Ugwayi kunokukhokelela isifo i-Alzheimer

Ugwayi ubusuku kwaye uhlale ngexesha mini daze ... Abantu abaninzi abajongene kubonakaliswa ugwayi. Ngokutsho uphando entsha, umgangatho ophantsi ebuthongweni kunye ukozela nga kwandisa ingozi yokuba nesifo i-Alzheimer.

An isifundo umdla

Abantu 101 babemenyiwe sifundo. Bonke aba bantu zange sebenzisa phi Ukuphazamiseka kwengqondo. Ubudala kwizifundo wayeneminyaka engama-63.

Emva nokuhlola, abathathi-nxaxheba sigcwaliswe ikhweshine malunga nomgangatho bubuthongo, ngamnye kubo wadlulisela kwisampula yabo ulwelo spinal. Injongo yale hlahlelo ukuchonga ubukho umonakalo test, ezo linophawu isifo i-Alzheimer. beza Izazinzulu wafikelela kwisigqibo sokuba umgangatho ukulala eliphantsi emini ezinxulumene kwenyuka lwezifo.

Isiphumo beta-amyloid xa kukuvela umonakalo engqondweni

Nangona unxulumano phakathi nokungalali kunye ne-dementia ayikho 100% ecacileyo, izifundo eziliqela izilwanyana ziye zafumanisa ukuba xa ulele ukukwazi ingqondo ukuba ikheswa ubuthi njenge beta-amyloid (iiproteni ezinetyhefu) buphucuka. Baqumbisa imbonakalo umonakalo kwi ubuchopho izigulane kunye nezigulane-Alzheimer, kwaye mhlawumbi yiloo nto kanye inkqubo efanayo lwenzeka ebantwini. Ukuqaliswa amyloid kwi esiqwini ingqondo yokuqala eyaziwayo Inqanaba preclinical sifo Alzheimer kunye kwenzeka kakuhle phambi ukubonakala iimpawu dementia.

Bonke abathathi sifundo zaye zachongwa imiba yesifo-Alzheimer. Ngaba kuthathelwa ingqalelo ufuzo, imbali yosapho kunye data kwi APOE sofuzo, ezo ezinxulumene namathuba omkhulu wokubhanga umsebenzi yengqondo. Umntu ngamnye wabanika uvavanyo wakhe inani leeyure ukulala, umgangatho nokulala ukozela sibonile.

"Abathathi-nxaxheba kolu phando babekulungele ukuba bangenele empontshwa phambili uphando ezibangela isifo i-Alzheimer - Wathi umbhali senior Barbara Bendlin umsebenzi lwenzululwazi kwiZiko loPhando of Disease Wisconsin. - Uhlalutyo kulwelo basivumela ukuba ukujonga ezo amakishayo ezinxulumene nesifo Alzheimer njengoko icwecwe, kwakunye izalathi si zokunikwa ukudumba kunye nemithambo umonakalo iseli ".

ubuthongo Poor ekwenyukeni esi sifo alukho kuzo zonke iimeko

Kufuneka kuqatshelwe ukuba asingabo bonke abanengxaki yobuthongo, ukuphuhlisa isifo i-Alzheimer. Barbara Bendlin, ngubani i unjingalwazi oncedisayo amayeza kwiYunivesithi Wisconsin School of Medicine, waxelela The New York Times: «amaqela abantu siyigcine yaye ngokufuthi babhiyozele ubudlelwane ubuthongo abaziintsizana amagosa amakishayo neurodegeneration. Kodwa xa ujonga abantu, hayi ebusweni konke ephawuleka of ugwayi. "

Ukuhlolwa impuku

Olu phando olutsha kokuqhubekayo izifundo ngaphambili lwezenzululwazi lubonisa ukuba ukulala ukuphazamiseka kunokuba ngunobangela yingqondo. Ezinye izifundo baye bafumana unxulumano phakathi zokulala ezingapheliyo kunye nophuhliso umonakalo amyloid. Studies in iimpuku wabonisa ukuba izilwanyana othe walala, inqanaba beta-amyloid lancipha. Zalisa ezinye ngempumelelo esusa ingqondo yeempuku ezivela izinto eziyityhefu.

Bendlin noogxa makakugcine abantu basengozini sisifo sika-Alzheimer. Ezi zifundo ziya kuvavanywa kwiilebhu ubuthongo, apho iimvavanyo injongo ukuba wenziwe.

Ukuthintela nayiphi na uphuculo ubuthongo nophuhliso lobulunga esi sifo?

"Ukuba kuvela ukuba ungenelelo, nto leyo eza kuphelisa imeko zophendlo lwezifo ezifana sokulibala, kukhokelela ekubeni ebuchotsheni ziya kudipozithwa amyloid ngaphantsi, kuya kunika inkxaso emandla ngokuphumeza amanyathelo olungiso phambi kokuba abantu baya kuqalisa ukubonisa ukuhla cognitive ezinxulumene nesifo i-Alzheimer "- Bendlin utshilo.

Bendlin kwakhona ithi phambi kokubuza emine ukuba wanibhalela ipilisi zokulala, ufanele wazi ngqo ukuba ichiza ukusombulula ubuthongo phezu iimpembelelo amyloid. Inyathelo elilandelayo liya kuba ukuqhubeka emisela ngokungqinelana nale salathisi.