"Nimesulide": reviews, ukusetyenziswa analogue

arhente Nonsteroidal antiinflammatory ziludidi akhethekileyo iziyobisi ukuba ezibalulekileyo imiphumela emithathu: antiinflammatory, antipyretic kunye iintlungu. Ngenxa ezi mpawu pharmacodynamic eli qela iziyobisi sisetyenziswa ngokubanzi yezonyango. Makhe sijonge iinkalo isicelo "Nimesulide" iziyobisi, angqina nomonde ngale mveliso amayeza, kwakunye neziphumo kunokwenzeka ezingalunganga kunye neempawu ze nomthamo.

iimpawu pharmacodynamic

"Nimesulide" emele liqela non-steroidal amachiza-ukudumba. Kwiqela oyisebenzisayo libhekisela ukukhetha inhibitors le cyclooxygenase-2 enzyme, ukuba iyasebenza ukuphumeza inhibition zokukhokhela prostaglandins in komtshiso oko.

Esinye isici esasenza indlela yokusebenza "nimesulide" kuqulunqo kukuba layo ukuze kuthintelwe kuvelisa enzyme ebizwa myeloperoxidase, apho abangaphangeliyo ngokubonakalayo imveliso radicals simahla ngaphandle kokuchaphazela iinkqubo chemo- kunye tigmotaksisa kunye phagocytosis. Ukongezelela, "nimesulide" inegalelo kwezithandani le ukuyilwa ithumba necrosis factor kunye nezinye mediators ababandakanyekayo ngayo yokukrala eziphilayo.

Ezona mpawu pharmacokinetic of

Indlela engundoqo zolawulo medicament lolokuthetha, ngenxa bioavailability eliphezulu ichiza, izinga ukuzikisa ingqondo ngokupheleleyo kwi-plasma lwezigulane. Ngoko ke, lo xi ubuninzi kuyafikelelwa emva kwemizuzu 120-180 emva nolawulo, kwaye iqondo nomphetho owujikelezileyo kweziyobisi kunye iiproteni plasma seliza 98% yokulungiselela kuqala zaziswa "nimesulide" (ratings izigulane kunye amagqirha, siyandingqinela ukuba andixoki).

Iqumrhu ephambili apho nethe isiyobisi isibindi. Xa inkqubo biotransformation ibe metabolite esebenzayo ebizwa hydroxynimesulide. Indlela engundoqo kukhuthaza ichiza zinomgutyulo yayo umchamo (ngoko ubonisa-65% iziyobisi), malunga nama-35% beziyobisi esiswini saso iingqatha.

Phantse zonke izigulane phambi kokuthatha ithuba naluphi ulwazi olongezelelweyo ngalo ichiza "Nimesulide". Imiyalelo yokusebenzisa, analogs, kubonakala kunye Izimo, ziziphumo ebezingalindelekanga - sesona ukubuzwa imibuzo.

Ubungqina obubonakalayo buxela

Izinto ezibonisa ukuba ichiza "Nimesulide" hayi kangako. Phakathi kwabo kubalulekile ukukhumbula lumngcungcuthekise ezivela, iintlungu osteoarthritis eziziiprayimari seTrojan lokuqala kwenzeka. Ekusebenzeni ezingabantwana nokusetyenziswa ngempumelelo ichiza. Oku kungqinwa nokwamkelwa ngasekhohlo "Nimesulide" uthetha ncomo. ayikhuthazwa ukuthenga kubantwana abangaphantsi kweminyaka eli-12 ubudala - kufuneka bazazi oku.

Izimo ukuba ichiza

Njengabo bonke anti-ukudumba amachiza "nimesulide" nonsteroidal yi contraindicated phambi kwethumba esiswini okanye isiphene duodenum (12 isilonda duodenal) kwinqanaba etsolo, bewuhlisele detoxifying umsebenzi kwesibindi, xa kutyunjwa ichiza kwiziyobisi hepatotoxic. Ichiza contraindicated kwizigulane kunye ukuhla okubonakalayo excretory umsebenzi kwezintso (ukucoca creatinine ngaphantsi kwe-30 ml / min), iingxaki hematological kunye neengxaki amahlwili, izigulane kakuhle sentliziyo umsebenzi.

"Nimesulide" into contraindicated phambi lezigulane ngezifo ngotyando, oomama abakhulelweyo kunye zokonga, kunye nabantwana abangaphantsi kweminyaka eli-12 ubudala ngenxa amathuba aphezulu basabele ezibi. Akukho mfuneko ukwabela "Nimesulide" kuba unyango lwe umkhuhlane kunye neemeko umkhuhlane-esinjengaso komzimba.

imiphumela emibi

Oku kuthetha ukuba kuphela ebonakala umsebenzi ophezulu anti-ukudumba kodwa obunamanani eliphezulu basabele ezibi. Kwenzeka ngokuqhelekileyo phakathi kwiveki yokuqala unyango with "Nimesulide". Izimvo kukuvela iziphumo ebezingalindelekanga ikhefu kangako.

