Yeyiphi analog "riboksin" ukukhetha: amacebo kunye nohlaziyo

iziyobisi steroid - iqela iziyobisi, indlela engundoqo amanyathelo olujoliswe ekwandiseni amandla nangoncedo iiseli, nokukhawulezisa ukukhula kwabo differentiation, inzuzo ubunzima kunye ukukhawulezisa iinkqubo metabolic. Enye abameli eli qela iziyobisi yi "Riboxinum".

iimpawu amayeza we ichiza

Ukulungiselela "Riboxinum" imele i imveliso steroid amayeza, isiphumo engundoqo iyileyo sibhekiswe ukwandisa ukumelana inyama kwiimeko hypoxia. Njengoko siphu- triphosphate adenosine, "Riboxinum 'inxaxheba kwiinkqubo ze cleavage glucose ngaphakathi kwi seli kwaye, ngenxa yoko, ukuyilwa triphosphate adenosine, nto leyo ke ezinkulu zeendawana amandla cell. Ngenxa yale isiphumo "Riboxinum" abonakalisa ukusebenza anti-hypoxic ngokwemiqathango yehle okubhalwe ATP.

Steroid ukusebenza "riboksin" kubonakaliswa ngokwanda iinkqubo pathways ebandakanya pyruvic acid kunye nokuvuselela ubulunga xanthine dehydrogenase. Ngenxa ezi ziphumo "Riboksin" kunempembelelo entle ekuhambeni neziphumo pathways phakathi kwiiseli, ekukhuthazeni unikezelo yabo yamandla ukusebenza eqhelekileyo.

Xa ndazi myocardium "Riboxinum" uzilungisele myocardiocytes, igalelo epheleleyo ngakumbi kuthanjiswa yabo (ukunyusa phosphorylation umntu iibhondi actin-myosin) kwaye iyazingenela iinkqubo okungenisa kwi myocardium.

Ngokwemiqathango yeenkqubo pharmacokinetic "Riboksin" babezalusa ngokugqibeleleyo waya kwegazi sele mithambo kweli phecana zesisu. Kuba iindlela parenteral lolawulo (i.v.) "Riboxinum" ngokwaneleyo isasazwe ngokukhawuleza kwinyama wawo ukuya kuvala ingxingwa manqanaba alandelayo iiseli pathways kwesibindi, apho wokuqhekeka ngokupheleleyo. Kukhuthaza metabolites unmetabolized kunye iimolekyuli beziyobisi kwenzeka ubukhulu becala kwi umchamo, yaye inxalenye encinane livela endleni kunye inyongo.

Ubungqina obubonakalayo buxela

Drug "Riboksin" kubonisiwe ukunyanga isifo sentliziyo, kubandakanywa nabo kuba unyango lwe-post-iqhosha ithi. Eli chiza nemiphumo enyangayo okulungileyo unyango kwiimo rhythm and Uhanjiso neziphithiphithi, libanda, amalungiselelo zokuma glycosides, unyango iziphene morphological kwemisipha intliziyo, nto leyo imvelaphi umthwalo ngokwasemzimbeni banda, okanye emva izifo ezosulelayo kunye arhabaxa.

"Riboxinum" kuboniswe nothomalaliso kwezifo kwenkqubo hepatobiliary, kuba ekuthinteleni izifo kwinkqubo yegazi ekulungiseleleni ngeedosi eziphezulu ionizing radiation. Ukuziqhelisa lwamehlo, ukusetyenziswa "riboksin" kunilungele kwi open-engile glaucoma.

"Riboksin": imiyalelo, analogs

Xa usebenzisa ifomu elucwecweni ichiza ukubambelela kwezi ngcebiso. Kuba abadala, idosi yemihla ngemihla ichiza zingaqala grams 0.6 ukuya 2.4. Ngokuqhelekileyo, idosi hlengiswe ngamnye, kwaye idosi yemihla ngemihla yohlulwe amathamo eziliqela imini yonke. Misa azipilisi kufuneka idosi ubuncinane, kwaye kuphela ukuba iidosi lincinane ngokuqhelekileyo zivunwe sisigulane, emva kweentsuku 2-3 kuyivusa. Ubude unyango kufuneka ukusuka kwiinyanga-1 ukuya ku-3.

Kulawulo parenteral, i-2% nesisombululo "Riboxinum" exutywe 250 ml ye-saline chloride sodium okanye iswekile. Nokuhlanganiswa wenziwa kancinci ngesantya ngamathontsi 40-60 ngomzuzu.

analogs ezongezelelweyo kunye Izikali efanayo kufuneka kuqatshelwe, "Inosine" yaye "Ribozin", nto leyo eza kuxoxwa ngezantsi.

