"Imipenem + Cilastatin": inkcazelo, izilinganiso umsebenzisi kunye nohlolo

Ezinye ezosulelayo izifo ukoyiswa asinto ilula kakhulu. Abakwazi nzulu kuphela akuphazamisi impilo, kodwa iyibeke isoyikiso sokwenene ubomi isigulane. Kwiimeko ezinjalo, kufuneka ingasetyenziswa umgangatho ophezulu kunye namayeza olusebenzayo ukuba litshitshiswe ngempumelelo usuleleko yingozi kwaye ubuyisele impilo. Ukuphelisa iintlobo zezifo ezosulelayo idla ngokusetyenziswa lithetha "Imipenem + Cilastatin". Ngokutsho iimpendulo zezigulane amagqirha, yeyokuba isebenza kakhulu. Phambi kokuba ugqibe ukuba ukuqala unyango lwe-mali, kuyimfuneko ukufumana ulwazi kangangoko malunga ichiza "Imipenem + Cilastatin": igama zorhwebo ichiza, ingakumbi intshukumo kunye nendlela isicelo sayo. Ngubani kufuneka usebenzise iziyobisi umbuzo? Zeziphi Izimo? Yintoni iziphumo ebezingalindelekanga I ulindele? Lonke olu lwazi uyakwazi ukufunda ngokufunda eli nqaku.

isakhiwo

Amalungiselelo "+ Imipenem Cilastatin" yi ngokulinganayo cilastatin ludibaniso (yinto inhibitor le enzyme digidropeptidazy sezintso) kunye neetyuwa sodium of imipenem (isibulala-zintsholongwane). Enye ukulungiselela isitsha ngokuqhelekileyo iqulethe milligrams ezimakhulu mahlanu zombini izinto.

release Form

iziyobisi kujongwa "+ Imipenem Cilastatin" ifumaneka kwifomu olungumgubo iinaliti (lolawulo emthanjeni) e nengqayi ezohlukeneyo ngobukhulu, ezizezi amathandathu nekhulu elinamashumi amabini ngeemililitha. Le umgubo kufuneka ichithwe ngayo isisombululo (yemphahla) kunye sodium hydrogen carbonate.

Kwimeko apho ichiza ezimiselweyo kulawulo intramuscular awazuze ezineengqayi, nganye 0.5 okanye 0.75 yegram imipenem kunye cilastatin (ngokuxhomekeke umthamo, apho elawulwa nomntu ogulayo ngugqirha khona).

Ubungqina obubonakalayo buxela

Le medicament "Imipenem + Cilastatin" emiselweyo ukuba isetyenziswe zizigulane phambi kwezifo ezosulelayo kunye ukudumba eziye zabangelwa naliphi novelwano yintshukumo izinto ezisisiseko esebenzayo amagciwane beziyobisi, ezibandakanya zombini polymicrobial elingumxube ngoko usuleleko aerobic-anaerobic (ezi ziquka esosulelayo izifo womchamo kunye iphecana zokuphefumla ongezantsi, nokudumba, usulelo lwe amalungu kunye namathambo; peritonitis, usulelo intra-esiswini, arhabaxa, njl iinkqubo ezithe zenzeka kwi amalungu zangasese ,. zizifo ezahlukahlukeneyo ezosulelayo ulusu nezihlunu ethambileyo, kwakunye endocarditis Kwakhona, ichiza isetyenziswa ngokufanelekileyo nje ukuthintela iingxaki emva kotyando.

imiphumela kwemithi

Ukusebenza ichiza "+ Imipenem Cilastatin" conditioner ukuhlanganiswa ngempumelelo macandelo mabini esebenzayo. Okokuqala, imipenem, umele ethile zintsholongwane beta-lactam esibulala ngononophelo ziibhaktheriya (ngaloo ndlela kubonelelwa isiphumo bactericidal). Le nto iye spectrum ngokubanzi ngokwaneleyo yomsebenzi. Oku kuthetha ukuba ngamagciwane abaninzi ecingela neziphumo zayo. Icandelo lesibini, cilastatin sodium eli ukusebenza enzyme leyo abole imipenem kwi kidney yomguli, abangaphangeliyo wesenzo, nto leyo inegalelo ekwandeni obaneleyo uyondelelwano lwee- olwa ngasentla kwifomu unmodified kumguli. Ngenxa yoko, ukusebenza ngokuncomeka ichiza "Imipenem + Cilastatin" lisanda.

isicelo

Ukuphumeza enempembelelo enkulu, yaye ukuze kuthintelwe naziphi na iziphumo ezibi unyango kubalulekile ukulandela ngononophelo iingcebiso malunga nokusetyenziswa kweziyobisi. Le medicament "Imipenem kunye Cilastatin Dzhodas" yenziwa nesigulana butofelwe (ithontsi).

