Aspartate aminotransferase anda, oko kuthetha ntoni, izizathu

umzimba wethu, mhlawumbi, ingaqatshelwa "ubugcisa" abaninzi, okwadala Mother Nature. Kuyo, umzimba nganye yahlukile kwi "isakhiwo" zayo izakhono zawo, ayikho ayimangalisi njengoko umxhelo. Kwaye ukuba sijonge isifundo yonke ephilayo, kusenokwenzeka ukuba inani elininzi amagama antsonkothileyo. Amaxesha amaninzi, ezi mvavanyo zonyango uyakwazi ukufumana ezifana ibinzana unpronounceable njengoko aspartate aminotransferase ukwanda. Ngelo xesha, ukuba libhekisela acid acid cleavage isihloko. Kubalulekile ukuba aqhelane kule kota kancinane ngakumbi.

Luhlobo luni gama?

Phantsi igama elinikiweyo ukuthini enzayimi leyo inxaxheba ukusebenza cleavage na, phantse naluphi asidi acid emzimbeni. Okwehlileyo wabiza SGOT okanye AST iboniswe ngoonobumba abakhulu. I-enzyme ise ancedisana ngamalungu ezininzi, ezifana:

• isibindi;
• intliziyo;
• inyama-luvo;
• sezintso;
• imisipha;
• pancreas;
• spleen;
• ekukhanyeni;
• isicwili sobuchopho.

Ngaphezu koko, inkoliso enzyme ancedisana zentliziyo, zezintso, iiseli zemithambo-luvo, isibindi.

Ngenxa yoko, lokufunyaniswa nasiphi na isifo enxulumene nezi imizimba kuthetha ukuba aminotransferase aspartate ukwanda. Emiphungeni, udakada kunye injeke enzyme ntlawulo esikhulu kangaka. Apho umzimba inkunzi wahlukile ukusuka kumsebenzi ophezulu female ACT.

ukusebenza AST

I-enzyme zinemoletyhule protein elikhutshwa izihlunu zeselula ngamalungu zangaphakathi. isakhiwo sayo yasekwa zizazinzulu Russian kwi 70s. Umsebenzi enzyme kukomeleza reactions kwemichiza iiseli. Ngenxa inxaxheba vitamin B6, oko utshintshiselwano asidi acid kunokwenzeka. Kwi inguqu oluntsonkothileyo asidi ezininzi acid, kuquka aspartic, ukuyilwa inamehlo entsha. Yaba Bulelani kuye ukuba kuyondelelaniswe glucose, nto leyo ngoko kuyimfuneko ukuze imizimba yethu.

iimpawu AST

Ngamnye kuthi nazo kungekudala kunye namabinzana ezifana aspartate aminotransferase ukwanda. Isho ukuthini, wazi wonke umntu. Kule meko, siza kutyhila kwekhuselo. Xa eziphilayo inempilo enzyme equlethwe iiseli enyama yangaphakathi bathi, Nguye lo eqhelekileyo. Kuphela inxalenye encinane AST kusichukumisa egazini. Ulwazi - ukufumaneka kwe-enzyme intliziyo ngaphezu umthamo wegazi kuqukuqela amawaka 10 amaxesha.

Kodwa ukuba esikule yeziko yonakele, lo aminotransferase aspartate, ukhupha, egazini kunye nemali ye-enzyme iqala ukwandisa. Izinga lokukhula ixhomekeke iqondo umonakalo kwithishyu. Ngokomzekelo, xa lokufunyaniswa iposi engabalulekanga, AST ndzo ufikelela kwincopho emva kosuku.

Kwezinye iimeko, inqanaba enzyme inokuba ngaphezu ireyithi izihlandlo ezi-5, kunye Isalathisi olo makagcinwe iintsuku ezisi-7. Kwaye ngoko omnye usenokuzibuza ukuba aminotransferase aspartate (AST) inyuke, oko kuthetha ntoni? Lo msebenzi eliphezulu olubalaseleyo imeko kakhulu yomguli, nto leyo edla uyaphela isiphumo esibi.

