Ichiza "Citalopram": Ukubuyekezwa oogqirha

ezifana imithi kakuhle kangakanani "citalopram"? Izimvo oogqirha ngale mveliso amayeza kuqwalaselwa izinto kweli nqaku. Kwakhona, inikeza inkcazelo malunga yintoni ebangela ziziphumo ebezingalindelekanga, wathi iindlela, ukuba iqhube kanjani yokwamkela yalo efanelekileyo oko iipropati pharmacodynamic ngayo anazo.

Ubume, inkcazo ichiza, ukumila kwayo nokupaka

Ziziphi fom ukuthenga amayeza "Citalopram"? Baqinisekiswa bathi kwikhonkco ivenkile sisixhobo ethengiswa ifomu ipilisi lenticular kunye nemilo setyhula, legqunyiwe ukutyabeka bhanya emhlophe. Le somhlathi cross eli yeza linomaleko bulubhelu kancinane ngaphakathi.

Yintoni eyenza "Citalopram 'iziyobisi? Imiyalelo, ukubuyekeza baxele ukuba isithako esebenzayo beziyobisi lulwelo yegama elifanayo - citalopram, nto leyo inikwa ngokohlobo hydrobromide. Ngokumalunga amacandelo abangabancedani, zisetyenziswa microcrystalline kwincindi, starch pregelatinized, kunye nemagnesium stearate.

Kufuneka kuqatshelwe ukuba le arhente filimu ukutyabeka equka Polyvinyl utywala, Opadry II, macrogol, talc kunye titanium dioxide.

Ekuthengisweni ithathwa ichiza engena iiseli aya eyenziwe PVC okanye aluminiyam, apho zipakishwe ngendlela kwibhokisi eyenziwe yekhadibhodi.

iimpawu Pharmacodynamic ye yeQela

Yintoni na ichiza "Citalopram"? Ukuphonononga bathi lo yeQela. indlela yayo yokusebenza enxulumene ne kwezithandani of (uyakhetha) serotonin reuptake umlamli langoku kwi leesynapse iiseli zemithambo-luvo, kwakunye mpembelelo incinane reuptake of neurotransmitters dopamine kunye norepinephrine. Kufuneka kuqatshelwe ukuba sixhobo asikusebenzeli ukubonisa ukukwazi azithethelele ezahlukeneyo receptors (abanye serotonin, dopamine, H1-histamine, adrenoceptors, m-cholinergic receptors, receptors Gaba kunye receptors benzodiazepine).

Asinako ukuba ichiza "citalopram", ncomo kuzo zidweliswe ngezantsi, kuyanceda ukuphucula isimo yesigulane, ofihla ixhala, inciphise ixhala, ntshikilelo, ephelisa ongase, nokuphelisa kukuthenga izinto. Ukongeza, yena phantse akangonobangela nomphumo soporific.

Ngokutsho kweengcali, nemiphumo ozinzileyo kweli chiza waphawula emva kweentsuku 7-10 emva ukusetyenziswa rhoqo.

Entshukumo amandla medicament

Yintoni Lubalasele pharmacokinetics beziyobisi 'Citalopram "? Iimpendulo ingxelo ukuba incopho ingqalelo yayo into esebenzayo egazini lwenzeka iiyure ezine emva kokungenisa. Utshintsho kwinqanaba yalo yomgama.

Le bioavailability beziyobisi iindlela 80%, kwaye iqhina kwiiproteni plasma yi 79%.

Egazini citalopram ekhona ifomu yayo yasekuqaleni. Le into lithuthwa yi igcwala, demethylation kunye deamination. Isiqingatha-kubomi beli candelo iintsuku 1.5. Waye asuswa kunye umchamo ngokusebenzisa iphecana emathunjini.

Iimpawu imithi bucala

Kutheni kufuneka sibe isixhobo ezifana 'citalopram'? Izimvo oogqirha bathi ichiza uboniswa yokwamkela kwi:

• one-;
• iziqephu depressive olunzima kunye zokumodareyitha.

Kufuneka kuqatshelwe ukuba amisele olu nyango kufuneka ibe oqeqeshiweyo nonamava kuphela.

Izimo ukuba isiqu iziyobisi

Kuphantsi kwaziphi iimeko apho abakwazi ukusebenzisa iziyobisi "Citalopram"?