Ngaphandle kwento yokuba sikhokelo inika ithamo avareji ichiza, phambi kokuqala unyango, kubalulekile ukuba ukunyenyisa ukuba inkqubo yonyango ngqo evela kugqirha ngubani na ufake kakuhle idosi efanelekileyo ngenxa kwimbali yomguli kunye neempawu zaso.

Lidle enoku medicament "+ Imipenem Cilastatin" umyalelo kwi into ingqalelo yenzelwe abo izigulane zabo ubunzima lidlula ngekhilogram asixhenxe. Ezo izigulane kufuneka incitshiswe ngokomlinganiselo yedosi yokusebenza ichiza ubunzima ogama umzimba ngaphantsi, (kubalulekile ukuba le nkqubo ekhokelwa ngumntu onobuchule).

Izigulane abadala zatshintshwayo idosi yemihla ngemihla ichiza "Imipenem and Cilastatin Dzhodas" yenye - grams ezimbini, ukuba ukwahlulwa kwayo ezintathu - wolawulo ezine. Kwangaxeshanye, idosi iphezulu owamkelekileyo lolawulo kuba imini enye amane anamanci mahlanu grams okanye milligrams kwekilogram ubunzima bomzimba (ukhetho kufuneka kuwa phezu ezincinane amathamo amabini avumelekile) nganye.

Kwakhona, ithamo kuyahlukana nedlela malunga nobungozi besi sifo. Ngenxa yoko, kwimeko umguli ngokuqatha mnene usulelo, ithamo yokusebenza kuya kuba milligrams ezimakhulu mabini anamanci mahlanu (iinaliti phindwa kufuneka ibe izihlandlo ezine ngosuku). Ukuba wononophelo sandla, isixa kuqulunqo ngenxa kulawulo olunye kufuneka ibe milligrams anamakhulu mahlanu. Input kuthetha kufuneka kube kathathu ngemini. Ukuba inqanaba lesi sifo is serious, ngoko ke ithamo amayeza kufuneka kusetyenziswe amaxesha amane ngosuku. Xa imeko yomguli unobuzaza kangangokuba kukho ingxaki enkulu ebomini bakhe, kufuneka ufakwe ngaphezu yegram enye ezintathu - kane ngemini. Ichiza kufuneka ilawulwe kancinci (grams ngeyure, elinamakhulu amabini, anamanci mahlanu - anamakhulu mahlanu milligrams - ezingamashumi - imizuzu engamashumi amathathu).

Ukuba ichiza isetyenziselwa nokuthintela usulelo postoperative kubalulekile ukuba kungafundiswa gram enye ngexesha zomzimba kunye idosi enye, iiyure ezintathu emva koko.

Ukuba ngexesha lokusebenza kwakukho intsongelo naluphi na uhlobo losulelo (ingakumbi ngokumalunga nemisebenzi kwi isikali kunye colon), "Imipenem + Cilastatin" imiyalelo ukusetyenziswa incoma ukungena milligrams ezimakhulu mahlanu, ezisibhozo iiyure ezilishumi elinesithandathu emva zomzimba.

Ukulungiselela isicombululo ngabasebenzi igutyana kuyimfuneko lusongeza izinto umgubo ikhulu ngeemililitha wesinyibilikisi ezizodwa, ezibandakanya iipesenti ezintlanu okanye ishumi ekhulwini dextrose zolwelo, 0.9% solution sodium chloride. Le isisombululo imipenem zintsholongwane xiyimiso mayingagqithi milligrams ezintlanu milliliter nganye.

It engamelanga ithathwe njenge ukusebenzisa iziyobisi kunye nezinye iziyobisi antibacterial, kwakunye ityuwa lactic acid.

Le into ayihambelani kunye nezinye antibiotics beta-lactam (eziquka cephalosporin, penicillin kunye monobactam). ukusebenzisa kwabo ngaxeshanye kunokukhokelela ngayo cross-komzimba.

Ukudibana ne ganciclovir maxa wambi omnye afune yombono jikelele.

izinto ezahlukahlukeneyo ezithintela secretion tubular, ukunyusa uyondelelwano lwee- imipenem kwi plasma igazi, yaye nexesha nakwisiqingatha ubomi bayo. Ngoko ke, ukuba unyango olusebenzayo kufuna kulawulo arhente ngeedosi eziphezulu akukho mfuneko ukusebenzisa ezi maqela kwezinto ngaxeshanye.

Akuvunyelwe ukuba ukusebenzisa iziyobisi mbuzo ixesha lokumitha umntwana, kwakunye nangexesha ubisi lwebele.

Ichiza akufunekanga ukuba isetyenziswe ukuze kunqandwe meningitis.

