Ichiza "Divigel": ncomo, iinkcazelo, isicelo

Transdermal gel "Divigel", izimvo zazo ezininzi kakhulu, kuba amachiza protivoklimaktericheskim zokwenziwa ezimiselweyo iimpawu ahlekise estrogen. Ngokwemvelo yalo yindlela unyango hormone, njengoko nempahla yayo esebenzayo - estradiol eyenziweyo - ngokwemiqathango kwemichiza kunye eziphilayo efana ngokupheleleyo ukuya iihomoni zendalo sex ababhinqileyo.

Ichiza "Divigel", izimvo zazo bamhlophe HIV, iphumelela kakhulu ixesha elide okanye unyango wovandlakanyo kwabafazi kwixesha postmenstrual. Ngenxa secretion ngokwaneleyo estrogen kwesi sigaba kukho dysfunctions ezahlukeneyo ephilayo, wabonakalaliswa yokulala, vasomotor ukungazinzi, yoma ngokuqhubekayo kwenkqubo enzala, yaye ngokufuthi umqolo osteoporotic. Eziphembelela efana kakhulu yintshukumo hormone zendalo, kunye nokukhuthaza uphuhliso kwinxenye yelungu lobufazi, tubes kunye wesibeleko yokulungiselela "Divigel" (ratings ukuliqinisekisa) ishenxisa ngokupheleleyo okanye kakhulu kunciphisa le symptomatology.

Pharmacodynamics ye ijeli ngolu hlobo. Xa iiseli ukuba ekujoliswe yi ichiza "Divigel" estradiol eyenziweyo ongenela iqhina imichiza kunye receptors ezithile, ukwakha kunye nabo receptor-ligand entsonkothileyo nokusebenzelana namacandelo estrageneffektornymi ufuzo, kwakunye iiproteni ezithile intracellular. Oku kubangela uqhelwaniso le Yindibanisela mRNA kunye nokukhululwa cytokines ezahlukeneyo.

Ngenxa yoko, transdermal lithetha "Divigel" ikhuthaza ukulahlwa ngexesha rhoqo sentlambululo ukopha endometrium. A ndzo enkulu ichiza ukuze akhuthaze hyperplasia endometrial, kwezithandani of lokwaphusa, inhibition of resorption esiqwini ithambo, yaye ukukhuthaza Yindibanisela ezithile zezithuthi iiprothini (thyroxine globulin ndibopha, transcortin, transferrin).

isicelo yangaphandle lithetha "Divigel" (ukungqina kule feedback) uye phantse akukho isiphumo icala ezifana noxinzelelo lwegazi. Oku ngokuqinisekileyo inzuzo enkulu xa kuthelekiswa ngamayeza ezahlukeneyo estradiolsoderzhaschimi ngomlomo.

Iindlela lolawulo transdermal "Divigel" IVF yabelwe xa kufuneka ukuba agcine umgangatho eyimfuneko estradiol ngayo. Iidosi ngabanye kakhulu kwaye sizimisele yiklinikhi ziingcali apho le nkqubo kwenziwa. izifundo Clinical "Divigel" iziyobisi wagqiba uhlobo wokuhambelana yayo kunye nentsebenziswano kunye namanye amachiza. Ngoko ke, oko kwazeka ukuba zithako yayo esebenzayo unokunciphisa impumelelo umfutho, amayeza antidiabetic kunye anticoagulants. Ulawulo ngaxeshanye arhente kunye amalungiselelo eziqulathe inductors kanye enzyme zesibindi (barbiturates, "Carbamazepine" "Griseofulvin" "rifampicin", njalo njalo) kunokubangela ukuhla estradiol kwi plasma yegazi.

Inkqubo unyango "Divigel" iziyobisi, apho ixabiso kakhulu eliphakathi, kufuneka sikhatshwe luphando rhoqo. Ubuninzi kwaye ichaza isethi iindlela gqirha ngokweemfuno ngamnye kwezonyango isigulane ngasinye. Kodwa umthetho, oqeshwe mammography kwiimeko ezininzi.

Njengoko lo myalelo yokulungiselela "Divigel" lineqela Izimo. Ngokukodwa, kwafunyaniswa ukuba okanye ekurhanelwa umthondo Oncology mammary ithumba Ukwakheka (fibroids zesibeleko, umhlaza womlomo wesibeleko, womntu obhinqileyo, amaqanda, njalo-njalo), hyperplasia Endometrial, izifo kwentamo izicwili nokuqina, isigaba giperestrogeniey climacteric, thrombophlebitis, nangezilonda isibindi kunye yebhinqa ukungathobeli stroke, isifo seswekile kunye nezinye izifo. Ngoko ke, lo isixhobo kufuneka kwenziwe kuphela ngokumiselwa kwaye phantsi elikhankanyiweyo ngokungqongqo lidle zabo.