Ukuphonononga zibonisa Izimo zilandelayo ukusetyenziswa kwale iyeza:

• yobudala yesigulane minor ngayo (ngokoxwebhu luka, ukhuseleko kunye nokusebenza kwezi tablets kweli phakade ziye iye ayasekwa);
• uvakalelo oluphezulu ze umguli citalopram, kwakunye naziphi na izinto zayo abangabancedani;
• ngexesha kokufumana kunye inhibitors of monoamine oxidase kuquka moclobemide, selegiline, linezolid (kwisithuba seeveki ezimbini emva kokuba ukupheliswa lolawulo lwabo);
• ngexesha uthatha amachiza QT ayolule ixesha le ECG (s kubandakanywa pimozide) kunye yokwandisa naso bekhefu).

Bucala "Citalopram": imiyalelo yokusebenzisa

iingcali Guest athi ingqalelo kufuneka banikwe ichiza, ngokuxhomekeke imeko yesigulane. "Citalopram" athathwa ngomlomo kanye ngemini. Ngaloo tablets azizaliswanga zingahlafunwa kwaye wahlamba phantsi omncinci bolwelo.

Olu nyango enokuphenduleka ngexesha elinye ingasetyenziswa naliphi na ixesha lemini kungakhathaliseki isidlo (ekukhethwa ukuba ngaxeshanye).

Xa therapy xi luqala kokufumana 20 mg ngosuku. Kuxhomekeka reactions mntu yomguli kunye ubungqongqo ukudakumba, idosi angandiswa ukuba ubuninzi, ngamanye malunga 40 mg ngosuku.

Njengoko one- kufuneka kuthathwe amayeza "Citalopram"? izigulane Ukubuyekezwa bathi kule meko chiza esebenzayo inikwa idosi ye-10 mg ngosuku (yeveki e-1), kwaye uyandiswa ku-20 mg ngosuku. Ngoko ke, lo idosi yemihla ngemihla ichiza bethembe impendulo isigulane lobuqu. Kamva isixa zingentla ichiza kufuneka kwandiswe ukuze mg-40 ngosuku.

Abantu abadala ngaphezu kweminyaka eyi-65 ubudala "Citalopram" kuchaziwe umthamo we-10 mg. Kuxhomekeka ebukhulwini ntshikilelo kunye impendulo eyodwa, iya kwandiswa ukuya kutsho kuma-mg-20 ngosuku.

Xa kakuhle umsebenzi kidney, kuquka ukusilela chronic kwezintso zemvelo eliphakathi nobukhali ezibuthathaka, indlela lolungelelwaniso kwirejimeni nomthamo iyafuneka. Kwabo ezinzima sezintso insufficiency indalo kufuneka ndinyanyekelwe ekukhetheni idosi zonyango.

Xa kakuhle umsebenzi kwesibindi, kuquka ukusilela hepatic nokulolonga kunye nowobulali, idosi lokuqala ichiza mg-10 yonke imihla (kuba iiveki ezi-2 zokuqala). Kuxhomekeka reactions buqu, oko kwandiswa ukuya mg-20. Abantu kakhulu hepatic insufficiency indalo kufuneka ndinyanyekelwe ekukhetheni idosi.

Abantu kunye nomsebenzi sezantsi kwesikhundla isoenzymes njengoko CYP2C19, i idosi yokuqala mg-10 ngosuku (iiveki ezi-2). Kuxhomekeka kwimpendulo ngamnye, oko kwandiswa ukuya mg-20.

Ngokutsho imiyalelo, isiphumo kwezonyango emva ulawulo yeQela isifundo sele kubonakala emva kweeveki 2-4. Kulo mzekelo, ixesha kwikhondo uthomalaliso emiselwe imeko yomguli kunye tolerability yonyango. Ngokuqhelekileyo, ichiza Kucetyiswa ukuba kweenyanga ezi-6.

Rhoxisa medicament

Yintoni abantu bathi ngoko kwenzeka ngayo kwindawo yokumisa elibukhali uthathe iziyobisi, "Citalopram" ncomo? Ngubani wathabatha lo sixhobo, ithi ukuba iimpawu evela emva nomhla ngesiquphe ukusetyenziswa kwale imithi aziqhelekanga. Kaninzi, izigulane ingxelo abanomoya nesiyezi, isicaphucaphu, ukudinwa, intloko ebuhlungu, sokulibala, paresthesia, ukuxhalaba, ukugabha kunye Barr.