Umchamo ngexesha unyango ukuze ezinemibala kancinane Tint bubomvu.

uhlobo umthamo ichiza (for efakwa kunye nolawulo intramuscular) ukuba kusetyenziswa ngqongqo loo njongo. They are interchangeable. Phambi kokuqala amayeza unyango ukuze ingqalelo kubalulekile ukuqhuba uphando obucokisekileyo kwisifundo komzimba okanye hypersensitivity ngamnye antibiotics beta-lactam.

Ukuba isigulane sele waba nezinye izifo phecana zesisu, ezifana ukudumba, ukuze xa usebenzisa ichiza phantsi kovavanyo, kukho amathuba enterocolitis pseudomembranous.

Ukwenzela ukuphepha ngempumelelo nayiphi abasabela ezigatya kwinkqubo luvo kwezo izigulane ukuba nawuphi na umonzakalo ebuchotsheni okanye unditsho ubunzima akhaphayo Kucetyiswa unyango amayeza arhente qualitative antiepileptic.

Kufuneka kukhunjulwe ukuba izigulane abadala kusenokwenzeka ukuba ezinxulumene-age kwekhono kwezintso, nto leyo efuna ukunciphisa idosi.

Kubalulekile ukukhumbula ukuba izigulane abadala kufuneka basebenzise eli chiza ngononophelo. Njengomgaqo, zibonisa iimpawu ezahlukeneyo ukuphazamiseka ezinxulumene kwiminyaka ekusebenzeni nezintso. Kulo mzekelo, ukuba kuyimfuneko, ukusetyenziswa kweziyobisi "Imipenem + Cilastatin" umyalelo manual lithethelela ukuba udibane nogqirha wakho ekunciphiseni idosi iziyobisi ezisetyenziswayo.

Kukho ezinye iimeko ezizodwa isicelo sale amayeza abantwana. Ukuba ubunzima bomzimba wabo lidlula kilogram mane, izikhokelo inye emalifakwe kubo njengoko ku abadala. Ukuba umntwana omdala ngaphezu kweenyanga ezintathu, kwaye ubunzima bayo ngu ngaphantsi kwe amane wayedla, idosi iphezulu yemihla ngemihla umguli bekuya kuba grams ezimbini. Kufuneka ufakwe milligrams elinesihlanu ikilogram kane ngemini.

Akukho mzekelo akakwazi ukusebenzisa amayeza "Imipenem + Cilastatin" kuba abantwana asikafikeleli iinyanga ezintathu, nabo abantwana ephazamisa eqhelekileyo yokusebenza nezintso, leyo ingavezwa kwinqanaba serum creatinine xi ngaphezu milligrams ezimbini deciliter nganye.

Izimo

Kukho ezinye bokuqonda ekufuneka ithathelwe ingqalelo xa usebenzisa i "+ Cilastatin Imepenem". Umyalelo icebisa ngenyameko bafunde Izimo ukuya kweli chiza. Phakathi kwazo kukho ezi zilandelayo:

• ixesha lokumitha umntwana;
• lwebele;
• Abantwana abangaphantsi kweminyaka iinyanga ezintathu;
• Abantwana abahluphekayo kakuhle ukusebenza sezintso ezinxulumene zoqhaphelo ophezulu creatinine serum;
• uvakalelo ngamnye ukuba amacandelo ngabanye ichiza phantsi ingqalelo, kwakunye nezinye nemithi beta-lactam kunye carbapenems.

Kubalulekile ukuba kukhunjulwe ukuba izigulane abadala kunye nabo bafumana ubunzima okanye wakha waba lixhoba kwizifo yenkqubo luvo okanye izifo iphecana zesisu kufuneka uthathe iziyobisi kunye isilumkiso phantsi kweliso lomgadi gqirha. Ukuba yena uyakwazi ngobuchule ukwabela idosi echanekileyo beziyobisi "Imipenem + Cilastatin". Izimo kubalulekile ukufunda phambi kokuba uqale unyango.

imiphumela emibi

Kubalulekile ukwazi into enye ngaphezulu ngalo isixhobo "Imipenem + Cilastatin". ukulungiselela Formula kukuba ezinye izigulane ukuze babe ezinye abasabela icala kwiinkqubo zomzimba ezahlukeneyo. Phakathi kwazo kukho: thrombophlebitis, incasa ukuphazamiseka, candidiasis, oliguria, myoclonus, nemibono, paresthesia, ukudideka, ukusilela etsolo kwezintso, ukuphazamiseka kwengqondo, ukuxhuzula, polyuria, anuria, urhudo, hepatitis, isicaphucaphu nokugabha, leukopenia, enterocolitis pseudomembranous, lymphocytosis, hyperbilirubinemia, eosinophilia, pruritus, leukopenia, irhashalala, thrombocytosis, hypercreatininemia, monocytosis, urticaria, basophils, a ngqo Coombs HIV.

