"Teopeka" (300 mg): imiyalelo ukusetyenziswa, izalathisi, umenzi

Abantu ophila nesi sifo, uyazi ixesha kubaluleke kangakanani ukuba bancedise bronchospasm. Ngamanye amaxesha isenzo esifanelekileyo kule meko ezinzima ukusindisa ubomi. A indima ebalulekileyo ekwenzeni abantu iingxaki zemiphunga idlala bronchodilators.

Inkcazelo yokulungiselela

"Teopeka" (300 mg), imiyalelo zokusetyenziswa oboniswe kule yephepha a macwecwe emhlophe ploskotsilindricheskoy imilo setyhula, ezo zipakishwe ukupakisha nentaba. Eyona nto iphambili ebonakalayo ichiza theophylline. Ayithandi elucwecweni olunye kumalungiselelo ale fomu 300 mg.

njani eli yeza?

Ngu wesenzo amayeza of theophylline, nto leyo yemvelaphi purine, onesiphumo ziyibuyisela umva le phosphodiesterase. Le esisebenza iibhloko zeziyobisi receptors purine ethile, elikhuthaza Inkampi sokuzuza zokugcina zeethishu, lihlisa isakhono smooth esiqwini umsipha nesivumelwano, ukunciphisa ubungakanani ion calcium simahla, nto leyo iya kusetyenziswa ingaphandle cell.

Uphawu sho vasodilating isiphumo lolwamkelo esikolweni "teopeka" ukulungiselela (300 mg). Imiyalelo yokusebenzisa ichaza ipropati ibe nempembelelo ezityeni yegazi peripheral. Theophylline kwandisa flow igazi ngokusebenzisa inkqubo kwezintso, ikhuthaza ukuthanjiswa iinqanawa inyumoniya izihlunu kunye negazi egudileyo. Kwakhona, yintshukumo icandelo esebenzayo uphawuleka njengoko umchamo. Theophylline ithintela ukukhululwa kwezinto ngaphakathi nangaphandle, ukumqumbisa impendulo komzimba kwakunye kwandisa nozinzo inwebu cell imasti. Ukuba into esebenzayo i hypokalemia isigulane esikhulayo umoya.

Theophylline inceda bunjani ukusebenza wokuphefumla, isebenze iziko olungqamelanayo kwi ebuchotsheni, nto leyo ngcono ioksijini igazi Ukwanda, oku kunciphisa uyondelelwano lwee- carbon dioxide. Drug "teopeka" ivuselela uvalo, ebangela ukuba itshone. Kwakhona kwandisa ixabiso kwisalathisi umsebenzi mucociliary sococeko uyayiqinisa izihlunu bokuphefumla intercostal.

Theophylline kukhokelela mikrotsirkullyatsiyu igazi oluqhelekileyo kunciphisa thrombus Ukwakheka, ofihla into ethile khipha udibaniso kweeseli zegazi. kweziyobisi kwenza kumsinga umgangatho kwegazi, kwandisa ukumelana deforming erythrocytes izinto.

"Teopeka" (300 mg), ngokwenjenjalo kuncitshiswe uxinzelelo iyonke kwegazi pulmonary, kwaye kananjalo kunciphisa uxhathiso kwi kwinkqubo pulmonary nemithambo. Ngenxa yoko, ithowuni ye integuments ulusu, wezintso kwaye nobuchopho kunciphisa. Ngenxa yoko yokufumana theophylline ephawulwe ukukhuthazwa yokumpompoza kwegazi coronary, bandisa umsebenzi kwentliziyo, ukwanda iiseli engabalulekanga emangalisayo kufuneka ioksijini, odlisa ubomi ubume, amandla izishunqulelo intliziyo linyukile.

Pharmacokinetics kunye pharmacodynamics beziyobisi

Emva kokuba isigulane wathabatha ipilisi kunye theophylline, iyeza ako ngokupheleleyo iphecana zesisu. nomnikelo Ukutya onesiphumo kwi izinga kukufakwa ichiza, kodwa iqondo ukufunxeka kunye yokususwa kuhlala ingatshintshanga. Ekubeni protein plasma sibophelela-40% ukwimo esebenzayo. nethe Theophylline kwenzeka esibindini yi cytochrome P450.

