Ichiza "salofalk": analogs kunye nemiyalelo yokusebenzisa

Umzimba womntu uyasokola iintlobo zezifo, ezilula kunye nezintsonkothileyo, ubomi bakhe bonke. Kunokuba kakhulu yakutshanje kuthotho iingxaki zempilo nokuhlala isifo wamathumbu arhabaxa. Ukuba alwe nabo ukuba inani amayeza ezahlukeneyo kunye nemigaqo ahlukeneyo amanyathelo.

Ukusetyenziswa mesalazine amaqela inqununu iqela elikhulu ngokwaneleyo lwamayeza ( "salofalk" analogs) ukulwa izifo ezithile yesisu arhabaxa.

Ukwakhiwa "salofalk", pharmacodynamics

Njengoko kuchaziwe ngaphambili, eyona nto iphambili esebenzayo i mesalazine medicament. Abangabancedani kufeza ezininzi, ingakumbi, ezifana sodium carbonate, glycine, povidone, microcrystalline kwincindi, silicas, kunye titanium, calcium stearate, isodiyam croscarmellose, hypromellose engundoqo butylmethacrylate copolymer.

"Salofalk" (granules, amacwecwe, suppositories, ukunqunyanyiswa) ezilawulayo (depresses) iinkqubo neutrophil kunye lipoxygenase kudibaniso ebantwini prostaglandins kunye leukotrienes. Le into esebenzayo kunciphisa izinga lokufuduka, phagocytosis kunye degranulation of neutrophils, kunciphisa secretion lymphocyte. Ngaphezu koko, lo medicament iyakwazi ibophelela radicals simahla yaye kamva kubatshabalalisa, ngamanye ebonisa ukusebenza antioxidant. Kwakhona mesalazine ekwaziyo iyabophelela kunye radicals ezamahala wabumba iintlobo ioksijini lovukelo.

Ubungqina obubonakalayo buxela ukuba ukusetyenziswa

Eyona ndawo iphambili apho wafumana ukusetyenziswa "salofalk" - unyango ngenxa yokudumba okwenziwa sisilonda sikabhobhosi kunye nesifo Crohn kaThixo.

Isifo lokuqala inkqubo esingapheliyo ukudumba akakafiki icaciswe uhlobo. uphuhliso wayo okubangelwe yinto impefumlelwano ufuzo kunye neemeko zokusingqongileyo.

isifo Crohn kaThixo ingachazwa njengoko ukudumba ezingapheliyo granulomatous nesiqephu zesisu. Le nkqubo kungaba thatha zonke iindawo inkqubo yokwetyisa, ichaphazela zonke ungqameko tube yokwetyisa. Isiphumo ibe uphuhliso lymphadenitis, izilonda nezibhaxu udonga namathumbu ayikho.

release kweziyobisi Form

Abavelisi zinika abathengi ichiza "salofalk" (efanayo malunga oku zisenokwahluka) kwindawo iindlela ezimbalwa ezahlukeneyo kwimveliso.

Azipilisi i elinokuqukatha 250 okanye 500 mg eli candelo engundoqo esebenzayo - mesalazine. Xa sachet omnye elinokuqukatha 500 mg okanye 1 g ukwimo engundoqo. Le medicament ngokwemo suppositories (suppositories yolawulo efakwa) ifumaneka iidosi ezimbini - 250 500 mg ingxenye enkulu. Kwakhona zinokuthengwa ezikhemisti amagwebu ukunqunyanyiswa lolawulo efakwa. Eyona ngokukuko ifomu release nomonde ngamnye kuya kukunceda ukuba ukhethe ugqirha okunyangayo.

amacwecwe nomthamo abakwisigaba

esithathwa eMiselweyo yaseMelika abadala - kathathu ngemini 500 mg. Ukuba unesifo degree kakhulu zesi sifo, ugqirha ukuya unelungelo lokuba ukwandisa ithamo ku 3-4 g ngosuku. Ikhosi unyango ungatsala ukusuka kwiinyanga ezi-2 ukuya kwemi-3. Ukuba iyeza sithathwa njengenyathelo lokuthintela, oko kwenziwa inkqubo eqhelekileyo (1.5 g ngeedosi ezintathu ebudeni bemini).

