"Rosuvastatin": imiyalelo ukusetyenziswa, ncomo. Cheap Togu "rosuvastatin"

Ichiza "Rosuvastatin" liye kwaziwa ukususela ngo-2003 kwaye wanikela njenge statin Generation IV. It is a inhibitor mihla ophezulu nomgangatho gamma-methylglutaryl-onx reductase. Le enzyme inoxanduva Yindibanisela cholesterol emzimbeni womntu. inhibition yayo kukhokelela ekuncipheni kwe cholesterol iqala kwaye zinciphisa amathuba okuba nesifo sentliziyo.

Ukongeza "rosuvastatin" kukho isasetyenziswa iklasi eziliqela, amalungu eqela statin le. Oku "Simvastatin" "Pravastatin", "cerivastatin," "Lovastatin," "Fluvastatin," "Atorvastatin", "pitavastatin." ukusebenza Clinical nesantya nokunciphisa iyonke cholesterol low-mninzi "Rosuvastatin" yesibini kuphela "pitavastatin," nto leyo kodwa Lusetyenziswa kakhulu ngenxa ledatha ngaphantsi ezingasetyenziswanga yolingo lwezonyango.

Ukuza kuthi ga ngoku, "atorvastatin" lisetyenziswa kaninzi ngaphezu kwezinye statins kuba leyo yeyona ebanzi indawo yophando ubungqina ngempumelelo yayo kwezonyango. Kwakhona, yena generics zakhe sitshiphu, "rosuvastatin". Kodwa njengoko isiphumo lokugqibela (kuqheleke yabucala lipid of plasma yegazi) ngokukhawuleza, yaye ke aqale ukusebenzisa ngakumbi ngokubanzi. Le imveliso esemgangathweni ngenene, kuba apho kufuneka ahlawule ixabiso.

Beka "rosuvastatin" in pharmacotherapy

Xa Elungiselela "Rosuvastatin" isicelo, nangona ubukho kunezixhobo iklasi, ebanzi. Kuchazwa ezibonisa kunye Izimo kuphela. Zabonisa ngoku phantse zonke iintlobo hypercholesterolemia kunye ukuphazamiseka emzimbeni lipid. Ukwehla atherogenic amaqhezu lipid kuba nemiphumo kwi eziphilayo. Ngenxa yoku, ukuba nokwenzeka kuphuhliso izilonda atherosclerotic sinciphile kwaye iminyaka yobomi (nomgangatho) ukunyuka.

Ukulungiselela "Rosuvastatin 'ukuze zingasetyenziswa nokuthintela izifo sentliziyo, kwaye awanyange. niche Last pharmacotherapy ikhona ngenxa yokubhuqwa iinkqubo yamafutha nokuzinziswa endothelial bathintele. Ekubeni iqhosha kunye nentliziyo yobuchopho iphuhlisa i thrombosis etsolo eziphambili imithambo, ngoko ke isiphumo lwezonyango inceda ngokwenene ukunqanda iziganeko zosulele sentliziyo.

Imiyalelo yokusebenzisa

Okuqhotyoshelwe ichiza "Rosuvastatin" yemiyalezo (analogue uxwebhu enjalo) iqulathe uluhlu elimxinwa kwakuthethwa zokusetyenziswa. Noko ke, loo nto ayenzi siqulethe naziphi na iinkcukacha nomonde into efunekayo phambi ukusebenzisa ukufumanisa iqhezu cholesterol. Kwixesha elizayo, utshintsho labo liya kuphonononga ukusebenza bezonyango belo unyango balawule ethile. Kwakhona ingxelo iqulathe ulwazi malunga ukhuseleko kunye neempawu unyango, Izimo, kunye neziphumo ebezingalindelekanga kakhulu rhoqo kunye ebalulekileyo.

Ubungqina obubonakalayo buxela

Phakathi zonke izifo ezinxulumene nokonyuka ngamaqhezu lipid plasma, ubonisa ezinye izikhokelo ezivela eklinikhi:

• sofuzo heterozygous (kwiintsapho) hypercholesterolemia;
• zihlelwa Fredrickson uhlobo hypercholesterolemia polygenic IIA;
• dyslipidemia zidibene, zihlelwa Fredrickson indlela IIb;
• Kwiintsapho (kwiintsapho) hypercholesterolemia Homozygous;
• coronary, ebuchotsheni okanye sezintso kwemithambo yegazi, occluding le mithambo kwemithambo;
• Yamafutha kwemithambo kweqondo asezantsi, kuquka Leriche syndrome ;
• (Uhlobo IV ngokutsho Fredrickson) hypertriglyceridemia;
• Unyango iposi engabalulekanga kunye nobuchopho, ukususela kwixesha oyingozi;
• ukuthintelwa iposi engabalulekanga kunye stroke.

