, ifom ukukhululwa, photo, analogs

Yintoni unyango 'glibenclamide "? Imiyalelo yokusebenzisa, ifom ukukhululwa, analogue nokubonakaliswa ngenxa kulawulo ichiza zidweliswe ngezantsi.

Ubume, ukupakishwa, agents ifomu ukukhululwa

Ziziphi ifomu yenziwe amayeza "glibenclamide"? Guide ingxelo ukuba sixhobo yaveliswa ngohlobo macwecwe neziwela kwimigqomo zeplastiki (umphandle yeseli) kunye ibhokisi eyenziwe yekhadibhodi, ngokulandelelana.

Ukubunjwa ichiza ethathelwa ingqalelo ziquka 5 mg glibenclamide kunye izithako abangabancedani ezifana neetapile starch monohydrate lactose, nemagnesium stearate, isodiyam croscarmellose, indigo carmine E 132 Colloidal lesilicon dioxide-25, kunye povidone.

isenzo Drug

Yintoni na ichiza 'glibenclamide "? Imiyalelo Sebenzisa uthi oku kuthetha bembonisa isiphumo hypoglycemic kubantu esempilweni izigulane seswekile lohlobo II.

Ukusebenza eli chiza ngenxa ukukwazi layo ukwandisa insulin secretion kweeseli beta pancreatic ngenxa inkanuko yabo. Ngokutsho iingcali, oku beziyobisi zinokukhuliswa phantsi kwempembelelo glucose.

Entshukumo features i kuqulunqo yomlomo

Ziziphi iimpawu uphawu iziyobisi pharmacokinetic "glibenclamide 'na? Imiyalelo yokusebenzisa bathi emva nomthamo yomlomo amacwecwe ukwimo esebenzayo ako ngokukhawuleza kwaye phantse ngokupheleleyo ukusuka lokugaya.

Ngaxeshanye ekudleni kukhokelela ekuncipheni kwe xi glibenclamide kwi plasma (xa kuthelekiswa ungatyanga). Umdibaniso yeli candelo kunye albumin ungaphezulu 98%.

isibindi glibenclamide yomguli iguqulelwa kule metabolites zilandelayo: 3-kaKishe-hydroxy-glibenclamide kunye 4-kwelentshona ye-hydroxy-glyburide. Yokuba imveliso ngomlinganiselo ofanayo yi izintso, kunye endleni.

Komndilili ukususwa isiqingatha-ubomi ichiza iiyure 2-3.5. Xa abantu abane umsebenzi kwesibindi kakuhle, eli nani lincitshiswe kakhulu.

Iimpawu zibonisa ukuba ukusetyenziswa kweziyobisi

Kwezinye iimeko, umntu iipilisi nomonde "glibenclamide" linokukwenziwa? Oku kuthetha sincoma ukuthatha izigulane seswekile lohlobo II, xa kungekho ithuba ukuze abuyekeze hyperglycemia ukutya engqongqo kunye nomsebenzi ngokwasemzimbeni, okanye ukwehla kobunzima bomzimba.

Siphelisa ukusetyenziswa

Ingaba kukho naziphi na Izimo kwi ichiza "glibenclamide"? Imiyalelo Sebenzisa ithi le ndawo kufuneka kwenziwa ukuba izigulane:

• ukutsha kakhulu;
• Hypersensitivity yecandelo esebenzayo, kwaye umchamo thiazide okanye sulfonamides;
• ketoacidosis;
• isiqaqa seswekile kunye namazwe prekomatosnoe;
• uphuhliso hypoglycemia;
• utyando kunye nezinye ukuhlukumezeka;
• gastroparesis kunye emathunjini;
• nokukhulelwa;
• diabetes Uhlobo lokuqala;
• ibele.

Medicament "glibenclamide": imiyalelo yokusebenzisa

Ithatyathwa ichiza kufuneka kuphela ligqwetha ngugqirha onamava. Eli chiza kufuneka kusoloko ukudityaniswa ukutya engqongqo. Kuphela kule meko iya kuba nempumelelo. umthamo yayo ixhomekeke kwiziphumo nomonde zovavanyo (amaqondo eswekile yegazi, izalathisi asuka umchamo, njalo njalo).

