"Indapamide": ezifanayo. "Indapamide": ukuhlolwa koogqirha

Yiyiphi iyeza "Indapamide"? Iziganeko zesi sixhobo, imiyalelo yayo, iziphumo ezibi kunye nezibonakaliso zokusetyenziswa ziya kuboniswa kamva. Ukongeza, kweli nqaku uza kufumanisa ukuba ngaba le nyanga lichasene, yintoni oyenzayo xa kunokugqithiseleyo, ukuba kufuneka kuthatyathwe njani, nokuba ingadibaniswa nezinye iziyobisi, kwaye yiziphi iingcali ezicinga ngazo.

Ukubunjwa kwemveliso yeyeza kunye nendlela yokukhululwa kwayo

Ngaliphi uhlobo le nkunkuma idayiswa? Kwikhemistiki inokufunyanwa kuphela kwimiqulu yamacwecwe e-biconvex, ehlanganiswe negobolondo elimhlophe.

Sisiphi isithako esisebenzayo esenza ukuba "i-Indapamide" ineyeza? Iziganeko zezilwanyana (ezininzi zazo) kunye nesilwanyana ngokwawo siqukethe isithako esisebenzayo njenge-indapamide. Ngokubhekiselele kuma-excipients, iipilisi ziquka ezi zinto zilandelayo: i-lactose monohydrate, crospovidone, i-povidone K-30, i-stearate ye-magnesium, i-talc kunye ne-lauryl sulfate.

Isenzo se-Pharmacological yesilwanyana

Ziziphi iipropati zesilwanyana "i-Indapamide", ixabiso elinikezwe ekupheleni kwalo nqaku? Esi sidakamizwa sibhekisela kwiziyobisi ezichasayo. Ngamanye amazwi, i-diuretic kunye ne-vasodilator.

Ngokweziphathamandla zalo zoshishino lwezilwanyana, le nkunkuma ifana kakhulu ne-thiazide diuretics kwaye ithathwa xa ukubuyiswa kwakhona kwe-sodium salts ekhoyo kwicandelo le-cortical le-Henle loop liphulwa. Iyakwazi ukwandisa ukukhululwa kwe-chlorine, i-magnesium, ionidi ne-potassium ion kunye nomchamo.

Iyintoni injongo yonyango i-Indapamide? Iziganeko zesilwanyana kunye nesilwanyana ngokwawo sinokukwazi ukuvimba "ukulibazisa" iziteshi ze calcium ngokukhethekileyo, ukwandisa ukunyaniseka kweendonga zeempahla kunye nokunciphisa ukuxhatshazwa kwe-vascular (peripheral).

Ukutyiwa kwesi sidakamizwa kuncitshiswe i-hypertrophy yentliziyo, okanye kunoko i-ventricle yakhe yekhohlo. Ayinomphumo kumthamo we lipids egazini, kunye ne-carbohydrates metabolism, kubandakanywa nabantu abaneesifo ezifana nesifo sikashukela.

Esi sidakamizwa sinciphisa ubukhulu bodonga lwe-vascular ukuze i-angiotensin II kunye ne-noradrenaline, kuncitshiswe ukuveliswa kwezinto ezizinzileyo kunye ne-free oxygen radicals, ezikhuthaza ukuhlanganiswa kwe-prostaglandin E2.

Emva kokusebenzisa iziyobisi, umphumo we-hypotensive uqala ngasekupheleni kweveki yokuqala yonyango. Kule meko, kuqhubeka iiyure ezingama-25 (emva kokuthatha iibhebhe enye)

Pharmacokinetics yeziyobisi

Kuphi na iyeza indapamide ethathwe? Imiyalelo, ukuphononongwa kweengcali kuthi emva kokuthabatha izidakamizwa ngaphakathi kuthi phantse ngokukhawuleza kwaye zithathwe ngokukhawuleza kwi-digestive tract. Ngokutsho kwamagqirha, i-bioava availability 93%. Ukutya okufanayo ngokukhawuleza kwanciphisa izinga lokumanyiswa, nangona akuchaphazeli umthamo wezinto ezisebenzayo.