Izimo ukuba ichiza

Izimo ukunika uvakalelo awongezelelekileyo amacandelo omnye okanye ngaphezulu beziyobisi, sifo kunye namanqanaba ephakamileyo uric acid kwi plasma yegazi. Ngononophelo kakhulu kufuneka imiselwe "Riboksin" kunye analogue "riboksin" "Inosine" izigulane ukusilela umsebenzi kwezintso excretory.

imiphumela emibi

Ngokuqhelekileyo, ichiza laye ukunyamezeleka kakuhle. Phakathi kwabo baye baphawula uvakalelo awongezelelekileyo okufumana ichiza inokubonakalisa nasesikhumbeni ethile. Ngomhla inxalenye yegazi kunokubangela iyangongoza, ukwanda koxinzelelo lwegazi, buthathaka.

Kwimeko yokuba umguli abafumana 'Riboksin "yathi iziphumo ebezingalindelekanga ngasentla, kufuneka udibane nogqirha wakho uze uyeke ezithatha ichiza.

imiyalelo Special ngokufumana

Ekubeni "Riboxinum" kunye metabolites yayo kwazona kakhulu nezintso, akukho ezifanele ukusetyenziswa kweziyobisi phambi ukusilela kwezintso. Ukusetyenziswa kweli chiza ukuze sigwetyelwe kuphela kwimeko apho iinzuzo ezilindelekileyo ichiza ngaphezu nobungozi ukusetyenziswa kwayo. Kulandelwe imithetho efanayo ekuqeshweni ichiza kubafazi abakhulelweyo kunye phindeke.

Xa ujonga impembelelo "riboksin" kwinqanaba uric acid kwi plasma yegazi ngexesha uthomalaliso Kucetyiswa esweni kwayo rhoqo ukwenzela ukuthintela okuvela hyperuricemia.

Ityiwe libanda, iziyobisi

Kwimeko yokufumana amathamo ophezulu medicament zakusa amanyathelo jikelele ejolise ekunciphiseni ichiza nghena egazini. Kwimeko iimpawu ityhefu - unyango nomqondiso. Xa negazi lakho, unyango iminjunju siyasebenza.

"Riboksin": nabalingani

Ukuza kuthi ga ngoku, imarike amayeza akukho namnye analogu "riboksin" kunye indlela steroid amanyathelo. Kulo mzekelo, kukho zombini analogs eziqulathe ezinye esisebenza, kwakunye ntonye epheleleyo beziyobisi, kufuneka kumafa yabo iyafana isithako esebenzayo.

"Inosine" ingase ifane kwaye analog ngokupheleleyo "Riboxinum" lolawulo intramuscular. Xa ezingundoqo zalo, ichiza kwebambela ngokupheleleyo "riboksin" nazo zonke iimpawu zibonisa zayo Izimo. Enye ntonye ingqalelo iziyobisi - "Ribonozin". Le ukulungiselela kwakhona iqulethe isithako esebenzayo, ichiza efanayo "Riboksin" kumafa yayo. Togu abantwana isiraphu - ichiza njengoko "Mildronat". Kwakhona unalo ukukwazi ukunika homeostasis amandla phantse zonke iiseli zomzimba.

Ukuba sicinga iqela amachiza non-steroidal steroid, sinako ukwahlula analogs ezinjalo "Riboxinum" iipilisi njenge "Methyluracil" kunye potassium orotate. La amayeza, nangona zezikaYe- kumaqela ahlukeneyo amayeza, nangona kunjalo, bayakwazi ekuphembeleleni isiphumo steroid. Ngokubanzi, oku kubangelwe nokukhuthaza iinkqubo pathways kuzo zonke iiseli kunye nezihlunu umzimba.

Ukuthelekisa ne ichiza "Riboksin" isasetyenziswa kwisizukulwana esitsha, siphawula ukuba babe ukusebenza aphezulu kunye neziphumo zonyango. A ummeli nilufanele qela yi "Citoflavin". Le Togu "riboksin" Ukongeza lweziphumo cytoprotective kunye antioxidant yaye kunempembelelo oluvuselela olumandla luvo ebuchotsheni.

isiphelo

iziyobisi steroid - iziyobisi iqela ezibanzi kobume kwemichiza ezahlukeneyo. Kuxhomekeka injongo apho uceba ukusebenzisa kubo, ungakhetha "Riboksin" analogue iziyobisi, okanye ahlawule ingqalelo engakumbi kwiqela steroid. Qaphela ukuba oku kucetyiswa isicelo ezizimeleyo kula machiza. Kuphela oyingcaphephe ofanelekileyo ukuba bakuncede ukhetho iziyobisi.