Isicelo salofalk "Umsebenzisi izigulane abaselula (analogs ungahluka idosi kwirejimeni) uncoma ukunika ngokungqinelana ubunzima umntwana. Abantwana abane ubunzima bomzimba hayi ngaphezulu kwe-40 kg, ugqirha umisela 250 mg beziyobisi kathathu ngemini. Ukuba ubunzima somntwana ingaphezulu kwe-40 kg, libonisa ukuba idosi enye ye abadala: 500 mg kathathu ngemini.

Iipilisi elihlolwa ngcono ezithathwe emva kokugqitywa kwesidlo, ayetyisi uze usele kolwelo (kukhethwa amanzi).

Le nkqubo we granules

Le fom Ukukhululwa "salofalk" drug (granules) ubekwa igqirha khona ngakumbi ngabanye, esekelwe kumfanekiso bezonyango belo yempilo yesigulane iyonke. Kwiimeko ezininzi ngexesha exacerbation of ukudumba okwenziwa sisilonda sikabhobhosi isigulane wabelwa ukuba afumane ne nedosi ye-500 mg okanye 1 g kathathu ngosuku (t. E. Umthamo ngemihla medicament uvela 1.5 ukuya 3.0 g). Unako ukuthatha idosi enye kanye iingxowa-3. Ukuba isigulana kuxolelwe, "salofalk" thatha umlinganiselo ongama-1.5 g ngemini, oko kwahlulwa ibe amathamo-3 kuthathwe okanye onke amachiza kanye.

Ukuba sithetha malunga exacerbation of ukudumba okwenziwa sisilonda sikabhobhosi ebantwaneni (kwiminyaka emi-6 nangaphezulu), ugqirha ukuya limisele ichiza ngomlinganiselo ne30-50 mg mesalazine nganye 1 kg ubunzima. Zonke ithamo kufuneka ithathelwe ngexesha elinye okanye yahlulwe amathamo 3 imini yonke.

Le granules kufuneka kwambatha kolwimi, ngaphandle ehlafuna, ukuginya. Ichiza kufuneka usele iziselo. Ukuba isiphumo enyangayo waba granules enganyangekiyo kufuneka athathwe rhoqo kwaye rhoqo. Isigaba Acute of ukudumba okwenziwa sisilonda sikabhobhosi kudla usweleka kwisithuba seenyanga 2-3, idosi eyamkelekileyo ngakumbi yemihla ngemihla lancitshiswa 1.5 g ngosuku.

Injongo indlela nesicelo suppositories

"Salofalk" (amakhandlela) yemiyalezo lithethelela ukuba umthamo 500 mg (1 efakwa suppository 500 mg okanye 2 - 250 mg) kathathu ngemini. Ukuba isifo kwinqanaba ebukhali, liphindwe idosi yemihla ngemihla. Ukuba isigulane yabelwe ikhosi elide unyango okanye reception ekujoliswe - kuphela umbala (ukuthintelwa ndiphinde), idosi njengesiqhelo kule meko mg 250 (1 ikhandlela) kathathu ngemini.

