Ursodeoxycholic acid: imiyalelo ukusetyenziswa, analogs, ncomo

Kutsha nje, ngokuba unyango izilonda ezahlukeneyo isibindi liya kusetyenziswa ursodeoxycholic acid. Imiyalelo zokusetyenziswa ikhemikhali ebonisa ukusebenza kwayo izifo ezininzi kakhulu. Yintoni na le nto? Yintoni ursodeoxycholic acid? Ziziphi izinto ke ngoku?

incazelo

Ursodeoxycholic acid, ukusetyenziswa olusekelwe imvelaphi yayo kunye neepropati, i ngumgubo crystalline emhlophe-yellow. It has a incasa ekrakra. Le nto kwindlu womuntu ngokuqhelekileyo ezisebenza lukhutshwe hi mpimo lowutsongo. lamandla ayo ngqo yi-5% ngokobunzima asidi inyongo iyonke. Kuyinto esibamba kwaye akukho cytotoxicity. Le ikhemikhali enyibilikayo utywala acetic acid glacial, ezinyibilikayo kancinane chloroform kwaye phantse ezingenakunyibilika emanzini. Ursodeoxycholic acid ayiqukethanga iimveliso. Kuye kwafunyanwa usenyongweni esinyini lebhere brown.

Ursodeoxycholic acid (UDCA) yi epimer of chenodeoxycholic acid. Ekuqaleni ukuba isetyenziselwa ukunyanga reflux gastritis kunye enyongweni ukuqhekeka. Ekuhambeni kwexesha, oko yaqala ukusetyenziswa, kwaye nezinye izifo ezininzi. UDKH ingqalelo kakhulu ekhuselekileyo ka-asidi inyongo.

Isiphumo ursodeoxycholic acid

Ukuza kuthi ga ngoku, ukusetyenziswa UDKH yi kwanonyango eqhelekileyo ukuba isifo sesibindi cholestatic ezahlukeneyo izakhi sokuhlasela. Indlela yesenzo yale arhente kukuzinzisa iiseli zomzimba. iimolekyuli yayo kudityaniswa inwebu leeseli zesibindi - hepatocytes. Ngenxa yoko bayakwazi ukwenza kubo ukumelana ngakumbi izinto ezonakalisayo. Le arhente hepatoprotective kunomphumela choleretic. UDKH ukunciphisa cholesterol kudibaniso esibindini kwaye uthintele kukufakwa yayo emathunjini. Eli chiza kwandisa kwaye uphakamisa lithogenicity isiqulatho inyongo acid kuyo. It kwandisa umsebenzi lipase, pancreatic kunye secretion esiswini. Ursodeoxycholic acid lubanesiphumo hypoglycemic kudaleke ukusekwa kunye ukwahlulwa inyongo, iyenza cholesterol.

Eli chiza ngokuya cleavage buso okanye epheleleyo ngamatye cholesterol. Kungenxa yoko le nto isetyenziswa kakhulu. Nokuxhuma cholesterol, kwenyusa ukunyibilika ziikristale zayo, nto leyo yenza deleteriously kwi enyongweni. UDKH na isenzo immunomodulating leyo kukwandisa umsebenzi lymphocyte, kunciphisa ibinzana antigen ezahlukeneyo inwebu of hepatocytes. Oku kuchaphazela inani T-lymphocyte, lunciphisa inani eosinophils.

UDKH kunciphisa uyondelelwano lwee- cholesterol inyongo yi kwiintsali yayo kunye nokutshintshwa kweziyobisi ngendlela wamanzi akhazimlayo isigaba. Ichaphazela ukuhamba enterohepatic of iityuwa inyongo. Ngenxa yale bancipha reabsorption ethunjini le iikhompawundi iqala hydrophobic kunye ityhefu. Eli chiza a hepatoprotective ngqo kunye nefuthe choleretic. Ursodeoxycholic acid, iiriviyu leengcali ukusuka apho hepatology ibonisa impumelelo yayo, unako zokunciphisa zesibindi abanesigulo xa esenza lwaso.

