Inducers Interferon, iziyobisi yabantwana: uluhlu lwe isenzo. Fast-ebambeleyo inducer of interferon kwedijithali

Ngenjongo yokuthintela unyango lwezifo wentsholongwane egazini interferon inducers ezisetyenzisiweyo. indlela yazo yokusebenza enxulumene nophuhliso kwezinto protein leyo ethintela phindo kwamagciwane. inductors ezisekelwe machiza alwa nezifo yokuphefumla, herpes kunye nosulelo hepatic kunye influenza.

Guquka interferon

Ngoko ke iqela iikhompawundi yokuba protein imvelaphi. Avelisa iiseli ukuba bosulelekile yi kwamagciwane wentsholongwane egazini.

izinto Interferon okulinganisela of non-ngqo indlela yokuzikhusela emzimbeni bacterium, lwechlamydial, usulelo olungenelelayo ezinzwaneni, izakhiwo cell ithumba. Kwakhona ukudlala indima nabalawuli yolwalamano intercellular nezifo systemic. Zibizwa immunomodulators kunye nohlobo iqala.

Kukho iintlobo ezininzi kwezinto interferon kwabantu leukocyte okanye i-interferon, fibroblast, okanye b-interferon, kunye nezifo okanye g-interferon.

indlela yokusebenza Driving luqala iiproteni ndibopha yaye zemizwa iiseli yohlobo oluthile. Xa intsebenziswano enjalo kuhlelwe iimolekyuli iiproteins zingadlulanga iintsuku ezingamashumi amathathu. Nge ukukhuthazwa peptides yemimiselo ndandithwele umsebenzi T-lymphocyte nezakhiwo macrophage-uhlobo kwenzeka ukuthintela ukungena iintsholongwane ngokusebenzisa inwebu yeseli kunye ukwanda kwabo. Ngabo abanoxanduva kwiipropati zokuzikhusela.

inducers interferon Natural - Iseli wegciwane ngokunyebelezela emzimbeni ephilileyo. Zizinto stimulators ukuzenza nezo bawe phantsi kuzo imveliso iiprothini zokuzikhusela. Uninzi arhente kwezifo enzulu inducers abahluphekayo. Ezi ziquka cytomegalovirus ne-HIV, i-herpes, hepatitis C kunye nefom B Ke ezininzi iintsholongwane ezibangela nokuphefumla izifo egazini, zithathwa stimulators ezinamandla ngokuveliswa iiprothini zokuzikhusela.

inducers Interferon (ARVs): yintoni

ngayo Ngokuqhelekileyo ibhekisa kudidi lwe zokwenziwa amachiza immunomodulators. Bona enziwe kwakhona ziinkampani zamachiza. inducers Interferon (ARVs) zichongwe kwiklasi enkulu lobume ezahlukeneyo eekhemikhali imichiza. components Active kungaba into ephantsi-eliphezulu-eziphilayo, a imvelaphi eyenziweyo okanye yendalo. Besabelana uphawu eqhelekileyo, nto leyo evumela umzimba eyenza iiseli ongowakho, okanye interferon iqala. Ezo amalungiselelo ungakwazi ukubonisa impembelelo antiviral kunye immunomodulating.

Indlela yokwenza isicelo

Inducers of interferon iqala - amalungiselelo ejoliswe, kwiimeko ezininzi, ukuba ulwe usulelo lohlobo. Indlela of ukusebenza kwabo kusekelwe phezu ukunxibelelana lwesiyobisi iziyobisi zeselula kunye inyama isiqulatho esisebenzayo leyo ebangela ekuvelisweni iproteni olukhuselayo.

inducers Interferon - Pharmaceuticals indalo zokuphuhlisa indlela Ukuqhela kwiproteni enziwe. nomphumela yabo efanayo mziba zendalo, eziquka, iiseli wentsholongwane egazini bacteria kunye nezinto ezahlukeneyo.

