Ichiza "Fluorouracil": imiyalelo ukusetyenziswa, inkcazo, ukwakheka, analogs kunye nohlolo

Umhlaza, ngelishwa, kukho ngoku rhoqo kakhulu. Ngokuqhelekileyo, asinakukwazi ukunikela phezulu, simele silwe esi sifo. Kuyo nayiphi na imeko kufuneka kwenziwe ngokuzimeleyo. Ngaphandle uncedo professional buyafuneka. Into yokuba ezinye machiza umiselwe ngokumiselwa kuphela kwaye isetyenziswa kuphela xa irejimeni okhethekileyo. Kwiimeko ezininzi, oogqirha ukumisela le neziyobisi "Fluorouracil". Imiyalelo zokusetyenziswa ichiza iya kuphuma koku.

iimpawu ngokubanzi

Ngoko ke, inikeza ichiza isetyenziswa Oncology, njengoko inesiphumo anti-ithumba. It nakubalwa phakathi antimetabolite. Oko kukuthi, ukuba into equlethwe engamanzi, unako kakhulu isantya ukutshintshisana kwezinto phakathi iiseli.

"Fluorouracil" (imiyalelo ukusetyenziswa lisoloko apakishwe kunye ichiza) uye isakhiwo esilula. Oku kubandakanya amanzi abulawe sodium hayidroksayidi. Kodwa icandelo engundoqo esebenzayo i fluorouracil.

Iifom Ukukhululwa neempawu ichiza

Kufuneka kuqatshelwe ukuba eli yeza na iintlobo eziliqela. Ukuba ufuna oko, "Fluorouracil" yemiyalezo ithi malunga ezi ndlela yayo:

1. A Isisombululo ulwelo lolawulo efakwa okanye intracavitary. Okunye Ngokufuthi kuyenzeka th zolwelo-5% umxube ampoules 5 ml. Kukho kwakhona isisombululo wamandla apho ifakwa kwibhotile 10 ml.

2. Ioli. Kwakhona ngokuqhelekileyo-5% of th. Isetyenziswa ukunyanga isikhumba, umz, Basile.

Ukuba uthe wamiselwa "Fluorouracil" yemiyalezo iqulethe ezi nkcukacha zilandelayo malunga iisekethe yolwamkelo:

- Yonke imihla ukufumana 0.5 g / m. okanye 12 mg / kg. unyango akuntsuku zingaphezu kwe-5. Emva koko kufuneka enye ikhefu ngenyanga.

- iintsuku kanye 7 ka-0.6 g / m. ke unyango imalunga 6-10 iiveki.

- Kudibaniso namanye amachiza anticancer - 1st kunye imini 8 lika-0.6 g / m.

Nakuba kunjalo, kuzo zonke iimeko, idosi indlela ulawulo ichiza kumiselwe ngamnye. konke kuxhomekeke ebukhulwini nebakala kwesi sifo, imeko jikelele isigulane, impilo yakhe kwakunye nesicwangciso sokuba kusetyenziswe amachiza.

Esingamanzi ufakwe bolus okanye ukumnika. Khumbula ukuba amanye amachiza ozinikiweyo kwisigulana ngokusebenzisana kulo, anike ukuncitshiswa idosi fluorouracil nge-20-30%.

imiphumela amayeza kunye nonxibelelwano namanye amachiza

Ngoko ke, i "Fluorouracil" (imiyalelo zokusetyenziswa, inkcazo yokulungiselela kufuneka ifundwe sisigulane) ibonelela ukusebenza anti-ukudumba kwaye ithintela kakhulu umchiza Basabela abo ezikhuthaza nokwahlukana kweeseli amabi. Oko kukuthi, izitena iziyobisi ekumisweni DNA.

Sokufunxa ithetha ngokukhawuleza, ukwakha ftoruridinmonofosfat. Oku wanamathela esibindini iiyure ezimalunga nama-20. I Ukurhoxiswa zemiphunga ababandakanyekayo (60-80%) kunye kwizintso (7-10%, ingaguqukanga).