isicelo

Ursodeoxycholic acid, isicelo lwenziwa phantsi kweliso gqirha ukuya wabelwa kwi iimeko ezinjalo zophendlo lwezifo:

• ubukho amatye cholesterol eyendayo senyongo okanye duct eqhelekileyo;

• ukungakwazi ukunyanga endoscopically okanye intsumpa;

• ezingapheliyo, Nedlac, kwaye etsolo hepatitis sokuhlasela ;

• ubukho amatye cholesterol emva lithotripsy ngoomatshini kunye extracorporeal;

• ityhefu (iziyobisi, utywala), nomonakalo wesibindi;

• cholangitis sclerosing;

• kwesibindi zamabanga biliary, kungekho zimpawu decompensation;

• atresia, iphecana biliary;

• abanesigulo esinganyangekiyo;

• hepatitis esebenzayo ezingapheliyo;

• cholestasis ngexesha ukutya parenteral;

• zeDyskinesia biliary;

• syndrome biliary dyspeptic kunye zeDyskinesia biliary kunye holetsistopatii;

• opistorhoze ezingapheliyo;

• atresia biliary bekhubazekile;

• biliary reflux esophagitis kunye reflux gastritis.

Ursodeoxycholic acid (UDKH) asetyenziselwa ukuthintelwa nomonakalo wesibindi kubefundisi ulawulo cytostatics kunye zokucwangcisa hormone. Oku ezimiselweyo nezinye izifo ezibangelwa kungekho kukhula of inyongo. UDKH esiwabelwe unyango adjuvant kwi esibindini abohlukeneyo okanye elinye iziko.

Izimo

Ursodeoxycholic acid, nto leyo kwakhona becala ezintle, uye Izimo kakhulu. Ezi ziquka:

• Izifo yokukrala inyongo isinyi, amathumbu kunye bile duct kwisigaba oyingozi;

• enyongweni rentgenopolozhitelnye enesiqulatho high calcium;

• ekuphazamiseni iphecana biliary;

• hypersensitivity;

• ukuqina ngexesha decompensation;

• Isifo Crohn kaThixo;

• libizwe nezitenxo ekusebenzeni zepancreas, isibindi nezintso.

abaziqondi ukusebenzisa

Ursodeoxycholic acid, imiyalelo zokusetyenziswa leyo ebonisa ngokucacileyo kukungabikho imida engqongqo kwisicelo sayo, ithe wabelwa iintsana ukuya kwiminyaka 3 kwifom capsule. Kuba ukusebenzisa kwabo ephatha oluludaka eliquka eli kweziyobisi iziyobisi. De kube ngoku, iingcali azikhange kuqhutywe izifundo ezifanelekileyo ezijoliswe nokumisela isiphumo sale cholelitolitic kweziyobisi ngokuxhomekeke ubudala bomntwana. Kwangaxeshanye, uphando oluqhutyiweyo apha phambi abantwana atresia biliary kunye izifo ezithile zesibindi ngengasibonisanga iingxaki ezithile yabantwana.

Amalungiselelo eziqulathe ursodeoxycholic acid, inikwa abasetyhini abakhulelweyo kuphela xa isiphumo ekujoliswe unyango le arhente mkhulu ingozi usana olungekazalwa. Asimele silibale ukuba yesayensi ngokupheleleyo ukhuseleko lweekhemikhali kolu didi izigulane ukuba akukho wachitha. Ekubeni yaziwa nokuba UDKH lingena singene ubisi lwebele, isilumkiso kuyafuneka ukuqeshwa ichiza ukuya nursing abafazi.

imiphumela emibi

Ursodeoxycholic acid, imiyalelo zokusetyenziswa leyo ibonisa nje kuphela umda kwisicelo sayo sezimali, kodwa yeziphumo ebezingalindelekanga kunokwenzeka, kungakhokelela ekubeni iziganeko zophendlo lwezifo ezifana:

• ukuqhina, sorhudo;

• isicaphucaphu;

• ukwanda transaminases;

• intlungu ikota yesangqa ekunene ongentla ummandla epigastric;

• ukusabela isikhumba komzimba (ukurhawuzelela, amaqhakuvana);

• amatye calcining.