Ukusetyenziswa inducers interferon kungabangela hyporesponsiveness. Kule meko, phezu ulawulo okuphindwayo ichiza akayi ukuphuhlisa iproteni impendulo yokhuselo, waphawula ingcinezelo yayo. Kweli nqanaba nzima ukulawula ichiza. Ngethuba lokuqhuba kwale uburhulumente kumiselwa inductor. Ukutshintsha isithako esebenzayo, kwakunye ukuphazanyiswa unyango kunye arhente efanayo uncedo ukuphelisa hyporesponsiveness.

Ukuqeshwa iziyobisi ukukhuthaza imveliso protein yokhuselo akuthethi ukuba iziphumo kakhulu ezibi efuna ukususwa zabo.

Ubuhle bokuba inducers protein kwedijithali

Kukho iindlela ezimbini ukwandisa nezifo interferon. Le ayimbumba ezilawulwa ngqo okanye exogenously ngendlela ephilayo. Enye indlela kubandakanya interferonizatsiyu zemveli kunye nokuqaliswa kwezinto ezivuselela imveliso interferon yayo. Le iproteni ubonisa akukho antigenicity, ingeyo interferon amayeza. ulawulo Ixesha elide a machiza protein ogqityiweyo kukhokelela kuphuhliso basabele ezibi.

Inducers of interferon iqala kwi ukufunda ngempumelelo yabo wabonisa umsebenzi amayeza kuluhlu olubanzi zizifo. Kwafunyanwa ipropati yabo bifunctional, esibonakala isiphumo ngokukhawuleza antiviral, nesiphumo immunomodulating.

Isenzo inducers interferon ikhokelele Yindibanisela iiprothini, nto leyo imisebenzi yabo ngathi iiproteni ukulungele-zokhuselo. Loo inkqubo kulinganiswa, iindlela zokulawula balo ngempumelelo ukukhusela kumzimba ukusuka ukwakheka ngokugqithiseleyo ezi zinto.

Ukuze isicelo esisodwa kumalungiselelo ngokuphembelela interferon yi ukujikeleza olude elide lwe kwiproteni akhuselayo ithamo efunekayo nezinyangayo. Ukuze ufumane onjalo idosi ekuqeshweni i protini angaphandle kufuneka ngokuphindaphindiweyo alawulwa imithamo emikhulu. Olu nyango ithathwa ukuba imali eninzi kakhulu.

Uluhlu amachiza

Okwangoku, oogqirha baya usebenzisa inducers interferon - neziyobisi uhla kunyaka ngamnye ukudibanisa amayeza amatsha. Inani elikhulu lee-arhente immunomodulating ikuvumela ukuba ulwe izifo ezininzi.

Njengenxalenye yale nkqubo omzimba abakhoyo amacandelo abenemfundo oqhagamshelwano phakathi eziqulathe ngaphandle kubulawe engaqhelekanga ephilayo imvelaphi iikhompawundi antigenic. isiqalelo ngasinye arhente ethile omzimba. Oku kuchaza ukwahluka iimveliso igalelo kuphuhliso iproteni olukhuselayo.

Kukho inducers ezahlukeneyo interferon (ARVs), uluhlu apho yonganyelwe iziyobisi "Poludan". Esi sixhobo ithathwa le stimulator iiproteni yokuqala yokhuselo, nto leyo eyaqala ukuba usetyenziswa 70s. Oku kuquka poliuridinovaya kunye polyadenylic acid. ukusebenza layo kukuphuhlisa interferon encinane. amathontsi Eye nezitofu beziyobisi "Poludan" baphathe keratitis herpetic kunye keratokonyunktivity. isisombululo Drug yenza izicelo unyango lwe-herpes හසුරුව isiphathi kunye vulvovaginitis.

inducers Interferon - iziyobisi "Aktaviron", "Lavomax", "Tilaksin" "dihydrochloride tilorona", "Amiksin", "Tiloram" - kwi ezakheke isithako tilorona esebenzayo.