Ukuba ufuna ukuthatha "Fluorouracil" yemiyalezo (inxalenye amayeza, sele sixubushe) uchaza ukuba kukho ezinye izinto ezingenako zidityaniswe kunye nabo. Umzekelo, iziyobisi sulfa, kunye phenylbutazone awahambisani nga bathi. Kodwa agents alpha-interferon kunye cytotoxic, phezu koko, ukunyusa isiphumo "Fluorouracil". Kufuneka ithathelwe ingqalelo ekuqeshweni idosi.

Qaphela ukuba ugonyo umguli, ngenxa omzimba buthathaka kufuneka wenziwe hayi ngaphambi ngaphezu kweenyanga ezi-3 - ngonyaka.

Ubungqina obubonakalayo buxela ukuba ukusetyenziswa

Ukuba ufuna "Fluorouracil", imiyalelo zokusetyenziswa (iziyobisi intengo kwi-avareji engange 3000-3990) ubalisa ibali ezi zempilo:

• Umhlaza ezicekethekileyo okanye ezinqeni, kuvuleke iminxunya emathunjini. Ngoko naxa ichiza unikwa nqanaba okanye metastases unresectable.
• umhlaza wesibindi Primary.
• izifo esibulalayo lwesinye inyongo, maqanda, ibele, wesizalo.
• Umhlaza adrenal.
• Umhlaza sisilonda esidumbileyoesingaphakathi wendlala.
• Kartsinoz okanye umhlaza penile.
• Yamathumba entanyeni kunye nentloko.
• Yimeko precancerous, kunye nangezilonda ezincinane.

Ezingeniswe ichiza zingasetyenziswa kwanaxa kolusu ezinzwaneni.

Zeziphi lawo Izimo?

Ngokuqhelekileyo, akukho yokulungiselela kwemichiza kunokuba luncedo ngokulinganayo kuzo zonke izigulana. Kulo mzekelo, impahla inazo Izimo.

• eliphezulu kakhulu uvakalelo kwezinye amacandelo isixhobo.
• Ukukhulelwa ne zisanyisa. Eli chiza onesiphumo zinetyhefu kakhulu ekukhuleni kosana olungekazalwa. Ukuba reception onyulwe ngexesha lokuncancisa, umntwana ebeleni-ekudleni.
• isifo isilonda Peptic 12 isilonda duodenal okanye isisu, leyo kwinqanaba oyingozi.
• igazi kakhulu kwaye rhoqo ukopha ekunzima okanye kungenakwenzeka ukuba ayeke (kubazali).
• Leukopenia.
• umsebenzi sezintso ongeva okanye isibindi.
• Zempilo isigulane ngaphambi kokufa begazi.
• degree kakhulu onamandla ka komzimba.

Ukongeza, kukho ezinye iintsilelo. Umzekelo, unonophelo amisele ichiza abantu abaphethwe ngamaxolo irhashalala. Kuyimfuneko ukuba anikele ingqalelo ekhethekileyo ukuqeshwa ichiza ukuba isigulane sele uthatha cytostatics.

ziphumo bezingalindelekanga kunokwenzeka

Ukuba emiselweyo ikhosi le neziyobisi "imiyalelo Fluorouracil-Lance 'zokusetyenziswa ichiza ayahlukanga ukusuka ngaphambili ebhaliweyo. Umbuzo osithandayo izigulane ezininzi, kukho iziphumo ezingalindelekanga. Inyaniso ukuba maxa wambi kuba nzima ngaphezu kwesifo ngokwaso. iziphumo ebezingalindelekanga Ngenxa yoko, emva kokufumana le into singabonakala:

