Isidakamizwa saseHormon "Dostinex": ukuphononongwa ngokunyuka kweprolactin kubafazi kunye namadoda. Indlela yokuthatha "i-Dostinex" kunye neprolactin eyandisiweyo?

Iprolactin yi-hormone eveliswa kwintsimbi ye-pituitary ekhoyo kwingqondo. Kwababini abasetyhini kunye namadoda, izinga le hormone egazini libaluleke kakhulu. Umxholo wayo kwimiqulu engaphezu kwesiqhelo ngokungaqhelekanga iyayichitha ukusebenza komsebenzi wokuzala. Ibhinqa ayikwazi ukukhulelwa, kodwa indoda ingalahlekelwa libido kwaye ihlakulele amandla.

Ukuze kulungiswe le ngxaki, ukulungiswa kwezonyango ezikhethekileyo kuye kwaphuhliswa, enye yazo i-Dostinex. Iingxelo kunye neprolactin eyandisiweyo zibonisa eli phepha njengolusebenzayo.

Yintoni "i-Dostinex"?

"I-Dostineksom" ibizwa ngokuba yiziyobisi ezenzelwe ukulwa ne-hyperprolactinemia kunye nazo zonke iintlobo zezifo ezicaphukisayo kunye nazo. Oko kukuthi, amayeza aya kusebenza kwiingxaki ezifana ne- amenorrhea (ukungabikho kokuya esikhathini ukuya kwimijikelezo emininzi), ukungabikho komzimba, i-galactorrhea (ngaphandle kwebisi kwiintlobo zezilwanyana ezincinci, ezingahambelani nokusondeza umntwana), i-proenctin-secreting-secreting adenoma ye-pituitary gland, i-acromegaly (ukungasebenzi kwe-lobe yangaphambili ye-pituitary gland , Ehamba kunye nokuqiniswa kwezandla, iinyawo, iinguvu).

Isigxina esiphezulu seziyobisi yi-cabergoline, i-lactose kunye ne-leucine zikhonza njengamacandelo encedisayo. Iifom ze "Dostinex" - iipilisi ze-0.5 mg, kwiphakheji enye - iziqwenga ezi-8. Ingundoqo yesichengisiso-ukuvimba ukuveliswa kweprolactin, okomzekelo, kumzimba wesetyhini kwenza ukuba kwenzeke ngexesha lokuvuthwa kwintollicle, ubuyisele umjikelezo wesini. Ngenxa yoko, kukho i-ovulation eqhelekileyo, umfazi unokukhulelwa.

Inqanaba leprolactin egazini

Xa, emva kokuvavanya ama-hormone egazini, ukwandiswa kweprolactin, unyango lwe "Dostinex" luyinkqubo eqhelekileyo yokusetyenziswa kwamanyathelo okwelapha. Ngokumalunga nabasetyhini, kucetyiswa ukuthatha igazi ukuhlalutya ukususela ngomhla wesi-3 ukuya kweyesi-8 kwimizuzu yokuya esikhathini (ukubala ukususela ngomhla wokuqala wokuya esikhathini). Uhlalutyo kufuneka lunikezwe kwisisu esingenalutho, mhlawumbi kungekudala emva kweeyure ezingama-2-3 emva kokuvuswa. Ngaphambi kokuba uthathe uvavanyo, kucetyiswa ukuba ungabandakanyi ukunyameka okukhulu komzimba, thintela iimeko ezixinzelelekileyo, ukuyeka isondo, ungadli iifomese.

Egazini lomntu, iprolactin iqulethwe kwiifom ezininzi. Ifomomeric yelo hormone yiyona nxalenye enkulu-ukuya kuma-80%. I-dimeric prolactin iqulethwe kwisixa sama-5 ukuya kuma-20% somthamo opheleleyo we-hormone, kunye ne-tetrameric - ayikho ngaphezu kwe-5%.