Unyango kwesibindi ephambili biliary le ukulungiselela maxa wambi kubangela ukuba ogulayo decompensation buyadlula, angabe emva zokurhoxa abafumana eli chiza.

amanyathelo okhuseleko

Ukuze ngempumelelo litholysis amatye cholesterol usebenzisa UDKH kufuneka ithathele ingqalelo ezi meko zilandelayo:

• Isayizi yabo hayi ngaphezulu kwe-2 cm;

• ke musa ukunika umthunzi kwi radiograph;

• senyongo usebenza ngokuqhelekileyo;

• imibhobho ukugcina patency;

• sinomoya ezizaliswe ngamatye ngaphantsi kwesiqingatha;

• ye bile duct eqhelekileyo aliqulathanga ngamatye.

Zeziphi izithintelo enye Akungenwa ursodeoxycholic acid? Imiyalelo kule amalungiselelo zonyango kubonisa ukuba unyango ixesha elide, nto leyo yinyanga ngaphezulu kwe-1, kufuneka rhoqo (1 zonke iintsuku ezingama-30) ukuba aqhube esweni transaminases hepatic, phosphatase, yibilirubin, igazi transferase wesigrike-glutamyl. Ukuqhuba wasiqwalasela ezinjalo kubalulekile ingakumbi ekuqaleni iinyanga ezi-3 unyango kunye UDKH. Nokulunga unyango kuqinisekiswa yi X-ray qho emva kweenyanga ezintandathu kunye ultrasound inyongo. Kuthintelo ukwenzeka uxhuzula ziqhubeka unyango cholelithiasis nasemva zokuchithwa olupheleleyo ngamatye. Kuthatha iinyanga ezininzi.

Ngexesha unyango UDKH namakhosikazi aselekhulile yokuzala Kucetyiswa ukuba basebenzise iindlela enokuthenjwa yokhuseleko ekukhulelweni. Kusenokuba iziyobisi non-hormone okanye zokucwangcisa equlathe imali encinci estrogen.

ifomu Ukukhululwa balawule

Ursodeoxycholic acid, apho umyalelo manual inika inkcazelo eneenkcukacha busebenze yayo yolwamkelo, yenziwa ngeendlela balawule ezifana:

• njengezingxobo kunye namacwecwe mg 150 no-250;

• ukumiswa abantwana.

Izikali UDCA ngokungqongqo abekwe ngamnye. Kuxhomekeke ebukhulwini imeko yoluntu kunye nokutha emzimbeni wakhe. Kwiimeko ezininzi, oko emiselwe 10-20 mg / kg ngosuku. Le ithamo kuthathwa ngexesha elinye, ngokuhlwa. Ubude unyango kuxhomekeke bungqina. Eli chiza ifunxwe emathunjini amancinci, yaye emva kweeyure 3 plasma elaziwa ingqalelo yayo ephezulu. imithi ukwamkelwa njalo eziqulathe ursodeoxycholic acid, yenza kube primary inyongo asidi emzimbeni womntu. Le izinto yathotyelwa kwimeko ezahlukeneyo utshintshwano kunye isiphumo lokugqibela output njengoko metabolites endleni kunye nomchamo.

Ubude uthomalaliso emiselwe ngugqirha khona. Inokubanomahluko ngokuxhomekeke kuhlobo sifo. Kwezinye iimeko kakhulu, ulwamkelo UDKH iziyobisi ihlala iminyaka.

Intsebenziswano kunye namanye amachiza

Xa ukwamkelwa ngokudibeneyo UDKH "Cyclosporine" kwandisa ongeke kukufakwa wamva. Xa plasma kunyusa lwee- ngamalungiselelo amayeza. Kwiimeko ezinqabe ulwamkelo UDKH ngaxeshanye kunye nokulungiselela "ciprofloxacin" yoxinaniso yokugqibela kunciphisa.