Ingxininiso ephezulu yecandelo elisebenzayo kwi-plasma yegazi ifikelelwe malunga neeyure ezingama-2 emva kokuthatha i-tablet enye. Isiqingatha-zobomi beziyobisi ngamahora angama-14-25. Ukuxhamla neeprotheni zegazi malunga ne-79%.

Esi sidakamizwa sidlula kakuhle nge-obstruction yakhe ye-hertohematological (kubandakanywa nesithintelo se-placental). Ibuye ingene kubisi lonina.

I-metabolism yeziyobisi yeziyobisi yenziwa esibindi. Ixutywe yizintso (ngendlela yemetabolites) kwisixa sama-60-80% kunye no-20% ngamathumbu.

Imiqondiso yokusetyenziswa kwemveliso yeyeza

Ziziphi iziganeko isigulane esinikwe isilwanyana "i-Indapamide"? Izibonakaliso zokusetyenziswa kwesi sixhobo ziquka imeko eyodwa kuphela yesifo somguli. Le ngxakini. Ukongeza, amayeza anokumiselwa kunye nokugcinwa kwamanzi emzimbeni. Njengoko umthetho, le meko idlalwa rhoqo kwi-heart failure.

Ukungqinelana nokusetyenziswa kwemveliso yeyeza

Ngoku uyazi ukuba imveliso yonyango "i-Indapamide" yenzelwe ukuba (izibonakaliso zokusetyenziswa kwezi cwangciso zinikezelwe ngasentla). Nangona kunjalo, ku funeka kuqatshelwe ukuba eli nyanga lichasene. Ezi zinto ziquka:

• Ukungathobeli i-lactose ngumguli;
• Ixesha lokukhulelwa;
• Galactosemia;
• Hypokalemia;
• I-Syndrome ye-malabsorption ye-galactose okanye i-glucose;
• Ixesha lokubamba;
• Ukusetyenziswa kwamanye amayeza anokwandisa ixesha le-QT;
• Ukungaphumeleli kwe-renal (okanye isigaba se-anuric);
• Ubudala bomntu oneminyaka engaphantsi kwe-18 ubudala (ukhuseleko kunye nokusebenza kweziyobisi ekhatyweni kwabantwana abangaqinisekanga);
• Ukubonakalisa i-hepatic, kubandakanywa nokuxhalabisa, ukungakwazi;
• Ukunyanzeliswa kweziyobisi kwiyeza kunye nezinye izidakamizwa ze-sulfonamide.

Ukulumkeleka kweyeza

Abantu abaninzi banomdla kuzo: ngaba kuyimfuneko ukuthenga imithi yokulungiselela isilwanyana "Indapamide"? Enyanisweni, ngaphambi kokufaka nayiphi na imishanguzo, kucetyiswa ukuba udibane nodokotela - kuphela oyingcali emva kokubhalwa kweemviwo kwaye ngenxa yeziphumo zeemvavanyo ziya kuba nakho ukwakha irejimeni yonyango. Ngokubhekiselele kwimeko yethu, siyaqaphela ukuba i-agent ejongene nokulumkisa okukhethekileyo imiselwe abantu abanesifo sikashukela, i-gout, kunye nezo zi gulane ezithintekayo kwiimvelaphi ze-sulfonamide.

Ukongezelela, isilwanyana kufuneka sithathwe ngokuqapha kwiimeko zesibindi, intso kunye nokungalingani kwamanzi.

Ngethuba lokunyanga, ugqirha kufuneka ahlale esweni kwinqanaba le-electrolytes kwigazi lomguli (i-potassium, i-sodium, i-calcium).

Ukulungiselela "i-Indapamide": umyalelo wesicelo, uphando lwengcali

Ngokomyalelo oqhotyoshelweyo, eli gama kufuneka lithathwe ngomlomo ngaphandle kokutya. Ithebhulethi kufuneka ihlanjwe ngexabiso elaneleyo lamanzi acocekileyo.

Indlela yokuthatha i-Indapamide? Ngokutsho kweengcali, le nkunkuma ibhetele ngakumbi kwi-digestive tract ekuseni. Ngako oko, kucetyiswa ukuba uthathe kuphela ngeli xesha lemihla.