Ezi zilandelayo zibonisi zezinga leprolactin egazini zibhekwa njengesiqhelo kwimeko yonyango:

• abafazi abangakhulelwe - 4-49 ng / ml (ukuguquka okuvumelekileyo, kuxhomekeke kwisigaba somjikelezo wesini);
• kubafazi abakhulelweyo - 34-386 ng / ml (ukuguquka okuvumelekileyo, kuxhomekeke kwithuba lokukhulelwa);
• kumadoda - 2.5-17 ng / ml.

Iimpawu kunye nezizathu zokunyuka kweprolactin kubafazi

Emva kokunyuswa kweprolactin, kuyimfuneko ukuqhuba uphando oluthile ukuseka izizathu. Oko kukuthi, ngaphambi kokucebisa ukufumana "i-Dostinex" kunye neprolactin eyandisiweyo, ngokuqhelekileyo ukuba oogqirha uya kumisa isigulane sakhe ukwenza i-tomogram yengqondo, i-radiography, uviwo lwe-fundus, njl.

Njengomthetho, kwiimeko ezininzi, ezi zinto zilandelayo zibangelwa umxholo wokwanda kwe-hormone-prolactin:

• Ubukho beprolactinoma (i-neoplasm kwi-pituitary - ngokuqhelekileyo iprolactin evelisa i-prolactin inomthamo omkhulu).
• I-ovary Polycystic.
• I-Hypothyroidism - ukungakwazi ukuvelisa i-hormone nge-thyroid gland.
• I-Anorexia (ukungabi nciphisa) kunye nezinye iingxaki zamalungu angaphakathi.

Ngokuqhelekileyo umzimba womfazi usayinqanaba elongeziweyo leprolactin kunye nesethi ethile yempawu. Eyona nto ibonwe rhoqo - ukuphuka kwimijikelezo yokuya esikhathini, ukufumana ubunzima, ukunyuka okukhawulezayo, ukuphuculwa kwengcinezelo, ukuphazamiseka kokulala.

Emva koko izigulane zixoxa ngokubonakala kwe-acne kunye nokukhula ngokweqile kweenwele kwiindawo ezingaqhelekanga kumzimba wesibini (ubuso, ummandla ojikeleze iinjenge, njl.). Ukunciphisa kwiintlanzi zamathambo kunye nokuphuhliswa kwengqondo, ngenxa yokungabikho kwe-ovulation okanye isithuba esifutshane kakhulu, nazo zizathu ezifanelekileyo zokugqirha ukuba ugqirha "Dostinex". Ukuphononongwa kunye neprolactin eyandisiweyo kubasetyhini banamathuba amaninzi kwaye banokubonisa ukuphumelela kweziyobisi.

Iimpawu kunye nezizathu zokunyuka kweprolactin kumadoda

Ngokungafani nabasetyhini, kumadoda inqanaba eliphezulu leprolactin egazini lisekondari - le nto ibangelwa yinkinga ekhoyo. Ukuba kukho into enjalo njengokwanda kweprolactin emadodeni, "I-Dostinex" iqeshwe ukuba ifumane ngokufanayo kunye namayeza aphakanyiswe ngugqirha ukulwa nesifo esifumeneyo.

Ukwanda kwinqanaba leprolactin kwiimpawu zesigxina esinamandla kunokususa izifo ezinjengeprolactinoma (i-tumor isifo, i-hypothyroidism (iyanciphisa umsebenzi we-thyroid), isifo esinobindi kunye neengxaki zengqondo, ukungasebenzi kakuhle kwe-cortex umsebenzi, Uhlobo lwesifo kunye neengqondo zesisu. Ukongezelela, ukwanda kwinqanaba leprolactin kumadoda kungabangela ukusetyenziswa kwamachiza athile-i-opiates, antipsychotics, i-anti-depressants, njl.

Uphawu oluphambili lomxholo we-hormone egazini lamadoda lifana nabasetyhini - ukuphulwa komsebenzi wokuzala, kwiimeko ezininzi ezihambisane nokungaqhelekanga kwi-fat and carbohydrate metabolism (ukukhuluphala). Kuloo ndoda isenzo sengqondo sesithintelo sinciphisa, iimpawu zokungazinzi zikhula. Ngamanye amaxesha ukunyuka kweengcambu ze-mammary kunye nokukhetha okuncinci kubo kubhalwe.