Izimo

Nayiphi analog "rosuvastatin" zitshiphu na iziphumo ebezingalindelekanga enye njenge "Crestor" wokuqala. Ngokusekelwe Izimo zabo spectrum kuyilwa, zezi zilandelayo:

• hepatic cytolysis isifo syndrome kunye hepatocytes kunye ulwando oluphindwe ezintathu-ngaphezu kwi transaminase lamanani;
• ukusilela kwesibindi, ukuqina abanamanqaku ka 9 Child-Pugh;
• ezingapheliyo imisebenzi Isalathisi ukusilela kwezintso kunye ukucoca creatinine ml ngaphantsi kwe-30 \ imiz.;
• Myopathy nasiphi na imvelaphi;
• kukwalisa kumacandelo ukuqulunqwa okanye "Rosuvastatin".

Kukho iqela ezinye Izimo for 40 mg balawule:

• ukusilela kwezintso ezingapheliyo kunye ukucoca Isalathisi creatinine hayi ml ngaphantsi kwe-60 \ imiz.;
• naziphi myopathies zofuzo;
• ukusetyenziswa ezihamba kunye fibrates;
• utshwala;
• uhlanga Mongoloid;
• sebenzisa le statin okokuqala.

Iimpawu beziyobisi

Zonke "rosuvastatin" - iziyobisi, analogue apho zifumaneka ngokubanzi ezivenkileni. Kwaye ngokukhetha igama elithile lophawu, isigulane kufuneka uthathe amayeza kunye. Oko kukuthi, ukutshintsha kwenye amayeza ngqiqweni. Sam ichiza kuthathwa ngaphandle ngokuphathelele izidlo ngalo naliphi na ixesha lemini. Kukho ezimbalwa kwezinye iingcebiso leengcaphephe wayesebenza kunye statins sizukulwana sokuqala. Bathi ziqulathe ulwazi statins kufuneka ithathwe ebusuku. Nangona zibaluleke kakhulu, yonke imihla iyeza sathathwa malunga ngexesha elifanayo narhoqo.

Lawula yimeko yabo kufuneka rhoqo de kwamkelwa "Rosuvastatin" (analogue). Ukuphonononga ukuba iingcali ukuze sisebenze ngaphandle nangemikhwa kakuhle lokuqaphela. Ngokukodwa, emva kokusekwa phambi hypercholesterolemia kufuneka ukuba uqale ukuthatha i-isiyobisi kunye idosi esisigxina. Emva kweenyanga ezi-2 esweni - lipidogram lwenziwa rhoqo kwaye zivavanywe umsebenzi aminotransferases.

Ukuba kukho kuqheleke yabucala lipid plasma yegazi, kufuneka ukuqhubeka samkela idosi enye. Ukuba cholesterol zizonke phezulu, kwaye isixa cholesterol loxinano ephantsi yehla kakhulu, ukwandisa umthamo efunekayo. Ukuba transaminase anda izihlandlo ezithathu, kufuneka ukususwa statins. Kufuneka ngokukodwa kuqatshelwe ukuba utyekelo incinane okubangela cytolysis zonke statins yi "Rosuvastatin." Analogs (Ukraine chu ayisafani "atorvastatin" kwi "rosuvastatin") eklasini ukhuseleko oluncinane. A "pitavastatin" kuhlala mncinane efunda.

Analogs "rosuvastatin"

Njengoko isifaniso, "rosuvastatin" ( "Crestor") sele inikeza iimveliso ngaphezulu kwe-10. Phakathi kwabo, "AKORT", "Merten", "Rozart", "Rozistark" "Rosuvastatin Canon", "Rosuvastatin SOTEX" "Rosuvastatin NW", "Rozulip", "Rozukard", "Roxer", "Rustor" " Tevastor ". Indleko sibaphathe kubo ezahlukeneyo, kwakunye nobuchule. Kuba ixabiso la machiza zingahlulwa ngokweendidi ezintathu:

• amaxabiso ephantsi (ukusuka engange-250 ukuya-650), "Rosuvastatin NW", "Rosuvastatin Canon", "AKORT" "Rosuvastatin SOTEX";
• amanani Umyinge (ukusuka engange 400 ukuya 900), "Merten", "Rozart", "Roxer", "Rozukard", "Tevastor", "Rozulip";
• amaxabiso aphezulu (ukusuka engange 1100 ukuya 2200): "Crestor".

uhlalutyo ixabiso lwenziwa ngokuthelekisa iindleko amayeza, ubunzima umchiza leyo-10 mg. Uhla amanani ibonisa iindleko kwinyanga enye unyango cholesterol-lisibekele. Analog ibiza "rosuvastatin" iveliswayo "Northern Star". "Rosuvastatin Canon" yaye "AKORT" kwakhona ezahlukeneyo kancinane ixabiso. ixabiso babo ungaphantsi ukuba ukutshintsha ngokuxhomekeke ukuhla ngerandi.