Umlinganiselo wesilwanyana kufuneka ube ngu-2.5 mg (i.e., ithebhulethi eli-1) ngosuku. Ukuba emva kweeyure ezingama-4-8 zonyango umphumo onqwenelekayo awuzange uphumelele, ngoko umlinganiselo weyeza kufuneka unganyuswa (nangona kaninzi uogqirha benza oko kanye). Le nyaniso kukuba ngenxa yokuba kwimiba ephezulu yengozi yemiphumo eyingozi. Endaweni yoko, unyango lweyeza kufuneka lufake esinye isilwanyana esichaphazelekayo esingekho isifo se-diuretic.

Indlela yokuthatha "i-Indapamide" kulo mzekelo? Ngokulawulwa kwangexesha elifanayo lamachiza amabini, umthamo weziyobisi ezicatshangelwayo zihlala zifanayo, oko kukuthi, 2.5 mg ngosuku (ekuseni kusasa).

Iimeko zokugqithisa ngokweqile: iimpawu, unyango

Yintoni eya kwenzeka xa uthatha isixa esikhulu seziyobisi "Indapamide"? Oogqirha bathi kwiimeko ezinjalo isigulane sinesiphene, sinobuthathaka nokuhlanza. Ukongezelela, isigulane siyaphazamiseka ngokulinganisela kwamanzi kunye nokusebenza kwenkqubo yokutya. Kwezinye iimeko, isigulane sinomlinganiselo ophantsi wexinzelelo lwegazi kunye nokuphefumula. Kwizigulane ezine-cirrhosis zesibindi, i-coma i-hep iyakwenzeka.

Indlela yokunyanga? Kwimeko yokudlula ngaphezulu, isiguli kufuneka sihlanjwe sisisu, silungise ukulinganisela kwamanzi-electrolyte, kwaye sisebenzise unyango olumqondiso.

Iziphumo emva kokuthatha amayeza

Ngaba ukuphendula okungalunganga kwenzeka emva kokuthatha isiza "Indapamide"? Kukho iziphumo ezichaphazelekayo zezi zibisi. Masibhale uluhlu ngoku.

• Inkqubo yokugaya: i-gastralgia, isicupunu, intlungu yesisu, ukuhlanza, i-anorexia, ukumbumba, umlomo owomileyo, i-pancreatitis, isifo sohudo, i-encephalopathy ye-hepatic.
• Inkqubo yokuphefumula: sinusitis, ukukhwehlela, i-rhinitis kunye ne-pharyngitis.
• Inkqubo yokukhathazeka: ukulala, ukulala, ukuphazamiseka, ukunyamekela, ukukhathazeka, intloko, ukukhathala, i-vertigo, ukuxakeka, ukuxinezeleka, ukulala, ukunyanzeliswa, ukunyanzeliswa, ukuxhalaba.
• I-urinary system: i-nocturia, ukusulelwa rhoqo kunye ne-polyuria.
• Intliziyo kunye nemithambo yegazi: i-arrhythmia, hypotension orthostatic, i-palpitations kunye neenguqu kwi-ECG (oko kukuthi hypokalemia).
• Ubungqingili: imisundu, i-rashes, i-vasculitis enegazi kunye nokubetha.
• Inkqubo ye-hemopoietic: i-thrombocytopenia, i-hemolytic anemia, i-leukopenia, i-bone marrow aplasia kunye ne-agranulocytosis.
• Izalathisi zelabhu: i-glucosuria, i-hyperuricemia, yandise urea nitrogen kwi-plasma yegazi, i-hyperglycemia, i-hypercreatininaemia, i-hypokalemia, i-hypercalcemia, i-hyponatremia kunye ne-hypochloraemia.
• Eminye: ukunyanzeliswa kwe-systemic lupus erythematosus.

Ukusebenzisana namanye amayeza

Isilwanyana "i-Indapamide", esenzelwe isenzo sokunciphisa uxinzelelo, alukhuthazwa ukuba kuthathwe kunye ne-cardiac glycosides, njengoko kunokwenzeka ukuba inxinxxu yexikisi yenyuka. Ukuba usebenzisa le sixhobo nge calcium kunye ne-metformin, isigulane sinokuphuhlisa i-hypercalcemia kwaye ikhulise i-lactic acidosis.