Ukuba imbangela yokuphuhliswa kwe-hyperprolactinemia yiprolactinoma, ngoko iimbonakalo ezahlukeneyo kwintsimi ye-neurology zibonakaliswe kwangangoko. Yonke into ingaqala ngeentloko, ukuxakeka kwezinto kunye nokukhubazeka okubonakalayo. Ukuba akukho nanyathelo ezithatyathwa ukuxazulula ingxaki, ukukhubazeka kwezihlunu ze-oculomotor kukhula, i-eyelid drooping, imbono kabini emehlweni, kunye nokufana nokukhula kwithuba. Ngokuhambelana nale mpawu, isifo somzimba siyancipha, sichaphazeleka, sisenokuxhalabisa, sithintela kwiindawo eziphazamisayo, singakwazi ukugxininisa ingqalelo, ukulahlekelwa kwememori. Ngokuqhelekileyo, amadoda ahlakulela uhlobo lwe-2 lweswekile, i-atherosclerosis. Yonke le mpawu ugqirha unokuqwalasela isizathu esaneleyo sokuqeshwa ukuba afumane unyango "Dostinex." Iingxelo kunye neprolactin eyandisiweyo kumadoda ibonisa umphumo omhle wokusebenzisa izibisi ngelixa ulandela iziphakamiso zegqirha.

"Dostinex" kunye nokukhulelwa

Ngokuqhelekileyo, abasetyhini abaneminyaka yobudala bokuzala kufuneka bazi ukuba ukukhulelwa ngenye yeengqinisiso eziphambili zokusetyenziswa kwe "Dostinex". Ukuphonononga ngokunyuka kweprolactin (ukukhulelwa ngokwayo yeso sizathu sokwanda kwenyuka kwinqanaba leprolactin egazini lomfazi), kungakhathaliseki ukuba lihle kangakanani, akufanele lilahlekise loo ntokazi.

Umgangatho weprolactin emzimbeni wowesifazane ozala umntwana uqala ukukhula ngokuthe ngcembe, ukuqala ngeveki ye-8 kwaye ufikelele kwiimpawu eziphezulu ngelixesha leeveki ezingama-20-25. Le hormone, ukongeza ekulungiseleleni izilwanyana zamancinci zokusondeza umntwana, nazo zinempembelelo enamandla ekwakheni izicubu zomphunga zentsana ekhulayo.

Ngaphambi kokuqala kokonyango "I-Dostinex" kuyimfuneko ukukhuphela ukufumaneka kokukhulelwa kunye nayo yonke inkqubo yokunyanga ukusebenzisa iindlela zokucatshungula. Ukuba inyaniso yokuqala kokukhulelwa ibhalisiwe kakade malunga nemvelaphi yenkqubo yokuqala yonyango, kufuneka uyeke ukuthatha i-Dostinex.

Isiqingatha-sobomi se-cabergoline (isithako esisebenzayo esisisigxina sesilwanyana) side kakhulu. Ngoko ke, ukuba ngaba umfazi uceba ukukhulelwa, "I-Dostinex" kufuneka ithathwe ingadlulanga inyanga 1 ngaphambi kokuba umklamo ohlongozwayo, ukwenzela ukuba ungabandakanyi amathuba okuphuhlisa imiphumo emibi kumntwana.

Iishedyuli zesicelo seziyobisi

Indlela yokusela ngokufanelekileyo "I-Dostinex" kunye neprolactin eyandisiweyo, ugqirha wakho kufuneka axelele isigulane sakho. Iskimu esisemgangathweni sokuthatha le mayeza ngenye (ubuninzi babini) ngamaxesha ngeliveki, ngelixa besidla. Ukuba isizathu sokuba kuqeshwe "i-Dostinex" yi-hyperprolactinaemia, umthamo ophezulu weziyobisi ngaphakathi kweveki akufanele ube ngaphezu kwe-4.5 mg (kufuneka ihlulwe ibe ngama-reception). Emva kokuqala kwekhosi yonyango, izigulane kufuneka zijonge izinga leprolactin egazini kunye nenyanga zithathe iimvavanyo ezifanelekileyo. Ngokuqhelekileyo izibonakaliso zibuyela kwizinto eziqhelekileyo emva kweveki ezi-2-4 ukususela ekuqaleni kokunyango.