Wayo i "CRESTOR" ingenandleko generic

Ichiza "Rosuvastatin" ezikhutshwe Astrazeneca, ubizwa ngokuba "Crestor". Le nto ke amayeza yokuqala, ekufuneka kuthelekiswa bonke abanye. Kunjalo izimvo: indlela ebonakala imveliso ethile generic kufuneka lusekelwe kuthelekiswa yayo "Krestorom". Kodwa ngenxa yexabiso layo eliphezulu, izigulane ezininzi nangoko ukuqala unyango lwe hypercholesterolemia kunye generics zitshiphu.

Injongo ulwazi kuphela iingcali bangavela kwi siyijonga, abo badla ngokujongana nokusetyenziswa generics kunye 'rosuvastatin "kunye" CRESTOR "wokuqala. A isicelo ichiza "imiyalelo Rosuvastatin 'ukusetyenziswa, angqina nomonde kunye namava zizehlo iya kuvumela ezinye izigulane ukuba ukhethe igama elithile lorhwebo.

Izimvo leengcali "Crestor" kunye generics

Thelekisa "CRESTOR" kwenziwa kuphela ziingcali ze-Russian Society of Cardiology. Olu lwazi kudla epapashwe kulindixesha "pharmacotherapy kusengqiqweni kwi zentliziyo." Ngokukodwa, uzithetha imiba bioequivalence ka iziyobisi generic "Crestor". Ngokutsho iziphumo zophando pharmacoeconomic lubonise ukuba iziyobisi "Merten", "Rozart", "Roxer", "Rozukard" yaye "Rozulip" "Crestor" bioequivalent.

Oku kuthetha ukuba nawuphi na "rosuvastatin" Lo mfanekiso kunempembelelo enyangayo efanayo ichiza yokuqala sine nani efanayo kunye nobukhali iziphumo ebezingalindelekanga. Kanti imithi "Rosuvastatin NW", "Rosuvastatin Canon", "Rosuvastatin SOTEX" yaye "AKORT" kwiimvavanyo ezinjalo azisetyenziswa. Ngenxa yokuba ezi zifundo manani akukho ngemali ziinkampani zamachiza, ulwazi eliphuma injongo kwaye uyazanelisa na iimpawu kwezonyango unyango hypercholesterolemia. Nakuba kunjalo, iziphumo kuphela generics angaphandle.

Izimvo leengcali generics cheap "rosuvastatin"

analogu yanamhlanje i "rosuvastatin" cheap umele bioequivalence "Crestor 'yabo emva koko kuba ngokuzenzekela intlonipho yeengcali. Ngaphandle izifundo bioequivalence ochwepheshe Sizakukhankanya kuphela iimpawu kwezonyango isicelo. Enye yazo oku: ukuba wasebenzisa isasetyenziswa zitshiphu "rosuvastatin" (iziyobisi ezidweliswe apha ngentla), nezihlandlo iziganeko ezibi ofana babona xa usebenzisa generic bioequivalent "Crestor".

Ukuhla kwi plasma xi "rosuvastatin" evela ekusetyenzisweni kwe ifomu idosi esiluqilima kunye sisincoko ezahlukeneyo, zithathwa kungabalulekanga kule meko. Ngenxa analogu cheap Russian of "rosuvastatin" ngaba ngokwenene indawo ichiza "Crestor" yoqobo kunye neziyobisi yayo lunezinto kunyango hypercholesterolemia.

Iimpawu ezigulane reviews

Ngokutsho iimpendulo ezigulane ababelana ngeembono zabo malunga nokusetyenziswa kweziyobisi kunye nogqirha wakho, kukho kwisigqibo eziliqela ezivakalayo. Okokuqala, izigulane izigwebo malunga nomgangatho ichiza uphambene. Okwesibini, ngenxa imperceptible ukuya isiphumo nomonde kwezonyango ukunamathela kunyango iphantsi, nangona unyango kuyimfuneko ukuthintela umngcipheko iziganeko zosulele coronary. Okwesithathu, izigulane zidla ukubaxa ngokubaluleka neziphumo ebezingalindelekanga ze lula Dynamics yeprofayili plasma lipid.