Akukho lwazi ngqo ukuba indlela yokujongana kunye libanda, beziyobisi ethathelwa ingqalelo. Nangona kunjalo kwakusazeka ukuba ezi izithako ezisebenzayo ukuba bangenele ngempumelelo olugqitha esikhumbeni. Noko ke, oku akwaziwa indlela ezinokubanceda nkqubo na kwimeko libanda. Kubalulekile ke ngoko ukuba bazigcine zonke iingcebiso, leyo iquka indlela yokusebenzisa "+ Imipenem Cilastatin" inkcazelo yokulungiselela.

iimeko yokugcina

Ukuze ukuba isicelo beziyobisi ukuba siphumelele, kubalulekile ukuba uthathe ingqalelo enye ingongoma ebalulekileyo. Oko kukuthi, indlela ukugcina amayeza "Imipenem + Cilastatin". Inkcazelo osisiqu ibandakanya ezi ngcebiso zilandelayo.

Le umgubo kufuneka iqulathwe kwigumbi apho lobushushu igumbi igcinwe. kufuneka zisetyenziswe ukulungiselela isisombululo ukusebenza ungadlulanga owe ngaphezu kweyure enye emva kungamampunge. sodium chloride isisombululo kubushushu igumbi kunokugcinwa ngaphezu kweeyure ezilishumi kwaye efrijini - hayi ngaphezulu kwe ezingamashumi amane anesibhozo. izisombululo glucose zingagcinwa iiyure akukho ngaphezulu kweminyaka emine kwaye ezingamashumi amabini anesine, ngokulandelelana kwazo.

analogs

Kukho inani iziyobisi yinxalenye yeqela kuthetha analogue "Imipenem + Cilastatin". Abo babambeleyo njenge neziyobisi - "Inemplyus", "Miksatsil", "Lastin", "Sinerpen", "Tiaktam", "Piminov", "Supranem" yaye "Tienam". Njengoko umthetho, zonke ezi mithi isithako esebenzayo efanayo njengoko ichiza ingqalelo. Izithako eziphambili ezisebenzayo zezi amayeza - imipenem, cilastatin (igama lorhwebo kwaye zibonisa la mayeza). Ngoko ke, la mayeza ababangela ngokufanayo, yaye Izimo kunye neziphumo ebezingalindelekanga kunye neziphumo imithi. Nangona kunjalo, kufuneka kukhunjulwe ukuba idosi kufuneka amisele gqirha oya kuba nako ingqalelo zonke bokuqonda. Ichiza "Imipenem + Cilastatin" analogue amayeza kufuneka ingasetyenziswa zizigulane ngaphandle kwemvume, ngaphandle ugqirha okunyangayo nolawulo lwakhe rhoqo. Kuqukwa ingcebiso yakhe ezifunekayo kunye nokukhethwa mzekeliso ezifanelekileyo.

gabalala

Practice kuqinisekisa ukusebenza ichiza "+ Imipenem Cilastatin". Ukuphonononga baxele iziphumo ngempumelelo unyango. Noko ke, koogqirha kunye nezigulane zigxininise yintoni ebalulekileyo ngokuchanekileyo ngqo iingcebiso eziqulathwe kule imiyalelo waza wanikela ugqirha khona. Kuphela le ndlela unyango nga kunceda umzimba isigulane.

Akufuneki ukuba zingahoywa Izimo, ubukho apho awuvumeli ukuba ukuqala unyango ingqalelo ichiza. Kungenjalo, isicelo yayo akanako nje ukunika iziphumo ezidibanisayo, kodwa inokubangela umonakalo omkhulu imeko yesigulana. Kwakhona, ukusetyenziswa olungachanekanga ichiza ingqalelo inokubangela iziphumo ebezingalindelekanga, ezinye zazo, kungaba kubi kakhulu imeko yesigulane. Kubalulekile ukuba unyango kwenzeka phantsi kweliso ugqirha abanobuchule, ngubani na kuphela kakuhle bazifunde awohluke kwesicelo beziyobisi, kodwa kananjalo kakuhle izakhono nolwazi oluyimfuneko ukuze ukumelana neemeko eqalayo ezinzima. Impilo yakho kufuneka ibe ezandleni yeengcali okwenyaniso.

Phambi kokuba ugqibe ukuba uqale unyango ingqalelo ichiza, kubalulekile ukufunda ngenyameko lonke ulwazi malunga nayo, nto leyo ebonakalisa iimpawu yeziphumo yayo emzimbeni. Into ekufuneka uyazi malunga nesakhono reactions ezibi, kukuvela apho inokubangela ezininzi ngenkxamleko kwisigulana kunye ubunzima ugqirha wakhe.

Xa ukhetho lonyango kubalulekile ukuphatha ngenkathalo. Khetha iimveliso ephezulu quality!