Ukwamkela okwamanye amayeza kunye ne-GCS, i-NSAID, i-sympathomimetics kunye ne-tetracosactide ephantsi kwempembelelo ye-hypotensive ye-yangaphambili. Ngokubhekiselele kwi "Baclofen", kunye naye, ngokuchaseneyo, kuyaqina.

Ukuhlanganiswa kweziyobisi kunye ne-potassium-sparing diuretics kusebenza kwinani elincinci lezigulane. Nangona kunjalo, amathuba okuphuhlisa i-hyper- or hypokalemia, ngakumbi kwizigulane ezinokuphelelwa yintsholongwane kunye nesifo sikashukela, asikhangeli.

I-ACE inhibitors inokunyusa umngcipheko wokungabikho komzimba kunye nokungaphumeleli kwe-renal.

Umsebenzi wezintso unokuphazamiseka kunye nokusetyenziswa kwangaphandle kwezidakamizwa ezine-iodine kwiqondo eliphezulu.

I-neuroleptics kunye ne-imipramine-anti-depressants inceda ukwandisa umphumo we-hypotensive kunye nokwandisa umngcipheko we-hypotension orthostatic.

Imiyalelo ekhethekileyo yokusetyenziswa kwemveliso yeyeza "Indapamide"

Kuziphi iimeko apho isiguli segazi lesiguli kufuneka sigqitywe emva kokulawulwa kwe-Indapamide? Oogqirha bathi la mayeza angatshintsha inani le-creinine kunye ne-potassium ions kulawo gulane athabatha i-laxatives, i-cardiac glycosides, kunye nabantu abangaphezu kweminyaka engama-60 ubudala.

Xa usebenzisa le sixhobo, iingcali zikwacetyiswa ukuba zisoloko zijonge ukuxinwa kwee-sodium, i-potassium kunye ne-magnesium ioni kwi-plasma yegazi, njengoko izigulane zinokuphuhlisa izifo zentsebenzo ye-electrolyte. Kwakhona kuyimfuneko ukujonga i-pH, ukuxutywa kwe-uric acid, i-glucose kunye ne-nitrogen eseleyo.

Ulawulo olulodwa lufanele lunikezwe izigulane ezine-cirrhosis zesibindi (nge-edema enzima okanye kwi-ascites), kwakunye nokusilela kwintliziyo kunye nesifo senhliziyo.

Iqela elinobungozi obuphezulu liquka izigulane ngexesha elongezelelweyo le-QT kwi-ECG (ingaba inzala okanye ifumaneke ngokubhekiselele kwimeko ekhoyo yonyango).

Umlinganiselo wokuqala wokuxinwa kwee-potassium kwigazi legulane kunconywa ngeveki yokuqala yonyango.

Ingqwalasela ingakumbi kufuneka ihlawulwe kwizigulane ezineesifo seswekile. Ngokukodwa, kuyimfuneko ukugcina izinga le-glucose egazini, ingakumbi ukuba umntu ufunyaniswa ne-hypokalemia.

Izigulisi ezithatha le nyilisi kufuneka zihlawule ukulahlekelwa kwamanzi ngokudla inani elininzi lomlambo ngosuku. Ngaphezu koko, ekuqaleni kwonyango kufuneka bajonge umsebenzi wezintso.

Omnye akanakunceda ukuthetha ukuba izidakamizwa "i-Indapamide", ezifana nezo ziza kuboniswa ngezantsi, zingenza umphumo omuhle ngexesha lolawulo lwe-doping.

Izigulane ezine-hyponatremia kunye nomfutho wexinzelelo kufuneka ziyeke ukuthatha i-diuretics iintsuku ezintathu ngaphambi kokusetyenziswa kwe-angiotensin ukuguqula i-enzyme inhibitors. Unyango luya kuphinda luqaliswe emva kancinci.