Ursodeoxycholic acid (analogue)

Ursodeoxycholic acid (njengezingxobo, tablets) ziveliswe phantsi amagama ahlukeneyo. arhente ezinjalo ziyahluka excipients kokungena ukwakhiwa kwawo. Ngoko ke, lo imarike unokumelana la machiza kunye ursodeoxycholic acid:

• njengezingxobo "Ursosan" emiselweyo unyango isifo sesibindi ehlasela, cholelithiasis, kunye gastritis biliary reflux kunye reflux esophagitis, ukuqina zaseprayimari, iziyobisi kunye nomonakalo wesibindi ityhefu, cholecystectomy, isifo utywala, sclerosing cholangitis, Biliary atresia, steatohepatitis nonalcoholic. Ursodeoxycholic acid ( "Ursosan") isetyenziselwa yokuthintela izilonda zesibindi.

• Amacwecwe "Ukrliv" abenza ngayo lomonakalo hepatic, kohlobo, cholelithiasis.

• njengezingxobo "Ursofalk" ikhethiwe ezahlukeneyo izifo senyongo kunye wesibindi, kunye cholestasis, ukuhla ezinye umsebenzi kwesibindi, amanqanaba cholesterol ophakamileyo. Ezi ziquka isifo lokuqala biliary kunye sclerosing cholangitis, reflux gastritis kunye reflux esophagitis, hepatitis of umyalezo ezahlukeneyo, amatye cholesterol, abanesigulo esinganyangekiyo, izilonda ezininzi kwesibindi, inyongo stasis. Le ukulungiselela isetyenziswa njenge umbala kwesibindi ukwenzakala xa ezifumana amachiza esinamandla.

• Amacwecwe "Ursodeks" ngubani, ungathatha kwesibindi biliary kungekho zimpawu decompensation kunye reflux gastritis. Zisetyenziswa ukunyibilika amatye cholesterol encinane ekusebenzeni eqhelekileyo lwesinye inyongo.

• njengezingxobo "Ursodez" kusetyenziswa ukwaphula amatye cholesterol, unyango reflux gastritis, kuba kunyango kwangumqondiso ukuba isifo ephambili kwesibindi kungekho zimpawu decompensation.

• njengezingxobo "Ursolizin" ikhethiwe ezinyibilikayo amatye cholesterol, kunye nonyango kwangumqondiso kwesibindi biliary, senyongo cholesterosis kunye reflux gastritis. Ichiza isetyenziswa kunyango ezintsonkothileyo izigulana kohlobo kunye ukuqina.

• njengezingxobo "Choludexan" ezisetyenziselwa ukunyanga cholelithiasis ayinzima, kohlobo esebenzayo, izilonda isibindi obunxilisayo kunye ityhefu, steatohepatitis nonalcoholic, ukuqina ephambili biliary, cholangitis sclerosing zaseprayimari, abanesigulo esinganyangekiyo, zeDyskinesia biliary, reflux gastritis kunye reflux esophagitis.

• njengezingxobo "Urdoksa 'ukuba emiselweyo kwesibindi zamabanga biliary, kungekho zimpawu decompensation, reflux gastritis. Ichiza waba kakuhle iyachithakala amatye cholesterol ezincinane kunye neziphakathi, lo gama kugcinwe umsebenzi eqhelekileyo lwesinye inyongo.

• njengezingxobo "Isalathisi C", eyabelwe kwi cholelithiasis ayinzima, ukuqina zaseprayimari, etsolo kunye kohlobo, sclerosing cholangitis, atresia iphecana intrahepatic, reflux gastritis kunye reflux esophagitis, cholestasis, ngexesha ukutya parenteral, zeDyskinesia biliary, isifo kwesibindi, abanesigulo esinganyangekiyo, gepatoze nenqatha, syndromes dyspeptic. Amalungiselelo isetyenziselwa zokuthintela nomonakalo wesibindi ekusebenziseni izicwangcisi hormone cytostatics, ukuyilwa ilitye ukutyeba.

Ursodeoxycholic acid, analogs zezi zixhobo zokufunda zithathwa ezimiselwe kuphela ngugqirha.