Kwimeko apho ibhinqa ngesizathu esithile ifuna ukukhusela i-lactation yokuhamba emva kokubeleka, inqunywe i-1 mg yesilwanyana kanye ngosuku lokuqala emva kokubeletha. Indlela yokuthatha i-"Dostinex" kunye neprolactin eyandisiweyo, ukuba inkqubo yoqeshiso sele ihleli?

Ukumisa, ugqirha uvame ukuphakamisa i-250 μg yesilwanyana nganye iiyure eziyi-12 kwiintsuku ezimbini. Ngale rejimeni, kukho imiphumo embalwa yempembelelo ngendlela yesifo sengxinzelelo segazi.

Imbonakalo engebiyo

Kwiimeko ezininzi malunga neziyobisi "I-Dostinex" kunye nokunyuka kweprolactin kunesimo esihle. Isidakamizwa kwiindawo zempilo yabasebenzi siyabonwa ngempumelelo, kungabikho miphumo emibi, kodwa nangona kunjalo ezinye iziphumo ezibi ziyabonwa. Ngokuqhelekileyo unokuva malunga nokunciphisa uxinzelelo lwegazi, intloko Ubuhlungu kunye nosizi, ukulala, ukungabi nasisulu kunye neentlungu kwisiginci sesisu.

Ngokwemvelo, kukho ukuhlaziywa kakubi malunga neziyobisi "Dostinex" ukuhlaziywa ngokunyuka kweprolactin. Imiphumo emibi ingabonakaliswa ekuphuhliseni i-gastritis, ukuhlanza, ukubethelwa, ukubonakala kokulala nokubuthathaka, kwi "tide" yegazi ebusweni, ekubonakaleni koxinzelelo kunye ne-paresthesia, kwintlupheko ebuhlungu yeengqungquthela zamathambo.

Enyanisweni, kuyafaneleka ukuthetha ukuba zonke ezi zibonakaliso ziphantse zichazwe ngokucacileyo. Uninzi lweziphumo ezisecaleni zivela ekuqaleni kwonyango - ngeveki ezimbini zokuqala. Ukuba i-dosage iyancipha kancane, iimpawu ezimbi ziya kutshabalala. Emva koko, unokuphinda ukhulise umthamo ngokuthe ngcembe kwisebe ephumelelayo. Ngokupheliswa ngokupheleleyo kwe "Dostinex" iimpawu ezingekho phantsi kuya kutshabalala kwiintsuku ezingama-1-2.

Ukungqinelana kokufumana "Dostinex", ukudlula ngaphezulu

Kukho ukuchaswa okumbalwa kwale mayeza, kodwa kunjalo. Okokuqala, i-hypersensitive to the components of the drug (kuyo yonke i-ergot derivatives, kubandakanywa). Okwesibini, ukukhulelwa. Umbuzo wendlela yokusela "I-Dostinex" kunye neprolactin eyandisiweyo ngexesha lokukhulelwa, akunjalo - oku akuvumelekanga kumfazi olindele umntwana. Ukongezelela, amayeza ayinakuthathwa ngexesha lokutya, ukuba loo ntokazi ayinayo isizathu esivakalayo sokuphelelwa kwimeko yokukhawuleza kwenkqubo. Ukongezelela, oogqirha abacebisi ukuba bathathe "Dostinex" kwabasetyhini abaneengcinezelo zengqondo emva kwesifo kunye ne- psychosis postpartum (nakwi-anamnesis).

Ngokunyamekela kwaye phantsi kweliso rhoqo, izigulane ezineengxaki zentliziyo, isifo sikaRaynaud, isifo sengqondo somzimba kunye nokungazi kakuhle, izilonda zesisu kunye nezilonda zomzimba, ukuphuma kumgudu wesisu kufuneka kuthathe imithi kwimpilo yabo.