Kukhuthaza metabolites eziveliswa uhlobo olusebenzisekayo nge nezintso, kodwa-10% ye ichiza ziphelisiwe ifomu yayo yasekuqaleni. Ezinye izinto zibe nefuthe elivakalayo nethe of theophylline. Ukutshaya, ngokuthatha amayeza athile, imikhwa yokutya, comorbidities, ubudala, nako ukwenza utshintsho ngokutshintshiselana iziyobisi esebenzayo emzimbeni womntu. Ukunciphisa zesigunyaziso theophylline uyaqapheleka nokudumba lung, isifo sesibindi, COPD, kwaye ukusilela entliziyweni.

Ngubani na ukwamukela lo sixhobo?

Kukho iimeko ezithile apho i "teopeka" (300 mg). Imiyalelo yokusebenzisa ichaza zifo zilandelayo:

• bronchitis obstructive kwifomu ezingapheliyo;
• belele;
• emphysema;
• somoya;
• BP pulmonary;
• intliziyo miphungeni.

Kwakhona, ichiza "teopeka" ingxelo entle ezinokusetyenziswa kunye nezinye iziyobisi ukunyanga nokudumba nature kwezintso. Izigulane qaphela ukusebenza eliphezulu sixhobo kunye nokwamkeleka yayo ngenxa yonyango izifo isixokelelwano sokuphefumla.

Izimo

Nangona kunjalo, eli chiza ingasetyenziswa wonke umntu, ngenxa yokuba ubukho eziliqela izilumkiso ezivela mali. "Teopeka" Izimo zezi zilandelayo:

• uhlobo stroke sophele;
• sokuwa;
• ukopha evela iphecana zesisu embalini;
• isilonda uluhlu izitho zokugaya;
• tachycardia severities phezulu;
• soxinzelelo lwegazi okanye hypotension;
• hypersensitivity;
• gastritis, ekhatshwa asidi;
• Abantwana ukuya kwiminyaka engama-12.

Phambi ubuncinane enye yezi syndromes okanye iimeko theophylline neziyobisi uhlukane

imiphumela emibi

Kukho kakhulu iqela elikhulu icala elingenzi nto-ekuthatheni "teopeka" ukulungiselela (300 mg). Imiyalelo yokusebenzisa izabelo zabo ezibonisa zenkqubo:

• ukuphazamiseka kwenkqubo luvo: ebuhlungu, isiyezi, ukuphazamiseka kokulala, iveze, ixhala eyonyukileyo kunye nochuku, Barr;
• kwekhono intliziyo negazi nempahla: tachycardia, arrhythmia, hypotension, yokubakho qho yokuhlaselwa angina, angina ababuxoki;
• iphula zesisu eqhelekileyo yokusebenza: isicaphucaphu, gastralgia, ukugabha, heartburn, reflux, izilonda exacerbation, urhudo, yehle emnyama;
• zokubonisa ziyabagulisa: irhashalala eluswini, ifiva, ukurhawuzelela;
• phakathi kwezinye iziganeko egwenxa evela ezithatha ichiza kwaqwalaselwa: tachypnea, albuminuria, diuresis anda, uqaqanjelwa kwentamo, hematuria, ukuhlisa, ukwanda ukubila, gipoglekemiya.

Ngokuqhelekileyo, lona uqeqesho idosi ukunciphisa imiphumela emibi zancitshiswa okanye iyayeka bebonke.

Indlela ukuthatha ichiza?

Kuthetha ukusuka iphika, ezifana "teopeka" unikwe kuphela igqirha khona kwaye umlinganiselo yabo ezikhethiweyo qho ngamnye. I-avareji fuzo imihla ilingana 400 theophylline mg. Ukuba isigulane uthwala kakuhle ichiza, emveni kweentsuku 2-3 ukusuka komthamo wokuqala amayeza, umthamo kunyuke nge-25% yaye ngakumbi ngengqondo kagqirha.