Xa ulawula i-Indapamide, iingcali kufuneka ziqaphele ukuba izixhobo ezivela kwi-sulphonamide zingabangela ukuba kubekho ukukhushulwa kwesifo esinjengenkqubo ye-lupus erythematosus.

Kuze kube ngoku, ukhuseleko kunye nokusebenza kweziyobisi kunyango lwabantwana abancinci nabaselula abakusiswanga.

Kwiimeko ezithile, iimpendulo ngabanye ziyakwenzeka ezinxulumene nezinguqu kwixinzelelo legazi. Ngokuqhelekileyo, oku kwenzeka ekuqaleni kwonyango, kunye nokusetyenziswa kwesinye isilonda esilwa ne-antihypertensive. Ngenxa yoko, ukukwazi ukulawula umatshini kunye nokusebenza nezinye iindlela kunokunciphisa, okufuna ukunyuselwa okongeziweyo.

Ukuphononongwa kweengcali kunye nezigulane malunga neziyobisi

Ngoku uyazi ukuba umkhiqizo we "Indapamide". Ukuphonononga, ixabiso leliyeza liya kuhanjiswa kwangoku.

Iingcali zithi la mayeza asebenza kakuhle nomsebenzi. Iyanciphisa ngokukhawuleza uxinzelelo lwegazi, kwaye iyakwenza njenge-diuretic.

Ukuphonononga ngezilwanyana "I-Indapamide" ibonisa ukuba emva kwesicelo sayo, i-hypertrophy ye-ventricular hypertrophy iyancipha, kwaye i-hypotrotic effect yayo ibonakala nakwezo zi gulane ezise-hemodialysis.

Ngenxa yeengxelo ezimbi malunga neli phephandaba, zihlala zidibaniswa nokubonakaliswa kwenani elikhulu leempendulo ezimbi. Nangona kunjalo, kufuneka kuqatshelwe ukuba iziphumo ezinjalo zigcinwa kuphela kulabo abaye banqumla umlinganiselo osisigxina weziyobisi okanye bayithatha, nangona kukho ukuchasana okukhoyo.

Ixabiso kunye neempawu zonyango

Ingakanani idiza "Indapamide" indleko? Ixabiso leliyeza lingahluke (kuxhomekeke kumenzi kunye nomatshini we-intanethi). Nangona kunjalo, ngokuqhelekileyo, le mveliso ingathengwa ngama-ruble angama-95-100 aseRussia (iipilisi ezi-30).

Kodwa kuthekani ukuba isigulane asinakufumana iyeza "Indapamide"? I-Analogues, ixabiso layo aliphezulu kakhulu, lithengiswa phantse kuwo onke amayeza. La mayeza afaka oku okulandelayo: I-Indapamide Retard, i-Acrypamide, i-Indapamid-Teva, i-CP-Indamed, i-Acrypamide Retard, i-Ravel SR, i-Acutter-Sanovel, i-Retapres, i-Arindap "," Lorvas "," Arifon "," Pamid "," Arifon "," Tensar "," Ipres Long "," Vero Indapamid "," Indipam "," Indap "," Indyur "," Indapamid-Verte " "," Ionik "," Indapamid retard-Teva "," Inpadres "," Indapamid Sandoz "," Ionik retard "," Indapamid-OBL "," Indapamid Stada "njalo njalo.

Thatha le mali ngokwengqiqo yabo kwaye ubeke endaweni yabo ngamachiza "Indapamide" ayinqatshelwe. Kuphela ugqirha kufuneka abhale, kwaye emva kokuhlolwa kwezonyango. Kwakhona, ngaphambi kokuba uthathe la mayeza, kufuneka ufunde imigaqo eqhotyoshelweyo.

Iimeko zokugcina ukulungiselela kunye nobomi bayo

Gcina loo mayeza kwindawo eyomileyo nendawo emnyama, engenakufikeleleka kubantwana abancinci. Ubushushu bokugcinwa kwesilwanyana akufanele kudlule ii-degrees ezingama-25. Umhla wokuphelelwa yisikhathi nguminyaka emithathu. Emva kolu xesha, kunqatshelwe ukuba kuthathe iyeza.