Urea egazini. Ukuphakamisa usehlisa umxholo

Urea ukuba kuhlelwe kwinkqubo neutralization of ammonia esibindini. It senziwa abasabela ngayo acid acid deamination. Urea inxulumene iikhompawundi ubunzima ezinto ephantsi. Oku uyakwazi, ukuba kudlula ngokukhululekiyo inwebu iseli ye erythrocytes kunye namaziko parenchymal. urea evela ukuhluza egazini kwenzeka glomeruli. Kodwa kwangaxeshanye reabsorption layo obonakalayo (passive) lwenziwa kwi tubules.

igazi Urea lugxile ngokutsho Yindibanisela rate ukuhluza glomerular kunye perfusion kwezintso.

Le compound iye zinetyhefu esezantsi, kodwa zinetyhefu avela guanidine ilifa ion potassium yande nayo. Urea kwakhona ichiza osmotically esebenzayo, ngoko xa kumakishwa ukuqokelelana nokudumba kwi nezihlunu amalungu parenchymatous, myocardium, inkqubo luvo, izihlunu ongama.

urea igazi (eyavela kwi plasma) kudla kugqalwa sisalathisi sezintso isixhobo umsebenzi glomerular. Nangona kunjalo, uqikelelo oluchanekileyo ngakumbi yenzelwa phezu ngomxholo creatinine.

Luyanda urea owabumba waphawula ekusebenziseni izixa kakhulu ngakwicala leeprothini ithi catabolic, kwakunye ukufunxeka protein amino acids emva ukopha esiswini. Luyanda eyavela kuvandlakanywa emzimbeni ngenxa yokwanda reabsorption isixando sokwenziwa tubules zezintso.

Ukuncipha urea yegazi (iplasma) phantsi kwe zokwenziwa hepatic umsebenzi disorder, kwakunye protini otyiwa ayonelanga. Umxholo ezimbaxa kwi serum kunokwandisa ngenxa yokwamkela iziyobisi ngamnye. La mayeza ziquka phenylbutazone, steroid, dopegit, amachiza yentsimbi, aldomet, iziyobisi nephrotoxic.

Ukunciphisa urea egazini kunokubonisa isifo kwesibindi (hepatitis, xa kubandakanywa wentsholongwane egazini, ukuqina kwesibindi, nangezilonda). Oku kungenxa yokuba lo mzimba kukho lokusekwa compound esisiseko. Xa sinqumo kunye nemveliso zesibindi disorder urea. Kulo mzekelo, iimpawu zesifo akakwazi kuhlala ichazwe ngokucacileyo. Iimpawu eziphambili kufuneka luthathwe buthathaka, ukungabi namdla, ukudinwa, nenyongo, belching ekrakra, ubuhlungu kwi hypochondrium ekunene.

Xa izifo kwinkqubo yokwetyisa, ekhatshwa malabsorption ye asidi acid ezakha iiproteni kwixesha postoperative ezinxulumene nongenelelo lwezifo isisu, pancreatitis esinganyangekiyo, ukugula olwaye lwamfimfitha zikwaqaphele zancitshiswa urea egazini. Unyango oku kufuneka mayibhekiswe ekujonganeni isifo ngxabano. Njengomgaqo, emva ukubatshabalalisa sifo kunye iimvavanyo nganye ezinga malungu abantu.

Kufuneka kuqatshelwe ukuba okukule umchiza kwi umchamo ixhomekeke eyavela egazini. Kwakhona ithatha ingqalelo ubungakanani ukuhluza kwi nezintso.

urea igazi yinto 2,8-8,3 mmol / l. Ngokuqhelekileyo, xa inkqubo eqhelekileyo protein ukutya, imixholo yawo akuvamanga kwaphawulwa ukuba ngaphezu kwe-6 mmol / l. Kwimeko kukho elisezantsi yokudla protein, xi compound liye lancitshiswa 2 mmol / ilitha.

Ukwanda urea egazini (idla ngokuba xi yi izihlandlo eziliqela izikhombisi aphezulu oqhelekileyo), ngokuqhelekileyo ikhatshwe ukunxila kakhulu, ebizwa uremia. It yaphawula imeko efanayo kwisiqalo kwezi zifo zilandelayo:

- sezintso Ukungaphumeleli ifomu oyingozi;

- pyelonephritis, glomerulonephritis;

- anuria (ukungabikho umchamo syndrome, umntu akafane azikhulula);

- diabetes;

- yamathumba okanye concrements kwi urethra okanye ureter;

- ukutsha;

- peritonitis;

- athuke;

- phenol Ityhefu, imetyhuri ityuwa, chloroform;

- gastro-emathunjini ukopha.