Musa ukumisela iilisi nakwazo zi gulane ezineembali zesifo sengqondo.

Ukuze ukhusele umthamo ophezulu, umbuzo wobukhulu kunye nendlela yokuthatha "i-Dostinex" kunye nokwanda kweprolactin kufuneka uhlale phantsi kolawulo loogqirha. Inyaniso yokugqithisa ngokugqithiseleyo kuboniswa ubukho beemeko ezinjengeentlungu zesisu, isicathulo kunye nokuhlanza, ubuthakathaka obunokukhawuleza, ukugungqa, ukujuluka, ukuxhamla kweengxube zenkomo, ukunyakaza kwengqondo, ukuphuhliswa kwengqondo, ukubonakala kwengqondo. Njengeendlela zokwelapha ekupheliseni imiphumo yezidakamizwa, ukugcoba isisu, ukunyamekela ukunyanzeliswa kwengcinezelo yegazi kunye nokutya kwamachiza okuchasene ne-dopamine.

Ulwazi oluKhethekileyo

Ukuba ukufumana "i-Dostinex" kunye neprolactin eyandisiweyo ayiyiphumeli, ngoko ke isizathu sokuphuhliswa kwe-hyperprolactinemia kwesi siguli kufuneka sifakwe kwenye indawo.

Abasetyhini kwimeko yokonyango kunye nale nkunkuma kwixesha elide kufuneka baqhube uhlolo lwemizimba ngokuqhelekileyo kunye novavanyo oluvakalayo lwentsholongwane lomzimba kunye nokuhlolwa kwakhe kwe-endometrium.

Kwinkqubo yokonyango, "I-Dostinex" kufuneka ihlale ijonge uxinzelelo lwegazi kunye nokusebenza kwendlela yokutya ngenxa yengozi yokuphuma kwegazi. Ukongezelela, izigulane ezithatha i-Dostinex (ukuphononongwa nokunyuswa kweprolactin kwizinto ezinjalo) akufanele zibandakanyeke okanye ubuncinci ixesha elithile kuyimfuneko ukuyeka ukubandakanyeka kwimisebenzi enobungozi efuna ukugxininiswa kwenyameko kunye nokunyuka kwejubane lokuphendula ngengqondo .

Umbono wezigulane malunga neziyobisi

Njengoko kuthethwe ngaphambili, "I-Dostinex" isicatshulwa samanje nesisebenzayo esingazibangeli iziganeko ezimbi. Isigxina esiphezulu sezigulane ezithatha eli liyeza ngabafazi. Izizathu eziqhelekileyo zokumisela le nkunkuma kukukho kweprolactinoma, ukungakwazi ukukhulelwa nokupheliswa kwesilwanyana eside. Kuzo zonke iimeko, iingxelo zezilwanyana ze-Dostinex kunye neprolactin ephakamileyo zilungile. Isilwayo sivimbela ukuphuhliswa kweprolactinoma (kunye namadoda), inceda abasetyhini ngexesha elifutshane ukugqiba ixesha lexesha elide nelininzi ngaphandle kokusongela ukuphuhlisa imastitis kunye nesidingo sokubopha isifuba. Abasetyhini abangenako ukukhulelwa ngenxa yokuba, njengoko kuvele, inqanaba eliphezulu leprolactin, eligqithise kakhulu kwinqanaba, libonisa ukuba isibonakaliso phakathi kweeveki ezi-2-4 kwafika kwisimo somzimba, kwaye emva kokupheliswa kwe "Dostineks" ukukhulelwa okude kulindeleke kwaqala.

Kukho, ngokuqinisekileyo, kwakhona ukuphononongwa malunga nokungalunganga kokusetyenziswa kwe "Dostinex". Nangona kunjalo, iziphumo zecala cishe azizange zibe nesicatshulwa esithethiweyo kwaye ngokukhawuleza zidlule ngokuzimeleyo xa isicatshulwa sikhoxiswa okanye umthamo wehlisiwe.