Iziyobisi "Ridostin" yaye "sodium ityiwa ribonucleic acid kabini-ndixakene 'ukwenziwa kunye sodium ribonukleat kweziyobisi olibambela.

into umifenovir ezingaqukwanga kwi "Arbidol" Pharmaceuticals, "Arbivir", "Immustat" yaye "Arpeflyu".

Kukho inducers nabo interferon, iziyobisi nibizwayo ngegama izinto esebenzayo. Ezi ziquka amacwecwe "Kagocel" yaye "tilorona".

Ngokusekelwe akridonatsetata meglumine eyenziweyo amayeza "Meglumine akridonatsetat" yaye "TSikloferon" kesodiyam oksodigidroakridinilatsetat ekhoyo kwi iziyobisi "Neovir".

Ukubunjwa lithetha "Jodantipyrin" ibandakanya 1-phenyl-2,3-dimethyl-4-yodpirazolon, kwaye "Alpizarin" macwecwe eziqulathwe magniferrina ityuwa.

Inductors interferon abantwana, inkcazo yazo

Kukho amayeza abadala abaninzi ezinokuthi kunikwa umntwana, kodwa kuphela xa ubudala buthile. Umzekelo, ichiza "TSikloferon" baqale ukunyanga abantwana abaneminyaka emine ngonyaka, yaye lithetha "Ridostin" omiswe kweminyaka esixhenxe. Zombini mithi uluhlu olubanzi yeziphumo. Bona ezilungele ukunyanga izifo zemiphunga zemvelo wentsholongwane egazini, umkhuhlane karhulumente, kohlobo, isifo herpes. Ububi wabo abasabela kunokwenzeka ezingafunekiyo icala.

inducers Interferon - ngamalungiselelo eyenzelwe ngokukodwa abantwana ifom yomntwana ethile. "Arbidol" Phakathi kwabo ziyindlela. Isetyenziswa kunye neminyaka emibini. Abantwana ifomu medicament yenziwe ngohlobo njengezingxobo lolawulo lwangaphakathi. Amalungiselelo anazo Iziphumo antiviral kunye immunomodulatory.

Oku kunxulumene arhente antiviral anqanda ntsholongwane yeseli B kunye A uhlobo. Kukuthatha kwakhe kwavusa ukuveliswa interferon lwangaphakathi, nto leyo ethintela zoqhagamshelwano ukungena kulo usulelo iseli. Phantsi yintshukumo okhuselayo lipid protein imvulophu load akanako connect with iseli ndizayo.

inducers Interferon abantwana igalelo ekwandiseni omzimba le humoral yohlobo umzimba wabo inyathelo uba ukumelana ngakumbi izinto ezosulelayo, kunciphise inani iingxaki.

Drug "Kagocel" kunempembelelo ofanayo emzimbeni yomntwana. Oveliswa ngokohlobo iipilisi ezisetyenziswa lwangaphakathi. Ubudala umda ukusetyenziswa kweziyobisi - kunye iminyaka emithathu.

Unyango lwezifo zemiphunga

inducers Interferon - ichiza lokunyanga SARS, leyo ukuba ukhokelele ekubeni kusekwe kwi kwiiseli ze ephilayo iproteni olukhuselayo. Kananjalo axhobe influenza nokugula.

Eyona ndlela inempumelelo zijongwa amayeza tilorona esekelwe, ezibandakanya iipilisi "tilorona" yaye "Amiksin". Kuba unyango of influenza kunye izifo ezihlasela zosulele viral zemiphunga kucetyiswa ukuba usebenzise umntu omdala ngaphakathi mg 125 ngexesha. Le ithamo zikhutshwe kwiintsuku ezimbini zokuqala, ngoko 125 mg ezithathiweyo ngenye imini. Ikhosi ubungakanani medicament yi 750mg.

Zokwenza amanyathelo othintelo esetyenziswa yi mg 125 ngexesha, ngoko ikhefu leentsuku ezi-6. Ikhondo iphindiwe malunga neeveki ezintandathu.

iziyobisi tilorona asekelwe contraindicated kwi ukunganyamezelani ezikhoyo ngamnye, ngethuba lokukhulelwa ngelixa lwebele-ukondla usana lwakho.