Emva kokufumana kuthetha ukusuka nephika "teopeka" kwi idosi yemihla ngemihla ngaphantsi kwe 900 mg ulawulo lwesiqulatho theophylline akuyomfuneko egazini yesigulane. Ukuba ukhangela ngokubonakala ukunxila, imfuno engxamisekileyo likwazi ukumisela ulawulo phezu inqanaba ingqalelo le nto esebenzayo ephambili egazini. Best kukhombisa micrograms 10-20 ml nganye. Ukuba umxholo theophylline igazi yomguli ingaphezulu kunesiqhelo, uphuhliso waphawula yokusabela kabi. Kule meko kuyimfuneko ukunciphisa umthamo ichiza, kunye nempembelelo nezinyangayo ziya buthathaka.

Ngaba kukho i libanda?

Bronchodilators ezifana "teopeka" kunokubangela izifo omzimba xa kuthe libanda. Xa afane kakuhle izinga imihla indlela abafumana ezi mpawu zilandelayo ezinokuvela:

• yehle emnyama;
• ugwayi;
• sorhudo;
• imilo arrhythmias ventricular;
• tachycardia;
• ukopha kwenkqubo wokugaya;
• tachypnea;
• lafa;
• ukukhathazeka;
• ukuthoba kwesikhumba ;
• ukwanda excitability;
• ukoyika yokukhanya;
• ukugabha igazi.

Kwakhona ukuphuhlisa Ityhefu kakhulu, esizibonakalisa ezi mpawu zilandelayo:

• isenzeko sokuwa;
• hypokalemia;
• ukusilela kwezintso, myoglobinuria;
• hypotension;
• ukudideka;
• hyperglycemia;
• lactic metabolic.

Kufuneka wenze ntoni kule meko?

Ukuba kukho ubungqina iimpawu okanye urhano kubo kufuneka wenze lavage esiswini, anike isigulane chelators, laxatives, iziyobisi, kwakunye hlela diuresis plasmasorption, ihaemodialysis kunye hemosorption. Ukuba isigulane ukuba ukuxhuzula, ngoko ke kucetyiswa ukuba ukuqalisa unyango oksijini "Diazepam" efakwa eziya kunceda ukuba bambambe ngempumelelo eyekile. Kwimeko isicaphucaphu lwaziwayo ukugabha kufuneka amisele efakwa "Ondansetron 'iziyobisi' Metaklopromida".

Ziziphi amayeza ayikwazi zidityaniswe "teopeka"?

Bronchodilators ezifana "teopeka kufuneka uthathe kunye macrolide-zintsholongwane" Allopurinol "," cimetidine "," Lincomycin "," isoprenaline ", kwakunye izivimbela kuba la machiza ukunceda ekunciphiseni zesigunyaziso theophylline.

Ayikhuthazwa ukudibanisa ezityiwa beta-blocker, ingakumbi non-uyakhetha, kunye "teopeka" iziyobisi, ukuze aphuhlise constriction inyumoniya kunye nesiphumo nokuncipha bronchodilator ye theophylline kuyo.

Ukuba 'teopeka "izicelo kunye" Furosemide "caffeine kunye nezinye izinto ezivuselela beta-2 adrenergic receptors, umsebenzi icandelo zalo eziphambili inyuswe kakhulu. Ukuba edibene theophylline "Aminoglutitemidom", izinto lokuqala uqala ukuba idubule elibonakalayo emzimbeni kunye amathontsi zayo kakuhle.

"Acyclovir" uyakwazi ukwandisa xi le nto "teopeka" engundoqo esebenzayo kunye kwandisa iimpembelelo ezingalunganga reception yayo. izenzakalo ezifanayo kuyagcinwa xa co-elawulwa namachiza theophylline "Dialteazem", "Felodipine" "Verapamil", "Nefedipin". Ezi amayeza musa ukutshintsha isiphumo bronchodilator, nangona kunjalo, isigulane bangafumana iimpawu reactions ezibi okanye libanda.

Iziyobisi "Disulfiram" okwaziyo ukwandisa igazi theophylline nezalathisi ezibalulekileyo eyingozi sisilonda esidumbileyoesingaphakathi ityhefu. "Propranolol", ngokuchaseneyo, kunciphisa "teopeka" kugqitywe ukwimo esebenzayo. Abasuka theophylline linyuke somestnom lolwamkelo yayo 'enoxacin "kunye fluoroquinolones. Xa therapy theophylline kusehla ngobuchule iityuwa Lithium.