Ngenxa yoko, Kwakugqitywa kunyango isixhobo kufuneka ayitshitshise ngokuthe ngcembe, kwiiveki eziliqela. Oku kuya kuvumela izigulane ukuba siphephe iimpawu ukurhoxiswa. Ngokuqhelekileyo, oko kwanele iiveki ezimbini, nangona kwimeko nganye umbuzo kufuneka kugqitywe ngugqirha qho ngamnye. Ngoko ke, abanye abantu kungathatha iinyanga ezi-3 okanye ngaphezulu.

reactions Ezingalunganga emva kokuthatha yeQela

Hlobo luni reactions kufuneka bazazi ubume elibi kwizigulana, phambi kokuba uthathe amayeza "Citalopram"? Ukuphonononga malunga neziphumo ebezingalindelekanga bathi, njengoko kunjalo ukusetyenziswa kwezinye amayeza SSRI, phezu imvelaphi "Citalopram" izigulane zabona iziphumo ezingafunekiyo. Nakuba kunjalo, kufanele kuqatshelwe ukuba bonke bephela siswele kakhulu kwaye zezomzuzwana.

Ngokubanzi, Kwiintshukumo Ezingalunganga Ezilandela ulawulo isiyobisi isifundo waphawula kwiiveki zokuqala 2 unyango. Ngelo xesha linye ukuba buthathaka kakhulu kuphuculo imeko yesigulane.

Ngoko ke, "Citalopram" kunokubangela iziphumo ebezingalindelekanga ezifana:

• uvakalelo oluphezulu, ukuphazamiseka, reactions anaphylactic, intloko ebuhlungu, ixhala, depersonalization, sinciphise yobuntu, kunesifo;
• ndlongo, waphula umthetho lokwaneliseka kwabasetyhini, mkhuba, amaphupha wasemzini, ixhala, yokuzibulala, ukudideka, isiyezi;
• ukozela, Barr, yoxinaniso kakuhle, ukuphazamiseka, ukuba nemibono, yombono;
• imincili, ukuphazamiseka extrapyramidal, uqaqanjelwa, legazi, ukwanda yobuntu;
• isicaphucaphu, ukopha yamanina, paresthesia, ukugabha, iyangongoza, serotonin syndrome, ukushaya, zokulala, bruxism, ukuqumba, silale, sorhudo;

• akathisia, ukopha zesisu, lwegazi, umlomo owomileyo, tachycardia, dyspnea, ukuqhina, bradycardia, iintlungu esiswini, ukukhohlela;
• unkenteza ezindlebeni, hepatitis, hypotension intolerance, nokuthimliswa, incasa ukuphazamiseka, kunciphise uxinzelelo lwegazi, ukuphazamiseka ezibonwayo, arrhythmia, ukuchama disorder, sinusitis, ukuphazamiseka yokuhlala, galactorrhea, kwekhono ngokwesondo, sinciphise ukutya, hyponatraemia;
• ukwehla kobunzima, polyuria, kwanda, bazigruzule secretion ngokwaneleyo adh, utshintsho kwi electrocardiogram, irhashalala, alopecia, ukutyeba, nokudumba angioneurotic, hypokalemia, ukuchama kabuhlungu, ukurhawuzelela;
• photosensitivity, ukwanda ukubila, basengozini enkulu zokonzakala kwizaphuko, urticaria, eDayalayo, purpura, myalgias, yawning, arthralgia kunye nabanye.