Kuba izigulane abaselula umthamo ixhomekeke ubunzima bomzimba. Abantwana ezinobunzima ngaphantsi kwama-40 kg "salofalk" (amakhandlela) imiyalelo ukusetyenziswa silawula amisele ½ esithathwa umntu omdala, t. E. izihlandlo 250 mg kathathu ngemini. Ukuba ubunzima umntwana esegqitha 40 kg, oko yabelwa esithathwa neziyobisi izigulane abadala (kathathu ngemini 500 mg).

ukumiswa efakwa

Drug "salofalk" - ukunqunyanyiswa iyafumaneka iibhotile ezinikiweyo lolawulo efakwa. Lenquba yenzelwa kanye ngokuhlwa ngaphambi kokuba balale. Isigulana phambi ulawulo ichiza Kucetyiswa ukukhulula amathumbu. Isixa ngemihla ichiza unyule isekelwe ubunzima yomguli (ngokwemimiselo malunga ne30-50 mg / kg). Ukuba isifo kakhulu okanye inkqubo lwakukhula, idosi iphezulu ngexesha lasemini unako ukufikelela ukuya kwiminyaka-3 ukuthintela ziingcali ekuphindeni ngokuqhelekileyo isincomo ukuthatha "salofalk" ngomlomo (tablets). Kulo mzekelo idosi (yonke imihla) nazo babelwa ubunzima - 15-30 mg / ubunzima bomzimba kg. Yonke umthamo imihla iyeza imini yonke Kucetyiswa ukuba kwahlulwa ngezigaba ezibini.

Izimo ekufumaneni "salofalk"

Sebenzisa i "salofalk" chiza (analogue - akukho ngaphandle) kukho contraindicated kubantu abane hypersensitivity ukuya amacandelo aphambili kunye abangabancedani na ichiza. Akuvumelekile ukuba amisele iipilisi abantwana abangaphantsi kweminyaka emi-3 ubudala, granules - nonyaka-6 ubudala. Akuyomfuneko kufuneka uthathe amayeza ukuze kubekho ukubandezeleka nomonde insufficiency kakhulu kwezintso okanye hepatic.

Musa iqeshe abantu "salofalk 'abo banotyekelo ukuphuhlisa ukopha, izifo ezahlukeneyo inkqubo hematopoietic. Ukubandezeleka ukusuka sophele diathesis uhlobo lwesifo isilonda nawuphi iphecana zesisu kufuneka uthathe amayeza ngokusekelwe mesalazine.

Le granules medicament engamkelekanga yenziwa izigulana phenylketonuria (isifo amafa ezinxulumene ukutya kakuhle of phenylalanine kukhokelela izibhaxu CNS ngokohlobo yokukhubazeka kwengqondo).

Ngokumalunga abasetyhini abakhulelweyo kunye phindeke, ukusetyenziswa kweziyobisi kwiinyanga zokuqala ezi-3 zokukhulelwa kufuneka sigwetyelwe ezibonisa engqongqo. Ngaphakathi 2-3 trimesters yokuqeshwa "salofalk" kunokwenzeka kuphela kwiimeko xa kusithiwa nempembelelo entle nempilo yomfazi ilawula ingozi yokuba usana. Ngokutsho ubungqina efanayo yamkelekile ukusebenzisa granules 'salofalk "zisanyisa. Noko ke, ukuba umntwana lowo urhudo, kuyimfuneko ukuba bayeke nokuncancisa. Kwaye ngokubanzi, ngokupheleleyo izicwangciso phambi kokuqala yokukhulelwa, bayayeka ukuthatha "salofalk" okanye, ubuncinane, ukunciphisa idosi ezifunyenweyo.

ziphumo bezingalindelekanga kunokwenzeka

ziphumo bezingalindelekanga phantse naliphi na ichiza. Bekukho ngaphandle kunye "salofalk" (isasetyenziswa Russian ngokunjalo). CNS imiphumela emibi iimpawu kunokwenzeka intloko ebuhlungu, isiyezi, iingcangcazela, ukuduma, ukudakumba, unditsho, paraesthesia. iphecana zesisu zinako ukuphendula ngokusetyenziswa "salofalk" yi iintlungu esiswini, ukuqunjelwa, urhudo, isicaphucaphu, ukugabha. na uphuhliso olunokubakho kwesibindi, amaxabiso transaminase hepatic utshintshe. Cardio nemithambo inkqubo angafumana tachycardia, kumahlandinyuka uxinzelelo lwegazi (hyper- okanye hypotension), iintlungu esifubeni, dyspnea.