Ukuba zihlangene unyango with "pentobarbital", "Carbamazepine", "i-isoniazid", "rifamycins", "sulfinpyrazone" lenyuka kugqitywe "teopeka" kwaye kunciphise ukusebenza kwayo. Xa concomitantly ne theophylline "phenytoin" kukho inhibition efanayo kwicandelo esebenzayo egazini yesigulane.

zibaluleke ngokukodwa Ezi zikhokelo, ngoyaba kubo izaliswe iingxaki zempilo. Ngoko ke, ngaphambi kokuba "teopeka", funda ngenyameko imiyalelo. Kwaye ukuba uphathwa nayiphi na amayeza ngasentla, qhagamshelana nogqirha wakho.

Indlela ukuthenga ichiza nendlela ichiza ubaluleke?

Ngenxa yale Izimo ezinzulu kunye neziphumo ebezingalindelekanga kweli chiza, "teopeka" sakhululwa kuphela ngokumiselwa ezikhemisti.

ixabiso "teopeka" Drug ngumlinganiselo eRashiya engange 160, enikezelwa abenzi ezahlukeneyo ezikhemisti. Enye iintlobo - eyanceda "Borschagovsky CPP SPC" iinkampani zoxubo Ukrainian. ixabiso layo 155 engange. Imveliso Russian of "teopeka" iziyobisi, 300 mg oluqhutywa phaya amashishini ka JSC "ishishini Pharmaceutical" yaye "Valens". la machiza malini engange-290 kunye engange 190 ngokulandelelana.

Ngokubanzi, ichiza "teopeka", ixabiso kwamkelekile, ingqalelo amayeza olufikelelekayo abaninzi abemi bethu. Xa kuthelekiswa zaseYurophu esi sixhobo ayibizi kakhulu. Imveliso Russian of "teopeka" ichiza wakwenza ezifikelelekayo.

Elumnkisa xa ukuthatha amayeza

Xa benikwa "teopeka" iziyobisi, izimvo zazo HIV, kufuneka sinikele ingqalelo le ngcaciso ilandelayo. Ukuba isigulana umntu insufficiency coronary okanye kwentliziyo, yegazi, cardiomyopathy, isilonda zesisu, isifo sesibindi, umhlaza yesinye, reflux nowomqala, ukukhulelwa, hypothyroidism okanye wayevuma olwandisiweyo sokuwa, lo theophylline ichiza kufuneka zithathwe ngononophelo.

Abantwana abangaphantsi kweminyaka eyi-12 ubudala kwaye izigulane nangaphezulu "teopeka" amisiweyo enqabile.

Mhlawumbi ukusetyenziswa iintlobo efakwa beziyobisi, kodwa kufuneka zisetyenziswe ngononophelo xa ezimbi ze isikali kunye urhudo syndrome. Izigulane kunye nomkhwa point ukutshaya yandisa ukusebenza konyango "teopeka".

Izincomo unyango ngokudibeneyo theophylline kunye xanthine nezakhi azamkeleki. Ukuba isigulane abadala liye wavakalisa izifo ezihamba, usuleleko wentsholongwane egazini, isifo sesibindi, imithambo intliziyo negazi, ugqirha kuyimfuneko ukulungisa ithamo amayeza.

Xana ndzi nga wu ichiza kubafazi abakhulelweyo?

Ibhinqa elikhulelweyo le medicament iboniswe ubukho ebonisa kakhulu ukususela theophylline uyakwazi zingene ngumkhaya. Ukuba lolwamkelo esikolweni "teopeka" ubonisa umama oncancisayo, lo lokwaphusa kufuneka kupheliswa.

Le ncwadana ngendlela elula imiyalelo epheleleyo, encamathele ichiza "teopeka". Kufuneka ufunde ngocoselelo phambi kokuba uyisebenzise. Ukuba kukho into udidekile okanye uyathandabuza, qhagamshelana nogqirha wakho.