Amacala libanda, iziyobisi

Drug "citalopram", analogue kuzo zidweliswe ngezantsi, kunokubangela ezi mpawu zilandelayo libanda: iingcangcazela, unditsho, ukugabha, tachycardia, ukozela, abafundi inimba, bradycardia, hypotonia, okanye lwegazi, isicaphucaphu, isikhumba cyanosis, serotonin syndrome, bundle block yesebe, ukuphazamiseka , isiyezi, insufficiency kwentliziyo, badengeka, hyperventilation, ukubila, arrhythmia ventricular, arrhythmia atrial, ukufa isiqaqa.

imithi

Ingqalelo njengendlela kakuhle kunye namanye amayeza. Ngoko ke, yawo co-nolawulo contraindicated ne-arhente zilandelayo:

• Mao inhibitor (inokuba ukuphuhlisa iziphumo ebezingalindelekanga ezimandundu, kuquka serotonin syndrome).
• Iziyobisi kongeza kwixesha QT (enokukhokelela ukuphazamiseka isingqi intliziyo, apho ekugqibeleni kuya kuba yingozi).
• "Pimozide" (mhlawumbi kululwa QT lokuphumla).

Kufuneka kuqatshelwe ukuba intsebenziswano kulawulo 'Citalopram "kunye nezinye iziyobisi kunganciphisa umbundu nokuhlutha izinto. Ukongeza, eli chiza ayikho enqwenelekayo ukudibanisa kunye arhente serotonergic, amayeza eziqulathe Wort Wort St. kaYohane, anticoagulants ngqo, "warfarin", utywala, desipramine.

amachiza afanayo

Yintoni ingqalelo amayeza analogue? Kukuphi na okulunge ngakumbi? "Citalopram"? Ukuphonononga bathi ichiza singavalwa yi amayeza zilandelayo: "Paxil", "cytological" "Pram", "Sedopram", "Oprah", "Umorap", "Siozam", "Tsitalorin" "Cipramil", "Tsitalek" "Tsitalift", "Tsitalon". Zonke ezi mali kufuneka anikwe kuphela ukuba ugqirha onamava.

izigulane ezininzi kakhulu abanomdla umbuzo wokuba yintoni kubhetele: "Citalopram" kunye "Paxil '? iingcali Ukuphonononga ingxelo ukuba ichiza lokuqala kakhulu ngempumelelo ngaphezu yesibini. Kufuneka kuqatshelwe ukuba side effects ezithi zenzeke emva kokuba isicelo le "Paxil", ezi ucaca ngakumbi. Ngoko ke, oogqirha abaninzi sincoma usebenzisa it "Citalopram".

Ukukhulelwa wamabele

Said bucala kufuneka kwenziwa ngabo abafazi abakhulelweyo kunye noomama zokonga. Ukusetyenziswa kweli chiza kwithuba leenyanga ezintathu lesithathu babe negalelo elibi ingqondo-emzimbeni umntwana. Ezi ukunyhashwa zilandelayo nazo kuyenzeka: cyanosis, ukukhathazeka yokuphefumla, hypoglycemia, ukuphelelwa umoya, ukugabha, unditsho, lafa, lobushushu ukungazinzi, uvalo, isondlo ubunzima, ukuba nochuku, lwegazi kwezihlunu, sokulibala, hyperreflexia, rhoqo bedanduluka, silale, ukozela.

Bucala "Citalopram": ncomo

Xa ichiza IBS emiselweyo ngokuqaphela okukhulu. Oku kungenxa yokuba ukuqeshwa kwakhe andzise nzima ngoko imeko yesigulane.

Ntoni kuthi ngeli xesha abathengi indlela? Izigulane ezininzi Ndithi malunga isiphumo unyango ngempumelelo "Citalopram" iziyobisi. Emva lokwaluka unyango, chaza zabo neemvakalelo kuye kwaphucula ngokukhawuleza kakhulu. Noko ke, abanye abasebenzisi bathi iziphumo zonyango abangazange walinda, ekubeni ichiza kuye kwabangela ukuqulunqwa inani yeziphumo ebezingalindelekanga.

Ke ukuba oogqirha, bexabana ukuba "Citalopram" yeQela yindlela kakuhle kakhulu kwaye olusebenzayo, kodwa kuphela kwiimeko apho kungekho elungele kuphuhliso yeziphumo ebezingalindelekanga. Ngoko ke, oogqirha abaninzi bazama ukumisela le amayeza kuphela kwiimeko kakhulu kwaye ngokwemithamo ezincinci. Ukuba kwiveki yokuqala yonyango iboniwe akukho reactions ezibi aye, ngoko unyango nalo eli chiza kuqhubeka kunye nokwanda yedosi layo (ukuba kuyimfuneko).