"Hydrea": umyalelo manual, ncomo, iifoto, analogue

Drug "Hydrea" bobabo anticancer iziyobisi. Eli chiza nefuthe cytostatic, indlela apho isekelwe inhibition iDNA yokuqaphela, kunye neziphumo kwi RNA kunye neprothini amagama engekhoyo.

Ziziphi uhlobo yenziwa iziyobisi, uchaze ukuba iqulathe ntoni na?

Le medicament alahlwa ngokohlobo njengezingxobo wenza hydroxycarbamide esekelwe, nto leyo 500 mg kwi capsule nganye. Ichiza ifumaneka igutyana yeglasi (100 njengezingxobo), okanye umqulu blister (10 njengezingxobo). Yeekhomponenti abancedisayo kusetyenziswa wemagniziyam stearate kunye citric acid. Kwakhona, lo yokuqamba neyongezelelwe sodium hydrogen phosphate dihydrate kunye monohydrate lactose.

Le izinto eyenza iqokobhe njengezingxobo imiyalelo "Hydrea" zezi titanium dioxide, idayi kunye gelatin. Lo mbhalo ukhandwa i-inki efunyanwa ngenxa ambaxa propylene ethers, shellac, utywala (isopropyl, nesipirithi mveliso kunye N-butyl), kwaye ngamanzi okuhlamba nentsimbi oxide emnyama.

pharmacodynamics

Ichiza i antimetabolite, isiphumo sawo wabonakaliswa kumjikelo yeseli S isigaba. "Hydrea" ivumela ukumisa uphuhliso leseli interphase G1-S, nto leyo ibaluleke kakhulu xa ngaxeshanye nangokwamkela medicament bamthwala radiotherapy, njengoko kwisigaba G1 iiseli ithumba avelana zokukhanya. Amalungiselelo kuphucula intshukumo ribonukleoziddifosfatreduktazoy ezwi (RNA reductase inhibitor). Ngokusebenzisa kangako DNA amagama yayo, kodwa ivuke protein RNA Ukwakheka.

Pharmacokinetics

Kukufakwa ichiza kwisiqwenga zesisu "Hydrea" yemiyalezo ichaza indlela ngokukhawuleza ngaphandle nguloyo ekudleni nezikhokelela kufikelele kwelona nqanaba liphezulu lezinto esebenzayo emzimbeni ezimbini iiyure emva kokuba ukusetyenziswa njengendlela lwangaphakathi. Le medicament udlula njengomqobo ngegazi-ingqondo, ebonakala ngu kunikezelo olukhawulezayo abafumanekayo ascites kunye neencindi fluid. Ichiza okongezeleke kwi erythrocytes kunye leukocytes ngokupheleleyo idubule kwisithuba seeyure ezintathu ukuya kwisine. nethe Partial esibindini. Uninzi ichiza salawo yi izintso eluhlobo hydroxyurea, kukho ixesha engumzekelo yale nkqubo iiyure ezilishumi elinesibini. It ayitshintshi ezinye ukubonakala kwaso, kukho imali encinci liyasuswa umzimba nomchamo. Igqitha ichiza iphecana zokuphefumla idubule njengoko carbon dioxide. Emva kokufumana "Hydrea" umyalelo ibhengeza Ukupheliswa ngokupheleleyo ngosuku. Ekubeni kwindawo engundoqo ye ichiza idlula nezintso, xa izigulane kuba ngezifo amalungu, ukunciphisa ithamo ichiza.

ubungqina

"Hydrea" umyalelo kwi isicelo ikuvumela ukuba abele phantsi kweemeko ezinjalo eziphilayo:

• wolusu;
• leukemia myelogenous;
• umhlaza, uphuhliso ethi ichaphazele wesibeleko, umphunga, yesinye, ikholoni okanye amaqanda (unyango kufuneka zidityaniswe);
• osteomyelofibrosis;
• erythremia;
• ubukho uhlobo amabi yamathumba entanyeni kunye nentloko, ngaphandle kuphela ngumhlaza ochaphazela imilebe (kukho imfuneko unyango olubanzi);
• thrombocythemia Kubalulekile;
• esizalweni horionepitelioma;
• etsolo flow leukemia lymphoblastic;
• thrombocytosis njenge kama of myeloproliferative syndrome;
• isifo Hodgkin kaThixo;
• isenzeko Ukudlulela kwi umhlaza, le ndlala eyonakalisayo mammary emathunjini.

