"Nebilong": imiyalelo ukusetyenziswa. "Nebilong": imihlolo analogue

"Nebilong" yi ichiza olusebenzayo ukunyanga izifo ezinxulumene nomsebenzi ngentliziyo kakuhle. Ukuphucuka ntoni emva ukuyisebenzisa inyanga enye. Emva kokuba isicelo "Nebilonga" ukubetha nganye ezinga malungu abantu kunye noxinzelelo lwegazi, ukuphumla semithambo sifikelelwayo, lo myocardium inikezelwa ioksijini eyaneleyo. Phantse kuyo yonke imiba iziphumo ezidibanisayo unyango igcinwe ixesha elide.

Ubume, Composition

Iyeza ifumaneka emacwecweni. tablet nganye anokuqulatha 2.5, 5 okanye 10 mg esisebenza. Iyeza senziwa ngenxa nebivolol hydrochloride. Kwezi excipients abakhoyo ukwakheka povidone, lactose, wemagniziyam stearate. Ukwakhiwa ezikhatshwa talc, microcrystalline kwincindi, isodiyam dioctyl sulfate, colloidal lesilicon dioxide, isodiyam croscarmellose, Beta-cyclodextrin.

imiphumela kwemithi

"Nebilong" ibonisa yemiyalezo njengendlela yokuba kubume bayo enantiomers ezimbini (L- and D-nebivolol). D-nebivolol - uyakhetha kakhulu, enokhuphiswano β1-adrenoceptor blocker, L-nebivolol ngobunono phezu imithambo yegazi, yandise kubo, apho kungenxa yokuba inkqubo le endothelium nemithambo (release vasodilating kwezwi factor).

Nebivolol kunciphisa uxinzelelo lwegazi kunye izinga intliziyo, isiphumo igcinwa nje kuphela zikarhulumente quiescent kodwa phantsi komthwalo. Emva ukuthatha iyeza ngeenxa kunye nesiphelo-ukuzala uxinzelelo ventricular lasekhohlo kuyehla, kukho nefuthe elakhayo kwenye imisebenzi eyenziwa yi intliziyo - ukuzala. Ngenxa yesicelo i "Nebilonga" kwandisa ejection lwamaqhezu, abantu abane IBS zimakishwe ukusebenza antianginal.

amanyathelo iqinile athathiweyo tablets "Nebilong" kuchaza ukuhla kumsebenzi kwinkqubo renin-angiotensin. isenzo Antiarrhythmic ifunyanwa ngokunciphisa AV-Uhanjiso kunye abathintela engaqhelekanga ukuzenzekela intliziyo. Lwandomeleza ukusebenza iqinile kwenzeka kwiintsuku 7-14 zonyango, ngokufuthi - ngenyanga. japan ezinzileyo ekuthatheni iipilisi waphawula emva kweenyanga omnye ukuya ezimbini zonyango.

Pharmacokinetics

Ichiza ongena ebantwaneni, wendele kakuhle, inkqubo isebenza ngokufanayo nokuba isidlo. Yokucolwa esibindini ikwagqibezela ukuyilwa gidroksimetabolitov esebenzayo. Le bioavailability avareji emva kokuba isicelo zomntu lwangaphakathi medicament kunye yokucola ukutya okukhawulezayo ka-12%, eli nani liphezulu kakhulu kunokuba kunye ukutya kade. Ekubeni nethe lwezigulane kungenzeka ngamazinga ahlukeneyo, "Nebilong" manual akukhuthazwa ukuba zisetyenziswe kunye iimpawu ngamnye womzimba yomguli. Ekubeni yokucola ukutya olucothayo zisetyenziswa ngeedosi phantsi ichiza. Kwizifundo kunye exchange ngokukhawuleza kwezinto lwenzeka isiqingatha-ubomi nama-10 iiyure, xa izigulane kuba ukutya kade, isiqingatha-ubomi banda izihlandlo 3-5. Emva kweentsuku ezisixhenxe unyango, malunga 38% efunyenweyo ichiza idubule yi nezintso, malunga 48% "Nebilonga" ekhoyo kwi esitulweni. Ukubunjwa umchamo imali encinci amayeza lingatshintshanga - ukuya kwi-0.5%.

ubungqina

Ngomhla isicelo of "Nebilong" yokufundela isetyenziselwe lwegazi, kuba ukuphunyezwa amanyathelo othintelo kwizigulane kunye CAD (maxa angina) kwaye ukuphunyezwa nothomalaliso entsonkothileyo ukusilela intliziyo ifomu ezigulo ezondeleyo.