• Ukunciphisa inani leukocytes neeplatelets egazini.
• Nokopha, apho kunzima ukuba ayeke.
• ukungaboni, iliso ngokukhawuleza.
• Isicaphucaphu, leyo iqhotyoshelwe ukugabha kunye norhudo. Kulo mzekelo, unyango kufuneka linqunyanyiswe okanye ilungiswe.
• isilonda Peptic.
• Stomatitis.
• Buso okanye iyonke alopecia (nenkqayi).
• ukusilela kobuchopho intliziyo, arrhythmia, angina, ukusilela intliziyo, iposi engabalulekanga, cardiomyopathy, thrombophlebitis.
• Intlungu kunomoya entloko, ukwanda imveliso iinyembezi, kunye nokoyika ukukhanya, nokudideka, ilahleko lokuqonda ukucaciselwa.
• Dysarthria.
• Incasa, ukopha esiswini, heartburn, ukudla kunye hepatic functionality.
• Ukuphelelwa umoya, ukukhohlela, bronchospasm.
• Ukungaqheleki kule nkqubo lokuzala: amabhinqa - ukungabi esexesheni, amadoda - azoospermia.
• hyperpigmentation esikhumba, kome nokuqhekeka.
• Urticaria, irhashalala, dermatitis.
• ubuthathaka kwimisipha ukujoyina usulelo bezicatshulwa ezahlukeneyo.

Njengoko ubona, ngokuxhomekeka engamanzi okanye "Fluorouracil" amafutha, yesikhokelo ukuba kucace, iziyobisi anobungozi. Ukongeza, uphando lubonisa indlela, kusenzokwenzeka yeziphumo toxigenic kwaye umhlaza ze ichiza.

Iimeko yeemveliso zokugcina

Ngoko ke, nina sele ufumene ulwazi oluninzi malunga ndlovu ezingenisiweyo. Ngoku kufuneka ukuba siqwalasele iimpawu yokugcina yayo. Ukuba "Fluorouracil" kufuneka kwindawo emnyama kakhulu. lobushushu yokugcina kufuneka ibe degrees 15-25. Kakade ke, ichiza kufuneka igcinwe kude kude ebantwaneni. ulwelo owayevunyelwe akukho kakhulu Kunconywa.

Ubude bethuba lokusetyenziswa kwe ichiza kwiminyaka emi-2. Emva kokuphela kwale mveliso awukwazi ukuthatha ixesha.

Kukho amaxesha xa intlenga ibonakala emazantsi ezineengqayi. Oku kwenzeka ebudeni yokugcina ixesha elide. Zama ukufudumeza ulwelo ukuya ° 60 kunye Abokuhlunguzelelwa ngamandla. into elandelayo cool degrees 35. Ukuba kwenze lichithakale, kwaye engamanzi kwakhona yaba ngaphaya, ngoko, ukulungiswa ilungele ukusetyenziswa.

analogue iyeza

Eyona nto ibalulekileyo kukuba into ekufuneka uyazi phambi kokuthatha "Fluorouracil" chiza - imiyalelo ukusetyenziswa. Kwakhona Reviews ziya kuba akufuneki. Uya kufumanisa kamva.

Ukuba isigulana awunayo imali yokuthenga amayeza, ugqirha ukubekwa analogue kuye. Baye umqobelo efanayo engundoqo esebenzayo - fluorouracil. Ngoku kukho analogue kweli chiza:

1. "Fluor-uracil."

2. "Efundeks".

3. "EPF-Ricks."

4. "Fluoropleks".

5. "Fluratsil".

6. "Flour".

7. "Kveropleks".

8. "Timazin".

reviews

Kufuneka kuqatshelwe ukuba iyeza lisetyenziswa kaninzi. Izigulane ezininzi ingxelo ngempumelelo phezulu ekulweni yamathumba.

Noko ke, bathi, kwaye inani elikhulu yeziphumo ebezingalindelekanga: isicaphucaphu, ukugabha, intloko ebuhlungu, nokudideka esithubeni. Akumangalisi oku, kuba ichiza yityhefu kakhulu.

Ngenxa yoko, siye zizinikile iinkcukacha malunga namayeza "Fluorouracil": imiyalelo ukusetyenziswa, ixabiso, ncomo. Khumbula ukuba self ukuthatha eli yeza, akufanele. Qiniseka ukuba udibane nogqirha. Kungenjalo wena engozini ukuba uzenzakalise ngakumbi. Okukhona ukuba ukuxilongwa oluchanekileyo ungacwangcisa kuphela oyingcaphephe emxinwa, emva kokuba uphando olufanelekileyo. Hlala uphilile!