Corinfar. Imiyalelo yokusetyenziswa

"I-Corinfar" ngumphikisi we-calcium, oko kukuthi, inqanda ukungena kweeCa2 + kwiiyunithi ze-muscle (cardiomyocytes) zeentliziyo kunye neempahla ezivela kwisithuba se-intercellular. Ngaloo ndlela, kukho ukuhla kwe-i-calcium ions. Ngenxa yoko, iiperipharal, i-coronary arteries (arrioles ezithambileyo) zanda. Iibhilebhe, ezinokuthatha ixesha elide, zineempembelelo ze-vasodilator.

Iyeza "Corinfar" liveliswa ngendlela yeepilisi ze-biconvex ezijikeleziweyo, ezifakwe i-membrane ephuzi. Elinye ipilisi liqukethe into esebenzayo - i-nifedipine (eyenziwe ngokuchanekileyo kwi-dihydropyridine) -10 mg. Njengezinto ezincedisayo ezizalisa i-tablet, i-lactose monohydrate, i-povidone K25, isitashi sezambane, i-cellulose microcrystine, i-stearate ye-magnesium isetyenziswa. "I-Corinfar" ithengiswa kwibhokisi yekhadibhodi ngamabhuleki amathathu (iipilisi ezili-10) okanye kwiibhotile zeglasi emnyama yeepilisi ezingama-50 ne-100.

Ngezifo ezinjenge-angina yoxinzelelo, umfutho wegazi ophezulu ( uxinzelelo oluphezulu lwegazi), izigulane zichazwe iCorfarfar. Umyalelo wokusetyenziswa kuseRashiya. Yonke ingcaciso ayincedo kuphela kubaqeshwa bezonyango kunye noogqirha, kodwa nakwizigulane, njengoko kuya kunceda ukuqonda ukuqeshwa kwabagqirha, kunye nokutshintsha komzimba ngenxa yempembelelo yalo myeza.

Kuyaziwa ukuba umonakalo okhuselayo uya kulibaziseka (ngaphandle kokunciphisa ukuchithwa kwezinto ezisetyenziswayo-nifedipine), ukuba ngexesha lokutya uthathe "uCorinfar". Imiyalelo yokusetyenziswa isincomo ukwenza oku (ngaphandle kokuhlafuna) emva kokutya kunye nokusela amaninzi amanzi. Ubude kunye nomthamo (oko kukuthi, inkqubo yokonyango) kukhethwe ngabanye kwaye kuqeshwe ngugqirha. Ukubonakalisa ububele ngokufanayo kwiKorinte kunye nokuqina kwesi sifo kuthathwa ingqalelo. Kwizigulane ezisebekhulile kunye nalabo abahluphekileyo ngenxa yesifo esiyingozi esiyingozi, isantya sinciphise.

Qala nge-10 mg ye-nifedipine (okanye 1 ithebulethi ezimbini okanye kathathu ngosuku) ukuthatha uCorinfar. Imiyalelo yokusetyenziswa ivumela ukunyuka okukodwa kwidayiti kwiipilisi ezimbini okanye 20 mg kanye okanye kabini ngosuku. Umthamo omkhulu wemihla ngemihla akufanele ube ngaphezu kwe-4 iipilisi okanye 40 mg. Kwimfuneko yongcinezelo ebalulekileyo (isifo soxinzelelo), i-dose yemihla ngemihla ekhuthazwayo kufuneka ibe yi-tablet 1 okanye 10 mg (ibonwa ngokuba yi-nifedipine) ezimbini ukuya kweyesithathu ngosuku. Ukuze ufezekise imiphumo efunekayo yeklinikhi, umthamo ugqirha lugqirha unyuselwa kwi-40 mg (ngokwe-nifedipine) ngosuku, okufuneka kuthathwe amaxesha amabini. Phakathi kweendlela ezimbini zeCorinfar, kunye nokuqokwa kwamathathu okanye amathathu, ixesha elifanelekileyo kufuneka libe neeyure ezine.

Kwezinye izifo akukhuthazwa ukuba ubeke uCorinfar. Imiyalelo yokusetyenziswa ibonisa ukuchasana kwayo, ukuphazamiseka kwengqondo, ukuphazamiseka, ukungaphumeleli kwintliziyo engapheliyo, kunye ne-aortic stenosis engaphephile, i-angina engaqinisekanga, i-acute myocardial infarction (ngexesha leveki zokuqala ezine), kunye kunye nesicelo se-rifampicin. Kukho ukuchasana kwakhona ngexesha lokutya, kwi-trimester yokuqala yokukhulelwa, kunye novelwano olwandisiweyo kwi-nifedipine okanye kwiinkalo ezincedisayo zeziyobisi.

Unonophelo olukhethekileyo luyadingeka nge-hypertrophic obstructive cardiomyopathy, i-mitral valve stenosis, i-sinus node ye-weakness syndrome, i-tachycardia enamandla okanye i-bradycardia, i-hypovolemia, i-hypertension eyingozi yingozi, i-myocardial infarction kunye nokungaphumeleli kwe-ventricular, ukuphazamiseka okukhulu kwe-cerebrovascular disorders. Kwakhona, kwi-renal ne-hepatic insufficiency, isithintelo sesisu, i-hemodialysis, ngexesha le-II kunye ne-III zokukhulelwa, eneminyaka eyi-18, kunye nokufumana i-beta-adrenoblockers, i-digoxin kanyekanye.

Isilwanyana esinomntu obizwa nge-hypotensive kunye ne-antianginal yempembelelo kunye nomphumo ongapheliyo ngenxa yezenzo ezilibazisekileyo zezinto ezisetyenziswayo zibizwa ngokuba yi "Corinfar". Uqeqesho luqulethe ulwazi kubasebenzi bezempilo kunye nezigulane. Into esebenzayo yokulungiselela ilula ngokukhawuleza kwindlela yokugaya. Impembelelo yokwelapha ayikho ngaphezu kwemizuzu engama-15 emva kokuthatha loo mayeza. I-Metabolism yamacandelo e "Corinfar" ivela esibindi ngenxa ye-hydrolysis kunye ne-oxidation. Kwi-metabolism ye-nifedipine, amaqhinga angasebenzi. "I-Corinfar" idityaniswe kakhulu kunye neentso, kunye neendwangu.