Ngoko ukuba ayinonophele njani ichiza "glibenclamide"? Therapy ithetha ukuqala kunye amathamo engephi. Oku kuyinyani ingakumbi kubantu eneengcinga hypoglycemia kunye ubunzima nomzimba ngaphantsi kwama-50 kg.

Ngokuqhelekileyo, ithamo yokuqala medicament yi 0,5-1 ipilisi nganye ngemini. Oku kuhambelana 2.5-5 mg esisebenza. Xa engaphumeleli isenzo kweziyobisi inani elikhankanyiweyo ukuba yaba yintsimi iipilisi ezintathu ngemini, ulungelelene-15 mg esisebenza. Oku kufuneka kwenziwe kwi ngamakhefu kwiintsuku ezimbalwa ukuya ngeveki enye, de afumane oko akufunayo kuyaphunyezwa.

Indlela ukudlulisela isigulana kwelinye ichiza amayeza "glibenclamide"? Ukusetyenziswa iyeza kulo mzekelo kufuneka wenziwe ngokuqaphela okukhulu. Okokuqala, isigulane emiselweyo iipilisi ngeeyure 0.5, yaye emva koko ngokuthe ngcembe kwandisa ithamo ukuba kakhulu ngempumelelo.

izigulane abadala kunye ephelile okanye izigulana kunye nokungondleki kunye kakuhle isibindi okanye kwizintso isekela umsebenzi okanye idosi lokuqala iyeza ayinqwenelayo ukunciphisa amathuba kuphuhliso hypoglycemia. Kwakhona isigqibo idosi echanekileyo ichiza kufuneka abe zinciphise ubunzima bomzimba okanye xa ukutshintsha indlela yayo yokuphila.

A indlela ngokufumana tablet hypoglycemic

Indlela yokusebenzisa ichiza "glibenclamide"? Imiyalelo yokusebenzisa (ifoto ichiza thaca kweli nqaku) ithi wabheka cwecwe kufuneka athathwe phambi kokuba izidlo kunye iglasi yamanzi yabonakala kwaye ngaphandle ukuhlafuna.

Xa idosi yemihla ngemihla amacwecwe-2, kucetyiswa ukuba bahlule medicament ngeedosi 2 umahlule (kusasa nangokuhlwa) xa umlinganiselo we-2: 1.

Kubaluleke kakhulu ukuba ukusebenzisa eli yeza ngexesha elifanayo. Ekususeni kuqulunqo reception tablet esalelweyo ethatyathwe kunye zilandelayo.

Ubude unyango le arhente kuxhomekeke sifo. Ukutyhubela unyango kufuneka ukuba enze uhlolo oluqhubekayo lombuso yomguli kwezinto lotshintshiselwano.

imiphumela emibi

Le medicament "Glibenclamide" analogs ezidweliswe ngezantsi, kunokubangela uphuhliso reactions ezingafunekiyo echaphazela, yonyango, iinkqubo-luvo neuropathy yokucola ukutya kunye hematopoietic. Kulo mba, isigulane unakho ukubonisa iimpawu ezingalunganga ezifana isicaphucaphu, hypoglycemia sandla ezahlukeneyo, kwekhono hepatic, urhudo, intloko ebuhlungu, cholestasis, ukutyhafa, isiyezi kunye nokudinwa.

Kufuneka kuqatshelwe ukuba inani le sixhobo asikusebenzeli ngaphandle imbonakalo reactions dermatological kwaye komzimba njengoko photosensitivity, ukurhawuzelela, irhashalala kunye nezinye iimpawu ezingemnandi.

amatyala libanda, izinto hypoglycemic

Ziziphi iimpawu kwenzeka xa eph lidle amayeza "glibenclamide"? Manual ukuba libanda, isigulane lisenokuba hypoglycemia, mhlawumbi ephelekwa ubuthathaka, imvakalelo yindlala, intloko ebuhlungu, ixhala, ukubila ngokugqithiseleyo, isiyezi, lafa kwezihlunu, iyangongoza, ukudumba yobuchopho, umbono kunye nentetho ukuphazamiseka.

Unyango kweemeko ezinjalo kufuna ukungena iswekile-ukutya ukutya engxamisekileyo. Umzekelo, incindi yeziqhamo, iswekile, isiraphu ingqolowa, neti eshushu amnandi okanye ubusi.