Ulusu kunye kwicala ulusu ziphumo enxulumene kubonakaliswa kukwalisa ichiza kwaye ziboniswa njengoko zisenzeka sokudlathuka kweenwele kolusu irhashalala, dermatitis, ukuba bomvu, urticaria. nemiphumela emibi kakhulu kangakanani kuthi ezifana ityhefu epidermal necrolysis, Stevens-Johnson syndrome.

Ngomhla inxalenye iphecana zesisu kunqabile kunokubangela ukopha, perforation izilonda. Okunye kuvele intlungu epigastric kummandla, isicaphucaphu, ukugabha, urhudo okanye ukuqhina.

Ngomhla inxalenye yenkqubo luvo kunokubangela silale, nobuthongo ngokugqithiseleyo, ebuhlungu zokunyanzelisa nesiyezi okungeyomfuneko, ukuphazamiseka vestibular.

Ukususela icala kwinkqubo hematopoiesis kunye nemithambo yegazi inokuphuhlisa eosinophilia, thrombocytopenia, kunye pancytopenia, ianemia syndrome, tachycardia, uxinzelelo lwegazi ophakamileyo, ukuphuhliswa hyperkalemia.

Ukusetyenziswa "Nimesulide" kunye nohlaziyo

Ukusebenzisa i "Nimesulide" kuthathwa ngokuqinileyo indawo yayo izifo onyango rheumatologic kwinkqubo musculoskeletal. Nangona kunzima kakhulu bubungqina ichiza "nimesulide" ingxelo entle ngayo ngenxa ukusebenza kwayo eziphakamileyo unyango lwezifo rheumatism. Oku kungenxa ingakumbi iziphumo cyclooxygenase-2 kunye iqondo eliphezulu selectivity ngenxa yale enzyme.

oyi

kufuneka Yintoni balumke xa uthatha le neziyobisi "Nimesulide"? Imiyalelo yokusebenzisa, ncomo nomonde ulwazi malunga ezinye izilumkiso. Enye ingongoma ebalulekileyo apha ukulungiselela le ndawo "nimesulide" kukusetyenziswa ithamo ubuncinane unyango olufanelekileyo lwechiza. Xa engekho ekuzibulaleni Umthamo encinci abafumana ichiza kufuneka kupheliswa.

Kwimeko hepatotoxicity beziyobisi (lowo esweni ngamachiza igazi) zokufumana ichiza nazo kufuneka simiswe ngoko nangoko. Eli qela lwezigulane (ababa isibindi iseli kukwenzakala) ngakumbi umsebenzi aluvumelekanga "Nimesulide." Kufuneka kuqatshelwe ukuba nkqu ukungabikho yeziphumo ebezingalindelekanga zesibindi ichiza kufuneka zidityaniswe iziyobisi hepatotoxic, ezinye NSAIDs, analgesics. Kwakhona, kufuneka uyeke ukusela utywala.

"Nimesulide" kufuneka kube kwiqondo eliphezulu isilumkiso enikwa izigulane ukuba hepatic okanye insufficiency sezintso ukunqanda umngcipheko ukuqhubeka yokugqibela.

ingqalelo ekhethekileyo kufuneka ihlawulwe nokunyulwa ichiza kwizigulane kunye neempawu yomkhuhlane-like. Oku kungenxa yokuba "nimesulide" anazo isiphumo antipyretic kwaye uyakwazi ukufihla iimpawu igciwane.

okwenziwa Drug

Ngenxa ubuchule ophezulu ichiza ukuba ukopha wamathumbu "Nimesulide" kufuneka zidityaniswe kunye anticoagulants ezifana "Warfarin" njengoko kukho umngcipheko omkhulu yeziphumo ebezingalindelekanga.

Ukukwazi kweziyobisi ukuphazamisa umsebenzi cytochrome P450. Ngenxa yomsebenzi yomsebenzi inhibition ye enzyme umthamo iziyobisi umzimba ngendlela cytochrome kufuneka iqwalaselwe phantsi.

"Nimesulide": analogue, ncomo

Le analogs eziphambili (njenge-arhente esebenzayo) are "Nimid", "Nimesil", "Remesulid", "inkunzi-sanovel". Ichiza ifumaneka tablet ifomu 100 neepakethana mg okanye ngohlobo yejeli kwi-10 mg (per-1 g of gel). umsebenzi kwezonyango of analogue beziyobisi kulungile, ngoko izigulane malunga ukubuyekeza kwabo eshiywe njengobuhle. Izigulane eshiya i "Nimesulide" ithetha ncomo, iipilisi kuba incinane ichiza ngokohlobo sachet.

isiphelo

"Nimesulide" esinamandla arhente anti-ukudumba ukunyanga izifo ukudumba, inkqubo ingakumbi musculoskeletal. qiniseka ukuba udibane nogqirha wakho malunga nokuthatha "Nimesulide" kweziyobisi ngenxa umngcipheko omkhulu yeziphumo ebezingalindelekanga kuyimfuneko. Ukuphonononga amagqirha emisela ichiza, kwaye izigulane ezithatha linenzuzo, kuba ikhuthaza nokwehliswa ngokukhawuleza iimpawu zesifo.