ALT yamihla

Alanine aminotransferase (ALT) - enye izalathisi eziphambili izitshanguba leeseli wesibindi umsipha. Iimpawu eziphambili ukusebenzisa ALT - i umonakalo kwesibindi ityhefu, iimviwo zothintelo kunye hepatitis wentsholongwane egazini.

ALT i-enzayimi nayo inxaxheba yokucolwa zeselula ye asidi acid. Inani elikhulu kwayo - in nezi ntso, nomhlehlo wesibindi, izihlunu skeletal kunye inhliziyo. Ekubeni ALT yenzelwe ikakhulu xa kukho icytoplasm yeseli, nawuphi na umonakalo othatha ukwanda umxholo okanye umsebenzi kule enzyme.

Xa izifo ezihlasela zosulele okanye esinganyangekiyo kuba sisilonda esidumbileyoesingaphakathi eziphilayo, neya kulandelwa iiseli necrosis umyalezo ezikhokelela uphumo ALT egazini ukusuka sisilonda. Abanye ukwanda umsebenzi we-enzyme acute iposi engabalulekanga kwenzeka malunga nowesi-6 -. Iiyure eziyi-12, yaye ingqamana kwincopho umsebenzi ALT.

Eyona Uphawu kukunyuka kumsebenzi ALT igazi izifo zesibindi ukuba zikhatshwa hepatitis okanye neziphumo ezinetyhefu. Kwakhona ALT enzyme sisalathisi yengxinano amanqaku hepatitis A, B na C. Not kuqwalaselwa umyalezo, hepatitis etsolo, umsebenzi ALT angandiswa izihlandlo ezilishumi abangele senyongo.

Kakhulu ukwanda aphezulu kumsebenzi enzyme uyaqapheleka hepatitis oyingozi wentsholongwane egazini. Xa umsebenzi isifo ezazihambisana kulo ukuzinza kwenzeka ngendlela ngenyanga. Kwimeko yokuba eli xesha elide, oko kusenokubonisa ukuba inguqu ukusuka abukhali kohlobo.

Xa kohlobo, metaphases kwesibindi, umhlaza wesibindi, ngokunjalo mononucleosis esosulelayo kukho ukwanda okuncinane kumsebenzi ALT. Kwakhona umsebenzi aminotransferase alanine ukuze nande iposi engabalulekanga, kodwa kakhulu ngaphantsi, kuthelekiswa ubuncinane kunye aminotransferase aspartate (AST). Ukuze ahlangule uxilongo ichanekileyo, ukubala lomlingani de Rytis, leyo lulwahlulo AST kumsebenzi ALT.

ALT AST lingu 1.3 ± 0.4. Oku kwadlulwa ngokoyiswa imisipha yenhliziyo. Necrosis kweeseli sesibindi hepatitis ALT rate AST wentsholongwane egazini liye lancitshiswa 0.6 - 0.8. La manani kakhulu yande eUkraine naseYurophu, kodwa ngenxa iikhemikhali ezithile, la manani ziyahluka kakhulu. Konke kuxhomekeke iseti yezi reactants ezibonakalisa ALT enzyme AST ngokunjalo kweelabhoratri kukuzimisela kwezalathisi transaminase ngesiqhelo rate bumba.

Xa hepatitis etsolo, amanqanaba ALT lagqithisa kummiselo ngaphezu ACT. A iposi engabalulekanga wedatha yokugqibela elide. Ekubeni for kokugula ALT rate ukunyuka anikwe ngaphantsi de Ritis ingumlingani ukunyuka kakhulu. A hepatitis rate ALT returns wentsholongwane egazini kwiiveki eziliqela.

Xa abadala kunye nabantwana unyaka nangaphezulu kwe omnye amadoda ukuba iiyunithi 10-40 ilitha igazi nganye, kwaye kwabasetyhini - 7-35. Ukususela ekuzalweni ukuya rate ALT unyaka omnye ebantwaneni ezimalunga nama-13 ukuya ku-45 ilitha igazi nganye.

Ubungqina obubonakalayo buxela ukuba olu hlalutyo bothi kuvame sisifo uphethwe isibindi, uxilongo umahluko, ukuvavanyela abaxhasi, izifundo xa kuqhambuka kwesibindi, ngezifo engabalulekanga mihle, kwakunye nesifo sezihlunu skeletal.

Amanqanaba ALT kufuneka ijongwe ungatyanga kusasa, kuba ngexesha umlinganiselo imini zingatshintsha. Isalathisi angandiswa kwimeko ubunzima umzimba engaphandle eqhelekileyo.

Study on ALT avelise indlela zengqo- usebenzisa serum ngaphandle hemolysis kwityhubhu uvavanyo okhethekileyo enesiciko ebomvu okanye iqhosha lemenyu cap yeplastiki. iisampulu egcinwe hayi ngaphezulu ngemini.