Ukufumana amayeza kunokubangela isicaphucaphu, ifiva, uxabane.

Ukulungiselela "umifenovir" Umsebenzi interferon-ngokuphembelela, ukukhuthazwa yeselula uhlobo sifo, ekukhuthazeni uzinzo yonke ephilayo arhente ezosulelayo.

Kuba amanyathelo othintelo xa edibana nabantu abagulayo emiselweyo idosi yemihla ngemihla mg 200 iveki enye. Ithuba zonyaka influenza nezifo zokuphefumla usebenzisa idosi yemihla ngemihla ye-100 mg ngexesha, ngoko wenze ikhefu iintsuku ezimbini. Le khosi ithatha iiveki ezintathu. Kuba unyango njengomkhuhlane eyabelwe 200 mg izihlandlo ezine ngosuku, iintsuku ezintathu.

Iziyobisi kunye umifenovir lisusiwe ukunyamezelana ezikhoyo ngamnye ngexesha ngezifo kakhulu somatic. Ukwamkelwa kumayeza anjalo kunokubangela negazi lakho.

Unyango lwezifo sokuhlasela

izifo ezifana ziquka ithi zophendlo lwezifo apho ukuphuhlisa izilwa okanye phinda clones iseli ngumbulali autoaggressive njengempendulo ephilile. Oku kukhokelela ukonakalisa nokonakaliswa ephilile, isiphumo leyo nangokurhala sokuhlasela.

Ngokwesiqhelo isetyenziswa kunyango inducers interferon. Imixube yaphathwa izifo samathambo, abo inyathelo immunosuppressive.

Kuba unyango lokusetyenziswa kweziyobisi multiple "Amiksin" saa. Yimiqondiso nakancinane ezihlasela zosulele ngokuphefumla usulelo endalo, nto leyo aggravates imeko yedosi elalabelwe 125 mg okanye 250 mg beziyobisi emva kokungenisa. Iipilisi usele ngemini, ubude ukwamkelwa - ukusuka kwiintsuku ezi-6 ukuya ku-12.

Kuthintelo lwe saa sclerosis exacerbation yabelwe 125 mg beziyobisi, amaxesha 2 iintsuku ezisi-7.

Xa isakhiwo kwesigaba esebenzayo zesi sifo ukunyanga imiqondiso akhoyo amayeza etsolo ezithathwe ngu-10 ukuya kwi-125 mg zonke iintsuku 30 iinyanga ezi-6. Ukulungiselela "Amiksin" yabelwa kunye peptide bioregulators nomphumela leyo kunciphisa ubuntununtunu umzimba ukuba ekwandeni protein myelin.

Ludityanisiwe therapy iziyobisi "TSikloferon" ikuvumela ukuba ulwe moya kunye isifo samathambo, izifo zenkqubo echaphazela kwizicwili. umsebenzi wakhe ejoliswe kwezithandani seenkqubo samathambo, ebonelela anti-ezithintela ukosuleleka kunye iintlungu nefuthe endalo. Ukusebenzisa iindlela ezilawulwayo imeko omzimba kwi ezinxaxhileyo ezahlukeneyo immunodeficient. "TSikloferon" Ichiza lukhutshwe azipilisi, ngokohlobo isisombululo injectable kunye liniment.

Kuba unyango lwe samathambo ichiza ilawulwa yegazi okanye intramuscularly 1 ixesha ngosuku. Le umthamo 250 mg usebenzisa lokuqala ngomhla weshumi kwi iintsuku. Xa izifo ezihlasela zosulele elibachaphazelayo ukwanda ithamo sokuqala mg 500.

Therapy yezifo wegciwane

Drug "Amiksin" libhekisela interferonovym inductors fluoreonovogo ephantsi udidi ubunzima eziphilayo. Nge inxaxheba sakhe zonke iintlobo iiprothini zokuzikhusela, apho umgangatho imini enye emva kokuba isicelo medicament ifikelela ixabiso eliphezulu kakhulu plasma.