Ukuba ukwanda enzyme ezixinene kwenzeka ngokuthe ngcembe kunye nezinga okwandayo, oko kuthetha ukuba ummandla infarct kwandisa. umsebenzi aminotransferase aspartate kungabangela abhubhe nya ijwabu zesibindi.

Yintoni ezisongela umsebenzi omkhulu AST?

Ngokufuthi, enamandla eliphezulu AST esihlambo igazi uyawafikisa iposi engabalulekanga. Xa le mali enzyme kusenokuba izihlandlo ezingaphezu kwama-10 kulo mmiselo, yaye aphezulu oko, kokukhona indawo izitshanguba izihlunu intliziyo. Ngosuku lwesine unyango kuvamise reanalysis. iziphumo zakhe zibonisa, aspartate aminotransferase inyusiwe okanye hayi. Kwimeko unyango olusebenzayo kufuneka ukunciphisa ingqalelo yayo.

inqanaba eliphezulu AST ibonakala izitshanguba kwesibindi ngenxa yezinto ezininzi:

• izifo Oncological.
• ubuthi Utywala.
• Ukutyeba.
• Ubukho abanesifo.

Kuphela kulo mzekelo, ukwenza ukuxilongwa, oko kuyimfuneko ukuqhuba iimvavanyo ezongezelelweyo. Noko ke, imigangatho ephakamileyo enzyme inokuba ngabantu ngenye besempilweni. Umzekelo, umsebenzi kungaba:

• Abantwana phambi komtshiso oko.
• Xa abafazi ngexesha ekhulelwe yokukhulelwa.
• Ukuba ukusetyenziswa ngokugqithisileyo iziselo ezinxilisayo.
• Xa uthatha iziyobisi ezithile: valerian, antibiotics ezahlukeneyo okanye paracetamol.

ziphethe, nathi, nayo kule nkalo ibe nefuthe elibi. Ukongeza, ukuba aspartate yandiswa, i nezizathu ihleli kusetyenziso ngamalungiselelo ngokusekelwe barbituric acid lokuthathwa zokucwangcisa lungadala ekwandeni AST.

Izizathu AST yokwanda

Oonobangela kumanqanaba ze enzyme, njengokuba sele kukhankanyiwe ngasentla, inokuba iposi engabalulekanga. Nale uphethwe ngo-95-98% yazo zonke izigulane ezibhalisiweyo umsebenzi ophezulu aspartate aminotransferase. Ixabiso lingaba units ukuya ku-3000 Isalathisi. / L. Kwezinye iimeko, amanqanaba aphezulu enzyme awayezibona zesibindi necrosis. Esi sifo, nazo, unokubangwa iintlobo ezahlukeneyo kwesibindi. Umgangatho AST kulo mzekelo kune amaxabiso eziqhelekileyo izihlandlo 10-100.

Phakathi kwezinye izifo ezixabisa angina ukuphawula, pancreatitis etsolo, indlela ezivaleke ngayo ibile ducts, iiseli umhlaza okanye metastases wesibindi. Enye enzyme xi ukuze kwandiswe ngenxa yokwenzakala, inkqubo itshileyo ukuqala ukufa iiseli kwezihlunu baboniswa ukufudumeza kukothuka. Oku kubandakanye isigulana kwixesha postoperative.

Yintoni aminotransferase aspartate kwandise umntwana, oko kusenokubonisa ukuba kukho kwesibindi, muscular dystrophy, myocarditis etsolo, senyongo.

Izizathu yandisa AST

Amanqanaba enzyme aziyi kuphela ukwandisa kodwa bunciphe. Oku kwenzeka ngenxa yezizathu ezahlukeneyo. Ngokuqhelekileyo, oko kwenzeka xa abasetyhini abakhulelweyo. Kwezinye iimeko abantwana kunye nabantu abadala ngenxa muscular dystrophy, ukwenzakala ubukhali ezahlukeneyo, iposi ebuchotsheni, hypothyroidism okanye pancreatitis etsolo babenayo aspartataminotraferazy kwinqanaba kuyehla. Ngenxa yokungabikho vitamin B6 okanye komsipha kwesibindi kwakhona kwafunyaniswa ukuswela kwemolekyuli protini.

