Inhibitors impompo Proton: indlela amanyathelo kunye nesicelo amayeza

Ngu Proton impompo inhibitors na iqela arhente amayeza zokunciphisa izinga secretion of zehydrochloric acid esiswini. Ukuba nefuthe ngqo kwi canaliculi secretory, bona eyiyo kukhokelela nangezilonda ezinqwenelekayo zonyango ukusebenza, gastritis ilunga, GERD. Iqela uquka ezininzi kwamachiza lwesakhiwo kwemichiza efanayo, kodwa ukuba pharmacodynamic iparameters ezahlukeneyo, ngamanye phantse amachiza efanayo ukuthobela iiseli secretory, kodwa oko ezahlukeneyo boxinzelelo kunye ngezantya ezahlukeneyo.

inhibitors impompo Proton: imiba emolekyuli impembelelo amalungiselelo

Impompo Proton imbaxa isakhiwo protein elawula kwii-ion ze-hydrogen le mithambo esiswini. Le nkqubo ibandakanya iinkalo ezimbini iikhemikhali ayaba, ebizwa subunits. Eyokuqala kuphela protein kwaye yakhiwe evela acid. Xa inwebu yeseli stuffer iziphatha ngendlela ekhethekileyo, wayiwela izihlandlo ezili-10, nto leyo ekhokelela kuseko kweziporo channel-5-secretory. Ehambahamba em- ion kuwa phakathi sayo esiswini uze unike Ukuba muncu medium yawa index hydrogen. Kule meko ke kwelinye semigaqo ngumbindi ebonakalayo kwiproteni - ukulandelelana 800 asidi acid, leyo catalyzes yokuwa ATP, engundoqo iseli amandla zeendawana.

Okunye enganeno imbaxa protein ukuba ubunjwe kulandelelwano polypeptide, ngokulandelelana isakhiwo ethile wayalela nezidanga glycoprotein. Inxalenye olungathethekiyo molecule ngaphandle icytoplasm, yaye inxalenye glycoprotein ayisiyiyo ekstratsitoplazmaticheskim receptor entsonkothileyo othwala umqondiso kokuba uqalile okanye ipoti ye-enzyme H + \ K + -ATPase. Kulo mzekelo inxalenye protein kwemolekyuli iwela inwebu kanye, nto leyo ebonisa ixabiso layo njengento yokungena phakathi olungaphandle kunye enganeno receptor yokuqala noxanduva ngokuqhuba indlela ebalulekileyo ekujonganeni of Yindibanisela protons.

Ngako oko, isakhiwo kwimpompo Proton tubules secretory iiseli Parietal sinokugqiba njani ngendlela elula itshixa ikhusi le secretion ye H + kuloo ndawo ibinomthwebeba emzimbeni. Lwalo kakhulu uyagwetyelwa - na inhibition ze enzyme onoxanduva njini ezenza pump Proton inhibitors.

Ukusetyenziswa inhibitor in practice clinical

Xa amayeza, impompo Proton inhibitors asetyenziswa ngokubanzi, ingakumbi Gastroenterology, nto leyo enxulumene banako ukunciphisa le asidi esiswini secretion, anciphise ngobunzulu umonakalo phezu kodonga isisu, nto leyo ibaluleke kakhulu xa kunokutshiseka. Kulo mzekelo isiphumo enyangayo elizimeleyo kwi-umyalezo we inkqubo kwiintetho ezikralayo, njengoko isuswe impembelelo ngxwaba kokusingqongileyo ekunyanisekeni umzimba. Kwakhona lwaseNtshona Koloni ziba ezimbi leyo unyango ekusetyenzisweni ngempumelelo Proton pump inhibitors iye yandiswa nge isilonda esiswini kunye isilonda duodenal, ilunga kunye neefom GERD non-ilunga.

Phakathi amayeza ixhaphakileyo ziquka Proton inhibitors impompo kunye amagama iqhelekileyo ilandelayo omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, kunye nabanye. Phakathi kwazo kukho amagama zorhwebo ume ngaphandle, ezifana "Omez". Amayeza ziyafumaneka kwifomu capsule. Bona athathwa ngomlomo idosi elimiselweyo oyingcali, leyo kuyahlukana nedlela uhlobo oluthile lwesifo. Ngelithuba self-zolawulo, njengoko kukho iqela izigulane ezikhala exacerbation zonyaka izilonda esinganyangekiyo esiswini okanye duodenal. Kwezinye iimeko, ulwamkelo leyo thethwana ugqirha ngexesha wokwamkelwa kwakhe.