Iyeza enoluhlu enkulu yesenzo antiviral. Ukongeza nezifo zokuphefumla, kusetyenziswa hepatitis C kunye etsolo kunye ezingapheliyo, herpes nezolo obuni, usulelo cytomegalovirus kunye nohlobo lwechlamydial.

Maninzi kakhulu amachiza antiviral - inducers interferon, akukho ngaphandle yindlela "Neovir". Kukuthatha yakhe, uvelisa isixa esikhulu kwiproteni yokhuselo, ingakumbi fibroblast-hlobo, nto leyo echaza immunomodulatory, anti-wentsholongwane egazini kunye anti-ithumba isiphumo kweli chiza. Drug "Neovir" imphathe kobuchopho, hepatitis C no B, urethritis, cervicitis, salpingitis zibangelwa yi-chlamydia.

Enye inducer efanayo protein akhuselayo ubunzima ezinto eziphilayo phantsi iziyobisi "TSikloferon", ezisetyenziswa ukuba karboksimetilenakridona amagama methylglucamine ityuwa. Nge inxaxheba kwakhiwa alpha interferon yakhe, umxholo othi ugcinwe inyama lymphoid iintsuku ezintathu.

B lymphocyte T and B-type macrophage yi ukuyilwa iproteni lokuvula akhuselayo ithambo izakhiwo Isiqu ingqondo, ukukhuthazwa imveliso units granulocyte. Ichiza asetyenziswe uphawu-azale kobuchopho, i-herpes, hepatitis, cytomegalovirus, immunodeficiency virus kwabantu papillomas.

Eminye antiviral iindlela exposure Umsebenzi in chlamydia etsolo kwaye ezondeleyo yintsholongwane, nangokurhala indalo erysipilatous, iphika, iingxaki postoperative, usulelo genitourinary, izilonda emathunjini.

Kubonakele kwimarike ichiza yamayeza "Lavomax" wavelisa "Nizhpharm" ngoku. Kuye ukusebenza immunomodulatory, ekwaziyo ngokuphembelela interferon, isiphumo antiviral uluhlu enkulu.

Njengenxalenye "Lavomax" macwecwe eziqulethwe 125 tilorona mg njengoko umchiza. Ichiza le analogu beziyobisi "Amiksin". umsebenzi waso ngqo kwisizukulwana ukukhuthazwa iintlobo ezintathu interferon e-T-lymphocyte, hepatocytes, iiseli epithelial eludongeni emathunjini.

Impembelelo ye immunomodulating iziphumo kungenxa ukubuyisela ulungelelwano phakathi kwiiseli omzimba kunye kuqheleke kwimveliso omzimba. Isiseko indlela komsebenzi antiviral na inhibition iiprotini yokuqaphela, iintsholongwane ezithile kwiindawo eyosulelekileyo komzimba. Oku kugxobha ukwanda kwabo phambili.

Ezifana nomkhuhlane ngamachiza ukunyanga ngempumelelo imeko, isifo, indalo yokuphefumla, hepatitis wentsholongwane egazini kunye herpes angawokubhuda.

Inductors amanyathelo ngokukhawuleza

Ngokuqhelekileyo, ukuqaliswa kwala mayeza kukhokelela ekuphuhliseni okukhawulezayo kwiprotheni ekhuselayo.
Ama-inducers aphezulu kwi-intereferon engamaxesha ambalwa okuhlala emzimbeni angabangela ukwakheka kweprotheni, ebonisa ubungqina babo.

Isixhobo seTyloron emva kwesicelo sangaphakathi sandisa ukwanda kweprotheni kwixabiso eliphezulu emva kweeyure ezingama-4. Kukhona ukusekwa ngokukhawuleza kwe-interferon kuqala emathunjini, ngoko kwintsholongwane, nangomhla - egazini.

Isilwanyana "I-Cycloferon" inciphisa iprotheni emva kweeyure ezingama-4, kwaye inqaku eliphezulu ligcinwa emva kweeyure eziyi-8, emva koko i-concentration iyancipha.