Kwezinye iimeko, izigulane unokuviwa kuphuhliso myalgia, arthralgia. Ukongeza, ichiza kungabangela anaemia, leukopenia, thrombocytopenia, anuria, oliguria, hematuria, crystalluria.

Of eziliqela negazi kunokwenzeka ukurhawuzelela, irhashalala, erythema, bronchospasm, pericarditis kunye myocarditis. Xa izigulane hypersensitivity ukuba mesalazine ukuze aphuhlise izifo ezifana nephritis Embi, nephrotic syndrome, isigaba nokoyika pancreatitis. Xa iqela elahlukileyo zezigulane 'salofalk "(efanayo yakhe ngokunjalo) ebangela iimpawu ezifanayo ukuya syndrome of systemic lupus zomzimba.

amayeza analogue

I 'salofalk "ubungakanani ezaneleyo amayeza analogue eli candelo engundoqo esebenzayo. Njani, umzekelo, endaweni "salofalk" - namakhandlela? Analogue, ezivame umdla kwabathengi kunye abanikezeli beenkozo zononophelo lwempilo bamiselwe - yi suppositories "Pentas" yaye "Samezil". Ezi amayeza Isithako engundoqo esebenzayo i mesalazine, ngoko ke kufuneka neziphumo ezifanayo amayeza emzimbeni womntu.

"Mesakol" - omnye analog "salofalk 'asetyenziswa kakhulu (xa granules, tablets).

Ngaphandle icandelo umsebenzi analog, kukho iqela elikhulu iziyobisi ezifanayo ukusebenza ngamayeza nokunyanga. La machiza ngokukhuselekileyo ukuthwala "Azathioprine" yaye "Alginatol", "hydrocortisone" yaye "Dexamethasone" "Diprospan" yaye "Irmalaks", "prednisolone" yaye "Sulfasalazine". Uluhlu iyaqhubeka.

izincomo ezithile

Phambi kokuba uqale unyango kunye ngexesha unyango kunye nasemva ngababoneleli ukupheliswa yaleza ukuba athathe uvavanyo igazi nomchamo eqhelekileyo. Kwakhona ngaphambi kokuba unyango kunye kwinkqubo kuyimfuneko ukuba esweni Ipharamitha sokusebenza kususwa kunye nezintso ezo. Esweni kakuhle kwenziwa emva kweentsuku ezili-14 emva kokuba unyango, yaye emva koko omnye amaxesha 2-3 emva kwesithuba seeveki 4. Ukuba iziphumo zovavanyo ngaphakathi kwemida eqhelekileyo, uphando esweni okwenziwa qho emva kweenyanga ezi-3. Ukuba ngequbuliso abathile uhlobo zokutenxa baza kuvandlakanywa kuhlalutyo, kuyimfuneko ukuba enze iimvavanyo ulawulo ngoko nangoko.

Ekuqeshweni naluphi na uhlobo lwamayeza "salofalk" (amakhandlela, analogue amacwecwe, granules, Ukunqunyanyiswa) ukuya izigulana asthma inyumoniya, ugqirha kufuneka esweni ngenyameko imeko izigulane ngexesha unyango. Ukuba isigulana unembali kuvela ithuba iziphumo ebezingalindelekanga xa uthatha "Sulfasalazine" nobume bempilo yabantu abanjalo kufuneka esweni ngenyameko kwisigaba sokuqala unyango "Salofalk." Ukuba wasibonisa reactions ukunyamezelana etsolo (unditsho, iintlungu esiswini, irhashalala, ifiva), ukusetyenziswa ichiza kufuneka kupheliswa ngoko nangoko.

Xa uqhuba okanye ukwenza imisebenzi ezifuna isantya esiphezulu reactions lengqondo, izigulane abafumana "salofalk", kufuneka ulumke kakhulu.