Treatment kunye ichiza "Nebilong"

BP

izigulane abadala alawulwa 5 mg "Nebilonga", nto leyo lihambisana ekuqulunqeni tablet idosi yemihla ngemihla. Iyeza Kucetyiswa ukuba usebenzise ngosuku ngexesha elifanayo. A sisiphumo esincinane kuba buqapheleke emva kweveki enye ukuya ezimbini unyango, eyona zomlomo wakhe, yena ngenyanga ngexesha apho unyango luyenziwa. Amacwecwe ezifanelekileyo ukuphunyezwa monotherapy kwaye unyango ngokusekelwe ekusetyenzisweni ezihlanganisiweyo kweziyobisi, nto leyo neziphumo iqinile. Abantu abathatha "Nebilong AM", imfundiso kuphakanyisiwe ukuze ufumane isiphumo eyongezelelweyo ukusebenzisa "Hydrochlorothiazide" ka 12.5-25 mg. unyango zidibene ngolo hlobo ukuphucula isenzo "Nebilonga", kodwa oko kungenziwa kuphela emva kokuba efumene icebiso gqirha khona.

ukusilela Heart yi luhlobo esingapheliyo

Okokuqala igcuntswana leyeza medicament, igqirha ngcembe kunyusa, banikwe iimpawu umguli. Kuba unyango iintlobo nokoyika "Nebilong" akufanelekanga, kwiimeko ezinjalo, amanye amachiza isetyenzisiwe. Ngokuqhelekileyo kuqala emiselweyo ku 1.25 mg iziyobisi ukuze sisetyenziswe kanye yonke imihla, emva kweeveki 1-2 ithamo kufuneka lenyuke 5 mg, yaye kamva - ukuya ku-10 mg. Le idosi yemihla ngemihla akufuneki ngaphezu 10 mg medicament "Nebilong". Imiyalelo yokusebenzisa ibonisa ukuba lokuqala inqanaba unyango isigulane eseleyo phantsi koqwalaselo iiyure ezimbini emva kokuba nokudla cwecwe, ukuze wenze ngalinye ezandayo kusho zedosi. ithamo Ukwanda kungancitshiswa kwakhona xa kukho imfuneko ikhona.

Ukuba iimpawu ukusilela intliziyo yavela ukunyamezelana ngokukhawuleza okanye umguli macandelo zeziyobisi kwafumaneka, ukunciphisa ithamo ichiza okanye ukuvelisa bupheliswe. Ngokuqhelekileyo, ukusilela intliziyo, uhlobo esinganyangekiyo of "Nebilongom" uyazinyanga ngokukhawuleza. Xa therapy ejoliswe ukuphelisa iimeko ezinjalo, ukupheliswa ichiza ukuba ngokucotha, aninako ukwenza esi senzo kabukhali, ngokuba le ngxaki ukuze mandundu. Ukuba ukurhoxisa ichiza veki nganye ukuze nciphisa ithamo ngesiqingatha. Kuba ukuthatha iipilisi "Nebilong AM" umyalelo ncwadana inika nezithintelo ethile.

izithintelo:

• insufficiency kwezintso. Okokuqala, ngokuba unyango usebenzisa 2.5 mg beziyobisi ngosuku, ithamo angandiswa kamva, kodwa akufuneki ngaphezu 5 mg.
• ubudala nangaphezulu. Ithamo yokuqala mawungabi ngaphezu kwe-2.5 mg ukuba kuyimfuneko, uvuka ukuya mg-5. Emva kweminyaka engama-65, zifuna uhlolo rhoqo izintso (omnye qho kwiinyanga ezine ukuya kwezintlanu).
• Ukukhulelwa. Usana inokuphuhlisa ezinye izifo, ezi ziquka ukukhubazeka yokuphefumla, hypoglycemia, hypotension, bradycardia, abasetyhini abakhulelweyo ngoko ichiza kumiselwe kunqabile kakhulu. Ukuba umfazi omithiyo isebenzisa efunekayo "Nebilong" ukurhoxiswa yakhe iiyure 48-72 phambi kokuba unikezelo. Ukuba oku akwenzeki, usana kufuneka babonwe iiyure 48-72.