Ubungqina obubonakalayo buxela ukuba uhlalutyo ngenjongo

Uhlalutyo ukuqinisekisa inqanaba enzyme AST kufuneka yenziwe ukuze akwazi ukufumanisa ubukho ezinye ezimbi kakhulu:

• kwenzeka ukuba iinkqubo umhlaza iiseli isibindi;
• nokuba kukho metastases;
• aspartate aminotransferase ukwanda igazi kubonisa ubukho mononucleosis ezosulelayo okanye igciwane lohlobo kwenkqubo emithanjeni;
• uhlobo lwesifo samathambo (umz, DMD-Becker) ;
• iposi engabalulekanga;
• ukuqina;
• Uhlalutyo zibonisa ubukho naziphi na iintlobo kwesibindi, kuquka isibindi necrosis.

Ukongeza, le engeyoyesiqhelo izihlunu kunye isibindi, ubuncinane, kufuneka wenze abantu bacinge malunga nokusiwa uhlalutyo.

isiphumo kuphela ukuqinisekisa okanye ukuphikisa uxilongo. Oku kuya kuvumela ukuthatha amanyathelo ayimfuneko kwexesha. Ukuba kukho naluphi na utshintsho emikhulu kwenzekileyo, oko kuphela ukuba ngcono.

Amalungiselelo - i imeko ebalulekileyo

Njengoko enkalweni ezinye kweemviwo Kwathi uhlalutyo kufuneka ziphathwe kakhulu njengoko ngokuthatha amayeza, nokuba na iyeza wokuqeshwa okanye decoction esintu kagqirha, ukuze kakubi kuchaphazela iziphumo zohlalutyo ukuba asichanekanga.

Ngoko ke, ukuze umazi kakuhle, aminotransferase aspartate ukwanda okanye hayi, kufuneka uyeke ukuthatha amayeza. Ukuba nangasiphi na isizathu oku akwenzeki, kufuneka wazise ugqirha lowo kufuneka inike lonke ulwazi malunga ichiza. Oko kukuthi, oyidlayo kunye nexesha wokwamkelwa layo. Abafazi nokuvavanywa kweelebhu kunokulonakalisa ukukhulelwa.

Uhlahlelo kunye nokusebenza nemigangatho

Material yophando siku igazi lwemithambo okanye serum. isampulu yayo yenzelwa phezu kwetafise ungatyanga kusasa. Inkqubo yonke akuthathi xesha lininzi kwaye kwenzeka ngaphandle intlungu. Isiphumo ilungele emva kweeyure 6-10. I-serum zingagcinwa iiyure 48 kubushushu degrees 15-25. Xa iimeko ukuphola (2-8 ° C) kuyaqhubeka malunga iintsuku ezi-6.

Ke ukuba lo mbuzo, apho kunokwenzeka Kwathi azihlole, kuyimfuneko ukuba isicelo kwiilebhu ezikhethekileyo ukuba enze cazululo nemvelo. Kwezinye iimeko, ukuze bafunde AST (aspartate aminotransferase) inyuswe okanye eziqhelekileyo, ungaya isifundo ekliniki emzini wakhe okanye naliphi na iziko likarhulumente zonyango. Kuphela kufuneka kuqala ufumanise ukuba ingaba ilebhu yakhe izixhobo eziyimfuneko kunye nezixhobo ukwenzela uhlalutyo.

amanqanaba lesiqhelo kwiqela ngalinye labantu zabo. Umzekelo, uyazikhomba AST sosana yi 25-75 U / L, ngelixa abantwana abadala kancinci (iminyaka 1-18), akukho 15-60 U / L. amanqanaba eqhelekileyo abafazi aqala ku-10 ukuya ku-36-U / l, yaye amadoda - ukususela-14 ukuya kwi-20 U / L.