Izimo

Kukho iimeko apho unyango akwamkelekanga lithetha "Hydrea". umyalelo Amayeza vala kutyumba kwiimeko ezinjalo:

• uvakalelo oluphezulu le njengezingxobo;
• thrombocytopenia kunye leukopenia ngamaxabiso engaphantsi kwe-100,000 kunye 2500 / ML ngokulandelelana;
• ukukhulelwa, lwebele-ukondla ngobisi lwebele.

Nangona kwezi meko zilandelayo kwaye ichiza na contraindicated, xa waqeshwa kwaye isicelo ufuna inkathalelo eyodwa:

• glucose-galactose malabsorption;
• nobandlululo lactose;
• ukungabikho yelactose;
• Heavy kak- igazi;
• ukusilela kwezintso nesibindi.

Ukuba isigulane owawuthe phantsi ichemotherapy okanye unyango radiation, umngcipheko erythema radiation acute kunye nophuhliso myelosuppression, ke, kule meko, kakhulu, kufuneka ukuba isicelo kakuhle amayeza.

Ngexesha unyango kufuneka kukhulelwa oluthembekileyo, ukuba kunjalo ukukhulelwa, isigulane kufuneka bazazi umngcipheko ukuba ikhona olungekazalwa. Ngenxa kwii-ichiza ibe ubisi lwebele loomama ibele, kuyimfuneko ukuba ayeke olu hlobo lokondla. Ukuba ichiza icetyelwe ukuba ukurhoxisa, ingcaphephe kufuneka athathe ingqalelo iingongoma ezahlukeneyo phambi kokuba kuya kuvumela isigulane ukwala unyango ngokusekelwe ulwamkelo njengezingxobo "Hydrea".

unyango

Ngexesha unyango lo medicament "Hydrea" yemiyalezo icebisa ukuba usebenzisa ngeedosi ezahlukeneyo arhente kumazwe ahlukeneyo, banikwe iimpawu umguli.

Ukuba isigulana kunzima ungavuleka philisi, kwamkelekile ukuvulwa beziyobisi ukuba ukunyibilika emanzini. Kwiimeko ezinjalo, i-arhente kufuneka ukusela ngoko nangoko. Kufuneka Makukhunjulwe ukuba asingawo onke amacandelo e-njengezingxobo iyanyibilika emanzini, ukuthi zinzi kwalo phezu kumphezulu wayo. Izigulane siphathwa "Hydrea", kubalulekile ukuba usele iziselo.

leukemia Myelogenous (ifom ezingapheliyo)

Unyango lwenziwa ngaphandle kokuphazanyiswa. Kuba wonke kwekilogram ubunzima bomzimba kuthathwa 20-30 mg beziyobisi. Le yangosuku, ichiza siyaphela kanye yonke imihla. Ithuba ukuvavanya ukusebenza nothomalaliso ubekho iinyanga 1.5 ukuphunyezwa kwayo. Ukuba iziphumo HIV kuphawuliwe, unyango kunokuba elide ngokwaneleyo (abakudingayo oko), xa ukuwa amanqanaba zegazi kunye leukocytes ngezantsi norm wayo wayeka. Ukuba emva kweentsuku ezintathu (hayi ngaphambi) igazi babuyela eziqhelekileyo, uyakwazi uqalise unyango with "Hydrea". Imiyalelo yokusebenzisa kubonisa ukuba amathuba sondela ngokukhawuleza.

erythremia

Ithamo wazifunela ulawulo ngemihla ka-15-20 mg. Njengoko kwimeko yangaphambili, esi sixa lwe ichiza ibalwa kwekilogram ubunzima bomzimba ngalinye. Ngosuku isigulane uqobo ilawulwa njengezingxobo 1 okanye 2. ithamo yokugqibela ukuze isigulane ngasinye ujongwa ubunzima bayo, kuxhomekeke imali kweziyobisi apho zegazi kunye namanqanaba hematocrit zizinto amaxabiso eziqhelekileyo.