Izimo

"Nebilong H" yemiyalezo lithintela ukusetyenziswa kwezi meko zilandelayo:

• yokuguga ngaphantsi kweminyaka eli-18;
• hypersensitivity amacandelo zeziyobisi;
• bronchospasm, isifuba (imbali);
• pheochromocytoma, leyo ayikhange baphathwa ngaphambili;
• lactic metabolic;
• ezenzeka nzima isifo sesibindi, ukusilela isibindi;
• hypotension ngabanye xi 90 mm HG okanye ngaphantsi ogama iSystolic. Inqaku.;
• AV-block (grade I, III), bradycardia, nto leyo sikhatshwa izinga intliziyo esilingana 60 BPM. ngomzuzu;
• ngexesha ngokuzala, isikhuselo-lweehagu;
• etsolo senhliziyo imilo;
• iingxaki namaphephandaba peripheral, kunye imizwa acacile;
• mothuko cardiogenic, imeko apho kuyimfuneko ukusebenzisa iziyobisi isotropic;
• syndrome, sinus lokugula sikhatshwe.

isilumkiso iyafuneka xa kutyunjwa ichiza kwizigulane kunye nemiqathango:

• diabetes;
• ukhwekhwe (imbali);
• Prinzmetal angina.

imiphumela emibi

Xa unyango lithetha "Nebilong" umyalelo manual, ukubuyekeza bathi amathuba kukuvela yeziphumo ebezingalindelekanga ethile, leyo ebonakaliswa umsebenzi sentliziyo, yokucola ukutya nokulwa luvo. Phakathi kwezinye ukwaphulwa - bronchoconstriction reaction echaphazela imeko yesikhumba.

oyi

"Nebilong 'ukuze siqinise uvakalelo zamavumba nezidlo, leyo esongela uphuhliso basabela kakhulu anaphylactic.

unyango ngamachiza aluchaphazeli inqanaba glucose emzimbeni phambi seswekile, kodwa izigulane kweli qela kufuneka basebenzise amayeza ngononophelo. Njengokuba isifo seswekile kunye hyperthyroidism neziyobisi bunokufihla iimpawu tachycardia, oko ucaca ngakumbi ngenxa ekurhoxisweni ngokukhawuleza amacwecwe.

Ukuba izigulane iingxaki kwinkqubo nokuphefumla isetyenziselwa "Nebilong" yemiyalezo yazisa malunga amathuba inzuzo constriction ye yomoya in COPD. Ukuba nokwenzeka yokudibanisa ichiza kunye namanye amachiza kufuneka zihlolwe kunye nogqirha wakho.

"Nebilong" kuchaphazela ukukwazi ukuqhuba isithuthi, kunokukhokelela wayedinwa kunye nesiyezi.

analogs

Kuyenzeka ukutshintsha ichiza elo akavumeli ukusebenzisa iziyobisi "Nebilong" umyalelo manual. analogue Drug ziquka "Nebilet", "Binelol". Ngu ababambeleyo zikwaquka "Nebikor" yaye "Nebivator".

reviews

Njengoko ukubuyekeza, ichiza isebenza xa isetyenziswe ngokuchanekileyo. Kubalulekile ukuba usebenzise amayeza uze ulandele iingcebiso zonke kagqirha. Le medicament yabelwa kunye Izimo kunye iimpawu yomguli, nto leyo nemiphumo emihle. Loo unyango zange kukhokelela kuphuhliso ziziphumo ebezingalindelekanga, kufuneka esweni rhoqo imeko yomguli.