Kwiimeko kakhulu ngakumbi, isigulana ilawulwa i-50% isisombululo iswekile, "Dextrose" "Glucagon" okanye "Diazoxide". Kufuneka kwakhona ulawulo ekhethekileyo glycemia, creatinine, urea nitrogen, electrolytes kunye pH isigqibo.

Intsebenziswano kunye nezinye iindlela zonyango

Ukudityaniswa ichiza ingqalelo kwiziyobisi anti-systemic, tetracyclines, fluoroquinolones, chloramphenicol, Mao inhibitors, kunye ACE, H2-blocker, "clofibrate" beta-blocker, probenecid, bezafibrate, "paracetamol", steroid, ethionamide, allopurinol, pentoxifylline, cyclophosphamide "reserpine", insulin kunye sulfonamides uyakwazi potentiate hypoglycemia.

isicelo ngaxeshanye of amayeza kunye phenothiazines, lengqula kunye glucocorticoid iihomoni, barbiturates, estrogen, diazoxide, progestins, glucagon, iityuwa lithium, Adrenomimeticalkie kuthetha nicotinic acid saluretikami nezakhi buthathaka ifuthe layo hypoglycemic.

imixube ezinjalo zenziwe muncu umchamo (kubandakanywa ammonium chloride, calcium chloride, ascorbic acid), ngoyo yintshukumo medicament ingqalelo.

Ukusetyenziswa "glibenclamide" ne "rifamycins" ibalekisa inactivation nokunciphisa ukusebenza kobokuqala.

ulwazi oluthile

arhente Hypoglycemic kufuneka ziqwalaselwe ngononophelo kwizigulana enesifo kwekhono kwezintso kunye wesibindi, kwakunye zophendlo lwezifo ndlala kunye adrenal, iimeko febrile kunye butywala ezigulo ezondeleyo.

Ukuze afeze unyango eqhelekileyo kufuna esweni rhoqo yamanqanaba glucose yegazi nomonde, ngokunjalo zinomgutyulo yayo.

Ukuba ukuthathwa amayeza isigulane iphuhlisa hypoglycemia, iswekile elimisiweyo langaphakathi (kwimeko ukuba umntu lisezingqondweni na). Ukuba zingqondweni, iswekile ilawulwa yegazi, kunye glucagon - kwesikhumba, intramuscularly okanye yegazi. Emva kokuba isigulane uyavuka, uya ngoko nangoko uzinike ukudla, esisityebi carbohydrate, ukwenzela ukuthintela ukwenzeka hypoglycemia.

Ixabiso kunye analogue (izithethantonye) iindlela

Khetha analogs kweli chiza kufuneka abe oqeqeshiweyo nonamava kuphela. Ukuze oogqirha ezifana neziyobisi ziquka ezi zilandelayo: "Manin", "Manin", "Maniglid", "Betanaz" yaye "Antibet".

Kufuneka kuqatshelwe ukuba ezikhemisti badla ukuthengisa ntonye esi sixhobo. Usebenziso oluqhelekilyo kubo, "Glidanil", "Glibeks", "Glibamid", "Gilemal", "Glibomet", "glibenclamide". Le umthamo kwezi mali esikhethwe ngamnye.

Njengoko ngexabiso "glibenclamide" iziyobisi, ikwatshintsha kuluhlu 280-360 engange.

Izimvo emithi

Ngoku uyazi ukuba sisiyobisi "glibenclamide". Imiyalelo ukusetyenziswa, nokumila analogue le ndlela ichazwe ngasentla.

Oko bathi ngale abasebenzisi iziyobisi? Njengomgaqo, yonke imiyalezo ngayo bancipha ingxoxo abo okanye kwezinye iirejimeni zonyango ukuba Kucetyiswa ukuba abantu abanesifo seswekile.

Abasebenzisi bathi amaninzi "glibenclamide" isetyenziswa njenge monotherapy. Nangona kukho abo izigulane ezimiselweyo ichiza zidityaniswe namanye amachiza hypoglycemic.

Ngokutsho oogqirha, ukuqeshwa ichiza ethathelwa ingqalelo kufuna indlela ngamnye. Kulo mzekelo, ingcali bafanele ukuba sele beyiqhelile zonke iziphumo wohlalutyo, kunye nezinye izifundo. Thatha "glibenclamide" nezigulane ngokwengqiqo yabo kuyingozi kakhulu impilo kunye nobomi.