thrombocythemia Essential

Yokuqala yedosi kwekilogram ubunzima bomzimba ngalinye ehambelana ku-15 mg. Le idosi yemihla ngemihla ilungiswa ngabanye ukuze izinto ezibalulekile kwinqanaba elifanelekileyo. Ukuba unyango ngamachiza akuvumelekanga "Hydrea" umyalelo izithethantonye ugqirha lihlola kwaye ichonge ndlela efanelekileyo.

wolusu

Nge unyango yamathumba ezinkulu isenokuba ngakanye okanye ngokuqhubekayo, ngokulandelelana, idosi eyimfuneko medicament nganye obunzima buyikhilogram enye ubunzima 80 mg okanye 20-30. Maxa iiveki ezintathu, ubude amayeza unyango rhoqo yonke imihla kusela kanye. Ukuba uthomalaliso ikhutshwa phandle nqapha iintsuku ezintathu, ukuwasela kanye kakhulu, kodwa idosi ephezulu.

Carcinoma (sisilonda esidumbileyoesingaphakathi wesibeleko, entloko okanye emqaleni)

Per umzimba kilogram lokulinganisa phezu 80 mg iziyobisi. Ithamo ezinqwenelekayo iyeza usetyenzisiwe zonke iintsuku ezintathu (kanye).

imiphumela emibi

Xa therapy iziyobisi "Hydrea" umyalelo, ukubuyekeza kuye ingxelo kwezinye ziziphumo ebezingalindelekanga kwinkqubo hematopoietic, luvo, wokuchama, yokuphefumla kunye neenkqubo esiswini. Kwakhona, isikhumba banokuchaphazeleka kunye waso zazo kunokwenzeka ukuba kuqulunqwe i usuleleko ezifana, njengoko ukubola. Ngaba kumakishwa nezinye ngayo elibi.

Ixabiso ichiza, analogue

Thenga iphakheji "Hydrea" ingaba kuba 243-250 engange. (20 njengezingxobo). Phakathi ababambeleyo - ngamalungiselelo leyo eziqulathe isithako esebenzayo efanayo njenge "Hydrea" kwaye iziyobisi kuba nemiphumo efanayo.

Of izithetha-ntonye unako ukuthenga "hydroxyurea" okanye "Hydroxycarbamide kadak." Xa othintela unyango guide "Hydrea", analogs kungenziwa kukhethwe inani elikhulu imithi, ezifana "Tromboreduktina" "amyl Fact", "Kolotekana", "Milanfor", "Prospidin", "iritis", "halava", "Estratsita" "Irinotela", "Kamptotekana" okanye "Estratsita". Unakho ukuthenga substitutes ezifana "Agrilin", "Kamptera" okanye "Erivedzh". Phakathi zakhiwo kukho iintshukumo ezifanayo "Aranoza", "Irinaks", "Arglabin". amayeza List efanayo i- "Zaltrap", "Irnokam", "Geksalen". Lunokunyangwa "Proksifeinom", "Gikamtinom", "Campto", "Verotekanom", "Hloditanom", "prospidin", "Onkofagom", "irinotecan" okanye "Velcade".

reviews

Izigulane ezininzi bakholelwa ukuba inkcazelo phambi kokuba unyango kokuqala kufuneka kuqwalaselwe lithetha "Hydrea" umyalelo. Amafoto ngaphambili kwaye kwakhona ukubukela post-unyango. Ngokuqwalasela ncomo, abantu bakhetha ukuba baphathwe kuphela phantsi kweliso unyango kunye nomngcipheko ukuba self-medicate, njengoko oku kuyingozi, usele iziselo. Ukuba akukho ukuthatha amayeza kudityaniswe unyango radiation, iziphumo ebezingalindelekanga okanye kuvela (kwiimeko apho ngaphambili akakho), okanye babe kubi ngakumbi. Kodwa akusoloko kwenzeka.